Email

jiahonglu@um.edu.mo

Tel

(853) 8822-4508

Office

N22-9005

Consultation Hours

Tue: 14:00~16:00
Wed: 14:00~16:00

Jia Hong LU 路嘉宏

Associate Professor

Deputy Director (Academic Affairs and Education)

 

Academic Qualifications

  • B.M., Xiangya School of Medicine, Central South University
  • M.S., State key lab of Medical genetics, Central South University
  • Ph.D., Hong Kong Baptist University

Teaching

  1. CMED7012-Targets and Models for Drug Screen
  2. GEST1017-Modern Drug Discovery Drugs and Health
  3. CMED7017-Across the Gap between Science and Industry
  4. CMED8010-Advanced pharmacology

Research Interests

1) Regulatory mechanisms and biological functions of autophagy in human diseases: physiological and translational studies.
2) Neuroprotective TCM compounds discovery and target identification by functional genomics and proteomics approaches.

Dr. Lu got his PhD in Hong Kong Baptist University. He spent 3 years in Icahn School of medicine at Mount Sinai for postdoctoral training before joining University of Macau as an assistant professor.  Dr. Lu is an expert in neurobiology, cell biology and pharmacology. His major research interests are autophagy in human diseases and pharmacological study on traditional Chinese medicine. Dr. Lu tries to combine biochemistry, cell biology and neurobiology approaches, and apply cell, fruit fly and transgenic mouse models to identify small molecular autophagy modulators with therapeutic potential for human diseases including neurodegenerative diseases, cancer and inflammatory diseases. Dr. Lu has published more than 100 papers in high profile journal including: Nature Biomedical Engineering, Nature Communications, Autophagy (15 articles), Molecular neurodegeneration, Acta Pharmaceutica Sinica B, PNAS, …, with a total citation of over 6,000 times (WoS).

Dr. Lu’s group has open position for Postdoc, postgraduate students and research assistants who are interested in autophagy and pharmacological research. For further information, please contact Dr. Lu at jiahonglu@um.edu.mo

  1. Xie C, Zhuang XX, Niu Z, Ai R, Lautrup S, Zheng S, Jiang Y, Han R, Gupta TS, Cao S, Lagartos-Donate MJ, Cai CZ, Xie LM, Caponio D, Wang WW, Schmauck-Medina T, Zhang J, Wang HL, Lou G, Xiao X, Zheng W, Palikaras K, Yang G, Caldwell KA, Caldwell GA, Shen HM, Nilsen H, Lu JH#, Fang EF#. Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow. Nat Biomed Eng. 2022 Jan 6. doi: 10.1038/s41551-021-00819-5. PMID: 34992270. #Co-corresponding author (Impact factor: 29.2)
  2. Dong Y, Zhu G, Wang SF, Keon KA, Rubinstein JL, Zeng SX, Zhang S, Chen QL, Fu J, Li M, Shen HM, Lu JJ, Chen XP, Lu JH#. Toosendanin, a novel potent vacuolar-type H+-translocating ATPase inhibitor, sensitizes cancer cells to chemotherapy by blocking protective autophagy. Int J Biol Sci. 2022 Mar 28;18(7):2684-2702. doi: 10.7150/ijbs.71041. (Impact factor: 10.8)
  3. Cai CZ, Zhuang XX, Zhu Q, Wu MY, Su HX, Wang XJ, Iyaswamy A, Yue ZY, Wang Q, Zhang B, Xue Y, Tan JQ, Li M, He HH#, Lu JH#. Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models. Theranostics. 2022; 12(4):1738-1755. doi:10.7150/thno.64148. (Impact factor: 11.6)
  4. Ai R, Zhuang XX, Anisimov A, Lu JH#, Fang EF#. A synergized machine learning plus cross-species wet-lab validation approach identifies neuronal mitophagy inducers inhibiting Alzheimer disease. Autophagy. 2022 Apr;18(4):939-941. doi: 10.1080/15548627.2022.2031382. #Co-corresponding author (Impact factor: 13.4).
  5. Deng ZQ, Dong Y, Zhou XT, Lu JH#, Yue ZY#. Pharmacological modulation of autophagy for Alzheimer’s disease therapy: Opportunities and obstacles. Acta Pharmaceutica Sinica B. 2022 Apr;12(4):1688-1706.. doi.org/10.1016/j.apsb.2021.12.009. #Co-corresponding author (Invited Review, Back cover story) (Impact factor: 14.9)
  6. Deng Z, Zhou X, Lu JH#, Yue ZY#. Autophagy deficiency in neurodevelopmental disorders. Cell Biosci. 2021 Dec 17;11(1):214. doi: 10.1186/s13578-021-00726-x. #co-corresponding author (Impact factor: 9.6)
  7. Ming-Yue Wu, Er-Jin Wang, Du Feng, Min Li, Richard D. Ye, Lu JH#. Pharmacological insights into autophagy modulation in autoimmune diseases. Acta Pharmaceutica Sinica B. 2021 Nov;11(11):3364-3378. doi.org/10.1016/j.apsb.2021. 026. (Impact factor: 14.9)
  8. Cai CZ, Yang C, Zhuang XX, Yuan NN, Wu MY, Tan JQ, Song JX, Cheung KH, Su H, Wang YT, Tang BS, Behrends C, Durairajan SSK, Yue Z, Li M# & Lu JH#. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy. 2021 May;17(5):1112-1130. DOI: 10.1080/15548627.2020.1760623. (Impact factor: 13.4)
  9. Wu MY, Liu L, Wang EJ, Xiao HT, Cai CZ, Wang J, Su H, Wang Y, Tan J, Zhang Z, Wang J, Yao M, Ouyang DF, Yue Z, Li M#, Chen Y#, Bian ZX#, Lu JH#. PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation. Autophagy. 2021 May;17(5):1096-1111. doi:10.1080/15548627.2020.1741332. (Impact factor: 13.4)
  10. Ke M, Chong CM, Zhu Q, Zhang K, Cai CZ, Lu JH#, Qin D#, Su H#. Comprehensive Perspectives on Experimental Models for Parkinson’s Disease. Aging Dis. 2021 Feb 1;12(1):223-246. doi: 10.14336/AD.2020.0331. #co-corresponding author (Impact factor: 9.97)
  11. Yu Dong, Yuanjia Hu, Sovan Sarkar, Wei-Xing Zong, Min Li, Du Feng, Ju-Xian Song, Min Li, Diego L. Medina, Jieqiong Tan, Zhuohua Zhang, zhenyu Yue and Lu JH#. “Autophagy Modulator Scoring System: a User-friendly Tool for Quantitative Analysis of Methodological Integrity of Chemical Autophagy Modulator Studies.” Autophagy. 2020 Feb;16(2):195-202. doi: 10.1080/15548627.2019.1704119. (Impact factor: 13.4)
  12. Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH#, Yue Z#. Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice. Mol Neurodegener. 2019 Nov 27;14(1):43. doi:10.1186/s13024-019-0342-4. #co-corresponding author (Impact factor: 18.9)
  13. Zhuang XX, Wang SF, Tan Y, Song JX, Zhu Z, Wang ZY, Wu MY, Cai CZ, Huang ZJ, Tan JQ, Su HX#, Li M#, Lu JH#. Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models. Cell Death Dis. 2020 Feb 18;11(2):128. doi: 10.1038/s41419-020-2322-6. (Impact factor: 9.7)
  14. Zhou H, Li S, Li C, Yang X, Li H, Zhong H, Lu JH#, Lee SM#. Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection viaActivation of Immunoproteasome. Aging Dis. 2020 May 9;11(3):559-574. #co-corresponding author (Impact factor: 9.97)
  15. Chen JY, Zhu Q, Zhang S, OuYang D, Lu JH#. Resveratrol in experimental Alzheimer’s disease models: A systematic review of preclinical studies. Pharmacol Res. 2019 Dec;150:104476. doi: 10.1016/j.phrs.2019.104476. (Impact factor: 10.3)
  16. Deng Y, Li M, Chen LX, Chen XQ, Lu JH#, Zhao J#, Li SP#. Chemical characterization and immunomodulatory activity of acetylated polysaccharides from Dendrobium devonianum. Carbohydr Polym. 2018 Jan 15;180:238-245. doi: 10.1016/j.carbpol.2017.10.026. #co-corresponding author (Impact factor: 10.7)
  17. Yang C, Cai CZ, Song JX, Tan JQ, Durairajan SSK, Iyaswamy A, Wu MY, Chen LL, Yue Z, Li M, Lu JH#. NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. Autophagy. 2017;13(12):2028-2040. (Impact factor: 13.4)
  18. Chong CM, Ke M, Tan Y, Huang Z, Zhang K, Ai N, Ge W, Qin D, Lu JH#, Su H#. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling. Cell Death Dis. 2018 Aug 29;9(9):879. #co-corresponding author (Impact factor: 9.7)
  19. Lu JH*, He L*, Behrends C, Araki M, Araki K, Jun Wang Q, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue Z. NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nature Communications. 2014; 5:3920, DOI: 10.1038/ncomms4920. (Impact factor: 14.9)
  20. Lu JH, Tan JQ, Durairajan SS, Liu LF, Zhang ZH, Ma L, Shen HM, Chan HY, Li M. Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy. 2012; 8(1):98-108. (Erratum in Autophagy. 2012; 8(5): 864-866.) (Impact factor: 13.4)

For full list of Publications, please visit Web of Science:
https://www.webofscience.com/wos/author/record/598462

  • 路嘉宏，巫明月，嶽振宇。(2019) 自噬與帕金森病. In 樂衛東 (Eds). 自噬:生物學與疾病臨床卷(第3版) (pp.1-42). 科學出版社。
  • Lu, JH., Wu, M, Yue, Z. (2019) Autophagy and Parkinson’s disease. Autophagy: Biology and Diseases (Clinic Volume) (The 3rd edition) (pp.1-42). Springer.
  • Jiahong Lu, Min Li, Mingyue Wu, Cuizan Cai (2016), Book Chapter, “Chinese medicine in neurological disease: pharmacological perspective”, in Book “Evidence-based research methods for Chinese medicine”
  • 路嘉宏，嶽振宇。(2015) 自噬與帕金森病. In 樂衛東 (Eds). 自噬:生物學與疾病臨床卷(第2版) (pp.234-255). 科學出版社

  • 澳門大學，方飛，英國阿拉丁健康科技有限公司。丹葉大黃素在製備用於治療或改善神經退行性疾病的藥物中的應用。中國專利申請號：202110432373.6
  • 路嘉宏, 陳修平, 董雨, 駱瑋瑋。川楝素在腫瘤治療中的應用。中國專利申請號：201910622457.9
  • 路嘉宏，巫明月。非洲防己堿的應用及藥物製劑。中國專利申請號：201910482193.1
  • 路嘉宏，莊旭旭。一種基於流式細胞術定量分析細胞核內轉錄因數含量的方法。中國專利申請號：201810900356.9
  • Li M., Durairajan S.S.K., Liu L.F., Lu J.H. “Berberine Alkaloid as a Medicament for Prophylaxis and Treatment of Alzheimer’s Disease” U.S. Provisional Patent Application No.61/609917, 2013.

2022    傑出青年學者（年度唯一），第四屆中醫腦科學大會，北京。

2020    粤港澳大湾区高价值专利培育布局大赛，优秀奖。

2014    Future of Science Fund Scholarship, Keystone Symposia, Austin, USA

2013    Best Poster Prize, EMBO Conference Autophagy: Molecular mechanism, physiology and pathology. Oslo, Norway.

  • Council member, the China genetic association (理事 中國遺傳學會)
  • Council member, Asia-Pacific association of medicine and bio-immunology (理事 亞太醫學和生物免疫學會)
  • Committee member, China anti-cancer association cancer immunology and metabolism group (委員 中國抗癌協會腫瘤代謝專委會免疫代謝學組)
  • Committee member, Chinese association of pathophysiology protein modification and disease committee (委員 中國病理生理學會蛋白質修飾與疾病專業委員會)
  • Associate editor, Frontiers in pharmacology
  • Editorial board, Neurochemistry International
  • Guest editor, Journal of leukocyte biology
  • Guest editor, Burns and trauma

External reviewer for Medical Research Council (MRC) United Kingdom (英國醫學研究委員會專案), Natural Science Foundation of China (NSFC) (中國自然科學基金), and Czech Science Foundation (捷克科學基金)