Email

rwang@um.edu.mo

Tel

(853) 8822-4689

Office

N22-8009

Consultation Hours

Tue: 9:00~10:00
Thu: 9:00~10:00

Group Website

https://rwang.sklqrcm.um.edu.mo/

Ruibing WANG 王瑞兵, PhD, FRSC

Professor

Group Webpage: https://rwang.sklqrcm.um.edu.mo/

Academic Qualifications

  • Ph.D. in Organic Chemistry, Queen’s University, Canada
  • B.Sc. in Chemistry (Gifted Class), Jilin University, China

Teaching

HSCI3007Biomedical MaterialsB.Sc. Course
GEST1017Modern Drug DiscoveryB.Sc. Course
CMED7013Emerging Materials in Clinical MedicineM.Sc. Course
CMED8002Advanced PharmaceuticsPhD Course

Research Interests

  • Supramolecular Medicine

We are interested in supramolecular interactions between macrocyclic molecules (such as cucurbiturils, cyclodextrins, pillararenes and calixarenes) and synthetic/natural drugs, with intentions to explore the beneficial roles of these macrocycles as emerging excipients for enhancing the water solubility, stability, transcellular activity, and ultimately therapeutic efficacy with reduced side effects of guest medicines. In some cases, these macrocycles may act as reversal agents (or antidotes) towards toxic effects of guest drugs. Our collaborators include colleagues here at UM, as well as external scientists from Canada, France, USA, Hong Kong and mainland China.

  • Supramolecular Biomaterials

We intend to incorporate high potency ingredients (e.g. particularly those of natural products) into stimuli-responsive, supramolecularly self-assembled materials for various biomedical applications such as precision medicine and controlled drug release for targeted therapy.  These material matrices include natural polysaccharides, natural and synthetic macrocycles and their derivatives. By placing real-world clinical applications as our study aim, we work closely with scientists and clinicians in the region and around the world.

  • Biomimetic and Cell-based Drug Delivery

Constantly inspired by Nature and ancient principles of Chinese medicine, we are highly interested in developing biomimetic and live-cell based drug delivery systems, particularly those based on intracellular and extracellular supramolecular assembly, for improved therapy of a variety of diseases, such as inflammatory diseases, infections and cancers. We have recently proposed the concept of “Supramolecular Cells” (or “Supramolecularly Engineered Cells”), where cells are either intracellularly and/or extracellularly engineered with supramolecular systems, for targeted treatment of a variety of diseases.

Dr. Ruibing Wang has multidisciplinary background and experience in Supramolecular Chemistry, Nanomaterials, Pharmaceutics, and Radiopharmaceuticals. During his PhD studies at Queen’s University, he was among the earliest group of researchers to look into a group of novel macrocyclic molecules, cucurbiturils, and their fascinating biomedical and pharmaceutical applications. Due to his excellent PhD thesis work, he was nominated for “Governor General Gold Medal” and received “Queen’s University Outstanding Thesis in Physical Sciences”. After graduation with PhD degree and a brief postdoctoral stay at Queen’s, he moved to the Steacie Institute for Molecular Sciences at the National Research Council (NRC) of Canada as a Research Associate (later promoted to Associate Research Officer) for about two years, where he worked on fluorescent quantum dots development and studied their various applications including bioimaging. He subsequently joined BTG International Canada (formerly known as Nordion, recently acquired by Boston Scientific) as a Senior Scientist, where he had led various innovation and applied research projects around radiopharmaceuticals and interventional medicine development (e.g. TheraSphere). In 2014, he joined the University of Macau (UM) as a principal investigator. His current research interest is mainly focused on supramolecular biomaterials and supramolecular cytopharmaceuticals. Since joining UM, he has published over 100 peer-reviewed research papers on journals such as Nature Comm., Sci. Adv., JACS, Angew, Matter, Adv. Mater., Mater. Today etc, with a total citation of over 10,000 times and H-index of 57 (Google Scholar, as of Jan. 2024). he has received several prestigious awards including Faculty-Level Academic Award in 2018, Macau Science and Technology Awards (3rd Prize, Natural Science Award) in 2018, Faculty-Level Best Teacher Award in 2019, UM Teaching Excellence Award in 2019, China Macrocyclic Arenes and Supramolecular Chemistry Symposium Rising Star Award in 2019, CCS Chinese Periodic Table of Young Chemist in 2019, Macau Science and Technology Awards (3rd Prize, Technological Invention Award) in 2020, Faculty-Level Outstanding Academic Staff Award in 2021, and 2022 Macau Science and Technology Awards (2nd Prize, Natural Science Award). He has become elected Fellow, the Royal Society of Chemistry since Nov. 2020. He is among the list of Stanford’s World’s Top 2% Scientists since 2020. He is an active grant examiner for National Natural Science Foundation of China (NSFC), French National Research Agency (ANR), Israel Science Foundation (ISF), Czech Science Foundation (GACR), and National Science Centre of Poland (NCN). In addition, he actively serves as Editorial Board Member of Chinese Chemical Letters, and Supramolecular Materials, and Editorial Advisory Board Member of ACS Applied Bio Materials, he is also a council member of Supramolecular Chemistry Advisory Committee of Chinese Chemical Society.
  1. Ruifeng Luo, Jinwei Liu, Qian Cheng, Mitsuhiko Shionoya, Cheng Gao*, and Ruibing Wang*, “Oral microsphere formulation of M2 macrophage-mimetic Janus nanomotor for targeted therapy of ulcerative colitis,” Science Advances, 2024,10, eado6798.
  2. Cheng Gao, Qingfu Wang, Yuan-Fu Ding, Cheryl Kwong, Jinwei Liu, Beibei Xie, Jianwen Wei, Simon Lee, Greta Mok, and Ruibing Wang*, “Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats,” Nature Communications, 2024, 15, 328.
  3. Mian Tang, Tianshun Duan, Yunfeng Lu, Jinwei Liu, Cheng Gao*, Ruibing Wang*, “Tyrosinase-Woven Melanin Nets for Melanoma Therapy through Targeted Mitochondrial Tethering and Enhanced Photothermal Treatment,” Advanced Materials, 2024, in press.
  4. Hang Yin, Roselyne Rosas, Stéphane Viel, Michel Giorgi, Valerie Monnier, Laurence Charles, Didier Siri, Didier Gigmes, Youssef Nassar, Floris Chevallier, Christophe Bucher*, Ruibing Wang*, Anthony Kermagoret*, David Bardelang*, “Internal Dynamics and Modular Peripheral Binding in Stimuli-Responsive 3:2 Host:Guest Complexes,” Angewandte Chemie International Edition, 2024, 63, e202315985.
  5. Ziyi Wang, Chen Sun, Yu Dong, Yuan-Fu Ding, Chen Zhao, Jiahong Lu,* Ruibing Wang*, “Supramolecular Manipulation of Intracellular Acidic Vesicles to Improve Cellular Self-repairs and Self-defense,” CCS Chemistry, 2024, 6, 1487–1498..
  6. Kui He, Yuanfu Ding, Zhipeng Zhao, Ben Liu, Wenyan Nie, Xiaoxi Luo, Hua Zhong Yu, Jinbin Liu*, Ruibing Wang*, “Cucurbit[7]uril-Mediated Organ-Specific Delivery of Ultrasmall NIR-II Luminescent Gold Nanocarriers for Therapy of Acute Kidney Injury,” Advanced Functional Materials, 2024, 34, 2309949.
  7. Cheng Gao, Cheryl H.T. Kwong, Mian Tang, Jinwei Liu, Hiotong Kam, Shengke Li, Simon M. Y. Lee, Chunhai Fan, Hua-Zhong Yu, Ruibing Wang*, “A bacterially engineered macrophage sponge as a neutralization decoy to treat bacterial infection,” Matter, 2023, 6, 3889-3911. Highlighted by Zhao et al, Matter, 2023, 6, 3695-3698.
  8. Ludan Yue, Cheng Gao, Junyan Li, Hanbin Chen, Simon M. Y. Lee, Ruifeng Luo, Ruibing Wang*, “Chemotaxis-guided self-propelled macrophage motor for targeted treatment of acute pneumonia,” Advanced Materials, 2023, 35, 202211626.
  9. Meng Xu, Haidong Zha, Jiamao Chen, Simon Ming-Yuen Lee, Qi Wang*, Ruibing Wang*, Ying Zheng*, ““Ice & Fire” Supramolecular Cell-Conjugation Drug Delivery Platform for Deep Tumor Ablation and Boosted Anti-Tumor Immunity,” Advanced Materials, 2023, 35, 2305287. 
  10. Beibei Xie, Huichao Zhao, Yuanfu Ding, Ziyi Wang, Cheng Gao, Shengke Li,Kehan Zhang, Seong Wan Ip, Huazhong Yu, Ruibing Wang*, “Supramolecularly Engineered Conjugate of Bacteria and CellMembrane-Coated Magnetic Nanoparticles for EnhancedFerroptosis and Immunotherapy of Tumors,” Advanced Science, 2023, 10, 2304407.
  11. Cheng Gao, Cheryl H.T. Kwong, Qingfu Wang, Hiotong Kam, Beibei Xie, Simon Ming-Yuen Lee, Guosong Chen, Ruibing Wang*, “Conjugation of macrophage-mimetic microalgae and liposome for antitumor sonodynamic immunotherapy via hypoxia alleviation and autophagy inhibition,” ACS Nano, 2023, 17, 4034-4049.
  12. Xingping Quan, Xiao Liang,Yuanfu Ding, Yan Han, Junyan Li, Mengchen Yuan, Yiyang Li, Zhen Yuan, Ruibing Wang*, Yonghua Zhao* “Cryo-shocked platelet coupled with ROS-responsive nanomedicine for targeted treatment of thromboembolic disease,” ACS Nano, 2023, 17, 6519–6533.
  13. Cheng Gao, Qingfu Wang, Junyan Li, Cheryl H.T. Kwong, Jianwen Wei, Beibei Xie, Siyu Lu, Simon M. Y. Lee,* and Ruibing Wang*, “In vivo hitchhiking of immune cells by intracellular self-assembly of bacteria-mimetic nanomedicine for targeted therapy of melanoma,” Science Advances, 2022, 8, eabn1805 (Selected as Science Advances feature article, with artworks showcased online).
  14. Ziyi Wang, Chen Sun, Kuikun Yang, Xiaoyuan Chen* and Ruibing Wang*, “Cucurbituril-Based Supramolecular Polymers for Biomedical Applications,” Angewandte Chemie International Edition, 2022, 61, e2022067.
  15. Kuikun Yang, Zhiqing Yang, Guocan Yu*, Zhihong Nie*, Ruibing Wang*, Xiaoyuan Chen*,“Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy,” Advanced Materials, 2022, 34, 2107434.
  16. Cheng Gao, Cheryl H.T. Kwong, Qingfu Wang, Hiotong Kam, Jianwen Wei, Qian Chen, Jian Zhang, Simon M. Y. Lee,* Dayong Gu and Ruibing Wang*, “Surface-engineered chlorella alleviated hypoxic tumor microenvironment for enhanced chemotherapy and immunotherapy of first-line drugs,” Materials Today, 2022, 58, 57-70.
  17. Qian Cheng, Meng Xu, Chen Sun, Kuikun Yang, Zhiqing Yang, Junyan Li, Jun Zheng, Ying Zheng and Ruibing Wang*,“Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage),” Materials Horizons, 2022, 9, 934-941. Selected as a front cover article.
  18. Kuikun Yang, Guocan Yu, Zhiqing Yang, Ludan Yue, Xiangjun Zhang, Chen Sun, Jianwen Wei, Lang Rao, Xiaoyuan Chen,* and Ruibing Wang,*“Supramolecular Polymerization-induced Nanoassemblies for Self-augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor,” Angewandte Chemie International Edition, 2021, 60, 17570-17578.
  19. Shuwen Guo, Qiaoxian Huang, Yuan Chen, Jianwen Wei, Jun Zheng, Leyong Wang, Yitao Wang and Ruibing Wang,*“Synthesis and Bioactivity of Guanidinium‐Functionalized Pillar[5]arene as a Biofilm Disruptor,” Angewandte Chemie International Edition, 2021, 60, 618-623 (hot paper and frontipiece highlight).
  20. Xue Yang, Qian Cheng, Valerie Monnier, Laurence Charles, Hakim Karoui, Olivier Ouari, Didier Gigmes, Ruibing Wang,* Anthony Kermagoret,* and David Bardelang,* “Guest exchange by a partial energy ratchet in water,” Angewandte Chemie International Edition, 2021, 60, 6617–6623.
  21. Hang Yin, David Bardelang* and Ruibing Wang,*“Macrocycles and Related  Hosts as supramolecular antidotes,” Trends in Chemistry, 2021, 3, 1-4.
  22. Kuikun Yang, Ludan Yue, Zhiqing Yang, Guocan Yu, Lang Rao, Rui Tian, Jianwen Wei, Chen Sun, Xiangjun Zhang, Mengze Xu, Zhen Yuan, Xiaoyuan Chen,* and Ruibing Wang,*“A Hypoxia Responsive Nanoassembly for Tumor Specific Oxygenation and Enhanced Sonodynamic Therapy,” Biomaterials, 2021, 275, 120822.
  23. Ludan Yue, Kuikun Yang, Xin-Yue Lou, Ying-Wei Yang* and Ruibing Wang,*“Versatile roles of macrocycles in organic-inorganic hybrid materials for biomedical applications,” Matter, 2020, 3, 1557–1588.
  24. Chen Sun, Ziyi Wang, Ludan Yue, Qiaoxian Huang, Qian Cheng and Ruibing Wang,*“Supramolecular Induction of Mitochondrial Aggregation and Fusion,” Journal of the American Chemical Society, 2020, 142, 16523–16527 (featured as a Supplementary Cover Article).
  25. Cheng Gao, Qian Cheng, Jianwen Wei, Chen Sun, Siyu Lu, Cheryl H.T. Kwong, Simon M.Y. Lee, Zhiyuan Zhong* and Ruibing Wang,*“Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery,” Materials Today, 2020, 40, 9-17 (selected as an Inside Cover Feature Article).
  26. Xue Yang, Ruibing Wang,*Anthony Kermagoret,* and David Bardelang,* “Oligomeric Cucurbituril Complexes: from Peculiar Assemblies to Emerging Applications,” Angewandte Chemie International Edition, 2020, 132, 21464–21476.
  27. Cheng Gao, Qiaoxian Huang, Conghui Liu, Cheryl H.T Kwong, Ludan Yue, Jian-Bo Wan, Simon M. Y. Lee* and Ruibing Wang,* “Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines,” Nature Communications, 2020, 11, 2622. Highlighted by Nature Review Cardiology, 2020.
  28. Chenwen Li, Yang Zhao, Juan Cheng, Jiawei Guo, Qixiong Zhang, Xiangjun Zhang, Jiong Ren, Fengchao Wang, Jun Huang, Houyuan Hu, Ruibing Wang,* and Jianxiang Zhang,* “A Proresolving Peptide Nanotherapy for Site-Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota,” Advanced Science, 2019, 6, 1900610.
  29. Sébastien Combes, Khoa Truong Tran, Mehmet Menaf Ayhan, Hakim Karoui, Antal Rockenbauer, Alain Tonetto, Valérie Monnier, Laurence Charles, Roselyne Rosas, Stéphane Viel, Didier Siri, Paul Tordo, Sylvain Clair, Ruibing Wang,* David Bardelang,* and Olivier Ouari,* “Triangular regulation of cucurbit[8]uril 1:1 complexes,” Journal of the American Chemical Society, 2019, 141, 5897-5907 (selected as a Supplementary Cover Article).
  30. Cheng Gao, Qiaoxian Huang, Qingping Lan, Yu Feng, Fan Tang, Maggie P.M. Hoi, Jianxiang Zhang, Simon M. Y. Lee,* and Ruibing Wang,* “A user-friendly herbicide derived from photo-responsive supramolecular vesicles,” Nature Communications, 2018, 9, 2967.
2022         Macau Science and Technology Awards (2nd Prize, Natural Science Award), Macau
2022         Excellent Mentor of Innovation and Entrepreneurship of “Guangdong Maker”
2022         Silver Prize for the Guangdong-Hong Kong-Macao Greater Bay Area High-value Patent Portfolio Layout Competition
2022        The First Prize for 2022 Bank of China Trophy One Million Dollar Macao Regional Entrepreneurship Competition
2021         ICMS Outstanding Academic Staff Award, University of Macau
2020         Macau Science and Technology Award (3rd Prize, Technological Invention Award)
2019         Periodic Table of Chinese Young Chemist (Chinese Chemical Society)
2019         China Macrocyclic Arenes and Supramolecular Chemistry Symposium Rising Star Award
2019         University of Macau Teaching Excellence Award
2019         Faculty Level Best Teacher Award, University of Macau
2018         Macau Science and Technology Award (3rd Prize, Natural Science Award)
2018         Faculty Level Academic Award, University of Macau
2013         Business Excellerator Stage Award, BTG plc, Ottawa, Canada
2011         Business Excellerator Sprinter Award, Nordion Inc., Ottawa, Canada
2008         Physical Sciences Outstanding Thesis Award at Queen’s University
2002         Outstanding Graduate of Jilin University
2022 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Chen Sun (PhD Student) and Ziyi Wang (MSc Student)
2020 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Qian Cheng (MSc Student)
2020 UM Macao Postdoctoral Fellowship (aka “Million Dollar Postdoc”): Cheng Gao (PhD Student)
2018 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Xue Yang (MSc Student)
2016 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Huanxian Chen (MSc Student)
2016/2017 Macao SAR Government MSc Student Scholarship: Jess Kuok (MSc Student)
Founding Member and President, Macau Society of Supramolecular Chemistry and Biomaterials (MSSCB), since 2020
Founding Member and Vice President, Macau Society of Nuclear Medicine and Molecular Imaging (MSNMMI), since 2016
Council Member, the 1st Board of Specialty Committee of TCM Network Pharmacology of World Federation of Chinese Medicine Societies, since 2015
Council Member, the 3rd Board of Specialty Committee of TCM Pharmaceutics of World Federation of Chinese Medicine Societies, since 2018
Senior Member, Chinese Chemical Society
Member, International Society for Chinese Medicine
Permanent Member, Macao Society for Promotion of Science and Technology
Editorial Advisory Board Member, ACS Applied Bio Materials, Jan. 2020-Present
Editorial Board Member, Chinese Chemical Letters, Aug. 2022-Present
Editorial Board Member, Supramolecular Materials (newly established journal jointly by Elsevier and Science Press), Jan. 2021-Present
Deputy Director, Editorial Office of Chinese Medicine, 2015-2021
Editorial Board member, Chinese Journal of Chemical Education (Chinese Core journal), Jan 2017-Present
Examiner for National Natural Science Foundation of China (NSFC)
Examiner for French National Research Agency (ANR)
Examiner for Czech Science Foundation (GACR)
Examiner for Israel Science Foundation (ISF)
Examiner for US-Israel Binational Science Foundation (BSF)
Examiner for National Science Centre Poland (NCN)