Jian bo Wan  萬建波

Associate Professor
Programme Coordinator of Biomedical Sciences (PhD)

 

Book & Chapter

  1. Wan JB, Chen Y, Li Ping, Huang WH, Zhang QW. Saponins from Panax Species: Chemistry, Isolation and Analysis. In: Saponins: Properties, Applications and Health Benefits. Rani Koh and Isaac Tay ed., Nova Science Publishers, Inc. New York, 2012.
  2. Zhang XJ, Su HX, Wang YT, Wan JB*,. Therapeutic Potential of Ginsenosides in Management of Atherosclerosis. In: Phytotherapies: Efficacy, Safety and Regulation. Iqbal Ramzan ed., Wiley, Inc. 2015: 236-258. (ISBN: 978-1-118-26806-3)

Journals (as first author or corresponding author)

  1. Xia FB, Wan JB*. Chemical Derivatization Strategy for Mass Spectrometry-based Lipidomics. Mass spectrometry Review, 2021, Accepted (IF 10.95)
  2. Chen YQ, Shen H, Yang RJ, Wan JB*. Accurate quantification of endogenous N-acylethanolamides by chemical isotope labeling coupled with liquid chromatography-tandem mass spectrometry. Anal. Chim. Acta 2021; 1179: 338839 (IF 6.56)
  3. Zuo X, Li Q, Ya F, Ma LJ, Tian Z, Zhao M, Fan D, Zhao Y, Mao YH, Wan JB*, Yang Y*. Ginsenosides Rb2 and Rd2 isolated from Panax notoginseng flowers attenuate platelet function through P2Y 12-mediated cAMP/PKA and PI3K/Akt/Erk1/2 signaling. Food Funct. 2021; 12: 5793-5805. (IF 5.40)
  4. Zou J, Wang SP, Wang YT, Wan JB*. Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury. Pharmacol Res. 2020 2021; 164: 105388 (IF 7.66)
  5. Hu Y, Wang Z, Xia F, Yang W, Liu YC, Wan JB*. Simultaneous quantification of bioactive components in Chinese herbal spirits by ultra-high performance liquid chromatography coupled to triple-quadrupole mass spectrometry (UHPLC-QQQ-MS/MS). Chin Med. 2021; 16: 26 (IF 5.45)
  6. Feng R, Ma LJ, Wang M, Liu C, Yang R, Su H, Yang Y, Wan JB*. Oxidation of fish oil exacerbates alcoholic liver disease by enhancing intestinal dysbiosis in mice. Commun. Biol. 2020; 3:481. (IF 6.27)
  7. Ma LJ, Cao JL, Meng FC, Wang SP, Deng Y, Wang YT, Li P*, Wan JB*. Quantitative Characterization of Ginsenoside Biotransformation in Panax notoginseng Inflorescences and Leaves by Online Two-Dimensional Liquid Chromatography Coupled to Mass Spectrometry. J Agric Food Chem. 2020; 68: 5327-5338. (IF 5.28)
  8. Xia F, He C, Ren M, Xu FG, Wan JB*. Quantitative profiling of eicosanoids derived from n-6 and n-3 polyunsaturated fatty acids by twin derivatization strategy combined with LC-MS/MS in patients with type 2 diabetes mellitus. Anal Chim Acta. 2020, 1120: 24-35. (IF 6.56)
  9. Xia F, Liu C, Wan JB*. Characterization of the cold and hot natures of raw and processed Rehmanniae Radix by integrated metabolomics and network pharmacology. Phytomedicine. 2019;74: 153071 (IF 5.34)
  10. Xia F, Feng R, Xu FG, Su H, He C, Hu YJ, Wan JB*. Quantification of phospholipid fatty acids by chemical isotope labeling coupled with atmospheric pressure gas chromatography quadrupole-time-of-flight mass spectrometry (APGC/Q-TOF MS). Anal Chim Acta. 2019; 1082: 86-97 (IF 6.56)
  11. Cao JL, Ma LJ, Wang SP, Deng Y, Wang YT, Li P, Wan JB*. Comprehensively qualitative and quantitative analysis of ginsenosides in Panax notoginseng leaves by online two-dimensional liquid chromatography coupled to hybrid linear ion trap Orbitrap mass spectrometry with deeply optimized dilution and modulation system. Anal Chim Acta. 2019; 1079: 237-251 (IF 6.56)
  12. Feng R, Chen JH, Liu CH, Xia FB, Xiao Z, Zhang X, Wan JB*. A combination of Pueraria lobata and Silybum marianum protects against alcoholic liver disease in mice. Phytomedicine. 2019; 58: 152824 (IF 5.34)
  13. Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB*. n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. Crit Rev Food Sci Nutr. 2019;59(sup1):S116-S129. (IF 11.18)
  14. Xia FB, Li A, Chai YS, Xiao X, Wan JB*, Li P, Wang YT. UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar. Front Pharmacol. 2018, 9: 618 (IF 5.81)
  15. Feng R, Wang Y, Liu C, Yan C, Zhang H, Su H, Kang JX, Shang CZ, Wan JB*. Acetaminophen-induced Liver Injury is Attenuated in Transgenic fat-1 Mice Endogenously Synthesizing Long-chain n-3 Fatty Acids. Biochem Pharmacol. 2018 154, 75-88 (IF 5.86)
  16. Zhang M, Wang Y, Zhang Q, Wang C, Zhang D, Wan JB*, Yan C*. UPLC/Q-TOF-MS-based metabolomics study of the anti-osteoporosis effects of Achyranthes bidentata polysaccharides in ovariectomized rats. Int J Biol Macromol. 2018; 112: 433-441 (IF 6.95)
  17. Wang M, Zhang XJ, Feng R, Jiang Y, Zhang DY, He C, Li P, Wan JB*. Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in mice. Chin Med. 2017 Oct 30;12:32 (IF 5.42)
  18. Fang Liu, Ni Ma, Fang-Bo Xia, Peng Li, Chengwei He, Zhenqiang Wu, Wan JB*, Preparative separation of minor saponins from Panax notoginseng leaves using biotransformation, macroporous resins and preparative high-performance liquid chromatography. Ginseng Res. 2019; 43: 105-115 (IF 6.06)
  19. Fang Liu, Ni Ma, Chengwei He, Yuanjia Hu, Peng Li, Meiwan Chen, Huanxing Su, Wan JB*, Qualitative and quantitative analysis of the saponins in Panax notoginseng leaves using ultra-performance liquid chromatography coupled with time-of-flight tandem mass spectrometry and high-performance liquid chromatography coupled with UV detector, J. Ginseng Res.2018 Apr;42(2):149-157 (IF 6.06)
  20. Feng RB, Wang Y, He C, Yang Y, Wan JB*, Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response. Food Chem Toxicol. 2018; 119: 479-488 (IF 6.02)
  21. Wang Y, Feng R, Wang R, Yang F, Li P, Wan JB*, Enhanced MS/MS coverage for metabolite identification in LC-MS-based untargeted metabolomics by target-directed data dependent acquisition with time-staggered precursor ion list. Anal Chim Acta. 2017; 992: 67-75 (IF 6.56)
  22. Wang M, Zhang X, Ma LJ, Feng RB, Yan C, Su H, He C, Kang JX, Liu B, Wan JB*, Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease. Biochim Biophys Acta Mol Basis Dis. 2017; 1863:3190-3201 (IF 5.19)
  23. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB*. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol. 2017;108(Pt B):375-391 (IF 6.02)
  24. Feng RB, Wang M, Yan C, Li P, Chen M, He CW, Wan JB*. Endogenous n-3 fatty acid alleviates carbon tetrachloride-induced acute liver injury in fat-1 transgenic mice. Oxid. Med. Cell. Longe. 2016; 2016: 7962948 (IF 6.54)
  25. Wang Y, Liu F, Li P, He C, Wang R, Su H, Wan JB*. An improved pseudotargeted metabolomics approach using multiple ion monitoring with time-staggered ion lists based on ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Anal Chim Acta. 2016; 927:82-8 (IF 6.56)
  26. Wang M, Zhang XJ, Feng K, He C, Li P, Hu YJ, Su H, Wan JB*. Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice. Sci Rep. 2016; 6: 26826 (IF 4.38)
  27. Zhang XJ, He C, Tian K, Li P, Su H, Wan JB*, Ginsenoside Rb1 attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the JNK and p38 signaling pathways. Vascul Pharmacol.2015 Apr 22. pii: S1537-1891(15)00072-5 (IF 5.77)
  28. Cao YW, Jiang Y, Zhang DY, Zhang XJ, Hu YJ, Li P, Su H, Wan JB*, Hepatoprotective effect of aqueous extracts of Penthorum chinense Pursh against acute alcohol-induced liver injury is associated with ameliorating hepatic steatosis and reducing oxidative stress. Food Funct., 2015, 6(5):1510-7 (IF 5.40)
  29. Ding RB, Tian K, Cao YW, Bao JL, Wang M, He C, Hu Y, Su H, Wan JB*. Protective Effect of Panax notoginseng Saponins on Acute Ethanol-induced Liver Injury is Associated with Ameliorating Hepatic Lipid Accumulation and Reducing Ethanol-mediated Oxidative Stress. J. Agric. Food Chem. 2015 63(9):2413-22 (IF 5.27)
  30. Wan JB, Huang LL, Rong R, Tan R, Wang J, Kang JX. Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation. Arterioscler. Thromb. Vasc. Biol. 2010; 30: 2487-94 (IF 8.31)

2021    The International TCM Development and Contribution Award,First Prize for the Science and Technology Progress (3rd author)

2020    World’s Top 2% Scientists 2020

2018    ICMS Outstanding Academic Staff Award, University of Macau

  • Member of Academic Committee, Key Laboratory for Marine Chinese Medicine Quality Research and Evaluation
  • Member of Executive Council, Specialty Committee of Li Shizhen Medicine, World Federation of Chinese Medicine Societies
  • Executive Council Member, Specialty Committee of Chinese Medicine Healthcare Products, World Federation of Chinese Medicine Societies
  • President of a Council, International Association of Quality Research in Chinese Medicine
  • Member of Chinese Medicine Professional Committee of Chinese Society of Integrated Medicine
  • Youth member, Analytical Pharmacology Committee of Chinese Pharmacological Society
  • Member, Macau Product Quality Certification Commission
  • Youth member, Pharmaceutical Analysis Technology Branch of China Medical Biotechnology Association
  • Editorial Board Member, Journal of Analysis and Testing.
  • Associate Editor, Frontiers in Pharmacology, Frontiers in Medicine
  • Editorial Board Member, World science and Technology – Modernization of Traditional Chinese Medicine and Materia Medica
  • Guest Editors for Molecules, Chinese Medicine and Evidence-Based Complementary and Alternative Medicine
  • Grant Reviewer for National Science Foundation of China (NSFC)