rwang

Email

rwang@um.edu.mo

Tel

(853) 8822-4689

Office

N22-8009

Consultation Hours

Tue: 9:00~10:00
Thu: 9:00~10:00

Group Website

https://rwang.sklqrcm.um.edu.mo/

Rui Bing WANG 王瑞兵

Associate Professor
Interim Director of Global Affairs Office

Group Webpage: https://rwang.sklqrcm.um.edu.mo/

Academic Qualifications

  • Ph.D. in Organic Chemistry, Queen’s University, Canada
  • B.Sc. in Chemistry (Gifted Class), Jilin University, China

Teaching

B.Sc. Courses

  • Modern Drug Discovery (GEST021)

M.Sc. and Ph.D. Courses

  • CMED7013 Emerging Materials in Clinical Medicine (M.Sc. Course)
  • CMED8002 Advanced Pharmaceutics (Ph.D. Course)

Research Interests

  • Supramolecular Medicine

We are interested in supramolecular interactions between macrocyclic molecules (such as cucurbiturils, cyclodextrins, pillararenes and calixarenes) and synthetic/natural drugs, with intentions to explore the beneficial roles of these macrocycles as emerging excipients for enhancing the water solubility, stability, transcellular activity, and ultimately therapeutic efficacy with reduced side effects of guest medicines. In some cases, these macrocycles may act as reversal agents (or antidotes) towards toxic effects of guest drugs. Our collaborators include colleagues here at UM, as well as external scientists from Canada, France, USA, Hong Kong and mainland China.

  • Supramolecular Biomaterials

We intend to incorporate high potency ingredients (e.g. particularly those of natural products) into stimuli-responsive, supramolecularly self-assembled materials for various biomedical applications such as precision medicine and controlled drug release for targeted therapy.  These material matrices include natural polysaccharides, natural and synthetic macrocycles and their derivatives. By placing real-world clinical applications as our study aim, we work closely with scientists and clinicians in the region and around the world.

  • Biomimetic and Cell-based Drug Delivery

Constantly inspired by Nature and ancient principles of Chinese medicine, we are highly interested in developing biomimetic drug delivery systems and live-cell based drug delivery systems, particularly those based on intracellular and extracellular supramolecular assembly, for improved therapy of a variety of diseases, such as inflammatory diseases, infections and cancers.

Dr. Ruibing Wang has multidisciplinary background and experience in Supramolecular Chemistry, Nanomaterials, Pharmaceutics, and Radiopharmaceuticals. During his PhD studies at Queen’s University, he was among the earliest group of researchers to look into a group of novel macrocyclic molecules, cucurbiturils, and their supramolecular encapsulation of various guest molecules including drug molecules for stability and water-solubility enhancement. Due to his excellent thesis work, he was nominated for “Governor General Gold Medal” and received “Queen’s University Outstanding Thesis in Physical Sciences”. After graduation with PhD degree and a brief postdoctoral stay at Queen’s, he moved to the Steacie Institute for Molecular Sciences at the National Research Council (NRC) of Canada as a Research Associate (later promoted to Associate Research Officer) for about two years, where he worked on fluorescent quantum dots development and studied their various applications including bioimaging. He subsequently joined BTG International Canada (recently acquired by Boston Scientific) as a Senior Scientist, where he had led various innovation and applied research projects around radiopharmaceuticals and interventional medicine development (e.g. TheraSphere). In late 2014, he joined the University of Macau (UM) as an Assistant Professor in Pharmaceutical Sciences and was promoted to Associate Professor in 2019. His current research interest is mainly focused on supramolecular medicine, supramolecular biomaterials and drug delivery systems. Since joining UM, he has received several prestigious awards including Faculty-Level Academic Award in 2018, Macau Science and Technology Awards (3rd Prize, Natural Science Award) in 2018, Faculty-Level Best Teacher Award in 2019, UM Teaching Excellence Award in 2019, China Macrocyclic Arenes and Supramolecular Chemistry Rising Star Award in 2019, Chinese Periodic Table of Young Chemist in 2019, Macau Science and Technology Awards (3rd Prize, Technological Invention Award) in 2020, and Faculty-Level Outstanding Academic Staff Award in 2021. Thus far, he has published over 170 peer-reviewed SCI papers with a total citation of over 5,000 times and an H-index of 40 (Google Scholar).

Selected Publications during the recent 3 years

  1. Kuikun Yang, Guocan Yu, Zhiqing Yang, Ludan Yue, Xiangjun Zhang, Chen Sun, Jianwen Wei, Lang Rao, Xiaoyuan Chen,* and Ruibing Wang,*“Supramolecular Polymerization-induced Nanoassemblies for Self-augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor,” Angewandte Chemie, 2021, 60, 17570-17578.
  2. Shuwen Guo, Qiaoxian Huang, Yuan Chen, Jianwen Wei, Jun Zheng, Leyong Wang, Yitao Wang and Ruibing Wang,*“Synthesis and Bioactivity of Guanidinium‐Functionalized Pillar[5]arene as a Biofilm Disruptor,” Angewandte Chemie, 2021, 60, 618-623 (hot paper and frontipiece highlight).
  3. Xue Yang, Qian Cheng Valerie Monnier, Laurence Charles, Hakim Karoui, Olivier Ouari, Didier Gigmes, Ruibing Wang,* Anthony Kermagoret,* and David Bardelang,* “Guest exchange by a partial energy ratchet in water,” Angewandte Chemie, 2021, 60, 6617–6623.
  4. Cheng Gao, Qian Cheng, Junyan Li, Jia Chen, Qingfu Wang, Jianwen Wei, Qiaoxian Huang, Simon M. Y. Lee,* Dayong Gu,* Ruibing Wang,*”Supramolecular macrophage-liposome marriage for cell-hitchhiking delivery and immunotherapy of acute pneumonia and melanoma,” Advanced Functional Materials, 2021, 2102440.
  5. Kuikun Yang, Guocan Yu, Rui Tian, Zijian Zhou, Hongzhang Deng*, Ling Li, Zhen Yang, Guofeng Zhang, Dahai Liu, Jianwen Wei, Ludan Yue, Ruibing Wang,*and Xiaoyuan Chen,* “Oxygen-Evolving Manganese Ferrite Nanovesicles for Hypoxia-Responsive Drug Delivery and Enhanced Cancer Chemoimmunotherapy,” Advanced Functional Materials, 2021, 31, 2008078.
  6. Ludan Yue, Kuikun Yang, Junyan Li, Qian Cheng and Ruibing Wang*“Self-Propelled Asymmetrical Nanomotor for Self-Reported Gas Therapy,” Small, 2021, 6, DOI:10.1002/smll.202102286.
  7. Chen Sun, Ziyi Wang, Kuikun Yang, Ludan Yue, Qian Cheng, Yan-long Ma, Siyu Lu, Guosong Chen, and Ruibing Wang,* “Polyamine-responsive Morphological Transformation of a Supramolecular Peptide for Specific Drug Accumulation and Retention in Cancer Cells,” Small,2021, DOI: 10.1002/smll.202101139.
  8. Kuikun Yang, Ludan Yue, Zhiqing Yang, Guocan Yu, Lang Rao, Rui Tian, Jianwen Wei, Chen Sun, Xiangjun Zhang, Mengze Xu, Zhen Yuan, Xiaoyuan Chen,* and Ruibing Wang,*“A Hypoxia Responsive Nanoassembly for Tumor Specific Oxygenation and Enhanced Sonodynamic Therapy,” Biomaterials, 2021,  275, 120822.
  9. Jia Chen, Shengke Li, Zeyu Wang, Yating Pan, Jianwen Wei, Siyu Lu, Qing-Wen Zhang, LianHui Wang and Ruibing Wang* “Synthesis of AIEgen Functionalized Cucurbit[7]uril for Subcellular Bioimaging and Synergistic Photodynamic Therapy and Supramolecular Chemotherapy“, Chemical Science,2021,  12, 7727-7734. Selected as a Chem Sci Pick!
  10. Hang Yin, David Bardelang* and Ruibing Wang,*“Macrocycles and Related Hosts as supramolecular antidotes,” Trends in Chemistry, 2021, 3, 1-4.
  11. Ludan Yue, Kuikun Yang, Xin-Yue Lou, Ying-Wei Yang* and Ruibing Wang,*“Versatile roles of macrocycles in organic-inorganic hybrid materials for biomedical applications,” Matter, 2020, 3, 1557–1588.
  12. Chen Sun, Ziyi Wang, Ludan Yue, Qiaoxian Huang, Qian Cheng and Ruibing Wang,*“Supramolecular Induction of Mitochondrial Aggregation and Fusion,” Journal of the American Chemical Society, 2020, 142, 16523–16527 (featured as a Supplementary Cover Article).
  13. Qiaoxian Huang, Hong Zhao, Mingju Shui, Dong-Sheng Guo* and Ruibing Wang,*“Heparin Reversal by an Oligoethylene Glycol Functionalized Guanidinocalixarene,” Chemical Science, 2020, 11, 9623-9629.
  14. Cheng Gao, Qian Cheng, Jianwen Wei, Chen Sun, Siyu Lu, Cheryl H.T. Kwong, Simon M.Y. Lee, Zhiyuan Zhong* and Ruibing Wang,*“Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery,” Materials Today, 2020, 40, 9-17 (selected as an Inside Cover Feature Article).
  15. Xue Yang, Ruibing Wang,*Anthony Kermagoret,* and David Bardelang,* “Oligomeric Cucurbituril Complexes: from Peculiar Assemblies to Emerging Applications,” Angewandte Chemie, 2020, 132, 21464–21476.
  16. Cheng Gao, Qiaoxian Huang, Conghui Liu, Cheryl H.T Kwong, Ludan Yue, Jian-Bo Wan, Simon M. Y. Lee* and Ruibing Wang,* “Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines,” Nature Communications, 2020, 11, 2622. Highlighted by Nature Review Cardiology, 2020.
  17. Chenwen Li, Yang Zhao, Juan Cheng, Jiawei Guo, Qixiong Zhang, Xiangjun Zhang, Jiong Ren, Fengchao Wang, Jun Huang, Houyuan Hu, Ruibing Wang,* and Jianxiang Zhang,* “A Proresolving Peptide Nanotherapy for Site-Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota,” Advanced Science, 2019, 6, 1900610.
  18. Sébastien Combes, Khoa Truong Tran, Mehmet Menaf Ayhan, Hakim Karoui, Antal Rockenbauer, Alain Tonetto, Valérie Monnier, Laurence Charles, Roselyne Rosas, Stéphane Viel, Didier Siri, Paul Tordo, Sylvain Clair, Ruibing Wang,* David Bardelang,* and Olivier Ouari,* “Triangular regulation of cucurbit[8]uril 1:1 complexes,” Journal of the American Chemical Society, 2019, 141, 5897-5907 (selected as a Supplementary Cover Article).
  19. Cheng Gao, Qiaoxian Huang, Qingping Lan, Yu Feng, Fan Tang, Maggie P.M. Hoi, Jianxiang Zhang, Simon M. Y. Lee,* and Ruibing Wang,* “A user-friendly herbicide derived from photo-responsive supramolecular vesicles,” Nature Communications, 2018, 9, 2967.
  20. Songling Han, Siyu Chen, Lanlan Li, Jin Li, Huijie An, Hui Tao, Yi Jia, Shan Lu, Ruibing Wang,* and Jianxiang Zhang,* “Multiscale and Multifunctional Emulsions by Host-Guest Interaction-Mediated Self-Assembly,” ACS Central Science, 2018, 4, 600-605 (Banner highlight).

2021         ICMS Outstanding Academic Staff Award, University of Macau

2020         Macau Science and Technology Award (3rd Prize, Technological Invention Award)

2019         2018-2019 Top 1% Reviewer in Cross-Fields by Publons

2019         2018-2019 Top 1% Reviewer in Chemistry by Publons 

2019         Periodic Table of Chinese Young Chemist (Chinese Chemical Society)

2019         China Macrocyclic Arenes and Supramolecular Chemistry Rising Star Award

2019         University of Macau Teaching Excellence Award

2019         Faculty Level Best Teacher Award, University of Macau

2018         Macau Science and Technology Award (3rd Prize, Natural Science Award)

2018         Faculty Level Academic Award, University of Macau

2013         Business Excellerator Stage Award, BTG plc, Ottawa, Canada

2011         Business Excellerator Sprinter Award, Nordion Inc., Ottawa, Canada

2008         Physical Sciences Outstanding Thesis Award at Queen’s University

2003-2007    Queen’s Graduate Awards, Kingston at Queen’s University

2005-2006    Graduate Dean’s Doctoral Field Travel Grant at Queen’s University

2002         Outstanding Graduate of Jilin University (top 1%)

1998-2002    Excellent Undergraduate Scholarship, Jilin University

2000-2001    Excellent Student Leader of Jilin University

2001-2002    Zhanhong Scholarship, Jilin University

1998-2000    Dong Rong Scholarship, Jilin University

Students Awards

2020 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Qian Cheng (MSc Student)

2020 UM Macao Postdoctoral Fellowship (aka “Million Dollar Postdoc”): Cheng Gao (PhD Student)

2018 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Xue Yang (MSc Student)

2018 UM Macao PhD Fellowship (aka “Million Dollar PhD Scholarship”): Qiaoxian Huang (MSc Student)

2016 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Huanxian Chen (MSc Student)

2016/2017 Macao SAR Government MSc Student Scholarship: Jess Kuok (MSc Student)

Founding Member and President, Macau Society of Supramolecular Chemistry and Biomaterials (MSSCB), since 2020

Founding Member and Vice President, Macau Society of Nuclear Medicine and Molecular Imaging (MSNMMI), since 2016

Council Member, the 1st Board of Specialty Committee of TCM Network Pharmacology of World Federation of Chinese Medicine Societies, since 2015

Council Member, the 3rd Board of Specialty Committee of TCM Pharmaceutics of World Federation of Chinese Medicine Societies, since 2018

Member, Chinese Chemical Society

Member, International Society for Chinese Medicine

Permanent Member, Macao Society for Promotion of Science and Technology

  • Member of Editorial Advisory Board, ACS Applied Biomaterials, Jan. 2020-Present
  • Editor, Journal of Nanomaterials, February 2012-Present
  • Editor, Chinese Journal of Chemical Education (Chinese Core journal), Jan 2017-Present
  • Member of Youth Editorial Board, Chinese Chemical Letters, Jan. 2019-Present
  • Grant Reviewer for National Science Foundation of China (NSFC), French National Research Agency (ANR) and Czech Science Foundation (GACR)