Email

MagHoi@um.edu.mo

Tel

(853) 8822-4876

Office

N22-7012

Consultation Hours

Tue: 11:00~12:00
Thu: 11:00~12:00

Pui Man (Maggie) HOI 許貝文

Associate Professor

Academic Qualifications

  • BSc (Hon), Pharmacology, University College London, U.K.
  • PhD (Cantab), Pharmacology, University of Cambridge, U.K.

Teaching

  • HSCI2009 Pharmacology (Undergraduate Course)
  • HSCI2010 Pharmacology Lab (Undergraduate Course)
  • GEST1019 Nutrition and Food Safety (Undergraduate Course)
  • CMED7001 Pharmacology and Safety Evaluation (Master Course)
  • CMED7036 Medical Innovation and Technology Management (Master Course)
  • CMED7038 Technical English for Healthcare Sector (Master Course)
  • CMED8001 Advanced Pharmacokinetics (PhD Course)
  • CMED8013 Research Writing (PhD Course)

Research Interests

Our team focuses on drug discovery from natural products for vascular dysfunction and inflammation in cardiometabolic and age-related disorders. Our current research investigates the role of oxidative stress and inflammatory responses in neurodegnerative disorders and its impact on cognitive functions by using in vitro and in vivo animal models.

  1. Yue, Q., Leng, X., Xie, N., Zhang, Z., Yang, D., & Hoi, M. P. M.* (Corresponding Author) (2024). Endothelial Dysfunctions in Blood–Brain Barrier Breakdown in Alzheimer’s Disease: From Mechanisms to Potential Therapies. CNS Neuroscience & Therapeutics, 30(11), e70079.
  2. Yue, Q., Li, S., Lei, C. L., Wan, H., Zhang, Z., & Hoi, M. P. M.* (Corresponding Author) (2024). Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease. Neural Regeneration Research, 10.4103/NRR.NRR-D-4124-00695. doi:10.4103/nrr.Nrr-d-24-00695.
  3. Zhang, G., Liang, Z., Wang, Y., Zhang, Z., & Hoi, P.-M.* (Corresponding Author) (2024). Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling. Antioxidants, 13(10), 1272.
  4. Chen, H., Hoi, M. P. M., & Lee, S. M. Y. (2024). Medicinal plants and natural products for treating overactive bladder. Chinese Medicine, 19(1), 56.
  5. Zhou, X., Zhu, Z., Kuang, S., …, Hoi, M. P. M.* (Co-corresponding Author), Yang, X.* (2024). Tetramethylpyrazine Nitrone (TBN) Reduces Amyloid β Deposition in Alzheimer’s Disease Models by Modulating APP Expression, BACE1 Activity, and Autophagy Pathways. Pharmaceuticals, 17(8), 1005.
  6. Yue, Q., & Hoi, M. P .* (Corresponding Author) (2023). Emerging roles of astrocytes in blood-brain barrier disruption upon amyloid-beta insults in Alzheimer’s disease. Neural Regeneration Research, 18(9), 1890-1902.
  7. Yang, L., Kou, K. I., Miao, J., Liu, Y., & Hoi, P. M.* (Corresponding Author) (2024). Quaternion tensor completion with sparseness for color video recovery. Applied Soft Computing, 154, 111322.
  8. Zhou, X., Huang, K., …,Hoi, M. P. M .* (Corresponding Author) (2023). Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis. Frontiers in Pharmacology, 14, 1082602.
  9. Yue, Q. Q., & Hoi, P. M. M.* (Corresponding Author) (2023). Expression patterns of astrocyte mRNA under numerous in vitro disease conditions and its applicability in drug development. Alzheimer’s & Dementia, 19, e071911.
  10. Yue, Q., & Hoi, P. M. M.* (Corresponding Author) (2024). Heterogeneity of brain endothelial cell transcriptome in Alzheimer’s disease brain tissue. Alzheimer’s & Dementia, 20, e092105.
  11. Yue, Q., Xu, Y., Lin, L., & Hoi, M. P. M.* (Corresponding Author) (2022). Canthin-6-one (CO) from Picrasma quassioides (D. Don) Benn. ameliorates lipopolysaccharide (LPS)-induced astrocyte activation and associated brain endothelial disruption. Phytomedicine, 101, 154108.
  12. Yue, Q., Zhou, X., Zhang, Z., & Hoi, M. P. M.* (Corresponding Author) (2022). Murine beta-amyloid (1–42) oligomers disrupt endothelial barrier integrity and VEGFR signaling via activating astrocytes to release deleterious soluble factors. International Journal of Molecular Sciences, 23(3), 1878.
  13. Yang, Y., Wang, B., Zhong, Z., Chen, H., Ding, W., & Hoi, M. P. M.* (Corresponding Author) (2021). Clonazepam attenuates neurobehavioral abnormalities in offspring exposed to maternal immune activation by enhancing GABAergic neurotransmission. Biochemical Pharmacology, 192, 114711.
  14. Zhao, C., Kam, H.-T., Chen, Y., Gong, G., Hoi, M. P. M.,…, Lee, S. M.Y.* (2021). Crocetin and its glycoside crocin, two bioactive constituents from Crocus sativus L.(saffron), differentially inhibit angiogenesis by inhibiting endothelial cytoskeleton organization and cell migration through VEGFR2/SRC/FAK and VEGFR2/MEK/ERK signaling pathways. Frontiers in Pharmacology, 12, 675359.

  • Member, Scientific Review Committee, Macao Regional Science Fair (Education and Youth Affairs Bureau, Macau SAR Government) (Affiliation of Intel International Science and Engineering Fair) (2012-present)
  • Technical Expert (ISO/IEC 17025 Accreditation Assessment), Innovation and Technology Commission (ITC), Hong Kong SAR Government. (2014-present)
  • Reviewer Editor, Frontiers in Cardiovascular and Smooth Muscle Pharmacology. (2014-present)