rwang

Email

rwang@um.edu.mo

Tel

(853) 8822-4689

Office

N22-8009

Consultation Hours

Tue: 9:00~10:00
Thu: 9:00~10:00

Group Website

https://rwang.sklqrcm.um.edu.mo/

Rui Bing WANG 王瑞兵

Associate Professor
Programme Director (State Key Laboratory of Quality Research in Chinese Medicine, University of Macau)

Academic Qualifications

  • Ph.D. in Organic Chemistry, Queen’s University, Canada
  • B.Sc. in Chemistry (Gifted Class), Jilin University, China

Teaching

B.Sc. Courses

  • Modern Drug Discovery (GEST021)

M.Sc. and Ph.D. Courses

  • CMED7013 Emerging Materials in Clinical Medicine (M.Sc. Course)
  • CMED7017 Across the Gap between Science and Industry (M.Sc. Course)
  • CMED8002 Advanced Pharmaceutics (Ph.D. Course)

Research Interests

  • Supramolecular Medicine
    We are interested in supramolecular interactions between macrocyclic molecules (such as cucurbiturils, cyclodextrins, pillararenes and calixarenes) and synthetic/natural drugs, with intentions to explore the beneficial roles of these macrocycles as emerging excipients for enhancing the water solubility, stability, transcellular activity, and ultimately therapeutic efficacy with reduced side effects of guest medicines. In some cases, these macrocycles may act as reversal agents (or antidotes) towards toxic effects of guest drugs. Our collaborators include colleagues here at UM, as well as external scientists from Canada, France, USA, Hong Kong and mainland China.
  • Supramolecular Biomaterials
    We intend to incorporate high potency ingredients (e.g. particularly those of natural products) into stimuli-responsive, supramolecularly self-assembled materials for various biomedical applications such as precision medicine and controlled drug release for targeted therapy.  These material matrices include natural polysaccharides, natural and synthetic macrocycles and their derivatives. By placing real-world clinical applications as our study aim, we work closely with scientists and clinicians in the region and around the world.
  • Biomimetic Drug Delivery
    Constantly inspired by Nature and ancient principles of Chinese medicine, we are highly interested in developing biomimetic drug delivery systems and live-cell based drug delivery systems, particularly those based on supramolecular assembly, for improved therapeutics in a variety of diseases, such as inflammatory diseases, infections and cancers.

Dr. Ruibing Wang has multidisciplinary background and experience in Supramolecular Chemistry, Nanomaterials, Pharmaceutics, and Radiopharmaceuticals. During his PhD studies at Queen’s University, he was among the earliest group of researchers to look into a group of novel macrocyclic molecules, cucurbiturils, and their supramolecular encapsulation of various guest molecules including drug molecules for stability and water-solubility enhancement. Due to his excellent thesis work, he was nominated for “Governor General Gold Medal” and received “Queen’s University Outstanding Thesis in Physical Sciences”. After graduation with PhD degree and a brief postdoctoral stay at Queen’s, he moved to the Steacie Institute for Molecular Sciences at the National Research Council (NRC) of Canada as a Research Associate (later promoted to Associate Research Officer) for about two years, where he worked on fluorescent quantum dots development and studied their various applications including bioimaging. He subsequently joined BTG International Canada (recently acquired by Boston Scientific) as a Senior Scientist, where he had led various innovation and applied research projects around radiopharmaceuticals and interventional medicine development. In late 2014, he joined the University of Macau (UM) as an Assistant Professor in Pharmaceutical Sciences and was promoted to Associate Professor in 2019. His current research interest is mainly focused on supramolecular medicine, supramolecular biomaterials, biomimetic drug delivery systems and molecular imaging. Since joining UM, he has received several prestigious awards including Faculty-Level Academic Award in 2018, Macau Science and Technology Awards (3rd Prize, Natural Science Award) in 2018, Faculty-Level Best Teacher Award in 2019, UM Teaching Excellence Award in 2019, China Macrocyclic Arenes and Supramolecular Chemistry Rising Star Award in 2019, Chinese Periodic Table of Young Chemist in 2019, and Macau Science and Technology Awards (3rd Prize, Technological Invention Award) in 2020. So far, he has published about 150 peer-reviewed SCI papers with a total citation of over 3,800 times and an H-index of 34.

Selected Publications during the recent 3 years

  1. Ludan Yue, Kuikun Yang, Xin-Yue Lou, Ying-Wei Yang,* and Ruibing Wang,* “Versatile roles of macrocycles in organic-inorganic hybrid materials for biomedical applications,” Matter, 2020, in press.
  2. Hang Yin, David Bardelang* and Ruibing Wang,* “Macrocycles and congeners as supramolecular antidotes,” Trends in Chemistry, 2020, DOI: 10.1016/j.trechm.2020.08.008, in press.
  3. Xue Yang, Ruibing Wang,* Anthony Kermagoret,* and David Bardelang,* “Oligomeric Cucurbituril Complexes: from Peculiar Assemblies to Emerging Applications,” Angewandte Chemie, 2020, DOI: 10.1002/anie.202004622, in press.
  4. Cheng Gao, Qian Cheng, Jianwen Wei, Chen Sun, Siyu Lu, Cheryl H.T. Kwong, Simon M.Y. Lee, Zhiyuan Zhong* and Ruibing Wang,* “Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery,” Materials Today, 2020, DOI: 10.1016/j.mattod.2020.05.023, in press.
    Selected as an inside Cover Story.
  1. Chen Sun, Ziyi Wang, Ludan Yue, Qiaoxian Huang, Qian Cheng and Ruibing Wang,* “Supramolecular Induction of Mitochondrial Aggregation and Fusion,” Journal of the American Chemical Society, 2020, 142, 16523–16527.
    Featured as a supplementary Cover Story.
  1. Qiaoxian Huang, Hong Zhao, Mingju Shui, Dong-Sheng Guo* and Ruibing Wang,* “Heparin Reversal by an Oligoethylene Glycol Functionalized Guanidinocalixarene,” Chemical Science, 2020, 11, 9623-9629.
  2. Cheng Gao, Qiaoxian Huang, Conghui Liu, Cheryl H.T Kwong, Ludan Yue, Jian-Bo Wan, Simon M. Y. Lee* and Ruibing Wang,* “Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines,” Nature Communications, 2020, 11, 2622.
    Highlighted by Nature Review Cardiology, 2020, 17, 454.
  1. Chen Sun, Ludan Yue, Qian Cheng, Ziyi Wang and Ruibing Wang,* “Macrocycle-Based Polymer Nanocapsules for Hypoxia-Responsive Payload Delivery,” ACS Materials Letters, 2020, 2, 266-271.
    Featured by X-Mol Platform at https://mp.weixin.qq.com/s/zy4tYTsXy6QAwFwf5uFFRw
  1. Chenwen Li, Yang Zhao, Juan Cheng, Jiawei Guo, Qixiong Zhang, Xiangjun Zhang, Jiong Ren, Fengchao Wang, Jun Huang, Houyuan Hu, Ruibing Wang,* and Jianxiang Zhang*, “A Proresolving Peptide Nanotherapy for Site-Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota,” Advanced Science, 2019, 6, 1900610.
  2. Sébastien Combes, Khoa Truong Tran, Mehmet Menaf Ayhan, Hakim Karoui, Antal Rockenbauer, Alain Tonetto, Valérie Monnier, Laurence Charles, Roselyne Rosas, Stéphane Viel, Didier Siri, Paul Tordo, Sylvain Clair, Ruibing Wang,* David Bardelang,* and Olivier Ouari,* “Triangular regulation of cucurbit[8]uril 1:1 complexes,” Journal of the American Chemical Society, 2019, 141, 5897.
    Featured as a Supplementary Cover Story
  1. Cheng Gao, Qiaoxian Huang, Qingping Lan, Yu Feng, Fan Tang, Maggie P.M. Hoi, Jianxiang Zhang, Simon M. Y. Lee,* and Ruibing Wang,* “A user-friendly herbicide derived from photo-responsive supramolecular vesicles,” Nature Communications, 2018, 9, 2967.
    Highlighted by X-MOL Platform (Aug. 18, 2018) http://www.x-mol.com/news/13859
  1. Songling Han, Siyu Chen, Lanlan Li, Jin Li, Huijie An, Hui Tao, Yi Jia, Shan Lu, Ruibing Wang,* and Jianxiang Zhang,* “Multiscale and Multifunctional Emulsions by Host-Guest Interaction-Mediated Self-Assembly,” ACS Central Science, 2018, 4, 600.
    Highlighted by Hero Image of the ACS Central Science home page
  1. Tianlei Sun, Cheryl H. T. Kwong, Cheng Gao, Jianwen Wei, Ludan Yue, Jianxiang Zhang, Richard Dequan Ye* and Ruibing Wang,* “Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine,” Theranostics, 2020, 10, 10106-10119.
  2. Linting Li, Min Liu, Ludan Yue, Rui Wang, Ning Zhang, Yujie Liang, Liang Zhang, Lixin Cheng,* Jiang Xia,* and Ruibing Wang,* “Host–Guest Protein Assembly for Affinity Purification of Methyllysine Proteomes,” Analytical Chemistry, 2020, 92, 9322-9329.
  3. Cheng Gao, Cheryl H. T. Kwong, Chen Sun, Zheng Li, Siyu Lu, Ying-Wei Yang,* Simon Ming-Yuen Lee,* and Ruibing Wang,* “Selective Decoating-Induced Activation of Supramolecularly Coated Toxic Nanoparticles for Multiple Applications,” ACS Applied Materials & Interfaces, 2020, 12, 25604–25615.
  4. Lin Qi, Ruibing Wang,* and Hua-Zhong Yu,* “Electrochemical Quantitation of Supramolecular Excipient@Drug Complexation: A General Assay Strategy based on Competitive Host Binding with Surface-Immobilized Redox Guest,” Analytical Chemistry, 2020, 92, 2168-2175.
  5. Yuanfu Ding, Jianwen Wei, Shengke Li, Yating Pan, Lianhui Wang and Ruibing Wang,* “Host-guest Interactions Initiated Supramolecular Chitosan Nanogels for Selective Intracellular Drug Delivery,” ACS Applied Materials & Interfaces, 2019, 11, 28665.
  6. Chen Sun, Haipeng Zhang, Ludan Yue, Shengke Li, Qian Cheng, and Ruibing Wang,* “Facile preparation of cucurbit[6]uril-based polymer nanocapsules for targeted photodynamic therapy,” ACS Applied Materials & Interfaces, 2019, 11, 22925.
    Highlighted by Polymer Technology Platform at http://www.polymer.cn/sci/kjxw15695.html
  1. Xiangjun Zhang, Qian Cheng, Lanlan Li, Liqing Shangguan, Chenwen Li, Shengke Li, Feihe Huang,* Jianxiang Zhang,* and Ruibing Wang,* “Supramolecular therapeutics to treat the side effects induced by a depolarizing neuromuscular blocking agent,” Theranostics, 2019, 9, 3107.
    Featured on Theranostics Wechat Page
  1. Wen-Chao Geng, Qiaoxian Huang, Zhe Xu, Ruibing Wang,* and Dong-Sheng Guo,* “Gene delivery based on macrocyclic amphiphiles,” Theranostics, 2019, 9, 3094.
  2. Xiangjun Zhang, Xiaoqiu Xu, Shengke Li, Lanlan Li, Jianxiang Zhang,* and Ruibing Wang,* “A synthetic receptor as a specific antidote for paraquat poisoning,” Theranostics, 2019, 9, 633.
    Featured on Theranostics Wechat Page
  1. Tangxin Xiao,*  Lijie Qi,  Weiwei Zhong,  Lin Chen,*   Ruibing Wang,* and  Leyong Wang,  “Stimuli-responsive nanocarriers constructed from pillar[n]arene-based supra-amphiphiles,” Materials Chemistry Frontiers, 2019, 3, 1973.
  2. Qian Cheng, Shengke Li, Chen Sun, Ludan Yue and Ruibing Wang,* “Stimuli-responsive perallyloxycucurbit[6]uril-based nanoparticles for selective drug delivery in melanoma cells,” Materials Chemistry Frontiers, 2019, 3, 199.
    Featured as an Inside Cover Story
  1. Qian Cheng, Kun-Xu Teng, Yuanfu Ding, Ludan Yue, Qing-Zheng Yang* and Ruibing Wang,* “Dual stimuli-responsive bispillar[5]arene-based nanoparticles for precisely selective drug delivery in cancer cells,” Chemical Communications, 2019, 55, 2340.
  2. Ludan Yue,   Chen Sun,   Qian Cheng,   Yuan-Fu Ding,   Jianwen Wei and Ruibing Wang,* “Gold nanorods with noncovalently tailorable surface for multi-modality image-guided chemo-photothermal cancer therapy,” Chemical Communications, 2019, 55, 13506.
    Invited contribution and Featured as a Front Cover Story
  1. Chen Sun, Haipeng Zhang, Shengke Li, Xiangjun Zhang, Qian Cheng, Yuanfu Ding, Lianhui Wang, Ruibing Wang,* “Polymeric Nanomedicine with “Lego” Surface Allowing Modular Functionalization and Drug Encapsulation,” ACS Applied Materials & Interfaces, 2018, 10, 25090.
  2. Qian Cheng, Hang Yin, Chen Sun, Ludan Yue, Yuanfu Ding, Wim Dehaen* and Ruibing Wang,* ”Glutathione-responsive homodithiacalix[4]arene-based nanoparticles for selective intracellular drug delivery,“ Chemical Communications, 2018, 54, 8128.
  3. Qiaoxian Huang,# Kit Ieng Kuok,#Xiangjun Zhang,  Ludan Yue, Simon M. Y. Lee, Jianxiang Zhang* and  Ruibing Wang,* “Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor,” Nanoscale, 2018, 10, 10333.
    Featured as a Front Cover Article
  1. Qiaoxian Huang, Shengke Li, Yuan-Fu Ding, Hang Yin, Lian-Hui Wang, and Ruibing Wang,* “Macrocycle-Wrapped Polyethylenimine for Gene Delivery with Reduced Cytotoxicity,” Biomaterials Science, 2018, 6, 1031.
    Featured as an inside Cover Article
  2. Yuan-Fu Ding, Shengke Li, Lijun Liang, Qiaoxian Huang, Lihui Yuwen, Wenjing Yang, Ruibing Wang,* and Lian-Hui Wang,* “Highly Biocompatible Chlorin e6-loaded Chitosan Nanoparticles for Improved Photodynamic Cancer Therapy,” ACS Applied Materials & Interfaces, 2018, 10, 9980

2020         Macau Science and Technology Award (3rd Prize, Technological Invention Award)

2019         2018-2019 Top 1% Reviewer in Cross-Fields by Publons

2019         2018-2019 Top 1% Reviewer in Chemistry by Publons 

2019         Periodic Table of Chinese Young Chemist (Chinese Chemical Society)

2019         China Macrocyclic Arenes and Supramolecular Chemistry Rising Star Award

2019         University of Macau Teaching Excellence Award

2019         Faculty Level Best Teacher Award, University of Macau

2018         Macau Science and Technology Award (3rd Prize, Natural Science Award)

2018         Faculty Level Academic Award, University of Macau

2013         Business Excellerator Stage Award, BTG plc, Ottawa, Canada

2011         Business Excellerator Sprinter Award, Nordion Inc., Ottawa, Canada

2008         Physical Sciences Outstanding Thesis Award at Queen’s University

2003-2007    Queen’s Graduate Awards, Kingston at Queen’s University

2005-2006    Graduate Dean’s Doctoral Field Travel Grant at Queen’s University

2002         Outstanding Graduate of Jilin University (top 1%)

1998-2002    Excellent Undergraduate Scholarship, Jilin University

2000-2001    Excellent Student Leader of Jilin University

2001-2002    Zhanhong Scholarship, Jilin University

1998-2000    Dong Rong Scholarship, Jilin University

Students Awards

2020 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Qian Cheng (MSc Student)

2020 UM Macao Postdoctoral Fellowship (aka “Million Dollar Postdoc”): Cheng Gao (PhD Student)

2018 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Xue Yang (MSc Student)

2018 UM Macao PhD Fellowship (aka “Million Dollar PhD Scholarship”): Qiaoxian Huang (MSc Student)

2016 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Huanxian Chen (MSc Student)

2016/2017 Macao SAR Government MSc Student Scholarship: Jess Kuok (MSc Student)

Founding Member and Vice President, Macau Society of Nuclear Medicine and Molecular Imaging (MSNMMI), since 2016

Council Member, the 1st Board of Specialty Committee of TCM Network Pharmacology of World Federation of Chinese Medicine Societies, since 2015

Council Member, the 3rd Board of Specialty Committee of TCM Pharmaceutics of World Federation of Chinese Medicine Societies, since 2018

Member, Chinese Chemical Society

Member, International Society for Chinese Medicine

Member, International Society of Quality Research of Chinese Medicine

Member, Macao Society for Promotion of Science and Technology

  • Member of Editorial Advisory Board, ACS Applied Biomaterials, Jan. 2020-Present
  • Editor, Journal of Nanomaterials, February 2012-Present
  • Editor, Chinese Journal of Chemical Education (Chinese Core journal), Jan 2017-Present
  • Member of Youth Editorial Board, Chinese Chemical Letters, Jan. 2019-Present
  • Grant Reviewer for National Science Foundation of China (NSFC), French National Research Agency (ANR) and Czech Science Foundation (GACR)