Email

CMWang@um.edu.mo

Tel

(853) 8822-4696

Office

N22-6011

Consultation Hours

Tue: 10:00~11:00
Wed: 10:00~11:00

Chun Ming WANG 王春明

Professor

Director, Research Services & Knowledge Transfer Office (RSKTO), University of Macau

Academic Qualifications

Chunming (CM) received BSc and MSc in Biochemistry from Nanjing University (China), where he entered biomaterials research in Professor Junfeng Zhang’s laboratory. He obtained his PhD in Biomedical Engineering from Nanyang Technological University (Singapore) under Professor Dong-An Wang’s supervision and undertook his postdoctoral training at the University of Cambridge (UK), working between Professor Wilhelm Huck’s group in the Chemistry Department and Professor Fiona Watt’s lab at the Wellcome Trust Centre for Stem Cell Research. He later assisted Dr Victor Nurcombe and Dr Simon Cool at the Institute of Medical Biology (Singapore) on an industry-led translational project. In Oct 2012, CM started his independent research at the University of Macau, as Assistant Professor and was promoted to Associate Professor in Aug 2018 and Professor in Aug 2022.

Currently, CM is also the Director of the Research Services & Knowledge Transfer Office (RSKTO), UM. Combining the functions of a research support office and a patent management department in many other institutions, RSKTO serves the UM community by overseeing a broad spectrum of the University’s research-affiliated matters – ranging from funding applications and management to talent programmes to collaboration agreements to patent applications, among others. Meanwhile, CM serves as Deputy Director of Zhuhai UM Science & Technology Research Institute (ZUMRI), UM’s powerhouse for Industry-Academia-Research Cooperation in the Greater Bay Area. In addition, CM is a co-founder of Genetrump Companhia Limitada (Macau), an award-winning spin-off from UM specialising in developing carbohydrate-based therapeutics for regenerative medicine.

  • 2020.10 – Outstanding Young Scholars Fund (国家自然科学基金-优青), National Natural Science Foundation of China
  • 2020.12 – ‘Qi-Huang’ Youth Scholarship (青年岐黄学者), the State Administration of TCM, China
  • 2021.01 – Fellow of the Royal Society of Biology (FRSB), UK
  • 2021.04 – Fellow of the Royal Society of Chemistry (FRSC), UK
  • 2023.08 – Sigma Xi, The Scientific Research Honor Society (ΣΞ)

Teaching

HSCI3007Biomedical MaterialsUndergraduate Module
BIOB210General MicrobiologyUndergraduate Module
CMED7013Emerging Materials in Clinical MedicineGraduate Module
CMED8013Research WritingGraduate Module

Research Interests

Cells and tissue microenvironment are like seeds and soil, and we aim to optimise the soil to improve the seeds’ growth. We design and test biomaterials- or cell-based therapeutic strategies in various models, ranging from bone defects to limb ischemia to diabetic skin ulcers. We particularly focus on: i) (poly-/oligo-) glucomannans & derivatives: studying the structure-activity relationship and designing immunoactive biomaterials and ii) engineering ‘new’ macrophages with reparative functions.

To date, CM has as PI won 20 research grants, notably including:

  • Macao Key R&D Project, awarded in 2022
  • National Natural Science Foundation of China (NSFC), Outstanding Young Scholars Fund, awarded in 2020
  • Macao Science & Technology Development Fund (abbreviation in Portuguese: FDCT): five research grants from 2013 to 2020 to date
  • A FDCT-NSFC joint sponsorship in 2019
  • A FDCT-GDST joint sponsorship in 2021
  • A Shenzhen S&T Innovation Commission grant in 2021
  • A Huafa-UM Joint Translational Research grant in 2021
  • University of Macau Research Committee
  • Two State Key Labs in Mainland universities.

These generous supports have enabled the thriving of ‘Chun Ming Tong Sui’ (春明糖水), a young and vibrant team devoted to weaving sweet polymer chains into new medicines. The team effort of CMTS has enabled CM to see himself twice among the winners of the Natural Science Award at the Macao Science and Technology Awards – 2nd and 3rd Prize in 2016 and 2018, respectively.

A spin-off company specialised in glycans for wound healing has won multiple national awards and attracted millions of investments in Macau and the Greater Bay Area.

Now, we invite you to join us, visit us and support us to invent SWEET recipes for our SOUR body!

‘Chun Ming Tong Sui’ (春明糖水) Team

  • CMTS Team 2021: the crew celebrate the good weather with incredibly delicious ‘capela’, arroz de pato e bacalhau à lagareiro! Two members were on research trips while ‘joining’ us afterwards in the picture – can you spot them?
  • [Standing on the left: Dr Senio de Souza, Zac Zhang; Sitting on the left: Zhencheng Liao, Connie Liu, Yuwei Li; Standing on the right: Yu Liu, Oliver Xie, Rita Mu; Sitting on the right: Dr CM Wang, Jessi Chen, Dr Yiming Niu]

Journal articles (in total 130; h-index 46): * (co-)corresponding author;  # co-first author

Full list: https://scholar.google.com/citations?user=IYa4XNQAAAAJ&hl=en

  1. LT Wang, YJ Sun, LF Yang, SC Wang, CY Liu, YL Wang, YM Niu, Z Huang, JF Zhang*, CM Wang*, L Dong*. Engineering an energy-dissipating hybrid tissue in vivo for obesity treatment. Cell Reports, 2024, 24, 114425;
  2. R Yong, RY Mu, CW Han, TW Chao, Y Liu, L Dong, CM Wang*. Optimizing a five-factor cocktail to prepare reparative macrophages for wound healing. Journal of Leukocyte Biology, 2024, qiae096;
  3. ZZ Wang#, DP Xie#, JY Li, ZY Zhai, ZJ Lu, XJ Tian, YM Niu, Q Zhao, P Zheng*, L Dong*, CM Wang*. Molecular force-induced liberation of transforming growth factor-beta remodels the spleen for ectopic liver regeneration. Journal of Hepatology, 2024, 80, 753;
  4. DP Xie#, CW Han#, CH Chen, ZC Liao, SC de Souza, YM Niu, JF Mano, L Dong*, CM Wang*. A scaffold vaccine to promote tumor antigen cross-presentation via sustained toll-like receptor-2 (TLR2) activation. Bioactive Materials, 2024, 37, 315;
  5. RY Mu, L Dong, CM Wang*. Carbohydrates as putative pattern recognition receptor (PRR) agonists in vaccine development. Trends in Immunology, 2023, 44, 845-57;
  6. XY Yin, LT Wang, YM Niu, DP Xie, QW Zhang, J Xiao*, L Dong*, CM Wang*. Unmasking chemokine-inducing specificity in oligosaccharide biomaterial to promote hair growth. Advanced Materials, 2023, 2304655;
    ~ Featured: Cover Story
  7. RY Mu, Z Zhang, CW Han, YM Niu, Z Xing, ZC Liao, JZ Xu, NY Shao, GK Chen, JF Zhang, L Dong*, CM Wang*. TAM-educated reparative macrophages promote diabetic wound healing. EMBO Molecular Medicine, 2023, 15 (2), e16671;
    ~ Featured: Cover Story
  8. CY Liu#, LT Wang#, MZ Xu, YJ Sun, Z Xing, JF Zhang*, CM Wang*, L Dong*. Reprogramming the spleen into a functioning ‘liver’ in vivo. Gut, 2022, 71, 2325;
  9. ZC Liao, YM Niu, ZZ Wang, JX Chen, XY Sun*, L Dong*, CM Wang*. A non-solvent quenching strategy for 3D printing of polysaccharide scaffolds with immunoregulatory accuracy. Advanced Science, 2022, 9,2203236;
    ~ Featured: Cover Story
  10. RY Mu#, S Campos de Souza#, ZC Liao, L Dong*, CM Wang*. Reprograming the immune niche for skin tissue regeneration – from cellular mechanisms to biomaterials applications. Advanced Drug Delivery Reviews, 2022, 185, 114298;
    ~ Invited by Dr Kara Spiller
  11. ZZ Wang, ZY Zhai, CY Chen, XJ Tian, Z Xing, PF Xing, YS Yang, JF Zhang*, CM Wang*, L Dong*. Air pollution particles hijack peroxidasin to disrupt immunosurveillance and promote lung cancer. eLife, 2022, e75345;
  12. RY Mu#, YH Zhang#, LL Yan, ZC Liao, YS Yang, HX Su, L Dong*, CM Wang*. A bridge-building glycan scaffold mimicking microbial invasion for in situ endothelialization. Advanced Materials, 2021, 33: 2103490;
    ~ Featured: Inside Back Cover
  13. YL Wang, JY Pang, QY Wang, LC Yan, LT Wang, Z Xing, CM Wang*, JF Zhang*, L Dong*. Delivering antisense oligonucleotides across the blood-brain barrier by tumor cell-derived small apoptotic bodies. Advanced Science, 2021, 8: 2004929;
    ~ Featured: Inside Back Cover
  14. CW Han, JJ Song, JQ Hu, HJ Fu, YX Feng, RY Mu, Z Xing, ZZ Wang, LT Wang, JF Zhang*, CM Wang*, L Dong*. Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy. Cell Reports, 2021, 34: 108706;
  15. ZZ Wang#, YM Niu#, XJ Tian, N Yu, XY Yin, Z Xing, YR Li, L Dong*, CM Wang*. Switching on and off macrophages by a bridge-burning coating improves bone-implant integration under osteoporosis. Advanced Functional Materials, 2021, 31: 2007408;
    ~ Featured: Inside Front Cover
  16. LT Wang, CM Wang*, ZZ Wang, JJ Gan, CY Liu, SH Xia, YM Niu, DH Chen, JF Zhang*, L Dong*. Transforming the spleen into a liver-like organ in vivo. Science Advances, 2020, 6: eaaz9974;
  17. PF Xing, YM Niu, RY Mu, ZZ Wang, DP Xie, HL Li, L Dong, CM Wang*. A pocket-escaping design to prevent the common interference with near-infrared fluorescent probes in vivo, Nature Communications, 2020, 11; 1573;
  18. W He, JZ Xu, RY Mu, Q Li, DL Lv, Z Huang, JF Zhang*, CM Wang*, L Dong*. High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation, Nature Communications, 2020, 11; 1732;
  19. YX Feng#, RY Mu#, ZZ Wang, PF Xing, JF Zhang, L Dong*, CM Wang*. A toll-like receptor agonist mimicking microbial signals to generate tumor-suppressive macrophages. Nature Communications, 2019, 10: 2272;
  20. ZZ Wang, XY Rui, JN Qiu, YQ Yan, JJ Gan, S Liu, LT Wang, JF Zhang*, CM Wang*, L Dong*. Growing trans-species islets in tumor extract-remodeled testicles. Advanced Science, 2019, 6: 1801694;
  21. YC Shi#, LT Wang#, YM Niu, N Yu, PF Xing, L Dong*, CM Wang*. Fungal component coating enhances titanium implant-bone integration. Advanced Functional Materials, 2018, 28: 1804483;
    ~ Featured: Cover Story
  22. YM Niu#, Q Li#, Y Ding, L Dong*, CM Wang*. Engineered delivery strategies for enhanced control of growth factor activities in wound healing. Advanced Drug Delivery Reviews, 2019, 146: 190-208;
  23. CM Wang, ZZ Wang, L Dong. Translating current bioanalytical techniques for studying corona activity. Trends in Biotechnology, 2018, 36: 661-672;
  24. JJ Gan, YY Dou, YR Li, ZZ Wang, LT Wang, S Liu, Q Li, HR Yu, CY Liu, CW Han, Z Huang, JF Zhang*, CM Wang*, L Dong*. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors. Biomaterials, 2018, 178: 95-108;
  25. ZZ Wang, CM Wang*, A Abudukeremu, X Rui, S Liu, XY Zhang, M Zhang, JF Zhang*, L Dong*. Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells. Advanced Science, 2018, 5: 1700666;
    ~ Featured: Back Cover
  26. Q Li, YM Niu, H Diao, LT Wang, XP Chen, YT Wang, L Dong*, CM Wang*. In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing. Biomaterials, 2017, 148: 54-68;
  27. YM Niu, Q Li, RY Xie, S Liu, RB Wang, PF Xing, YC Shi, YT Wang, L Dong*, CM Wang*. Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: design of a glucomannan coating material. Biomaterials, 2017, 139: 39-55;
  28. YX Feng, Q Li, D Wu, YM Niu, C Yang, L Dong*, CM Wang*. A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis. Biomaterials, 2017, 134: 128-142;
  29. Q Li, GX Guo, FC Meng, HH Wang, YM Niu, QW Zhang, JF Zhang, YT Wang, L Dong*, CM Wang*. A naturally-derived, growth factor-binding polysaccharide for therapeutic angiogenesis. ACS Macro Letters, 2016, 5: 617-621;
  30. CM Wang, L Dong. Exploring ‘new’ bioactivities of polymers at the nano-bio interface. Trends in Biotechnology, 2015, 33: 10-14;
  31. XD Zhan, LX Jia, YM Niu, HX Qi, XP Chen, QW Zhang, JF Zhang, YT Wang, L Dong*, CM Wang*. Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy. Biomaterials, 2014, 35: 10046-10057;
  32. CM Wang, S Poon, S Murali, CY Koo, TJ Bell, SF Hinkley, H Yeong, K Bhakoo, V Nurcombe, SM Cool*. Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy. Biomaterials, 2014, 35: 6776-6786;
  33. L Dong, CM Wang*. Harnessing the power of macrophages/monocytes for enhanced bone tissue engineering. Trends in Biotechnology, 2013, 31: 342-6;
  34. JE Gautrot, CM Wang, X Liu, SJ Goldie, B Trappmann, WTS Huck*, FM Watt*. Engineered micro-epidermis mimics normal tissue architecture and perturbation in cancer. Biomaterials, 2012, 33: 5221-9.

  • Fellow, Royal Society of Biology (FRSB)
  • Outstanding Youth Science Fund, NSFC
  • ‘Qi Huang’ Young Scholar
  • Young Committee Member (2018 – present), Chinese Orthopaedic Association
  • Young Committee Member (2015-2019), Chinese Society for Cell Biology
  • A biotechnology spin-off project ‘Golden Wound Dressing’ from our group and led by group member Mr, Zhe Zhang won
    • Gold Award; China’s Internet+ Innovation & Entrepreneurship 2017
    • First Prize; Bank of China Million Dollar Entrepreneurship Competition (Macau)
    • Excellence Award; HKUST Million Dollar Entrepreneurship Competition (National)