Email

HeSONG@um.edu.mo

Tel

(853) 8822-4537

Office

N22-2056

Consultation Hours

He SONG 宋賀

Assistant Professor

Institute of Chinese Medical Sciences

University of Macau

Academic Qualifications

  • Staff Research Associate, University of California, Los Angeles, Los Angeles, CA, USA
  • Postdoctoral Fellow, National Cancer Institute, NIH, Frederick, MD, USA
  • Ph.D., Mississippi State University, Starkville, MS, USA
  • B.S., Ocean University of China, Qingdao, Shandong, China

Teaching

CMED7007Biomedical InformaticsMSc Course
CMED7020Computational ChemistryMSc Course
CMED7035Application of Computer Technology in PharmacyMSc Course
HSCI2013Medicinal ChemistryBSc Course

Research Interests

My laboratory adopts an interdisciplinary methodology to uncover the therapeutic potential of traditional Chinese medicine in cancer treatment. By harmoniously merging enzymology, biochemistry, biophysics, structural biology, and computational biology, we provide a robust platform to investigate the efficacy of bioactive ingredients derived from traditional Chinese medicine. My specialized knowledge delves deep into the realms of biomolecular interactions, structure-based drug design, computational biology, and the intricate processes of DNA/RNA metabolism and biogenesis.

I am adept at creating pioneering drugs from a spectrum of sources, such as natural extracts, peptides, and antibodies, with a particular emphasis on targeting critical cancer-associated proteins like KRAS, METTL3, and RIPK1. Beyond this, I am fervently involved in studying RNA processing proteins, RNA binding proteins, and the expansive world of non-coding RNAs. This rigorous research is not only geared toward identifying novel drug targets for cancer but also potential markers for neurodegenerative conditions.

Dr. SONG’s team is on the lookout for budding researchers passionate about our molecular pharmacology projects. For more information, kindly reach out to Dr. Song at hesong@um.edu.mo.

Representative peer-reviewed journal papers (* denotes co-first author, # denotes corresponding author)

  1. He, Y.*, Song, H.*, Chan, H., Wang, Y., Liu, B., Susac, L., Zhou, Z. & Feigon, J. Structure of Tetrahymena telomerase-bound CST with Polymerase a-Primase. Nature (2022)
  2. Liu, B., He, Y., Wang, Y., Song, H., Zhou, Z. & Feigon, J. Structure of active human telomerase with telomere shelterin protein TPP1. Nature 604, 578-583 (2022)
  3. Wang, Y., Jones, MG., Susac, L, Song, H. & Feigon, J. A structurally conserved human and Tetrahymena telomerase catalytic core. Proceedings of the National Academy of Sciences 117, 31078-31087 (2020)
  4. Song, H.*, Dharmasena, MN.*, Wang, C., Ding, JJ. & Ji, X. Structure and activity of PPX/GppA Homologs from Escherichia coli and Helicobacteer pylori. The FEBS Journal 287, 1865-1885 (2019)
  5. Song, H. & Ji, X. The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X. Nature Communication 10, 1-8 (2019)
  6. Jin, L., Song, H., Tropea, JE., Needle, D., Waugh, DS., Gu, S., & Ji, X. The molecular mechanism of dsRNA processing by a bacterial Dicer. Nucleic Acids Research 47, 4707-4720 (2019)
  7. Yu, F.*, Song, H.*, Wu, Y.*, Chang, S., Wang, L., Li, W., Hong, B., Xia, S., Wang, C., Khurana, S., Feng, Y., Sun, Z., He, B., Hou, D., Manischewitz, J., King, LR., Song, Y., Min, J., Golding, H., Ji, X., Lu, L., Jiang, S., Dimitrov, DS. & Ying, T. A potent germline-like human monoclonal antibody targets a pH-sensitive epitope on H7N9 influenza hemagglutinin. Cell Host & Microbe 22, 471-483 (2017)
  8. Song, H., Fang, X., Jin, L., Shaw, GX., Wang, YX. & Ji, X. The functional cycle of Rnt1p: Fiver consecutive steps of double-stranded RNA processing by a eukaryotic ribonuclease III. Structure 25, 353-363 (2017)
  9. Nettles, WL., Song, H., Farquhar, ER., Fitzkee, NC. & Emerson, JP. Characterization of the copper(II) binding sites in human carbonic anhydrase II. Inorganic Chemistry 54, 5671-5680 (2015)
  10. Song, H., Weitz, AC., Henderich, EA., Lewis, EA. & Emerson, JP. Building reactive copper centers in human carbonic anhydrase II. Journal of Biological Inorganic Chemistry 18, 595-598 (2013)
  11. Song, H., Wilson, DL., Farquhar, ER., Lewis, EA. & Emerson, JP. Revisiting zinc coordination in human carbonic anhydrase II. Inorganic Chemistry 51, 11098-11105 (2012)