Hua YU

Hua YU   
Assistant Professor, Institute of Chinese Medical Sciences

Teaching

  • CMED7006 Introduction to Research in Medical Administration (Msc. Course)
  • CMED8001 Advanced Pharmacokinetics (Ph.D. Course)

Academic Qualifications

  • BSc., Pharmaceutics, China Pharmaceutical University, Nanjing China
  • MSc., Chinese Medicinal Sciences, University of Macau, Macao, China
  • MSc., Pharmacognosy, China Pharmaceutical University, Nanjing China
  • PhD., Biomedical Sciences, University of Macau, Macao, China

Research

Research Interests

  • Pharmaceutical Sciences

1) Innovative pharmaceutical designs and development;

2) Functional polymeric nanoparticles for drug delivery.

  • Bioactive components and quality control for Chinese Medicines

1) Chinese medicines for inflammatory diseases

2) Quality control and standards for Chinese medicines

 

We are actively looking for high-caliber postdoctoral fellows, MSc and PhD students, as well as research assistants who are interested in Pharmaceutical Sciences, and/or Pharmacological Evaluation/Quality Control for Chinese Medicines. For further information, please contact Dr. Yu (bcalecyu@um.edu.mo).


Current Group Members

PhD students

Xiong wei (2016- )                 Linghu Kegang (2017- )

Zhao Mingming (2018-)         Chen Qiling (2019-)

 

Master students  

Zhao Guanding (2017-)          Ma Qiushuo (2017-)

Xiong Shihang (2017-)           Hua Tianyi (2019-)


Selected publications in recent 3 years (* Corresponding Author)

Pharmaceutical Sciences

  1. Xiong W, Zhao GD, Yin X, Linghu KG, Chu JMT, Wong GTC, Li H, Yu H (*), Wang YT. Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations. Carbohydr Polym. 2019 Jan 15; 204: 89-96.
  2. Li ZX, Zhao GD, Xiong W, Linghu KG, Ma QS, Cheang WS, Yu H (*), Wang Y. Immunomodulatory effects of a new whole ingredients extract from Astragalus: a combined evaluation on chemistry and pharmacology. Chin Med. 2019 Mar 27; 14: 12.
  3. Xiong W, Sang W, Linghu KG, Zhong ZF, Cheang WS, Li J, Hu YJ, Yu H (*), Wang YT. Dual-functional Brij-S20-modified nanocrystal formulation enhances the intestinal transport and oral bioavailability of berberine. Int J Nanomedicine. 2018 Jun 28; 13: 3781-3793.
  4. Li Z, Cai Y, Zhao Y, Yu H, Zhou H, Chen M. Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy. Int J Nanomedicine. 2017 Sep 6; 12: 6595-6604.
  5. Liu Y, Fu S, Lin L, Cao Y, Xie X, Yu H, Chen M, Li H. Redox-sensitive Pluronic F127-tocopherol micelles: synthesis, characterization, and cytotoxicity evaluation. Int J Nanomedicine. 2017 Apr 3; 12: 2635-2644.
  6. Chen FQ, Zhang JM, Fang XF, Yu H, Liu YL, Li H, Wang YT, Chen MW. Reversal of paclitaxel resistance in human ovarian cancer cells with redox-responsive micelles consisting of α-tocopheryl succinate-based polyphosphoester copolymers. Acta Pharmacol Sin. 2017 Jun; 38(6): 859-873.

 

Quality Research/Evaluation of Chinese medicines for inflammatory diseases

  1. Wang Z, Linghu K-G, Hu Y, Zuo H, Yi H, Xiong S-H, Lu J, Chan G (*), Yu H (*), Huang R-Y. Deciphering the Pharmacological Mechanisms of the Huayu-Qiangshen-Tongbi Formula Through Integrating Network Pharmacology and In Vitro Pharmacological Investigation. Front. Pharmacol. 2019, 10: 1065.
  2. Chen XM, Zhao Y, Wu XD, Wang MJ, Yu H, Lu JJ, Hu YJ, Huang QC, Huang RY, Lu CJ. Novel findings from determination of common expressed plasma exosomal microRNAs in patients with psoriatic arthritis, psoriasis vulgaris, rheumatoid arthritis, and gouty arthritis. Discov Med. 2019 Jul; 28(151): 47-68.
  3. Wang Z, Lin HH, Linghu K, Huang RY, Li G, Zuo H, Yu H, Chan G, Hu Y. Novel Compound-Target Interactions Prediction for the Herbal Formula Hua-Yu-Qiang-Shen-Tong-Bi-Fang. Chem Pharm Bull (Tokyo). 2019; 67(8): 778-785.
  4. Zhang QR, Zhong ZF, Sang W, Xiong W, Tao HX, Zhao GD, Li ZX, Ma QS, Tse AKW, Hu YJ (*), Yu H (*), Wang YT. Comparative comprehension on the anti-rheumatic Chinese herbal medicine Siegesbeckiae Herba: Combined computational predictions and experimental investigations. J Ethnopharmacol. 2019 Jan 10; 228: 200-209.
  5. Linghu KG, Wu GP, Fu LY, Yang H, Li HZ, Chen Y, Yu H, Tao L, Shen XC. 1,8-Cineole Ameliorates LPS-Induced Vascular Endothelium Dysfunction in Mice via PPAR-γ Dependent Regulation of NF-κB. Front Pharmacol. 2019 Mar 7; 10: 178.
  6. Chu JMT, Xiong W, Linghu KG, Liu Y, Zhang Y, Zhao GD, Irwin MG, Wong GTC, Yu H (*). Siegesbeckia Orientalis L. Extract Attenuates Postoperative Cognitive Dysfunction, Systemic Inflammation, and Neuroinflammation. Exp Neurobiol. 2018 Dec; 27(6): 564-573.
  7. Tao HX, Xiong W, Zhao GD, Peng Y, Zhong ZF, Xu L, Duan R, Tsim KWK, Yu H (*), Wang YT. Discrimination of three Siegesbeckiae Herba species using UPLC-QTOF/MS-based metabolomics approach. Food Chem Toxicol. 2018 Sep; 119: 400-406.
  8. Sang W, Zhong Z, Linghu K, Xiong W, Tse AKW, Cheang WS, Yu H (*), Wang Y. Siegesbeckia pubescens Makino inhibits Pam3CSK4-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-κB activation. Chin Med. 2018 Jul 5; 13: 37.
  9. Cai X, Chen XM, Xia X, Bao K, Wang RR, Peng JH, Liu HJ, Yang QW, Yan JY, Wang MJ, Yu H, Lu JJ, Hu YJ, Jakobsson PJ, Wen ZH, Huang RY, Huang QC. The Bone-Protecting Efficiency of Chinese Medicines Compared With Western Medicines in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Comparative Studies. Front Pharmacol. 2018 Aug 30; 9: 914.
  10. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol. 2017 Oct;108(Pt B):375-391.

 


Book Chapters

  1. Yu H, Yang FQ, Han YF, Li SP. “Recent development on sample preparation for quality control of Chinese herbs” in Pharmacological Activity-Based Quality Control of Chinese Herbs (Edited by S.P. Li and Y.T. Wang). Nova Science Publishers, Inc. New York. 2008: 21-72.
  2. Cui W, Choi TC, Mak SH, Yu H, Hu SQ, Li WM, Zuo Z, Han YF. “Bis(12)-hupyridone, a promising multi-functional anti-Alzheimer’s dimer derived from Chinese medicine” in When Things Go Wrong – Diseases and Disorders of the Human Brain (Edited by Theo Mantamadiotis). InTech Open Access publisher, Rijeka, Croatia. 2012: 151-174.

Patents

  1. Yu H, Wang YT, Xiong W. A series of novel Brij-grafted-chitosan, method of preparation and the use thereof. China, CN 201811024505.6. 2018.
  2. Yu H, Wang YT, Li ZX, Zhao GD. “Whole Ingredients System” herbal extract for healthcare, method of preparation and the use thereof. China, CN201811029369.X. 2018.
  3. Wang YT, Yu H, Li P, Lai CM, Wang SP, Zhang JM, Zhong ZF. Solubilization and taste-masking techniques and astragalus effervescent tablet, method of preparation and the use thereof. China, CN 201910170512.5. 2019.
  4. Wang YT, LI P, Yu H, Wang CM, Wang SP, Zhang JM. Development of solid-liquid capsules for Chinese medicine. China, CN106963742A. 2016.

Selected Awards and Honors

  1. Wang YT, Yu H, Wang CM, Li P, Wang SP, Lai CM, Zhang JM, Luo H, Li ZX, Gao CF, Zhao GD, Xiong W, Chen ZJ, Zhao MM, Linghu KG. Innovative Healthcare Products from Chinese Herbs. Gold Award of the 47th International Exhibition of Inventions of Geneva. 2019-04.
  2. Zhao GD, Xiong SH, Ma QS, Zhao MM, Linghu KG, Xiong W, Yu H (*), Wang YT(*). A type of innovative granules for Chinese Medicines. Top 100 projects of the 2019 Competition of the high-valuable patents (Development and Layout) of Guangdong-Hong Kong-Macao Greater Bay Area. 2019-06.

Qualifications

  1. Specialty Committee of Network Pharmacology of World Federation of Chinese Medicine Societies (WFCMS), Council Member
  2. Specialty Committee of TCM Pharmaceutical of World Federation of Chinese Medicine Societies (WFCMS), Council Member
  3. Precision Medicine Association of Macau, Committee Member

Contact Details

Institute of Chinese Medical Sciences
SKL of Quality Research in Chinese Medicine
University of Macau, Room 8008, N22
Avenida da Universidade, Taipa, Macau
Tel: +853-8822 8540
Fax: +853-2884 1358
Email: bcalecyu@um.edu.mo