Email

HuanxingSu@um.edu.mo

Tel

+853 8822 8518

Office

N22-7013

Consultation Hours

Tue 16:00-17:00
Wed 16:00-17:00

Huanxing Su 蘇煥興

Professor, Institute of Chinese Medical Sciences

Academic Qualifications

B. Med           Zhejiang University, Clinical Medicine
MPhil             The Chinese University of Hong Kong, Neuroscience
PhD               The University of Hong Kong , Neuroscience

Working experience

16/08/2020- Present                      Professor, University of Macau
16/08/2015- 15/08/2020                Associate Professor, University of Macau
13/09/2011-15/08/2015                 Programme Coordinator of Bachelor of Science (Biomedical  Science), University of Macau
16/08/2011-15/08/2015                 Assistant Professor, University of Macau
01/09/1994-01/08/2005                 Lecturer, School of Medicine, Zhejiang University

Teaching

HSCI2008Human Anatomy
Biomedical StatisticsUndergraduate Course
Anatomy and Physiology IUndergraduate Course
Anatomy and Physiology IIUndergraduate Course
Final Year ProjectsUndergraduate Course
Targets and Models for Drug ScreenPostgraduate Course
Research EthicsPostgraduate Course
Functional Food Product Development in Chinese MedicinePostgraduate Course

Research Interests

  1. Establishing human induced pluripotent stem cells (iPSCs)-based cell models to elucidate pathogenic mechanisms in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis
  2. Investigating beneficial effects of omega-3 polyunsaturated fatty acids and finding effective treatments for cerebral small vessel disease and vascular dementia
  3. Studying glymphatic function in brain disorders

(1). Mechanistic studies on cell cycle and cell division during cell reprograming (Ministry of Science and Technology 973 program of China; Project Code: 2012CB966802; Duration: 2012, 01-2016, 12). PI.

(2). Application of induced pluripotent stem cells in treatment of multiple sclerosis (Start-up Research Grant (SRG) 2012; Project Code: SRGO14.ICMS12-SHX; Duration: 2012, 01-2012, 12). PI.

(3). Using patient-derived induced pluripotent stem cells for drug screens for efficacy and preclinical predictive toxicology (Multi-year research grant from the University of Macau; Project Code: MYRG122 (Y1-L3)-ICMS12-SHX; Duration: 2012, 06-2015, 05). PI.

(4). Therapeutic potentials of ginsenoside and neural progenitor cell transplantation in stroke (Multi-year research grant from the University of Macau; Project Code: MYRG110 (Y1-L2)-ICMS13-SHX; Duration: 2013, 05-2016, 04). PI.

(5). Therapeutic potentials of a combination of ginsenoside Rd administration and neural progenitor cell transplantation in stroke (Macao Science and Technology Development Fund; Project Code: FDCT 003/2012/A; Duration: 2012, 10-2014, 04). PI.

(6). Using patient-specific induced pluripotent stem cells to establish drug screening platforms for neurodegenerative diseases (Macao Science and Technology Development Fund; Project Code: FDCT 018/2013/A1; Duration: 2014, 01-2016, 12). PI.

(7). Driving metabolite clearance from the brain to maintain its homeostasis via activating the Glymphatic System and exploring its underlying mechanisms (Macao Science and Technology Development Fund; Project Code: FDCT 063/2015/A2; Duration: 2016, 01-2018, 06). PI.

(8). Mechanistic studies on the development of cerebral small vessel diseases and therapeutic potentials of omega-3 polyunsaturated fatty acids in the treatment of cerebral small vessel diseases and vascular cognition impairment (Macao Science and Technology Development Fund; Project Code: FDCT 020/2017/A1; Duration: 2017, 08-2020, 07). PI.

(9). Driving metabolite clearance from the brain to maintain its homeostasis via activating the Glymphatic System (Multi-year research grant from the University of Macau; Project Code: MYRG2016-00184-ICMS-QRCM; Duration: 2017, 01-2019, 12). PI.

(10). Roles and action mechanisms of SENP3 in autism (FDCT-NSFC; Project Code: FDCT 039/2017/AFJ; Duration: 2018, 01-2020, 12). PI.

(11). Study of neprilysin gene therapy targeting the glymphatic pathway for the treatment of Alzheimer’s disease and cerebral amyloid angiopathy (Multi-year research grant from the University of Macau; Project Code: MYRG2018-00242-ICMS; 2018, 09-2021, 08). PI.

(12). Mechanistic studies on clearance of amyloid beta in the brain and therapeutic roles of glymphatic pathways in prevention and treatment of neurodegenerative diseases (Macao Science and Technology Development Fund; Project Code: FDCT 049/2019/A1; Duration: 2019, 07-2022, 06). PI.

(13). Study of pathophysiological mechanisms and cognitive consequences of microinfarcts and beneficial effects of omega-3 polyunsaturated fatty acids on attenuating microinfarcts and improving vascular dementia (Multi-year research grant from the University of Macau; Project Code: MYRG2019-00160-ICMS; 2020, 01-2021, 12). PI.

Peng Y, Shi Z, Kumaran Satyanarayanan S, He C, Li P, Wan JB, Su H*. Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments. Brain Behav Immun. 2020 Nov;90:393-402.

Tong J, Satyanarayanan SK, Su H*. Nutraceuticals and probiotics in the management of psychiatric and neurological disorders: A focus on microbiota-gut-brain-immune axis. Brain Behav Immun. 2020 Nov;90:403-419.

Ke M, Chong CM, Zeng H, Huang M, Huang Z, Zhang K, Cen X, Lu JH, Yao X, Qin D*, Su H*. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020 Feb 18;11(2):130.

Liu Q, Yan L, Huang M, Zeng H, Satyanarayanan SK, Shi Z, Chen D, Lu JH, Pei Z, Yao X, Su H*. Experimental alcoholism primes structural and functional impairment of the glymphatic pathway. Brain Behav Immun. 2020 Mar;85:106-119.

Yan L, Xie Y, Satyanarayanan SK, Zeng H, Liu Q, Huang M, Ma Y, Wan JB, Yao X, Su KP, Su H*.  Omega-3 polyunsaturated fatty acids promote brain-to-blood clearance of β-Amyloid in a mouse model with Alzheimer’s disease. Brain Behav Immun. 2020 Mar;85:35-45.

Tan Y, Ke M, Huang Z, Chong C, Cen X, Lu JH, Yao X*, Qin D*, Su H*. Hydroxyurea facilitates manifestation of disease relevant phenotypes in patients-derived iPSCs-based modeling of late-onset Parkinson’s disease. Aging and disease. 2019 Oct 1;10(5):1037-1048.

Chong CM, Ke M, Tan Y, Huang ZJ, Zhang K, Ai N, Ge W, Qin DJ, Lu JH, Su H*. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling. Cell Death Dis. 2018 Aug 29;9(9):879.

Luo C, Ren H, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su KP, Su H*. Enriched Brain Omega-3 Polyunsaturated Fatty Acids Confer Neuroprotection against Microinfarction. EBioMedicine. 2018 Jun;32:50-61.

Luo C, Liang F, Ren H, Yao X, Liu Q, Li M, Qin D, Yuan TF, Pei Z, Su H*. Collateral blood flow in different cerebrovascular hierarchy provides endogenous protection in cerebral ischemia. Brain Pathology. 2017 Nov;27(6):809-821.

Ren H, Yang Z, Luo C, Zeng H, Li P, Kang JX, Wan JB, He C, Su H*. Enriched Endogenous Omega-3 Fatty Acids in Mice Ameliorate Parenchymal Cell Death After Traumatic Brain Injury. Mol Neurobiol. 2017 Jul;54(5):3317-3326.

Huang X, Chen Y-Y, Shen Y, Cao Y,  Li A, Liu Q, Li Z, Zhang L-B, Dai W, Tan T, Arias-Carrion O, Xue Y-X, Su H* and Yuan T-F*. Methamphetamine abuse impairs motor cortical plasticity and function. Molecular Psychiatry 2017 Sep;22(9):1274-1281.

Ren H, Luo C, Feng Y, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su H*. Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system. FASEB J, 2017 Jan;31(1):282-293.

Luo C, Yao X, Li J, He B, Liu Q, Ren H, Liang F, Li M, Lin H, Peng J, Yuan TF, Pei Z, Su H*. Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control. Cell Death Dis. 2016 Mar 31;7:e2160.

Editorial Board Member: Brain, Behavior, and Immunity

Editorial Board Member: Aging and disease