Jia-Hong LU

Jiahong Lu 路嘉宏

Assistant Professor
Programme Director, State Key Laboratory of Quality Research in Chinese Medicine

Academic Qualifications

  • B.M., Xiangya School of Medicine, Central South University
  • M.S., State key lab of Medical genetics, Central South University
  • Ph.D., Hong Kong Baptist University

Teaching

CMED7012-Targets and Models for Drug Screen
GEST 1017-Modern Drug Discovery Drugs and Health
CMED 7017-Across the Gap between Science and Industry
CMED8010-Advanced pharmacology


Research

Research Interests

  • 1) Regulatory mechanisms and biological functions of autophagy in human diseases: physiological and translational studies.
  • 2) Neuroprotective TCM compounds discovery and target identification by functional genomics and proteomics approaches.

Dr. Lu got his PhD in Hong Kong Baptist University. He spent 3 years in Icahn School of medicine at Mount Sinai for postdoctoral training before joining University of Macau as an assistant professor.  Dr. Lu is an expert in neurobiology, cell biology and pharmacology. His major research interests are autophagy in human diseases and pharmacological study on traditional Chinese medicine. Dr. Lu tries to combine biochemistry, cell biology and neurobiology approaches, and apply cell, fruit fly and transgenic mouse models to identify small molecular autophagy modulators with therapeutic potential for human diseases including neurodegenerative diseases, cancer and inflammatory diseases. Dr. Lu has published a series of papers as first author or corresponding author in high profile journal including: Nature Communications, Autophagy (5), Molecular neurodegeneration, Cell death and disease (2), Pharmacological research…, with a total citation of over 3,600 times (WoS).

Dr. Lu’s group is now looking for Postdoc, postgraduate students and research assistants who are interested in autophagy and neurodegenerative diseases research. For further information, please contact Dr. Lu at jiahonglu@um.edu.mo


10 Selected Publications 

  1. Cai CZ, Yang C, Zhuang XX, Yuan NN, Wu MY, Tan JQ, Song JX, Cheung KH, Su H, Wang YT, Tang BS, Behrends C, Durairajan SSK, Yue Z, Li M# & Lu JH#. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy, 2020. DOI: 10.1080/15548627.2020.1760623. (Impact factor: 11.1)
  2. Wu MY, Liu L, Wang EJ, Xiao HT, Cai CZ, Wang J, Su H, Wang Y, Tan J, Zhang Z, Wang J, Yao M, Ouyang DF, Yue Z, Li M#, Chen Y#, Bian ZX#, Lu JH#. PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation. Autophagy. 2020;1-16. doi:10.1080/15548627.2020.1741332. (Impact factor: 11.1)
  3. Yu Dong, Yuanjia Hu, Sovan Sarkar, Wei-Xing Zong, Min Li, Du Feng, Ju-Xian Song, Min Li, Diego L. Medina, Jieqiong Tan, Zhuohua Zhang, zhenyu Yue and Lu JH#. “Autophagy Modulator Scoring System: a User-friendly Tool for Quantitative Analysis of Methodological Integrity of Chemical Autophagy Modulator Studies.” Autophagy, 2020 Feb;16(2):195-202. doi: 10.1080/15548627.2019.1704119. (Impact factor: 11.1)
  4. Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH#, Yue Z#. Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice. Mol Neurodegener. 2019 Nov 27;14(1):43. doi:10.1186/s13024-019-0342-4. #co-corresponding author (Impact factor: 8.27)
  5. Zhuang XX, Wang SF, Tan Y, Song JX, Zhu Z, Wang ZY, Wu MY, Cai CZ, Huang ZJ, Tan JQ, Su HX#, Li M#, Lu JH#. Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models. Cell Death Dis. 2020 Feb 18;11(2):128. doi: 10.1038/s41419-020-2322-6.
  6. Wang J, Wu MY, Su H, Lu J, Chen X, Tan J, Lu JH#. iNOS Interacts with Autophagy Receptor p62 and is Degraded by Autophagy in Macrophages. Cells. 2019 Oct 15;8(10). pii: E1255. doi: 10.3390/cells8101255. (Impact factor: 5.7)
  7. Yang C, Cai CZ, Song JX, Tan JQ, Durairajan SSK, Iyaswamy A, Wu MY, Chen LL, Yue Z, Li M, Lu JH#. NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. Autophagy. 2017;13(12):2028-2040. (Impact factor: 11.1)
  8. Chong CM, Ke M, Tan Y, Huang Z, Zhang K, Ai N, Ge W, Qin D, Lu JH#, Su H. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling. Cell Death Dis. 2018 Aug 29;9(9):879. (Impact factor: 5.6)
  9. Lu JH*, He L*, Behrends C, Araki M, Araki K, Jun Wang Q, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue Z. NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nature Communications. 2014; 5:3920, DOI: 10.1038/ncomms4920. (Impact factor:  12. 1)
  10. Lu JH, Tan JQ, Durairajan SS, Liu LF, Zhang ZH, Ma L, Shen HM, Chan HY, Li M. Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy. 2012; 8(1):98-108. (Erratum in Autophagy. 2012; 8(5): 864-866.) (Impact factor: 11.1)

For full list of Publications, please visit Publon:
https://publons.com/researcher/1742866/jiahong-lu/publications/ 


Book Chapters

  • 路嘉宏,巫明月,岳振宇。(2019) 自噬与帕金森病. In 乐卫东 (Eds). 自噬:生物学与疾病临床卷(第3版) (pp.1-42). 科学出版社(正在付印)
  • Lu, JH., Wu, M, Yue, Z. Autophagy and Parkinson’s disease. Autophagy: Biology and Diseases (Clinic Volume) (The 3rd edition) (pp.1-42). Springer.(In press)
  • Jiahong Lu, Min Li, Mingyue Wu, Cuizan Cai (2016), Book Chapter, “Chinese medicine in neurological disease: pharmacological perspective”, in Book “Evidence-based research methods for Chinese medicine”
  • 路嘉宏,岳振宇。(2015) 自噬与帕金森病. In 乐卫东 (Eds). 自噬:生物学与疾病临床卷(第2版) (pp.234-255). 科学出版社

Patents:

  • 路嘉宏, 陈修平, 董雨, 骆玮玮。川楝素在肿瘤治疗中的应用。中国专利申请号:201910622457.9
  • 路嘉宏,巫明月。非洲防己碱的应用及药物制剂。中国专利申请号:201910482193.1
  • 路嘉宏,庄旭旭。一种基于流式细胞术定量分析细胞核内转录因子含量的方法。中国专利申请号:201810900356.9
  • Li M., Durairajan S.S.K., Liu L.F., Lu J.H. “Berberine Alkaloid as a Medicament for Prophylaxis and Treatment of Alzheimer’s Disease” U.S. Provisional Patent Application No.61/609917, 2013.

Community Service

Council member, the China genetic association (理事 中国遗传学会) 2018 – Present

Council member, Asia-Pacific association of medicine and bio-immunology (理事 亚太医学和生物免疫学会) 2017 – Present

Committee member, China anti-cancer association cancer immunology and metabolism group (委员 中国抗癌协会肿瘤代谢专委会免疫代谢学组) 2019 – Present

Associate editor, Frontiers in pharmacology. 2019- Present

External reviewer for Medical Research Council (MRC) United Kingdom (英国医学研究委员会项目), Natural Science Foundation of China (NSFC) (中国自然科学基金), and Czech Science Foundation (捷克科学基金)


Contact Details

Institute of Chinese Medical Sciences, University of Macau, Macao, China
Room: N22-5010
Telephone: (853) 8822-4508
E-mail: jiahonglu@um.edu.mo