Huanxing Su 蘇煥興

Professor, Institute of Chinese Medical Sciences

(1). Mechanistic studies on cell cycle and cell division during cell reprograming (Ministry of Science and Technology 973 program of China; Project Code: 2012CB966802; Duration: 2012, 01-2016, 12). PI.

(2). Application of induced pluripotent stem cells in treatment of multiple sclerosis (Start-up Research Grant (SRG) 2012; Project Code: SRGO14.ICMS12-SHX; Duration: 2012, 01-2012, 12). PI.

(3). Using patient-derived induced pluripotent stem cells for drug screens for efficacy and preclinical predictive toxicology (Multi-year research grant from the University of Macau; Project Code: MYRG122 (Y1-L3)-ICMS12-SHX; Duration: 2012, 06-2015, 05). PI.

(4). Therapeutic potentials of ginsenoside and neural progenitor cell transplantation in stroke (Multi-year research grant from the University of Macau; Project Code: MYRG110 (Y1-L2)-ICMS13-SHX; Duration: 2013, 05-2016, 04). PI.

(5). Therapeutic potentials of a combination of ginsenoside Rd administration and neural progenitor cell transplantation in stroke (Macao Science and Technology Development Fund; Project Code: FDCT 003/2012/A; Duration: 2012, 10-2014, 04). PI.

(6). Using patient-specific induced pluripotent stem cells to establish drug screening platforms for neurodegenerative diseases (Macao Science and Technology Development Fund; Project Code: FDCT 018/2013/A1; Duration: 2014, 01-2016, 12). PI.

(7). Driving metabolite clearance from the brain to maintain its homeostasis via activating the Glymphatic System and exploring its underlying mechanisms (Macao Science and Technology Development Fund; Project Code: FDCT 063/2015/A2; Duration: 2016, 01-2018, 06). PI.

(8). Mechanistic studies on the development of cerebral small vessel diseases and therapeutic potentials of omega-3 polyunsaturated fatty acids in the treatment of cerebral small vessel diseases and vascular cognition impairment (Macao Science and Technology Development Fund; Project Code: FDCT 020/2017/A1; Duration: 2017, 08-2020, 07). PI.

(9). Driving metabolite clearance from the brain to maintain its homeostasis via activating the Glymphatic System (Multi-year research grant from the University of Macau; Project Code: MYRG2016-00184-ICMS-QRCM; Duration: 2017, 01-2019, 12). PI.

(10). Roles and action mechanisms of SENP3 in autism (FDCT-NSFC; Project Code: FDCT 039/2017/AFJ; Duration: 2018, 01-2020, 12). PI.

(11). Study of neprilysin gene therapy targeting the glymphatic pathway for the treatment of Alzheimer’s disease and cerebral amyloid angiopathy (Multi-year research grant from the University of Macau; Project Code: MYRG2018-00242-ICMS; 2018, 09-2021, 08). PI.

(* corresponding author)
Tan Y, Ke M, Huang Z, Chong C, Cen X, Lu JH, Yao X*, Qin D*, Su H*. Hydroxyurea facilitates manifestation of disease relevant phenotypes in patients-derived iPSCs-based modeling of late-onset Parkinson’s disease. Aging and disease. 2019 http://dx.doi.org/10.14336/AD.2018.1216.

Yan L, Xie Y, Satyanarayanan SK, Zeng H, Liu Q, Huang M, Ma Y, Wan JB, Yao X, Su KP, Su H*.  Omega-3 polyunsaturated fatty acids promote brain-to-blood clearance of β-Amyloid in a mouse model with Alzheimer’s disease. Brain Behav Immun. 2019 May 24. pii: S0889-1591(18)31175-9.

Shi Z, Xie Y, Ren H, He B, Wang M, Wan J, Yuan TF*, Yao X*, Su H*. Fish oil treatment reduces chronic alcohol exposure induced synaptic changes. Addiction Biology. 2019 July, 24, 577-589.

Habib MR, Li H, Kong Y, Liang T, Obaidulla SM, Xie S, Wang S, Ma X, Su H*, Xu M*. Tunable photoluminescence in a van der Waals heterojunction built from a MoS2 monolayer and a PTCDA organic semiconductor. Nanoscale. 2018 Aug 30;10(34):16107-16115.

Chong CM, Ke M, Tan Y, Huang ZJ, Zhang K, Ai N, Ge W, Qin DJ, Lu JH, Su H*. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling. Cell Death Dis. 2018 Aug 29;9(9):879.

Luo C, Ren H, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su KP, Su H*. Enriched Brain Omega-3 Polyunsaturated Fatty Acids Confer Neuroprotection against Microinfarction. EBioMedicine. 2018 Jun;32:50-61.

Chong CM, Ai N, Ke M, Tan Y, Huang Z, Li Y, Lu JH, Ge W, Su H*. Roles of Nitric Oxide Synthase Isoforms in Neurogenesis. Mol Neurobiol. 2018 Mar;55(3):2645-2652.

He B, Zheng M, Liu Q, Shi Z, Long S, Lu X, Pei Z, Yuan TF, Su H*, Yao X*. Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice. Mol Neurobiol. 2018 Feb;55(2):1703-1713.

Shi Z, Ren H, Huang Z, Peng Y, He B, Yao X, Yuan T, Su H*. Fish oil prevents Lipopolysaccharide -induced depressive-like behavior by inhibiting neuroinflammation. Mol Neurobiol. 2017 54:7327-7334.

Luo C, Liang F, Ren H, Yao X, Liu Q, Li M, Qin D, Yuan TF, Pei Z, Su H*. Collateral blood flow in different cerebrovascular hierarchy provides endogenous protection in cerebral ischemia. Brain Pathology. 2017 Nov;27(6):809-821

Huang X, Chen Y-Y, Shen Y, Cao Y, Li A, Liu Q, Li Z, Zhang L-B, Dai W, Tan T, Arias-Carrion O, Xue Y-X, Su H* and Yuan T-F*. Methamphetamine abuse impairs motor cortical plasticity and function. Molecular Psychiatry 2017 Sep;22(9):1274-1281.

Ren H, Yang Z, Luo C, Zeng H, Li P, Kang JX, Wan JB, He C, Su H*. Enriched Endogenous Omega-3 Fatty Acids in Mice Ameliorate Parenchymal Cell Death After Traumatic Brain Injury. Mol Neurobiol. 2017 Jul;54(5):3317-3326.

Ren H, Luo C, Feng Y, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su H*. Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system. FASEB J, 2017 Jan;31(1):282-293.

Shi Z, Ren H, Luo C, Yao X, Li P, He C, Kang JX, Wan JB, Yuan TF, Su H*. Enriched Endogenous Omega-3 Polyunsaturated Fatty Acids Protect Cortical Neurons from Experimental Ischemic Injury. Mol Neurobiol. 2016 Nov;53(9):6482-6488.

Luo C, Yao X, Li J, He B, Liu Q, Ren H, Liang F, Li M, Lin H, Peng J, Yuan TF, Pei Z, Su H*. Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control. Cell Death Dis. 2016 Mar 31;7:e2160.

Tan Y, Ren H, Shi Z, Yao X, He C, Kang JX, Wan JB, Li P, Yuan TF, Su H*. Endogenous Docosahexaenoic Acid (DHA) prevents Aβ1–42 oligomers induced neuronal injury. Mol Neurobiol. 2016 Jul;53(5):3146-53.

Yang X, Li J, Liang T, Chen H, Hanagata N, Su H*, and Xu M*. Antibacterial activity of two-dimensional MoS2 sheets. Nanoscale 2014 Aug 7;6 (17):10126-33.

Luo C, Ren H, Wan JB, Yao X, Zhang X, He C, So KF, Kang JX, Pei Z, Su H*. Enriched endogenous omega-3 fatty acids in mice protect against global ischemia injury. J Lipid Res. 2014 May 29; 55 (7):1288-1297.

Editorial Board Member: Brain, Behavior, and Immunity; Elsevier, IF6.3

Editorial Board Member: Aging and disease; IF 5.1