Email

KevinyLI@um.edu.mo

Tel

8822-4695

Office

N22-2055

Consultation Hours

Kevin, Yue LI 李越

Associate Professor

 

Academic Qualifications

Postdoctoral Fellow, University of Wisconsin-Madison, Madison, USA

Ph.D., The University of Hong Kong, China

M.M., Tianjin University of Traditional Chinese Medicine, Tianjin, China

B.S., Tianjin University of Traditional Chinese Medicine, Tianjin, China

Teaching

HSCI7007Advanced Nutrition and Food SafetyUndergraduate Module

Research Interests

Neurogenesis

Drug Discovery

Chinese Herbal Medicine

Neurological disorders (e.g., Autism spectrum disorder, Fragile X syndrome and Stroke)

Dr. Li is broadly interested in regenerative medicine, neurorehabilitation, drug discovery and neural stem cell biology for the study of human mental and intellectual disorders. He employs a combination of genetics, genomics, proteomics, metabolomics, bioinformatics, medicinal chemistry, pharmacology, multi-electrode array, molecular imaging, micromanipulation and behavioral methods to understand the molecular mechanisms that regulate neural stem cells and neurodevelopment with the goal of applying this knowledge in the rehabilitative treatment of human neurological disorders such as Autism spectrum disorder, Fragile X syndrome and Stroke.

Dr. Li (co-) supervised more than 20 under- and postgraduate students. Three undergraduate students received the prestigious Hilldale Fellowship and Waisman Intellectual and Developmental Disabilities Research award, respectively (2016, 2017, 2018) in USA. One Ph.D. student was awarded a prestigious Wisconsin Distinguished Graduate Fellowship (2019) in USA. Two graduate students were awarded highly competitive National Scholarship (2021, 2022) in China.

There are available positions for postdoctoral fellows and graduate students who are interested in neurobiology, pharmacology of Chinese Medicine and drug discovery. Ideal candidates are highly motivated, organized, and have extensive laboratory experience. The postdoctoral fellows will work on several exciting projects. The lab accepts the students from a variety of disciplines. For further information, please contact Dr. Li at KevinyLi@um.edu.mo

 (*: Corresponding authorship; #: First-authorship)

  1. Guo PF, Yang XY, Guo XM, Yang HE, Pan J*, Li Yue*. Dietary fish oil improves autistic behaviors and gut homeostasis by altering the gut microbial composition in a mouse model of fragile X syndrome. Brain Behavior and Immunity, 2023,110:140-151
  2. Liu X, Yuan MM, Lau BWM, Li Yue*. SHANK family on stem cell fate and development. Cell Death & Disease, 2022,13(10):880
  3. MaWX#, Xu D#, Zhao L, Yuan MM, Cui YL*, Li Yue*.Therapeutic role of curcumin in adult neurogenesis for management of psychiatric and neurological disorders: a scientometric study to an in-depth review. Critical Reviews in Food Science and Nutrition,2022:1-13
  4. Huang PF, Zuo QW, Li Y, Tan FX, Wang YY, Liu XH, Li J, Guo F*, Li Yue*, Yang L*. A vicious cycle: in severe and critically ill COVID-19 patients. Frontiers in Immunology, 2022,13:930673
  5. Li L#, Wu YZ#, Wang JB, Yan HM, Lu J, Wang Y, Zhang BL, Zhang JH, Yang J, Wang XY, Zhang M, Li Yue*, Lin M*, Zhang H*. The potential treatment on COVID-19 by Traditional Chinese Medicines: Which herbs help us win the battle raised by SARS-CoV-2? Engineering, 2022:139-152
  6. Yuan MM#, Zhao Lucy#, Li YH, Gao XM, Zhang BL, Zheng DQ*, Li Yue*. Capsaicin on stem cell proliferation and fate determination-a novel perspective. Pharmacological Research, 2021,167:105566
  7. Li Yue*, Guo WX*. Neural Stem Cell Niche and Adult Neurogenesis. The Neuroscientist, 2021, 27(3):235-245
  8. Liu BT#, Li Yue#, Stackpole, Novak A, Gao Y, Zhao Y, Zhao X*, Richter JD*. “Regulatory Discrimination of mRNAs by FMRP Controls Mouse Adult Neural Stem Cell Differentiation”. Proc Natl Acad Sci USA (PNAS), 2018, 115(48): E11397-E11405
  9. Li Yue*, Stockton ME, Eisinger BE, Zhao Y, Miller JL, Bhuiyan I., Gao Y, Wu Z, Peng J, Zhao X*. “Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome”. Nature Communications, 2018, 9: 2494
  10. Li Yue,Stockton ME, Bhuiyan I, Eisinger BE, Gao Y, Bhattacharyya A, Zhao X*. “MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome”. Science Translational Medicine, 2016, 8(336): 336ra61

  1. 李越；张师愚；陈晓鹏；田晓轩。黄芩素在制备治疗脆性X染色体综合征的药物中的应用。中国发明专利 (专利号：ZL202210872645.9)
  2. 李越；陈晓鹏。辣椒素在制备治疗脆性X染色体综合征的药物中的应用。中国发明专利 (专利号：ZL202210858681.X)
  3. 李越；陈晓鹏；崔元璐。青蒿琥酯在制备治疗脆性X染色体综合征的药物中的应用。中国发明专利 (专利号：ZL202210861160.X)
  4. Zhao XY and Li Yue. METHODS FOR TREATING COGNITIVE DEFICITS ASSOCIATED WITH FRAGILE X SYNDROME. U.S Patent (No.: US10,350,204 B2)

  1. 2nd Class Prize Tianjin Science and Technology Progress Award (1st recipient), 2021
  2. Tianjin Natural Science Foundation for Distinguished Young Scholars, 2020
  3. 12th National Conference on Pharmacology of Traditional Chinese Medicine and Natural medicine (Forum for Young Scholars), Tianjin, China. October 11-13, 2019. Oral presentation second Prize Award.
  4. 13th Tianjin 1000-Youth Talents Program Award, 2018
  5. 12th Annual Wisconsin Stem Cell Symposium. Engineering Cells and Tissues for Discovery and Therapy. Wisconsin, USA. April 19, 2017. Poster presentation second Prize Award.
  6. Gregory F. Daniels for the Annual Fall Conference. Wisconsin, USA. September 30, 2016. Outstanding poster presentation Award.

  1. Editorial Board: Pharmacological Research: Modern Chinese Medicine
  2. Editorial Board: Acupuncture and Herbal Medicine
  3. External Reviewer for journals: Nature Communications, EMBO Molecular Medicine, Molecular Psychiatry, Critical Reviews in Food Science and Nutrition, Stem Cell Reports, Stem Cells, Phytomedicine, Neural Regeneration Research, etc. 
  1. External Reviewer for Natural Science Foundation of China (NSFC)