Xiuping CHEN 陳修平


(Prof. Chen has > 200 SCI publications in peer-reviewed journals with >10,000 citations and the h index is 51. (Google scholar, Mar, 2022))

  1. Yu J, Zhong B, Xiao Q, Du L, Hou Y, Sun HS, Lu JJ, Chen X*. Induction of programmed necrosis: A novel anti-cancer strategy for natural compounds. Pharmacol Ther. 2020 Oct;214:107593.
  2. Zhao W, Feng H, Sun W, Liu K, Lu J, Chen X*. Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion. Redox Biology. 2017 Jan 5;11: 524 -534.
  3. Sun W, Wang S, Zhao W, Wu C, Guo S, Hongwei G, Hongxun T, Lu JJ, Wang Y, Chen XP*. Chemical Constituents and Biological Research on Plants in the Genus Curcuma. Crit Rev Food Sci Nutr. 2017 ; 57(7):1451-1523.
  4. Chen X, Zhong Z, Xu Z, Chen L, Wang Y. 2′,7′-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy. Free Radic Res. 2010; 44(6):587-604.
  5. Zhao W, Li C, Zhang H, Zhou Q, Chen X, Han Y, Chen X*. Dihydrotanshinone I Attenuates Plaque Vulnerability in Apolipoprotein E-Deficient Mice: Role of Receptor-Interacting Protein 3. Antioxid Redox Signal. 2020 Jun 4.
  6. Sun W, Yu J, Gao H, Wu X, Wang S, Hou Y, Lu JJ, Chen X*. Inhibition of Lung Cancer by 2-Methoxy-6-Acetyl-7-Methyljuglone Through Induction of Necroptosis by Targeting Receptor- Interacting Protein 1. Antioxid Redox Signal. 2019 Jul 10;31(2):93-108.
  7. Yu J, Zhong B, Zhao L, Hou Y, Wang X, Chen X. Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors Necrostatin-1 (Nec-1) and 7-Cl-O-Nec-1 (Nec-1s) are potent inhibitors of NAD(P)H: Quinone oxidoreductase 1 (NQO1). Free Radic Biol Med. 2021 Sep;173:64-69.
  8. Zhong B, Yu J, Hou Y, Ai N, Ge W, Lu JJ, Chen X*. A novel strategy for glioblastoma treatment by induction of noptosis, an NQO1-dependent necrosis. Free Radic Biol Med. 2021 Apr;166:104-115.
  9. Yu J, Zhong B, Jin L, Hou Y, Ai N, Ge W, Li L, Liu S, Lu JJ, Chen X*. 2-Methoxy-6-acetyl- 7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1). Free Radic Biol Med. 2020 May 20;152:336-347.
  10. Sun W, Wu X, Gao H, Yu J, Zhao W, Lu JJ, Wang J, Du G, Chen X*. Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells. Free Radic Biol Med. 2017 Jul;108:433-444.
  11. Sun W, Bao J, Lin W, Gao H, Zhao W, Zhang Q, Leung CH, Ma DL, Lu J, Chen X*. 2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H(2)O(2)-dependent JNK activation in cancer cells. Free Radic Biol Med. 2016 Jan 21;92:61-77.
  12. Gao H, Cui Y, Kang N, Liu X, Liu Y, Zou Y, Zhang Z, Li X, Yang S, Li J, Wang C, Xu QM, Chen X*. Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking TLR4 dimerization. Br J Pharmacol. 2017 Sep; 174(17):2880-2896.
  13. Wu C, Chen J, Yang R, Duan F, Li S, Chen X*. Mitochondrial protective effect of neferine through the modulation of Nrf2 signalling in ischemic stroke. Br J Pharmacol. 2019 Feb;176(3):400-415.
  14. Hou Y, Liu R, Xia M, Sun C, Zhong B, Yu J, Ai N, Lu JJ, Ge W, Liu B, Chen X. Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo. Pharmacol Res. 2021 Sep 7;173:105870.
  15. Wang M, Lin L, Lu JJ, Chen X*. Pharmacological review of isobavachalcone, a naturally occurring chalcone. Pharmacol Res. 2021 Mar;165:105483.
  16. Sun C, Zhao W, Wang X, Sun Y, Chen X. A pharmacological review of dicoumarol: An old natural anticoagulant agent. Pharmacol Res. 2020 Oct;160:105193.
  17. Chen X*, Yu J, Zhong B, Lu J, Lu JJ, Li S, Lu Y. Pharmacological activities of dihydrotanshinone I, a natural product from Salvia miltiorrhiza Pharmacol Res. 2019 Jul;145:104254.
  18. Zhou Y, Zhong B, Min X, Hou Y, Lin L, Wu Q, Shi J, Chen X. Therapeutic potential of isobavachalcone, a natural flavonoid, in murine experimental colitis by inhibiting NF-κB p65. Phytother Res. 2021 Aug 25.
  19. Min X, Zeng X, Zhao W, Han Z, Wang Y, Han Y, Pei L, Chen X*. Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation. Phytother Res. 2020 Oct;34(10):2639-2648.
  20. Luo W, Liu X, Sun W, Lu JJ, Wang Y*, Chen X*. Toosendanin, a natural product, inhibited TGF-β1- induced epithelial-mesenchymal transition through ERK/Snail pathway. Phytother Res. 2018 Oct;32 (10): 2009-2020.
  21. Wu X, Gao H, Sun W, Yu J, Hu H, Xu Q, Chen X*. Nepetoidin B, a Natural Product, Inhibits LPS- stimulated Nitric Oxide Production via Modulation of iNOS Mediated by NF-κB/MKP-5 Pathways. Phytother Res. 2017 Jul;31(7):1072-1077.
  22. Yu J, Wang C, Kong Q, Wu X, Lu JJ, Chen X*. Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products. Phytomedicine. 2018 Feb 1;40:125-139.
  23. Ren G, Luo W, Sun W, Niu Y, Ma DL, Leung CH, Wang Y, Lu JJ, Chen X*. Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells. Phytomedicine. 2016 Aug 15;23(9):939-47.
  24. Chen X, Pei L, Zhong Z, Guo J, Zhang Q, Wang Y. Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. Phytomedicine. 2011 Nov 15;18(14): 1238-43.
  25. Wang X, Wang X, Zhu Y, Chen X*. ADME/T-based strategies for paraquat detoxification: Transporters and enzymes. Environ Pollut. 2021 Sep 9;291:118137.
  26. Liu X, Zhang Y, Gao H, Hou Y, Lu JJ, Feng Y, Xu Q, Liu B, Chen X*. Induction of an MLKL mediated non-canonical necroptosis through reactive oxygen species by tanshinol A in lung cancer cells. Biochem Pharmacol. 2020 Jan;171:113684.
  27. Gao H, Liu X, Sun W, Kang N, Liu Y, Yang S, Xu QM, Wang C, Chen X*. Total tanshinones exhibit anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway. Cell Death Dis. 2017 Aug 17;8(8):e3004.
  28. Wu C, Zhao W, Zhang X, Chen X*. Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9.
  29. Chen X*, Guo J, Bao J, Lu J, Wang Y. The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review. Med Res Rev. 2014 Jul;34(4):768-94.
  30. Guo J, Wu G, Bao J, Hao W, Lu J, Chen X*. Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. PLoS One. 2014 Feb 4;9(2):e88140.
  31. Chen X, Lu J, Bao J, Guo J, Shi J, Wang Y. Adiponectin: a biomarker for rheumatoid arthritis? Cytokine Growth Factor Rev. 2013 Feb;24(1):83-9.
  32. Chen X, Zhang H, McAfee S, Zhang C. The reciprocal relationship between adiponectin and LOX-1 in the regulation of endothelial dysfunction in ApoE knockout mice. Am J Physiol Heart Circ Physiol. 2010; 299(3): H605-12.
  • 17th SERVIER Young Pharmacologist Award (2013)
  • Macao Science and Technology Awards (Second prize) (2012)(3rd)
  • Macao Science and Technology Awards (Second prize) (2014)(5th)