Tel
(853) 8822 4680
Office
N22-6034
Consultation Hours
Tue: 10:00-18:00
Wed: 10:00-18:00
Thu: 10:00-18:00
Jianbo WAN 萬建波
Professor
Assistant Director (Teaching/Research)
Academic Qualifications
- BSc., Wuhan University, Wuhan, China
- MSc., China Pharmaceutical University, Nanjing China
- MSc., University of Macau, Macao, China
- PhD., University of Macau, Macao, China
- Postdoctoral fellow, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Teaching
CMED717 | Development of New Drugs and Health Products | |
CMED724 | Application of Pharmacokinetics and Metabonomics in Drug Development | |
CMED806 | Functional Food Product Development in Chinese Medicine |
Research Interests
- Chemical Derivatization Strategy for Mass Spectrometry-based Lipidomics and metabolomics;
- Quality Evaluation of Chinese Medicines (Panax notoginseng roots and leaves);
- Pharmacological Study on Chinese Medicines for the Prevention of Metabolic Diseases, including fatty liver and atherosclerosis
Dr. Jian-Bo Wan is currently an Associate Professor at the Institute of Chinese Medical Sciences (ICMS) and State Key Laboratory of Quality Research in Chinese Medicine, University of Macau. He received his B.S. degree in Pharmacy from Wuhan University in 2001, and his Ph.D. degree in Biomedical Sciences from the University of Macau in 2008. Then, he moved to Massachusetts General Hospital, an affiliated hospital of Harvard Medical School as a Postdoctoral Research Fellow from 2008 to 2011. His current research interest mainly focuses on quality research in Chinese Medicine, chemical derivatization strategy for mass spectrometry-based lipidomics and metabolomics, and pharmacological study on Chinese Medicines for the prevention of metabolic diseases, including fatty liver and atherosclerosis. Dr. Wan has published over 200 peer-reviewed SCI papers, including Nat. Commun., Acta Pharm. Sin. B, Redox Biol., Arterioscler. Thromb. Vasc. Biol., Anal. Chem., with a total citation of over 6,800 times and an H-index of 47 (web of science).
Book & Chapter
- Wan JB, Wang YT, Li SP. Panax notoginseng (Sanqi 三七). In Chinese herbs: Pharmacological Activities and Quality Control. Shaoping Li, Ed. Nova Science Publishers, Inc.: New York, 2008: 179-203. (ISBN: 978-1-60456-823-3).
- Wan JB, Chen Y, Li Ping, Huang WH, Zhang QW. Saponins from Panax Species: Chemistry, Isolation and Analysis. In: Saponins: Properties, Applications and Health Benefits. Rani Koh and Isaac Tay ed., Nova Science Publishers, Inc. New York, 2012: 51-98. (ISBN: 978-1-62100-942-9).
- Zhang XJ, Su HX, Wang YT, Wan JB*. Therapeutic Potential of Ginsenosides in Management of Atherosclerosis. In: Phytotherapies: Efficacy, Safety and Regulation. Iqbal Ramzan ed., Wiley, Inc. 2015: 236-2322258. (ISBN: 978-1-118-26806-3).
- Liu JY, Wan JB*. Omics in Quality Research of Chinese Medicines. In: Quality Control of Chinese Medicines – Strategies and Methods. Shaoping Li and Jing Zhao ed., Springer Singapore, 2024: 759–836. (ISBN: 978-981-99-9870-8).
Journals (as first author or corresponding author)
- Ma LJ, Liu X, Guo L, Luo Y, Zhang B, Cui X, Yang K, Cai J, Liu F, Ma N, Yang FQ, He X, Shi SP, Wan JB*. Discovery of plant chemical defence mediated by a two-component system involving β-glucosidase in Panax Nat. Commun., 2024; 15 :602 (IF 14.6, Citation 0).
- Zhang K, Jia J, Li T, Liu W, Tu P, Wan JB*, Li J*, Song Y*. Triple three-dimensional MS/MS spectrum facilitates quantitative ginsenosides-targeted sub-metabolome characterization in notoginseng. Acta Pharm Sin B. 2024; In press. (IF 14.7, Citation 1).
- Dai JK, Dan WJ, Cao YD, Gao JX, Wang JR, Wan JB*. Discovery of new quaternized norharmane dimers as potential anti-MRSA agents. J Adv Res. 2023; In press. (IF 11.4, Citation 3).
- Zou J, Yang R, Feng R, Liu J, Wan JB*. Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice. J Pharm Anal. 2023; 13: 999-1012. (IF 6.1, Citation 4).
- Yang RJ, Zou J, Liu JY, Dai JK, Wan JB*. Click chemistry-based enrichment strategy for tracing cellular fatty acid metabolism by LC-MS/MS. J Pharm Anal., 2023; 13: 1221-1231. (IF 6.1, Citation 1).
- Qiu L, Feng RB, Wu QS, Wan JB*, Zhang QW*. Total saponins from Panax japonicus attenuate acute alcoholic liver oxidative stress and hepatosteatosis by p62-related Nrf2 pathway and AMPK-ACC/PPARα axis in vivo and in vitro. J Ethnopharmacol. 2023; 317: 116785. (IF 4.8, Citation 7)
- Tian B, Liu J, Guo S, Li A, Wan JB*. Macromolecule-based hydrogels nanoarchitectonics with mesenchymal stem cells for regenerative medicine: A review. Int J Biol Macromol. 2023; 243: 125161. (IF 7.7, Citation 7).
- Shao L, Wang L, Shi YY, Zhang W, Tan LW, Wan JB*, Huang WH. Biotransformation of the saponins in Panax notoginseng leaves mediated by gut microbiota from insomniac patients. J Sep Sci 2023; 46: e2200803. (IF 2.8, Citation 2).
- Tian B, Liu J, Yang W, Wan JB*. Biopolymer Food Packaging Films Incorporated with Essential Oils. J Agric Food Chem. 2023; 71: 1325-1347. (IF 5.7, Citation 27).
- Xia F, Wan JB*. Chemical derivatization strategy for mass spectrometry-based lipidomics. Mass Spectrom Rev. 2023; 42: 432-452. (IF 6.9, Citation 27).
- Hu Y, Wang Z, Liu J, Yang W, Yang Q, Liu YC, You QY, Chen XJ, Wan JB*. Chemical Stability of a Chinese Herbal Spirit Using LC-MS-Based Metabolomics and Accelerated Tests. Front Pharmacol. 2022; 13: 857706. (IF 4.4, Citation 0).
- Chen JF, Lu PD, Liu JY, Yang L, Li Y, Chen Y, Wang Y, Wan JB*, Zhao, YH*. 20(S)-Protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis. Phytother Res. 2023; 37:4690-4705. (IF 6.1, Citation 5)
- Lu PD, Chen JF, (…); Wan JB*, Zhao, YH*. 20(S)-Protopanaxadiol saponins isolated from Panax notoginseng target caveolin-1 against intestinal barrier dysfunction by alleviating inflammatory injury and oxidative stress in experimental murine colitis. Food Front. 2023, 4: 2081-2096. (IF 7.4, Citation 2)
- Tian B, Liu J, Liu Y, Wan JB*. Integrating diverse plant bioactive ingredients with cyclodextrins to fabricate functional films for food application: a critical review. Crit Rev Food Sci Nutr. 2022; 63: 7311-7340. (IF 7.3, Citation 2).
- Dai JK, Dan WJ, Wan JB*. Natural and synthetic β-carboline as a privileged antifungal scaffolds. Eur J Med Chem. 2022; 229: 114057. (IF 6, Citation 17).
- Zou J, Yan C, Wan JB*. Red yeast rice ameliorates non-alcoholic fatty liver disease through inhibiting lipid synthesis and NF-κB/NLRP3 inflammasome-mediated hepatic inflammation in mice. Chin Med. 2022;17: 17. (IF 5.3, Citation 13).
- Liu J, Tian B, Liu Y, Wan JB*. Cyclodextrin-Containing Hydrogels: A Review of Preparation Method, Drug Delivery, and Degradation Behavior. Int J Mol Sci. 2021; 22:13516. (IF 4.9, Citation 29).
- Ma LJ, Ma N, Cao JL, Wan JB*. Characterizing the influence of different drying methods on chemical components of Panax notoginseng leaves by heart-cutting two-dimensional liquid chromatography coupled to orbitrap high-resolution mass spectrometry. Food Chem. 2022; 369: 130965. (IF 8.5, Citation 21).
- Chen YQ, Shen H, Yang RJ,Wan JB*. Accurate quantification of endogenous N-acylethanolamides by chemical isotope labeling coupled with liquid chromatography-tandem mass spectrometry. Anal Chim Acta. 2021; 1179: 338839. (IF 5.7, Citation 4).
- Li G, Liu H, Feng R, Kang TS, Wang W, Ko CN, Wong CY, Ye M, Ma DL, Wan JB*, Leung CH. A bioactive ligand-conjugated iridium (III) metal-based complex as a Keap1-Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury. Redox Biol. 2021; 48: 102129. (IF 10.7, Citation 23).
- Zuo X, Li Q, Ya F, Ma LJ, Tian Z, Zhao M, Fan D, Zhao Y, Mao YH, Wan JB*, Yang Y*. Ginsenosides Rb2 and Rd2 isolated from Panax notoginseng flowers attenuate platelet function through P2Y 12-mediated cAMP/PKA and PI3K/Akt/Erk1/2 signaling. Food Funct. 2021; 12: 5793-5805. (IF 5.1, Citation 16).
- Ma LJ, Ma N, Wang BY, Yang K, He X, Wan JB*. Ginsenoside distribution in different architectural components of Panax notoginseng inflorescence and infructescence. J Pharm Biomed Anal. 2021; 203: 114221 (IF 3.1, Citation 2).
- Sun H, Ma LJ, Wan JB*, Tong S*. Preparative separation of gypenoside XVII, ginsenoside Rd2, and notoginsenosides Fe and Fd from Panax notoginseng leaves by countercurrent chromatography and orthogonality evaluation for their separation. J Sep Sci. 2021; 44:1-8. (IF 2.8, Citation 5).
- Xu DD, Hou XY, Wang O, Wang D, Li DT, Qin SY, Lv B, Dai XM, Zhang ZJ, Wan JB*, Xu FG*. A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan. Chin J Nat Med. 2021; 19: 364-375. (IF 4, Citation 19).
- Yang R, Xia F, Su H, Wan JB*. Quantitative analysis of n-3 polyunsaturated fatty acids and their metabolites by chemical isotope labeling coupled with liquid chromatography – mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2021; 1172: 122666 (IF 2.8, Citation 6).
- Hu Y, Wang Z, Xia F, Yang W, Liu YC, Wan JB*. Simultaneous quantification of bioactive components in Chinese herbal spirits by ultra-high performance liquid chromatography coupled to triple-quadrupole mass spectrometry (UHPLC-QQQ-MS/MS). Chin Med. 2021; 16: 26 (IF 5.3, Citation 6).
- Zou J, Wang SP, Wang YT, Wan JB*. Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury. Pharmacol Res. 2020 2021; 164: 105388 (IF 9.1, Citation 25).
- Feng R, Ma LJ, Wang M, Liu C, Yang R, Su H, Yang Y, Wan JB*. Oxidation of fish oil exacerbates alcoholic liver disease by enhancing intestinal dysbiosis in mice. Biol. 2020; 3: 481. (IF 5.2, Citation 26).
- Yang YY, Wu ZY, Xia FB, Zhang H, Wang X, Gao JL, Yang FQ*, Wan JB*. Characterization of thrombin/factor Xa inhibitors in Rhizoma Chuanxiong through UPLC-MS-based multivariate statistical analysis. Chin Med. 2020; 15: 93. (IF 5.3, Citation 15).
- Ma LJ, Cao JL, Meng FC, Wang SP, Deng Y, Wang YT, Li P*, Wan JB*. Quantitative Characterization of Ginsenoside Biotransformation in Panax notoginseng Inflorescences and Leaves by Online Two-Dimensional Liquid Chromatography Coupled to Mass Spectrometry. J Agric Food Chem. 2020; 68: 8755-8756. (IF 5.7, Citation 0).
- Xia F, He C, Ren M, Xu FG, Wan JB*. Quantitative profiling of eicosanoids derived from n-6 and n-3 polyunsaturated fatty acids by twin derivatization strategy combined with LC-MS/MS in patients with type 2 diabetes mellitus. Anal Chim Acta. 2020, 1120: 24-35. (IF 5.7, Citation 27).
- Peng Y, Ren, HX, Tao HX, He CW, Li P, Wan JB*, Su HX*. Metabolomics study of the anti-inflammatory effects of endogenous omega-3 polyunsaturated fatty acids. RSC Advances, 2019; 9: 41903-41912. (IF 3.9, Citation 6).
- Guo WQ, Chen YG, Shi RZ, He K, Wang JF, Shao JH, Wan JB*, Gao JL. 20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse. Evid Based Complement Alternat Med. 2020; 2020: 8747023 (IF 2.65, Citation 10).
- Liu C, Feng R, Zou J, Xia F, Wan JB*. 20(S)-Protopanaxadiol Saponins Mainly Contribute to the Anti-Atherogenic Effects of Panax notoginseng in ApoE Deficient Mice. Molecules. 2019; 24: 3723 (IF 4.2, Citation 17).
- Xia F, Liu C, Wan JB*. Characterization of the cold and hot natures of raw and processed Rehmanniae Radix by integrated metabolomics and network pharmacology. Phytomedicine. 2019;74: 153071 (IF 6.7, Citation 36).
- Xia F, Feng R, Xu FG, Su H, He C, Hu YJ, Wan JB*. Quantification of phospholipid fatty acids by chemical isotope labeling coupled with atmospheric pressure gas chromatography quadrupole-time-of-flight mass spectrometry (APGC/Q-TOF MS). Anal Chim Acta. 2019; 1082: 86-97 (IF 5.7, Citation 13).
- Cao JL, Ma LJ, Wang SP, Deng Y, Wang YT, Li P, Wan JB*. Comprehensively qualitative and quantitative analysis of ginsenosides in Panax notoginseng leaves by online two-dimensional liquid chromatography coupled to hybrid linear ion trap Orbitrap mass spectrometry with deeply optimized dilution and modulation system. Anal Chim Acta. 2019; 1079: 237-251 (IF 5.7, Citation 41).
- Feng R, Chen JH, Liu CH, Xia FB, Xiao Z, Zhang X, Wan JB*. A combination of Pueraria lobata and Silybum marianum protects against alcoholic liver disease in mice. Phytomedicine. 2019; 58: 152824 (IF 6.7, Citation 29).
- Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB*. n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. Crit Rev Food Sci Nutr. 2019; 59: S116-S129. (IF 7.3, Citation 90).
- Wang Y, Ma L, Zhang M, Chen M, Li P, He C, Yan C, Wan JB. A Simple Method for Peak Alignment Using Relative Retention Time Related to an Inherent Peak in Liquid Chromatography-Mass Spectrometry-Based Metabolomics. J Chromatogr Sci. 2019; 57: 9-16 (IF 1.5, Citation 12).
- Xia FB, Li A, Chai YS, Xiao X, Wan JB*, Li P, Wang YT. UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar. Front Pharmacol. 2018, 9: 618 (IF 4.4, Citation 28).
- Wang Y, Feng R, He C, Su H, Ma H, Wan JB*. An integrated strategy to improve data acquisition and metabolite identification by time-staggered ion lists in UHPLC/Q-TOF MS-based metabolomics. J Pharm Biomed Anal. 2018, 157:171-179 (IF 3.1, Citation 11).
- Feng R, Wang Y, Liu C, Yan C, Zhang H, Su H, Kang JX, Shang CZ, Wan JB*. Acetaminophen-induced Liver Injury is Attenuated in Transgenic fat-1 Mice Endogenously Synthesizing Long-chain n-3 Fatty Acids. Biochem Pharmacol. 2018 154, 75-88 (IF 5.3, Citation 16).
- Zhang M, Wang Y, Zhang Q, Wang C, Zhang D, Wan JB*, Yan C*. UPLC/Q-TOF-MS-based metabolomics study of the anti-osteoporosis effects of Achyranthes bidentata polysaccharides in ovariectomized rats. Int J Biol Macromol. 2018; 112: 433-441 (IF 7.7, Citation 36).
- Wang M, Zhang XJ, Feng R, Jiang Y, Zhang DY, He C, Li P, Wan JB*. Hepatoprotective properties of Penthorum chinense Pursh against carbon tetrachloride-induced acute liver injury in mice. Chin Med. 2017 Oct 30;12:32 (IF 5.3, Citation 37).
- Fang Liu, Ni Ma, Fang-Bo Xia, Peng Li, Chengwei He, Zhenqiang Wu, Wan JB*, Preparative separation of minor saponins from Panax notoginseng leaves using biotransformation, macroporous resins and preparative high-performance liquid chromatography. J. Ginseng Res. 2019; 43: 105-115 (IF 6.8, Citation 22).
- Fang Liu, Ni Ma, Chengwei He, Yuanjia Hu, Peng Li, Meiwan Chen, Huanxing Su, Wan JB*, Qualitative and quantitative analysis of the saponins in Panax notoginseng leaves using ultra-performance liquid chromatography coupled with time-of-flight tandem mass spectrometry and high-performance liquid chromatography coupled with UV detector, J. Ginseng Res.2018; 42: 149-157 (IF 6.8, Citation 47).
- Ma LJ, Liu F, Zhong ZF,Wan JB*. Comparative Study on Chemical Components and Anti-inflammatory Effects of Panax notoginseng Flower Extracted by Water and Methanol., J Sep Sci. 2017; 40: 4730-4739 (IF 2.8, Citation 29).
- Feng RB, Wang Y, He C, Yang Y, Wan JB*, Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response. Food Chem Toxicol. 2018; 119: 479-488 (IF 3.9, Citation 56).
- Wang Y, Feng R, Wang R, Yang F, Li P, Wan JB*, Enhanced MS/MS coverage for metabolite identification in LC-MS-based untargeted metabolomics by target-directed data dependent acquisition with time-staggered precursor ion list. Anal Chim Acta. 2017; 992: 67-75 (IF 5.7, Citation 45).
- Wang M, Zhang X, Ma LJ, Feng RB, Yan C, Su H, He C, Kang JX, Liu B, Wan JB*, Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease. Biochim Biophys Acta. 2017; 1863: 3190-3201(IF 4.2, Citation 45).
- Zhang C, Li C, Chen S, Li Z, Ma L, Jia X, Wang K, Bao J, Liang Y, Chen M, Li P, Su H, Lee SM, Liu K, Wan JB*, He C. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Sci Rep. 2017; 7:41082 (IF 3.8, Citation 57).
- Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB*. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol. 2017; 108: 375-391 (IF 3.9, Citation 120).
- Bao J, Liu F, Zhang C, Wang K, Jia X, Wang X, Chen M, Li P, Su H, Wang Y, Wan JB*, He C. Anti-melanoma activity of Forsythiae Fructus aqueous extract in mice involves regulation of glycerophospholipid metabolisms by UPLC/Q-TOF MS-based metabolomics study. Sci Rep. 2016; 6: 39415 (IF 3.8, Citation 22).
- Feng RB, Wang M, Yan C, Li P, Chen M, He CW, Wan JB*. Endogenous n-3 fatty acid alleviates carbon tetrachloride-induced acute liver injury in fat-1 transgenic mice. Oxid. Med. Cell. Longe. 2016; 2016: 7962948 (IF 7.31, Citation 18).
- Chen XJ, Zhang XJ, Shui YM, Wan JB*, Gao JL. Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites. Evid Based Complement Alternat Med. 2016; 2016: 5738694. (IF 2.65, Citation 69).
- Wang Y, Liu F, Li P, He C, Wang R, Su H, Wan JB*. An improved pseudotargeted metabolomics approach using multiple ion monitoring with time-staggered ion lists based on ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Anal Chim Acta. 2016; 927: 82-8 (IF 5.7, Citation 45).
- Wang M, Zhang XJ, Feng K, He C, Li P, Hu YJ, Su H, Wan JB*. Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice. Sci Rep. 2016 May 25; 6: 26826 (IF 3.8, Citation 48).
- Liu F, Bai X, Yang FQ, Zhang XJ, Hu Y, Li P, Wan JB*. Discriminating from species of Curcumae Radix (Yujin) by a UHPLC/Q-TOFMS-based metabolomics approach. Chin Med. 2016; 11: 21 (IF 5.3, Citation 18).
- Wang M, Zhang XJ, Yan CY, He C, Li P, Chen M, Su H, Wan JB*. Preventive effect of α-linolenic acid-rich flaxseed oil against ethanol-induced liver injury is associated with ameliorating gut-derived endotoxin-mediated inflammation in mice. J Functional Foods, 2016; 23: 532-541. (IF 3.8, Citation 24).
- Wang Y, Zhou S, Wang M, Liu S, Hu Y, He C, Li P, Wan JB*. UHPLC/Q-TOFMS- based metabolomics for the characterization of cold and hot properties of Chinese materia medica. J Ethnopharmacol.2016,79: 234-242 (IF 4.8, Citation 38).
- Chen XJ, Qiu JF, Wang YT, Wan JB*. Discrimination of Three Panax Species Based on Differences in Volatile Organic Compounds Using a Static Headspace GC-MS-Based Metabolomics Approach. Am J Chin Med. 2016, 24:1-14 (IF 4.8, Citation 13).
- Chen YX, Zhang XJ, Huang J, Zhou SJ, Liu F, Jiang LL, Chen M, Wan JB*, Yang DZ. UHPLC/Q-TOFMS-based plasma metabolomics of polycystic ovary syndrome patients with and without insulin resistance. J Pharm Biomed Anal. 2016; 121:141-150 (IF 3.1, Citation 32).
- Wang M, Zhang XJ, Liu F, Hu Y, He C, Li P, Su H, Wan JB*. Saponins isolated from the leaves of Panax notoginseng protect against alcoholic liver injury via inhibiting ethanol-induced oxidative stress and gut-derived endotoxin-mediated inflammation. J Functional Foods, 2015; 19: 214–224 (IF 3.8, Citation 51).
- Wang Y, Liu S, Hu YJ, Li P, Wan JB*. Current state-of-the-art of mass spectrometry-based metabolomics studies-A review focusing on wide coverage, high throughput and easy identification. RSC Adv. 2015; 5: 78728-78737 (IF 3.9, Citation 76).
- Qiu JF, Zhang KL, Zhang XJ, Hu YJ, Li P, Shang CZ, Wan JB*, Abnormalities in Plasma Phospholipid Fatty Acid Profiles of Patients with Hepatocellular Carcinoma. Lipids, 2015; 50: 977-85 (IF 1.8, Citation 28).
- Liu F, Ding RB, Hu YJ, Su H, Wan JB*, UPLC/Q-TOFMS-based metabolomics studies on the protective effect of Panax notoginseng saponins on alcoholic liver injury. Am J Chin Med. 2015, 1-20 (IF 4.8, Citation 24).
- Zhang XJ, He C, Li P, Su H, Wan JB*, Ginsenoside Rg1, a potential JNK inhibitor, protects against ischemia/reperfusion-induced liver damage. J Funct Foods, 2015; 15, 580–592 (IF 3.8, Citation 7).
- Zhang XJ, He C, Tian K, Li P, Su H, Wan JB*, Ginsenoside Rb1 attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the JNK and p38 signaling pathways. Vascul Pharmacol. 2015; 73: 86-95(IF 3.5, Citation 45).
- Cao YW, Jiang Y, Zhang DY, Zhang XJ, Hu YJ, Li P, Su H, Wan JB*, Hepatoprotective effect of aqueous extracts of Penthorum chinense Pursh against acute alcohol-induced liver injury is associated with ameliorating hepatic steatosis and reducing oxidative stress. Food Funct., 2015; 6:1510-17 (IF 5.1, Citation 33).
- Ding RB, Tian K, Cao YW, Bao JL, Wang M, He C, Hu Y, Su H, Wan JB*. Protective Effect of Panax notoginseng Saponins on Acute Ethanol-induced Liver Injury is Associated with Ameliorating Hepatic Lipid Accumulation and Reducing Ethanol-mediated Oxidative Stress. J. Agric. Food Chem. 2015; 63: 2413-22 (IF 5.7, Citation 75).
- Cao Y, Jiang Y, Zhang D, Wang M, Chen W, Su H, Wang Y, Wan JB*. Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice. J Ethnopharmacol. 2015; 161: 92-98 (IF 4.8, Citation 116).
- Xu FX, Yuan C, Wan JB*, Yan R, Hu H, Li SP, Zhang QW. A novel strategy for rapid quantification of 20(S)-protopanaxatriol and 20(S)-protopanaxadiol saponins in Panax notoginseng, ginseng and P. quinquefolium. Nat Prod Res. 2015; 29: 46-52 (IF 1.9, Citation 17).
- Zhang XJ, Huang LL, Su H, Chen YX, Huang J, He C, Li P, Yang DZ, Wan JB*, Characterizing plasma phospholipid fatty acid profiles of polycystic ovary syndrome patients with and without insulin resistance using GC-MS and chemometrics approach. J Pharm Biomed Anal. 2014; 95:85-92 (IF 3.1, Citation 32).
- Zhang XJ, Su H, He CW, Wang YT, Yang FQ, Wan JB*. Discrimination of Pterocephalus hookeri collected at flowering and non-flowering stages using GC-MS-based fatty acid profiling. Anal. Methods, 2014; 6: 2141-2149 (IF 2.7, Citation 1).
- Zhang XJ, Qiu JF, Guo LP, Wang Y, Li P, Yang FQ, Su H, Wan JB*. Discrimination of multi-origin Chinese herbal medicines using gas chromatography-mass spectrometry-based Fatty Acid profiling. Molecules. 2013,18:15329-43 (IF 4.2, Citation 22).
- Wan JB*, Bai X, Cai XJ, Rao Y; Wang, YS, Wang YT. Chemical differentiation of Da-Cheng-Qi-Tang, a Chinese medicine formula, prepared by traditional and modern decoction methods using UPLC/Q-TOFMS-based metabolomics approach. J Pharm Biomed Anal, 2013, 83: 34-42(IF 3.1, Citation 59).
- Huang LL, Wan JB1, Wang B, He CW, Ma H, Li TW, Kang JX. Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. Prostaglandins Leukot. Essent. Fatty Acids. 2013, 88: 347-53 (IF 2.9, Citation 61).
- Zhang XJ, Huang LL, Cai XJ, Li P, Wang YT, Wan JB*. Fatty acid variability in three medicinal herbs of Panax species. Chem Cent J. 2013; 7: 12. (IF 4.2, Citation 29).
- Ding RB, Tian K, He CW, Jiang Y, Wang YT, Wan JB*. Herbal medicines for the prevention of alcoholic liver diseases: a review. J Ethnopharmacol. 2012; 144: 457-65. (IF 4.8, Citation 111).
- Wan JB, Li P, Yang RL, Zhang QW, Wang YT. Separation and purification of 5 saponins from Panax notoginseng by preparative high-performance liquid chromatography. J Liq Chromatogr RT. 2013, 36:406–417. (IF 1, Citation 17).
- Wan JB, Zhang QW, Hong SJ, Li P, Li SP, Wang YT. Chemical investigation of saponins in different parts of Panax notoginseng by pressurized liquid extraction and liquid chromatography-electrospray ionization- tandem mass spectrometry. Molecules. 2012,17(5):5836-53. (IF 4.2, Citation 50).
2021 The International TCM Development and Contribution Award,First Prize for the Science and Technology Progress (3rd author)
2020 World’s Top 2% Scientists 2020
2018 ICMS Outstanding Academic Staff Award, University of Macau
- Member of Academic Committee, Key Laboratory for Marine Chinese Medicine Quality Research and Evaluation, National Medical Products Administration
- Member of Executive Council, Specialty Committee of Li Shizhen Medicine, World Federation of Chinese Medicine Societies
- Executive Council Member, Specialty Committee of Chinese Medicine Healthcare Products, World Federation of Chinese Medicine Societies
- President of a Council, International Association of Quality Research in Chinese Medicine
- Member of Chinese Medicine Professional Committee of Chinese Society of Integrated Medicine
- Youth member, Analytical Pharmacology Committee of Chinese Pharmacological Society
- Member, Macau Product Quality Certification Commission
- Youth member, Pharmaceutical Analysis Technology Branch of China Medical Biotechnology Association
- Deputy Editor, Director of Editorial Office, Chinese Medicine (https://cmjournal.biomedcentral.com/)
- Editorial Board Member, Journal of Analysis and Testing.
- Associate Editor, Frontiers in Pharmacology, Frontiers in Medicine
- Editorial Board Member, World science and Technology – Modernization of Traditional Chinese Medicine and Materia Medica
- Guest Editors for Molecules, Chinese Medicine and Evidence-Based Complementary and Alternative Medicine
- Grant Reviewer for National Science Foundation of China (NSFC),