Email

CMWang@um.edu.mo

Tel

(853) 8822-4696

Office

N22-6011

Consultation Hours

Tue: 10:00~11:00
Wed: 10:00~11:00

Chun Ming WANG 王春明

Associate Professor
Programme Director (Teaching / Research)

 

Academic Qualifications

Dr Chunming Wang (CM) received his Bachelor and Master’s degrees in Biochemistry from Nanjing University (China), completing his Master thesis under the supervision of Junfeng Zhang. He obtained his PhD in Biomedical Engineering from Nanyang Technological University (Singapore) under the supervision of Dong-An Wang. Then, CM undertook his postdoctoral training at the University of Cambridge (UK), working between Wilhelm Huck’s group in the Chemistry Department and Fiona Watt’s lab at the Wellcome Trust Centre for Stem Cell Research. He later assisted Victor Nurcombe and Simon Cool at the Institute of Medical Biology (Singapore) on an industry-led drug discovery project. In Oct 2012, CM took the Assistant Professorship to start his independent research at ICMS, University of Macau, and was promoted to Associate Professor in Aug 2018.

CM is a recipient of Outstanding Youth Science Fund by National Natural Science Foundation of China for (国家自然科学基金-优青), as well as ‘Qi-Huang’ Young Scholars (青年岐黃學者) by the State Administration of TCM, China. He is also a Fellow of the Royal Society of Biology (FRSB).

Teaching

Undergraduate modules

  • BIOB210          General Microbiology
  • BIOB211          General Microbiology – Laboratory

Graduate modules

  • CMED718        Pharmaceutical Science
  • CMED721        Emerging Materials in Clinical Medicine
  • CMED812        Pharmaceutical Engineering & Biomaterials Science
  • GRSC802         Research Writing

Research Interests

Cells and tissue microenvironment are like seeds and soil; the ‘soil’ supports the ‘seeds’ to grow, while the ‘seeds’ remodel the ‘soil’ through secretion. We aim to optimise the soil to improve the seeds’ growth. We are testing our concepts and designs with various models ranging from bone defects to dental implants to diabetic skin ulcers. Some major directions are:

  • (poly-/oligo-) glucomannans and derivatives: study of structure-activity relationship and design of immunoactive biomaterials for tissue repair and immunotherapy
  • Designing acidic polysaccharides to stabilise growth factor activities for wound healing
  • Engineering ‘new’ macrophages to create a pro-regenerative niche

To date, CM has as PI won 15 research grants, notably including:

  • National Natural Science Foundation of China (NSFC), Outstanding Youth Science Fund (国家优青) awarded in 2020
  • Macao Science & Technology Development Fund (abbreviation in Portuguese: FDCT): five research grants from 2013 to 2020 to date
  • A FDCT-NSFC joint sponsorship in 2019
  • University of Macau Research Committee
  • Two State Key Labs in Mainland universities.

These generous supports have enabled the thriving of ‘Chun Ming Tong Sui’ (春明糖水), a young and vibrant team devoted to weaving sweet polymer chains into new medicines. The team effort of CMTS has enabled CM to see himself twice among the winners of the Natural Science Award at the Macao Science and Technology Awards – 2nd and 3rd Prize in 2016 and 2018, respectively. A start-up project specialised in wound healing, which has won several awards nationally and regionally, is also under the support of several parties from the local community.

Now, we invite you to join us, visit us and support us to invent SWEET recipes for our SOUR body!

‘Chun Ming Tong Sui’ (春明糖水) Team

Journal articles (in total 89; h-index 28)

* (co-)corresponding author;  # co-first author

  1. CW Han, JJ Song, JQ Hu, HJ Fu, YX Feng, RY Mu, Z Xing, ZZ Wang, LT Wang, JF Zhang*, CM Wang *, L Dong*. Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy. Cell Reports, in press;
  2. ZZ Wang#, YM Niu#, XJ Tian, N Yu, XY Yin, Z Xing, YR Li, L Dong*, CM Wang *. Switching on and off macrophages by a bridge-burning coating improves bone-implant integration under osteoporosis. Advanced Functional Materials, in press;
  3. S Liu#, ZZ Wang#, XB Jiang, JJ Gan, XJ Tian, Z Xing, YQ Yan, JH Chen, JF Zhang, CM Wang, L Dong *. Denatured corona proteins mediate the intracellular bioactivities of nanoparticles via the unfolded protein response. Biomaterials, 2021, 265: 120452;
  4. YM Niu#, ZZ Wang#, YC Shi, L Dong, CM Wang*. Modulating macrophage activities to promote endogenous bone regeneration: biological mechanisms and engineering approaches. Bioactive Materials, 2020, 6: 244-61;
  5. YC Yao, CM Wang*. Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine. NPJ Regenerative Medicine, 2020, 5: 14;
  6. YM Niu, LT Wang, N Yu, PF Xing, ZZ Wang, ZF Zhong, YX Feng, L Dong, CM Wang*. An all-in-one scaffold targeting macrophages to direct endogenous bone repair in situ. Acta Biomaterialia, 2020, 111: 153-69;
  7. LT Wang, CM Wang*, ZZ Wang, JJ Gan, CY Liu, SH Xia, YM Niu, DH Chen, JF Zhang*, L Dong*. Transforming the spleen into a liver-like organ in vivo. Science Advances, 2020, 6: eaaz9974;
  8. PF Xing, YM Niu, RY Mu, ZZ Wang, DP Xie, HL Li, L Dong, CM Wang*. A pocket-escaping design to prevent the common interference with near-infrared fluorescent probes in vivo, Nature Communications, 2020, 11; 1573;
  9. W He, JZ Xu, RY Mu, Q Li, DL Lv, Z Huang, JF Zhang*, CM Wang*, L Dong*. High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation, Nature Communications, 2020, 11; 1732;
  10. YX Feng#, RY Mu#, ZZ Wang, PF Xing, JF Zhang, L Dong*, CM Wang *. A toll-like receptor agonist mimicking microbial signals to generate tumor-suppressive macrophages. Nature Communications, 2019, 10: 2272;
  11. JJ Gan, CY Liu, HL Li, SC Wang, ZZ Wang, ZQ Kang, Z Huang, JF Zhang, CM Wang, DL Lv*, L Dong*. Accelerated wound healing in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors. Biomaterials, 2019, 219: 119340;
  12. ZZ Wang, XY Rui, JN Qiu, YQ Yan, JJ Gan, S Liu, LT Wang, JF Zhang*, CM Wang *, L Dong*. Growing trans-species islets in tumor extract-remodeled testicles. Advanced Science, in press;
  13. YC Shi#, LT Wang#, YM Niu, N Yu, PF Xing, L Dong*, CM Wang *. Fungal component coating enhances titanium implant-bone integration. Advanced Functional Materials, 2018, 28: 1804483;
    ~ Featured: Cover Story
  14. PF Xing#, Z Zhang#, YM Niu, YN Qi, L Dong*, CM Wang *. Water solubility is essential for fluorescent probes to image hypochlorous acid in live cells. Chemical Communication, 2018,54, 9889-9892
    ~ Featured: Cover Story
  15. JJ Gan, YY Dou, YR Li, ZZ Wang, LT Wang, S Liu, Q Li, HR Yu, CY Liu, CW Han, Z Huang, JF Zhang*, CM Wang *, L Dong*. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors. Biomaterials, 2018, 178: 95-108;
  16. YM Niu#, Q Li#, Y Ding, L Dong*, CM Wang *. Engineered delivery strategies for enhanced control of growth factor activities in wound healing. Advanced Drug Delivery Reviews, 2019, 146: 190-208;
  17. CM Wang, ZZ Wang, L Dong. Translating current bioanalytical techniques for studying corona activity. Trends in Biotechnology, 2018, 36: 661-672;
  18. PF Xing, YX Feng, YM Niu, Q Li, Z Zhang, L Dong*, CM Wang *. A water-soluble, two-photon probe for imaging endogenous hypochlorous acid in live tissue. Chemistry – A European Journal, 2018, 22: 5748-53;
  19. ZZ Wang, CM Wang *, A Abudukeremu, X Rui, S Liu, XY Zhang, M Zhang, JF Zhang*, L Dong*. Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells. Advanced Science, 2018, 5: 1700666;
  20. Q Li, YM Niu, H Diao, LT Wang, XP Chen, YT Wang, L Dong*, CM Wang *. In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing. Biomaterials, 2017, 148: 54-68;
  21. YM Niu, Q Li, RY Xie, S Liu, R Wang, PF Xing, YC Shi, YT Wang, L Dong*, CM Wang *. Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: design of a glucomannan coating material. Biomaterials, 2017, 139: 39-55;
  22. YX Feng, Q Li, D Wu, YM Niu, C Yang, L Dong*, CM Wang *. A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis. Biomaterials, 2017, 134: 128-42;
  23. H Yin, F Dumur, YM Niu, MM Ayhan, O Grauby, W Liu, CM Wang, D Siri, R Rosas, A Tonetto, D Gigmes, R Wang, D Bardelang, O Ouari. Chameleonic dye adapts to various environments shinning on macrocycles of peptide and polysaccharide aggregates. ACS Applied Materials & Interfaces, 2017, 9: 33220-8;
  24. Y Wang#, GX Guo#, YX Feng, HY Long, DL Ma, CH Leung, L Dong*, CM Wang *. A tumour microenvironment-responsive polymeric complex for targeted depletion of tumour-associated macrophages. Journal of Materials Chemistry B, 2017, 5: 7307-18;
    ~ Featured: Hot Paper 2017
  25. Q Li, YX Feng, W He, LT Wang, R Wang, L Dong, CM Wang*. Post-screening characterisation and in vivoevaluation of an anti-inflammatory polysaccharide fraction from Eucommiaulmoides. Carbohydrate Polymers, 2017, 169: 304-14;
  26. W He #, CM Wang #, RY Mu, P Liang, Z Huang, JF Zhang*, L Dong*. MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles. Oncogene, 2017, 36: 4212-23;
  27. ZZ Wang, CM Wang*, S Liu, W He, LT Wang, JJ Gan, Z Huang, ZH Wang, HY Wei, JF Zhang*, L Dong*. Specifically formed corona on silica nanoparticles enhances transforming growth factor-β1 activity in triggering lung fibrosis. ACS Nano, 2017, 11: 1659-72;
  28. WI Chan #, GP Zhang #, X Li, CH Leung, DL Ma, L Dong*, CM Wang*. Carrageenan activates monocytes via type-specific binding with interleukin-8: an implication for design of immune-active biomaterials. Biomaterials Science, 2017, 5: 403-7;
    ~ Featured: Cover Story
  29. LT Wang, Q Chen, HX Qi, CM Wang, C Wang, JF Zhang* and L Dong*. Doxorubicin-induced systemic Inflammation is driven by upregulation of Toll-like receptor TLR4 and endotoxin leakage.
    Cancer Research, 2016, 76: 6631-42;
  30. Q Li, GX Guo, FC Meng, H Wang, YM Niu, QW Zhang, JF Zhang, YT Wang, L Dong, CM Wang*. A naturally-derived, growth factor-binding polysaccharide for therapeutic angiogenesis.
    ACS Macro Letters, 2016, 5: 617-21;
  31. Z Huang, JJ Gan, ZY Long, GX Guo, XF Shi, CM Wang, YH Zang, Z Ding, JN Chen, JF Zhang*, L Dong*. Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection. Biomaterials, 2016, 90: 72-84;
  32. Z Huang, JJ Gan, LX Jia, GX Guo, CM Wang, YH Zang, Z Ding, JN Chen, JF Zhang*, L Dong*. An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease. Biomaterials, 2015, 48: 26-36;
  33. JJ Liu, XD Zhan, JB Wan, YT Wang, CM Wang *. Review for carrageenan-based pharmaceutical biomaterials: Favourable physical features versusadverse biological effects. Carbohydrate Polymers, 2015, 121: 27-36;
  34. CM Wang, L Dong. Exploring ‘new’ bioactivities of polymers at the nano-bio interface. Trends in Biotechnology, 2015, 33: 10-14;
  35. XD Zhan#, LX Jia#, YM Niu, HX Qi, XP Chen, QW Zhang, JF Zhang, YT Wang, L Dong*, CM Wang *. Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy. Biomaterials, 2014, 35: 10046-57;
  36. YM Niu#, J Bai#, RD Kamm, YT Wang*, CM Wang *. Validating anti-metastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment. Molecular Pharmaceutics, 2014, 11: 2022-29;
  37. CM Wang, S Poon, S Murali, CY Koo, TJ Bell, SF Hinkley, HQ Yeong, K Bhakoo, V Nurcombe, SM Cool*. Engineering a vascular endothelial growth factor-165-binding heparan sulfate for vascular therapy. Biomaterials, 2014, 35: 6776-86;
  38. L Dong, CM Wang *. Harnessing the power of macrophages/monocytes for enhanced bone tissue engineering. Trends in Biotechnology, 2013, 31: 342-6;
  39. JE Gautrot, CM Wang, X Liu, SJ Goldie, B Trappmann, WTS Huck*, FM Watt*. Engineered micro-epidermis mimics normal tissue architecture and perturbation in cancer. Biomaterials, 2012, 33: 5221-9;
  40. K Su, YH Gong, CM Wang, DA Wang*. A novel shell-structure cell microcarrier (SSCM) for cell transplantation and bone regeneration medicine. Pharmaceutical Research, 2011, 28:1431-41;
    ~ Featured: Cover Story
  41. CM Wang, RR Varshney, DA Wang*. Therapeutic cell delivery and fate control in hydrogels and hydrogel hybrids. Advanced Drug Delivery Reviews, 2010, 62: 699-710;
    ~ Featured: Cover Story
  42. CM Wang, DA Wang*. An injectable, nanoaggregate-based system for mesenchymal stem cell (MSC) delivery: enhancement of cell adhesion and prevention of cytotoxicity. Journal of Materials Chemistry, 2010, 20: 3166-70;
  43. CM Wang, GN Adrianus, N Sheng, SK Toh, YH Gong, DA Wang*. In vitro performance of an injectable hydrogel / microsphere based immunocyte delivery system for localised anti-tumour activity. Biomaterials, 2009, 30: 6986-95;
  44. CM Wang, YH Gong, Y Zhong, YC Yao, K Su, DA Wang*. The control of anchorage- dependent cell behavior within a hydrogel / microcarrier system in an osteogenic model. Biomaterials, 2009, 30: 2259-69;
  45. YC Yao #, CM Wang #(#co-first author), RR Varshney, DA Wang*. Antisense makes sense in engineered regenerative medicine. Pharmaceutical Research, 2009, 26:263-75;
  46. YH Gong, CM Wang, RC Lai, K Su, F Zhang, DA Wang*. A novel injectable polysaccharide hydrogel: modified gellan gum for long-term tissue regeneration in vitro. Journal of Materials Chemistry, 2009, 19: 1968 – 1977;
    ~ Featured: Cover Story of Journal of Materials Chemistry, Vol. 19, Issue 14, 2009;
    ~ Quoted: in “Application Highlights”, Chemical Technology, 6(2009), 3: T20.
  47. CM Wang, YH Gong, YM Lin, JB Shen, DA Wang*. A novel gellan gel-based microcarrier for anchorage-dependent cell delivery. Acta Biomaterialia, 2008, 4: 1226-34;
  48. CM Wang, J Bai, YH Gong, F Zhang, JB Shen, DA Wang*. Enhancing cell affinity of non-adhesive hydrogel substrate: the role of silica hybridization. Biotechnology Progress, 2008, 24: 1142-6;
    ~ Featured: Cover Image of Biotechnology Progress, Vol. 25.
  49. TT Jiang, JB Chang, CM Wang, Z Ding, JF Zhang, ET Kang. Adsorption of plasmid DNA onto poly 2-(dimethylamino) ethyl-methacrylate grafted PLLA for promotion of gene delivery. Biomacromolecules, 2007, 8: 1951-7;

  1. CM Wang, Q Li, Z Zhang, YT Wang. A new bioactive polysaccharide dressing for wound healing. Chinese Patent Application No. 201810172465.3;
  2. CM Wang, Q Li, YM Niu, YT Wang. An artificial tear hydrogel. Chinese Patent Application No. 2014105282269;
  3. JT Sun, JF Zhang, CM Wang, Yi Luo. An embolic liquid for aneurysm treatment. Chinese Patent. CN1634119.

  1. CM Wang, CK Lei, RB Wang, JB Xiao, YT Wang. Ten years of exploration, a new journey to start: advancing Chinese Medicineto the next level. Chinese Medicine, 2017, 12: 28;
  2. H Hu, YZ Shi, CM Wang. Contract research organisations (CROs) in China: Integrating Chinese research & development capabilities for global drug innovation. Globalization and Health, 2014, 10: 78.

  1. CM Wang. ‘Devising ‘Sweet’ Natural Tools for Therapeutic Applications’, 2nd International Symposium on Phytochemicals in Food and Medicine (2-ISPMF) & Annual Meeting of Phytochemical Society of Europe (PSE 2017), Fuzhou, China, 7th-10th Apr 2017; (Invited Lecture)
  2. Q Li, YM Niu, CM Wang. ‘Sequestering of PDGF-BB and FGF-2 with an acidic polysaccharide for in situ vascularization’, 4th Symposium on Innovative Polymers for Controlled Delivery (SIPCD) 2016, Suzhou, China, 24th-26th Sep 2016; (poster)
  3. CM Wang, YM Niu, GP Zhang, YX Feng. ‘Designing carbohydrate biomaterials to modulate macrophage behaviour for immunotherapy and tissue regeneration’, TERMIS-AP 2016, Tamsui, Taiwan, 03rd-06th Sep 2016; (oral presentation)
  4. YM Niu, Y Wang, GP Zhang, CM Wang. ‘Modulation of innate immune cells with polymer tools for therapeutic applications’, 2015 International Conference for Leading and Young Materials Scientists (IC-LYMS 2015), Sanya, China, 24th-27th Dec 2015; (oral presentation)
  5. YM Niu, CM Wang. ‘Macrophage-affinitive Glucomannan Biomaterials for Targeted Drug Delivery and Bone Tissue Regeneration’, 5th China-Europe Symposium on Biomaterials, Hangzhou, China, 8th-10th May 2015; (oral presentation)
  6. XD Zhan, YM Niu, CM Wang, ‘Glucomannan biomaterials targeting c-type lectins for drug delivery and tissue regeneration’, TERMIS-AP 2014, Daegu, Korea, 24th-27th Sep 2014; (oral presentation)
  7. CM Wang, S Poon, S Murali, CY Koo, TJ Bell, FS Hinkley, HQ Yeong, K Bhakoo, V Nurcombe, SM Cool. ‘Engineering a heparan sulphate for vascular therapy’, TERMIS-AP 2014, Daegu, Korea, 24th-27th Sep 2014; (poster)
      ~ Best poster award, TERMIS-AP 2014
  8. CM Wang, S Poon, S Murali, HQ Yeong, T Bell, S Hinkley, V Nurcombe, SM Cool, ‘Modulation of VEGF activity by heparan sulphate’, 8th International Conference on Proteoglycans, Frankfurt/Main, Germany, 25th-29th, Aug 2013; (oral presentation)
  9. CM Wang, XD Zhan, YM Niu, YT Wang, ‘A natural polysaccharide based drug delivery vehicle targeting tumour-associated macrophages for cancer immunotherapy’, 17th European Carbohydrate Symposium (Eurocarb 17), Tel-Aviv, Israel, 7th-11th Jul 2013; (oral presentation)
  10. CM Wang, JE Gautrot, B Trappmann, ‘Cell micro-patterning: a promising tool for cell biology study’, Cambridge Cancer Centre Postdoctoral Meeting, Cambridge, UK, 22 Oct 2010; (oral presentation)
  11. CM Wang, DA Wang, ‘Delivery of therapeutic cells in hydrogel composite free of apoptotic depletion’, ICCM-17 – 17th International Conference on Composite Materials, Edinburgh, UK, 27 – 31 Jul 2009; (oral presentation)
  12. CM Wang, DA Wang, ‘The control of anchorage-dependent cell behavior within a hydrogel / microcarrier system in an osteogenic model’, ICMAT 2009 – International Conference on Materials for Advanced Technologies, Singapore, 28 Jun 28 – 3 Jul 2009; (oral presentation)
  13. JT Sun, JF Zhang, CM Wang, ‘A Novel Liquid Embolic Material for Aneurysm Treatment’, 7th Endovascular Neurosurgery Conference of China, the Three Gorges, China, Aug, 2005. (oral presentation)

  • Fellow, Royal Society of Biology (FRSB)
  • Outstanding Youth Science Fund, NSFC
  • ‘Qi Huang’ Young Scholar
  • Young Committee Member (2018 – present), Chinese Orthopaedic Association
  • Young Committee Member (2015-2019), Chinese Society for Cell Biology
  • A biotechnology spin-off project ‘Golden Wound Dressing’ from our group and led by group member Mr, Zhe Zhang won
    • Gold Award; China’s Internet+ Innovation & Entrepreneurship 2017
    • First Prize; Bank of China Million Dollar Entrepreneurship Competition (Macau)
    • Excellence Award; HKUST Million Dollar Entrepreneurship Competition (National)
  • 2nd Prize, Natural Science Award, 2016 Macao Science and Technology Award
    (awarded to YT Wang, SP Li, MY Lee, CH Leung and CM Wang)
  • Executive Editor, Chinese Medicine (BMC;  Impact Factor ® : 1.6)
  • Editorial Board, Biotechnology Letters (Springer; Impact Factor ® 2013: 1.6)
  • Outstanding Reviewer of 2015 of Biotechnology Letters
  • Outstanding Reviewer of 2010 of Pharmaceutical Research (official journal of the American Association of Pharmaceutical Scientists, AAPS)
  • Ad hoc journal referee for peer-reviewed academic journals:
ACS Applied Materials & Interfaces (2016 –)
Acta Biomaterialia (2017 –)
Advanced Drug Delivery Reviews (2010 – ) Biomaterials (2009 – )
Journal of Biomedical Materials Research (2008 – ) Journal of Cellular and Molecular Medicine (2008 – ) Pharmaceutical Research (2010 – )
Trends in Biotechnology (2015 – )
  • Young Scientist’s Referee (certified by Editor-in-chief, Prof David F Williams, 2009), Biomaterials
  • Trustee Committee Member, International Society for Chinese Medicine (ISCM)
  • Member and Chartered Chemist, RSC (Royal Society of Chemistry)
  • Member, TERMIS (Tissue Engineering & Regenerative Medicine International Society)
  • Representative of University of Macau at Global Young Scientists Summit 2016, Singapore