Chun Ming WANG 王春明

Interim Director, Research Services & Knowledge Transfer Office (RSKTO), University of Macau

Deputy Director, Zhuhai UM Science & Technology Research Institute (ZUMRI)

Professor, Institute of Chinese Medical Sciences (ICMS) & Department of Pharmaceutical Sciences, Faculty of Health Science (FHS)


Journal articles (in total 120; h-index 42)

* (co-)corresponding author;  # co-first author

  1. RY Mu, Z Zhang, CW Han, YM Niu, Z Xing, ZC Liao, JZ Xu, NY Shao, GK Chen, JF Zhang, L Dong*, CM Wang*. Tumor-associated macrophages-educated reparative macrophages promote diabetic wound healing. EMBO Molecular Medicine, in press;
     ~ To Be Featured as Cover Story
  2. ZC Liao, YM Niu, ZZ Wang, JX Chen, XY Sun*, L Dong*, CM Wang*. A non-solvent quenching strategy for 3D printing of polysaccharide scaffolds with immunoregulatory accuracy. Advanced Science, 2022, 9,2203236;
     ~ Featured: Cover Story
  3. RY Mu#, S Campos de Souza#, ZC Liao, L Dong*, CM Wang*. Reprograming the immune niche for skin tissue regeneration – from cellular mechanisms to biomaterials applications. Advanced Drug Delivery Reviews, 2022, 185, 114298;
     ~ Invited by Dr Kara Spiller
  4. CY Liu#, LT Wang#, MZ Xu, YJ Sun, Z Xing, JF Zhang*, CM Wang*, L Dong*. Reprogramming the spleen into a functioning ‘liver’ in vivoGut, 2022, 71, 2325;
  5. ZZ Wang, ZY Zhai, CY Chen, XJ Tian, Z Xing, PF Xing, YS Yang, JF Zhang* CM Wang*, L Dong*. Air Pollution Particles Hijack Peroxidasin to Disrupt Immunosurveillance and Promote Lung Cancer. eLife, 2022, 75345;
     ~ Featured: public review by Senior Editor Dr Paul Nobel
  6. DP Xie, YM Niu, RY Mu, S Campos de Souza, XY Yin, L Dong*, CM Wang*. A toll-like receptor-activating, self-adjuvant glycan nanocarrier. Frontiers in Chemistry, 2022, 10, 864206;
     ~ Invited by Dr Keith Stine
  7. RY Mu#, YH Zhang#, LL Yan, ZC Liao, YS Yang, HX Su, L Dong*, CM Wang*. A bridge-building glycan scaffold mimicking microbial invasion for in situ endothelialization. Advanced Materials, 2021, 33: 2103490;
    ~ Featured: Inside Back Cover
  8. YL Wang, JY Pang, QY Wang, LC Yan, LT Wang, Z Xing, CM Wang*, JF Zhang*, L Dong*. Delivering antisense oligonucleotides across the blood-brain barrier by tumor cell-derived small apoptotic bodies. Advanced Science, 2021, 8: 2004929;
        ~ Featured: Inside Back Cover
  9. CW Han, JJ Song, JQ Hu, HJ Fu, YX Feng, RY Mu, Z Xing, ZZ Wang, LT Wang, JF Zhang*, CM Wang*, L Dong*. Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy. Cell Reports, 2021, 34: 108706;
  10. ZZ Wang#, YM Niu#, XJ Tian, N Yu, XY Yin, Z Xing, YR Li, L Dong*, CM Wang*. Switching on and off macrophages by a bridge-burning coating improves bone-implant integration under osteoporosis. Advanced Functional Materials, 2021, 31: 2007408;
    ~ Featured: Inside Front Cover
  11. S Liu#, ZZ Wang#, XB Jiang, JJ Gan, XJ Tian, Z Xing, YQ Yan, JH Chen, JF Zhang, CM Wang, L Dong*. Denatured corona proteins mediate the intracellular bioactivities of nanoparticles via the unfolded protein response. Biomaterials, 2021, 265: 120452;
  12. YM Niu#, ZZ Wang#, YC Shi, L Dong, CM Wang*. Modulating macrophage activities to promote endogenous bone regeneration: biological mechanisms and engineering approaches. Bioactive Materials, 2020, 6: 244-61;
  13. YC Yao, CM Wang*. Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine. NPJ Regenerative Medicine, 2020, 5: 14;
  14. YM Niu, LT Wang, N Yu, PF Xing, ZZ Wang, ZF Zhong, YX Feng, L Dong, CM Wang*. An all-in-one scaffold targeting macrophages to direct endogenous bone repair in situ. Acta Biomaterialia, 2020, 111: 153-69;
  15. LT Wang, CM Wang*, ZZ Wang, JJ Gan, CY Liu, SH Xia, YM Niu, DH Chen, JF Zhang*, L Dong*. Transforming the spleen into a liver-like organ in vivoScience Advances, 2020, 6: eaaz9974;
  16. PF Xing, YM Niu, RY Mu, ZZ Wang, DP Xie, HL Li, L Dong, CM Wang*. A pocket-escaping design to prevent the common interference with near-infrared fluorescent probes in vivoNature Communications, 2020, 11; 1573;
  17. W He, JZ Xu, RY Mu, Q Li, DL Lv, Z Huang, JF Zhang*, CM Wang*, L Dong*. High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation, Nature Communications, 2020, 11; 1732;
  18. YX Feng#, RY Mu#, ZZ Wang, PF Xing, JF Zhang, L Dong*, CM Wang*. A toll-like receptor agonist mimicking microbial signals to generate tumor-suppressive macrophages. Nature Communications, 2019, 10: 2272;
  19. JJ Gan, CY Liu, HL Li, SC Wang, ZZ Wang, ZQ Kang, Z Huang, JF Zhang, CM Wang, DL Lv*, L Dong*. Accelerated wound healing in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors. Biomaterials, 2019, 219: 119340;
  20. ZZ Wang, XY Rui, JN Qiu, YQ Yan, JJ Gan, S Liu, LT Wang, JF Zhang*, CM Wang*, L Dong*. Growing trans-species islets in tumor extract-remodeled testicles. Advanced Science, 2019, 6: 1801694;
  21. YC Shi#, LT Wang#, YM Niu, N Yu, PF Xing, L Dong*, CM Wang*. Fungal component coating enhances titanium implant-bone integration. Advanced Functional Materials, 2018, 28: 1804483;
    ~ Featured: Cover Story
  22. PF Xing#, Z Zhang#, YM Niu, YN Qi, L Dong*, CM Wang*. Water solubility is essential for fluorescent probes to image hypochlorous acid in live cells. Chemical Communication, 2018,54, 9889-9892
        ~ Featured: Cover Story
  23. JJ Gan, YY Dou, YR Li, ZZ Wang, LT Wang, S Liu, Q Li, HR Yu, CY Liu, CW Han, Z Huang, JF Zhang*, CM Wang*, L Dong*. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors. Biomaterials, 2018, 178: 95-108;
  24. YM Niu#, Q Li#, Y Ding, L Dong*, CM Wang*. Engineered delivery strategies for enhanced control of growth factor activities in wound healing. Advanced Drug Delivery Reviews, 2019, 146: 190-208;
  25. CM Wang, ZZ Wang, L Dong. Translating current bioanalytical techniques for studying corona activity. Trends in Biotechnology, 2018, 36: 661-672;
  26. PF Xing, YX Feng, YM Niu, Q Li, Z Zhang, L Dong*, CM Wang*. A water-soluble, two-photon probe for imaging endogenous hypochlorous acid in live tissue. Chemistry – A European Journal, 2018, 22: 5748-53;
  27. ZZ Wang, CM Wang*, A Abudukeremu, X Rui, S Liu, XY Zhang, M Zhang, JF Zhang*, L Dong*. Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells. Advanced Science, 2018, 5: 1700666;
  28. Q Li, YM Niu, H Diao, LT Wang, XP Chen, YT Wang, L Dong*, CM Wang*. In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing. Biomaterials, 2017, 148: 54-68;
  29. YM Niu, Q Li, RY Xie, S Liu, R Wang, PF Xing, YC Shi, YT Wang, L Dong*, CM Wang*. Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: design of a glucomannan coating material. Biomaterials, 2017, 139: 39-55;
  30. YX Feng, Q Li, D Wu, YM Niu, C Yang, L Dong*, CM Wang*. A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis. Biomaterials, 2017, 134: 128-42;
  31. Y Wang#, GX Guo#, YX Feng, HY Long, DL Ma, CH Leung, L Dong*, CM Wang*. A tumour microenvironment-responsive polymeric complex for targeted depletion of tumour-associated macrophages. Journal of Materials Chemistry B, 2017, 5: 7307-18;
        ~ Featured: Hot Paper 2017
  32. Q Li, YX Feng, W He, LT Wang, R Wang, L Dong, CM Wang*. Post-screening characterisation and in vivoevaluation of an anti-inflammatory polysaccharide fraction from EucommiaulmoidesCarbohydrate Polymers, 2017, 169: 304-14;
  33. W He#CM Wang#, RY Mu, P Liang, Z Huang, JF Zhang*, L Dong*. MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles. Oncogene, 2017, 36: 4212-23;
  34. ZZ Wang, CM Wang*, S Liu, W He, LT Wang, JJ Gan, Z Huang, ZH Wang, HY Wei, JF Zhang*, L Dong*. Specifically formed corona on silica nanoparticles enhances transforming growth factor-β1 activity in triggering lung fibrosis. ACS Nano, 2017, 11: 1659-72;
  35. WI Chan#, GP Zhang#, X Li, CH Leung, DL Ma, L Dong*, CM Wang*. Carrageenan activates monocytes via type-specific binding with interleukin-8: an implication for design of immune-active biomaterials. Biomaterials Science, 2017, 5: 403-7;
    ~ Featured: Cover Story
  36. LT Wang, Q Chen, HX Qi, CM Wang, C Wang, JF Zhang* and L Dong*. Doxorubicin-induced systemic Inflammation is driven by upregulation of Toll-like receptor TLR4 and endotoxin leakage. Cancer Research, 2016, 76: 6631-42;
  37. Q Li, GX Guo, FC Meng, H Wang, YM Niu, QW Zhang, JF Zhang, YT Wang, L Dong, CM Wang*. A naturally-derived, growth factor-binding polysaccharide for therapeutic angiogenesis. ACS Macro Letters, 2016, 5: 617-21;
  38. Z Huang, JJ Gan, ZY Long, GX Guo, XF Shi, CM Wang, YH Zang, Z Ding, JN Chen, JF Zhang*, L Dong*. Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection. Biomaterials, 2016, 90: 72-84;
  39. Z Huang, JJ Gan, LX Jia, GX Guo, CM Wang, YH Zang, Z Ding, JN Chen, JF Zhang*, L Dong*. An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease. Biomaterials, 2015, 48: 26-36;
  40. JJ Liu, XD Zhan, JB Wan, YT Wang, CM Wang*. Review for carrageenan-based pharmaceutical biomaterials: Favourable physical features versusadverse biological effects. Carbohydrate Polymers, 2015, 121: 27-36;
  41. CM Wang, L Dong. Exploring ‘new’ bioactivities of polymers at the nano-bio interface. Trends in Biotechnology, 2015, 33: 10-14;
  42. XD Zhan#, LX Jia#, YM Niu, HX Qi, XP Chen, QW Zhang, JF Zhang, YT Wang, L Dong*, CM Wang*. Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy. Biomaterials, 2014, 35: 10046-57;
  43. YM Niu#, J Bai#, RD Kamm, YT Wang*, CM Wang*. Validating anti-metastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment. Molecular Pharmaceutics, 2014, 11: 2022-29;
  44. CM Wang, S Poon, S Murali, CY Koo, TJ Bell, SF Hinkley, HQ Yeong, K Bhakoo, V Nurcombe, SM Cool*. Engineering a vascular endothelial growth factor-165-binding heparan sulfate for vascular therapy. Biomaterials, 2014, 35: 6776-86;
  45. L Dong, CM Wang*. Harnessing the power of macrophages/monocytes for enhanced bone tissue engineering. Trends in Biotechnology, 2013, 31: 342-6;
  46. JE Gautrot, CM Wang, X Liu, SJ Goldie, B Trappmann, WTS Huck*, FM Watt*. Engineered micro-epidermis mimics normal tissue architecture and perturbation in cancer. Biomaterials, 2012, 33: 5221-9;
  47. CM Wang, RR Varshney, DA Wang*. Therapeutic cell delivery and fate control in hydrogels and hydrogel hybrids. Advanced Drug Delivery Reviews, 2010, 62: 699-710;
        ~ Featured: Cover Story
  48. CM Wang, DA Wang*. An injectable, nanoaggregate-based system for mesenchymal stem cell (MSC) delivery: enhancement of cell adhesion and prevention of cytotoxicity. Journal of Materials Chemistry, 2010, 20: 3166-70;
  49. CM Wang, GN Adrianus, N Sheng, SK Toh, YH Gong, DA Wang*. In vitro performance of an injectable hydrogel / microsphere based immunocyte delivery system for localised anti-tumour activity. Biomaterials, 2009, 30: 6986-95;
  50. CM Wang, YH Gong, Y Zhong, YC Yao, K Su, DA Wang*. The control of anchorage- dependent cell behavior within a hydrogel / microcarrier system in an osteogenic model. Biomaterials, 2009, 30: 2259-69;
  51. YC Yao#CM Wang#, RR Varshney, DA Wang*. Antisense makes sense in engineered regenerative medicine. Pharmaceutical Research, 2009, 26:263-75;
  52. YH Gong, CM Wang, RC Lai, K Su, F Zhang, DA Wang*. A novel injectable polysaccharide hydrogel: modified gellan gum for long-term tissue regeneration in vitro. Journal of Materials Chemistry, 2009, 19: 1968 – 1977;
    ~ Featured: Cover Story
  53. CM Wang, YH Gong, YM Lin, JB Shen, DA Wang*. A novel gellan gel-based microcarrier for anchorage-dependent cell delivery. Acta Biomaterialia, 2008, 4: 1226-34;
  54. CM Wang, J Bai, YH Gong, F Zhang, JB Shen, DA Wang*. Enhancing cell affinity of non-adhesive hydrogel substrate: the role of silica hybridization. Biotechnology Progress, 2008, 24: 1142-6;
        ~ Featured: Cover Image of the entire Vol. 25 of Biotechnology Progress
  1. CM Wang, Q Li, Z Zhang, YT Wang. A new bioactive polysaccharide dressing for wound healing. Chinese Patent Application No. 201810172465.3;
  2. CM Wang, Q Li, YM Niu, YT Wang. An artificial tear hydrogel. Chinese Patent Application No. 2014105282269;
  3. JT Sun, JF Zhang, CM Wang, Yi Luo. An embolic liquid for aneurysm treatment. Chinese Patent. CN1634119.
  1. CM Wang, CK Lei, RB Wang, JB Xiao, YT Wang. Ten years of exploration, a new journey to start: advancing Chinese Medicineto the next level. Chinese Medicine, 2017, 12: 28;
  2. H Hu, YZ Shi, CM Wang. Contract research organisations (CROs) in China: Integrating Chinese research & development capabilities for global drug innovation. Globalization and Health, 2014, 10: 78.
  1. CM Wang. ‘Devising ‘Sweet’ Natural Tools for Therapeutic Applications’, 2nd International Symposium on Phytochemicals in Food and Medicine (2-ISPMF) & Annual Meeting of Phytochemical Society of Europe (PSE 2017), Fuzhou, China, 7th-10th Apr 2017; (Invited Lecture)
  2. Q Li, YM Niu, CM Wang. ‘Sequestering of PDGF-BB and FGF-2 with an acidic polysaccharide for in situ vascularization’, 4th Symposium on Innovative Polymers for Controlled Delivery (SIPCD) 2016, Suzhou, China, 24th-26th Sep 2016; (poster)
  3. CM Wang, YM Niu, GP Zhang, YX Feng. ‘Designing carbohydrate biomaterials to modulate macrophage behaviour for immunotherapy and tissue regeneration’, TERMIS-AP 2016, Tamsui, Taiwan, 03rd-06th Sep 2016; (oral presentation)
  4. YM Niu, Y Wang, GP Zhang, CM Wang. ‘Modulation of innate immune cells with polymer tools for therapeutic applications’, 2015 International Conference for Leading and Young Materials Scientists (IC-LYMS 2015), Sanya, China, 24th-27th Dec 2015; (oral presentation)
  5. YM Niu, CM Wang. ‘Macrophage-affinitive Glucomannan Biomaterials for Targeted Drug Delivery and Bone Tissue Regeneration’, 5th China-Europe Symposium on Biomaterials, Hangzhou, China, 8th-10th May 2015; (oral presentation)
  6. XD Zhan, YM Niu, CM Wang, ‘Glucomannan biomaterials targeting c-type lectins for drug delivery and tissue regeneration’, TERMIS-AP 2014, Daegu, Korea, 24th-27th Sep 2014; (oral presentation)
  7. CM WangS Poon, S Murali, CY Koo, TJ Bell, FS Hinkley, HQ Yeong, K Bhakoo, V Nurcombe, SM Cool. ‘Engineering a heparan sulphate for vascular therapy’, TERMIS-AP 2014, Daegu, Korea, 24th-27th Sep 2014; (poster)
      ~ Best poster award, TERMIS-AP 2014
  8. CM Wang, S Poon, S Murali, HQ Yeong, T Bell, S Hinkley, V Nurcombe, SM Cool, ‘Modulation of VEGF activity by heparan sulphate’, 8th International Conference on Proteoglycans, Frankfurt/Main, Germany, 25th-29th, Aug 2013; (oral presentation)
  9. CM WangXD Zhan, YM Niu, YT Wang, ‘A natural polysaccharide based drug delivery vehicle targeting tumour-associated macrophages for cancer immunotherapy’, 17th European Carbohydrate Symposium (Eurocarb 17), Tel-Aviv, Israel, 7th-11th Jul 2013; (oral presentation)
  10. CM Wang, JE Gautrot, B Trappmann, ‘Cell micro-patterning: a promising tool for cell biology study’, Cambridge Cancer Centre Postdoctoral Meeting, Cambridge, UK, 22 Oct 2010; (oral presentation)
  11. CM WangDA Wang, ‘Delivery of therapeutic cells in hydrogel composite free of apoptotic depletion’, ICCM-17 – 17th International Conference on Composite Materials, Edinburgh, UK, 27 – 31 Jul 2009; (oral presentation)
  12. CM Wang, DA Wang, ‘The control of anchorage-dependent cell behavior within a hydrogel / microcarrier system in an osteogenic model’, ICMAT 2009 – International Conference on Materials for Advanced Technologies, Singapore, 28 Jun 28 – 3 Jul 2009; (oral presentation)
  13. JT Sun, JF Zhang, CM Wang, ‘A Novel Liquid Embolic Material for Aneurysm Treatment’, 7th Endovascular Neurosurgery Conference of China, the Three Gorges, China, Aug, 2005. (oral presentation)
  • Fellow, Royal Society of Biology (FRSB)
  • Outstanding Youth Science Fund, NSFC
  • ‘Qi Huang’ Young Scholar
  • Young Committee Member (2018 – present), Chinese Orthopaedic Association
  • Young Committee Member (2015-2019), Chinese Society for Cell Biology
  • A biotechnology spin-off project ‘Golden Wound Dressing’ from our group and led by group member Mr, Zhe Zhang won
    • Gold Award; China’s Internet+ Innovation & Entrepreneurship 2017
    • First Prize; Bank of China Million Dollar Entrepreneurship Competition (Macau)
    • Excellence Award; HKUST Million Dollar Entrepreneurship Competition (National)
  • 2nd Prize, Natural Science Award, 2016 Macao Science and Technology Award
    (awarded to YT Wang, SP Li, MY Lee, CH Leung and CM Wang)
  • Executive Editor, Chinese Medicine (BMC;  Impact Factor ® : 1.6)
  • Editorial Board, Biotechnology Letters (Springer; Impact Factor ® 2013: 1.6)
  • Outstanding Reviewer of 2015 of Biotechnology Letters
  • Outstanding Reviewer of 2010 of Pharmaceutical Research (official journal of the American Association of Pharmaceutical Scientists, AAPS)
  • Ad hoc journal referee for peer-reviewed academic journals:
ACS Applied Materials & Interfaces (2016 –)
Acta Biomaterialia (2017 –)
Advanced Drug Delivery Reviews (2010 – ) Biomaterials (2009 – )
Journal of Biomedical Materials Research (2008 – ) Journal of Cellular and Molecular Medicine (2008 – ) Pharmaceutical Research (2010 – )
Trends in Biotechnology (2015 – )
  • Young Scientist’s Referee (certified by Editor-in-chief, Prof David F Williams, 2009), Biomaterials
  • Trustee Committee Member, International Society for Chinese Medicine (ISCM)
  • Member and Chartered Chemist, RSC (Royal Society of Chemistry)
  • Member, TERMIS (Tissue Engineering & Regenerative Medicine International Society)
  • Representative of University of Macau at Global Young Scientists Summit 2016, Singapore