Email

emilyywang@um.edu.mo

Tel

(853) 8822-4673

Office

N22-7010

Consultation Hours

Mon: 16:00~17:00
Tue: 16:00~17:00

Ying Wang 王穎

Associate Professor

Academic Qualifications

  • B.Sc., Jilin University and Shenyang Pharmaceutical University, China
  • Ph.D., The University of Hong Kong, HK
  • Postdoctoral training, Yale University, USA

Teaching

GEST2003Exploring Chinese MedicineUndergraduate Course
HSCI2009PharmacologyUndergraduate Course
HSCI2010Pharmacology LabUndergraduate Course
CMED7002Introduction to Research in Chinese Medicinal ScienceMaster Course
CMED7015Progress in Contemporary Study of Chinese MedicineMaster Course
CMED8010Advanced PharmacologyPhD Course

Research Interests

我們的研究方向主要為開發對天然免疫反應具有抑制作用的天然產物及衍生物，尤其是針對Toll樣受體、炎症小體、泛素化和去泛素化、和核受體啟動的信號傳導通路。我們會在如潰瘍性結腸炎、巨噬細胞極化、和膿毒血症等疾病模型上進一步驗證候選抑制劑的體內活性。例如，我們以分析天然產物穿心蓮內酯不同位置衍生物的結構與其抗炎作用的相關性為基礎，與合作課題組設計了新型穿心蓮內酯衍生物，正在炎症性腸病模型上進一步檢測其生物活性和作用機制。

我們竭誠歡迎對分子藥理學感興趣的青年學者加入我們的研究隊伍。詳情請諮詢王穎教授 emilyywang@um.edu.mo.

We are broadly interested in developing small molecule inhibitors from natural products and derivatives to control innate immune reaction. In particular, our research revolves around the signal transduction related to signaling initiated by the Toll-like receptors, inflammasomes, ubiquitination and deubiquitination, and nuclear receptor. We investigate the potential therapeutic efficacy of candidate inhibitors to control the appropriate immune response in disease conditions like inflammatory bowel disease, macrophage polarization, and sepsis. For example, we analyzed structure-activity relationship (SAR) of a series of andrographolide analogs, and then synthesized a novel andrographolide analog based on the SAR results. The therapeutic potential of the novel andrographolide analog in inflammatory bowel disease is currently under investigation.

We are actively looking for young talents who are interested in our research projects on molecular pharmacology. For further details, please contact Dr. Wang at emilyywang@um.edu.mo.

  1. Shao-Ru Chen, Zheng-Qing Li, Jun Xu, Mo-Yu Ding, Yaming Shan, Yung-Chi Cheng, Gao-Xiao Zhang, Ye-Wei Sun, Yu-Qiang Wang, Ying Wang*. Celastrol attenuates hepatitis C virus translation and inflammatory response in mice by suppressing heat shock protein 90β. Acta Pharmacologica Sinica, 2023, https://doi.org/10.1038/s41401-023-01067-w.
  2. Mo-Yu Ding, Yuran Peng, Feng Li, Zheng-Qing Li, Decai Wang, Guo-Chun Zhou, Ying Wang*. Andrographolide derivative as antagonist of vitamin D receptor to induce lipidation of microtubule associate protein 1 light chain 3 (LC3). Bioorganic & Medicinal Chemistry, 51: 116505, 2021.
  3. Zheng-Qing Li, Xiu-Ping Chen*, Ying Wang*. Small molecules targeting ubiquitination to control inflammatory diseases. Drug Discovery Today, 26: 2414-2422, 2021.
  4. Qiu-Ling Chen#, Hao-Ran Yin#, Qing-Yu He*, Ying Wang*. Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease. Biomedicine & Pharmacotherapy, 138: 111442, 2021.
  5. Bin Xu, Mo-Yu Ding, Zhibing Weng, Zheng-Qing Li, Feng Li, Xia Sun, Qiu-Ling Chen, Yitao Wang, Ying Wang*, Guo-Chun Zhou*. Discovery of fused bicyclic derivatives of 1H-pyrrolo[1,2-c]imidazol-1-one as VDR signaling regulators. Bioorganic & Medicinal Chemistry, 27: 3879, 2019.
  6. Shen-Fei Wang, Xin Liu, Mo-Yu Ding, Shuangcheng Ma, Jing Zhao*, Ying Wang*, Shaoping Li*. 2-O-β-D-Glucopyranosyl-L-ascorbic acid, a novel vitamin C derivative from Lycium barbarum, prevents oxidative stress. Redox Biology, 24: 101173, 2019.
  7. Bao-Jian Guo#, Zhuyun Liu, Mo-Yu Ding#, Feng Li, Mei Jing, Li-Peng Xu, Yu-Qiang Wang, Zai-Jun Zhang, Yitao Wang, Decai Wang, Guo-Chun Zhou*, Ying Wang*. Andrographolide derivative ameliorates dextran sulfate sodium-induced experimental colitis in mice. Biochemical Pharmacology, 163: 416-424, 2019.
  8. Chao Zhao, Jinlin Fan, Yuanyuan Liu, Weiling Guo, Hui Cao, Jianbo Xiao, Ying Wang*, Bin Liu*. Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis. Food Chemistry, 271:148-156, 2019.
  9. Ying Wang, Yaming Shan, Xinyu Gao, Rui Gong, Jun Zheng, Xiaohua Douglas Zhang, Qi Zhao*. Screening and expressing HIV-1 specific antibody fragments in Saccharomyces cerevisiae. Molecular Immunology, 103: 279-285, 2018.
  10. Shao-Ru Chen#, Feng Li#, Mo-Yu Ding, Decai Wang, Qi Zhao, Yitao Wang, Guo-Chun Zhou, Ying Wang*. Andrographolide Derivative as STAT3 Inhibitor that Protects Acute Liver Damage in Mice. Bioorganic & Medicinal Chemistry, 26: 5053-5061, 2018.
  11. Feng Li#, Xiao-Min Li#, Dekun Sheng, Shao-Ru Chen, Xin Nie, Zhuyun Liu, Decai Wang, Yitao Wang, Qi Zhao, Ying Wang*, Guo-Chun Zhou*. Discovery and preliminary SAR of 14-aryloxy-andrographolide derivatives as antibacterial agents with immunosuppressant activity. RSC Advances, 8: 9440-9456, 2018.
  12. Xian-Qiang Chen, Jing Zhao*, Ling-Xiao Chen, Shen-Fei Wang, Ying Wang*, Shao-Ping Li*. Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against alpha-glucosidase. Phytochemistry, 149: 103-115, 2018.
  13. Yan Dai#, Shao-Ru Chen#, Ling Chai, Jing Zhao, Yitao Wang*, Ying Wang*. Overview of Pharmacological Activities of Andrographis paniculata and its Major Compound Andrographolide. Critical Reviews in Food Science and Nutrition, 10: 1-13, 2018.
  14. Shao-Ru Chen, Yan Dai, Jing Zhao, Ligen Lin, Yitao Wang*, Ying Wang*. A mechanistic overview of Triptolide and Celastrol: natural products from Tripterygium wilfordii Hook F. Frontiers in Pharmacology, 9: 104, 2018.
  15. Ying Wang, Shao-Ru Chen, Xiaoming Yang, Kuo-Hsiung Lee, Yung-Chi Cheng. Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. Bioorganic & Medicinal Chemistry, 26: 630-636, 2018.
  16. Min Li, Ling-Xiao Chen, Shao-Ru Chen, Yong Deng, Jing Zhao, Ying Wang*, Shao-Ping Li*. Non-starch polysaccharide from Chinese yam activated RAW 264.7 macrophages through the Toll-like receptor 4 (TLR4)-NF-κB signaling pathway. Journal of Functional Foods, 37: 491-500, 2017.
  17. Ying Wang, Sangwon Lee, Ya Ha, Wing Lam, Shao-Ru Chen, Ginger E. Dutschman, Elizabeth A. Gullen, Susan P. Grill, Yao Cheng, Alois Fürstner, Samson Francis, David C. Baker, Xiaoming Yang, Kuo-Hsiung Lee, and Yung-Chi Cheng*. Tylophorine analogs allosterically regulates heat shock cognate protein 70 and inhibits hepatitis C virus replication. Scientific Reports, 7: 10037, 2017.
  18. Bao-Jian Guo, Zhao-Xiang Bian, Hong-Cong Qiu, Yitao Wang, Ying Wang*. Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease. Annals of the New York Academy of Sciences, 1401: 37-48, 2017.
  19. Xin Nie, Shao-Ru Chen, Kun Wang, Yuran Peng, Yitao Wang, Decai Wang, Ying Wang*, Guo-Chun Zhou*. Attenuation of innate immunity by andrographolide derivatives through NF-κB signaling pathway. Scientific Reports, 7: 4738, 2017.
  20. Lie-Jun Huang#, Shao-Ru Chen#, Chun-Mao Yuan, Wei Gu, Bao-Jian Guo, Yi-Tao Wang, Ying Wang*, Xiao-Jiang Hao*. C21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents. Bioorganic & Medicinal Chemistry, 25: 3512-3524, 2017.
  21. Min Li, Yi-Xi Yan, Qing-Tao Yu, Yong Deng, Ding-Tao Wu, Ying Wang, Ya-Zhong Ge, Shao-Ping Li*, Jing Zhao*. Comparison of immunomodulatory effects of fresh garlic and black garlic polysaccharides on RAW 264.7 macrophages. Journal of Food Science, 82: 765-771, 2017.
  22. Ying Wang, Wing Lam, Shao-Ru Chen, Fulan-Guan, Ginger Dutchman, Samson Francis, David Baker, Yung-Chi Cheng*. Tylophorine analog DCB-3503 inhibited cyclin D1 translation through allosteric regulation of heat shock cognate protein 70. Scientific Reports, 6: 32832, 2016.
  23. Shao-Ru Chen, An-Qi Wang, Hong-Cong Qiu, Li-Gen Lin, Yi-Tao Wang*, Ying Wang*. In Vitro Study on Anti-Hepatitis C Virus Activity of Spatholobus suberectus Dunn. Molecules, 21: 1367, 2016.
  24. Shao-Ru Chen, Hong-Cong Qiu, Yang Hu, Ying Wang*, Yi-Tao Wang*. Herbal medicine offered as an initiative therapeutic option for the management of hepatocellular carcinoma. Phytotherapy Research, 30: 863, 2016.
  25. Shao-Ru Chen, Xiu-Ping Chen, Jin-Jian Lu, Ying Wang*, Yi-Tao Wang*. Implications of natural product and herbal medicine for the treatment of liver fibrosis. Chinese Medicine, 10: 7, 2015.
  26. Ying Wang*, Qing-Yu He, Jen-Fu Chiu*. Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line. European Journal of Pharmacology, 735: 52, 2014.
  27. Ying Wang, Hui-Chyn Wong, Elizabeth A. Gullen, Wing Lam, Xiaoming Yang, Qian Shi, Kuo-Hsiung Lee, Yung-Chi Cheng*. Cryptopleurine analogs with modification of E ring exhibit different mechanism to Rac-cryptopleurine and tylophorine. PLoS ONE, 7: e51138, 2012.
  28. Ying Wang, Wenli Gao, Yuri V. Svitkin, Annie Pei-Chun Chen, Yung-Chi Cheng*. DCB-3503, a tylophorine analog, inhibits protein synthesis through a novel mechanism. PLoS ONE, 5: e11607, 2010.
  29. Ying Wang, Qing-Yu He, Sai-Wah Tsao, Yim-Hing Cheung, Anita Wong, Jen-Fu Chiu*. Cytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization. Cancer Letters, 265: 188, 2008.
  30. Chi-Chun Wong, Ying Wang, Jen-Fu Chiu, Qing-Yu He*, Feng Chen*. Comparative proteomic analysis of indioside D-triggered cell death in HeLa cells. Journal of Proteome Research, 8: 2420, 2008.
  31. Ying Wang, Qing-Yu He, Chi-Ming Che, Sai Wah Tsao, Raymond Wai-Yin Sun, Jen-Fu Chiu*. Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways. Biochemical Pharmacology, 75: 1282, 2008.
  32. Ying Wang, Jen-Fu Chiu*. Proteomic approaches in understanding action mechanisms of metal-based anticancer drugs. Metal Based Drugs, 2008: 716329, 2008.
  33. Andy T.Y. Lau#, Ying Wang#, Jen-Fu Chiu*. Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. Journal of Cellular Biochemistry, 104: 657-667, 2008.
  34. Ying Wang, Jen-Fu Chiu, Qing-Yu He*. Isolation of cytoplasmic proteins from cultured cells for two-dimensional gel electrophoresis. 2D PAGE: Sample Preparation and Fractionation. Methods in Molecular Biology, 425: 101-112, 2008.
  35. Ying Wang, Chi-Ming Che, Jen-Fu Chiu, Qing-Yu He*. Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study. Journal of Proteome Research, 6: 4703, 2007.
  36. Ying Wang, Qing-Yu He, Hongmin Chen, Jen-Fu Chiu*. Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization. Experimental Cell Research, 313: 357, 2007.
  37. Ying Wang, Qing-Yu He, Raymond Wai-Yin Sun, Chi-Ming Che*, Jen-Fu Chiu*. Cellular pharmacological properties of gold(III) porphyrin 1a, a potential anticancer drug lead. European Journal of Pharmacology, 554: 113, 2007.
  38. Ying Wang, Yim Hing Cheung, Zhiqi Yang, Jen-Fu Chiu, Chi-Ming Che*, Qing-Yu He*. Proteomic approach to study the cytotoxicity of dioscin (saponin). Proteomics, 6: 2422, 2006.
  39. Ying Wang, Qing-Yu He, Chi-Ming Che*, Jen-Fu Chiu*. Proteomic characterization of the cytotoxic mechanism of gold(III) porphyrin 1a, a potential anticancer drug. Proteomics, 6: 131, 2006.
  40. Ying Wang, Jen-Fu Chiu, Qing-Yu He*. Proteomics approach to illustrate drug action mechanisms. Current Drug Discovery Technologies, 3: 199-209, 2006.
  41. Ying Wang, Qing-Yu He, Raymond Wai-Yin Sun, Chi-Ming Che*, Jen-Fu Chiu*. Gold(III) porphyrin 1a induced apoptosis by mitochondrial death pathways related to reactive oxygen species. Cancer Research, 65: 11553, 2005.

  • The Consortium for Globalization of Chinese Medicine      Member