Email

cmchong@um.edu.mo

Tel

(853) 8822-4512

Office

N22-7014

Consultation Hours

Tue: 16:30-17:30
Thu: 16:30-17:30

Cheong Meng CHONG 鍾昌明

Assistant Professor

Academic Qualifications

  • Postdoctoral training, National University of Singapore, Singapore
  • Ph.D., University of Macau, Macau

Teaching

CMED8003Functional Food Product Development in Chinese Medicine
CMED7009Development of Drugs and Health Product
CMED7001Pharmacology and Safety Evaluation
HSCI3000Neuroscience and Neurodegenerative Diseases

Research Interests

  1. Understanding the molecular basis of cellular pathology in neurodegenerative diseases.
  2. Identifying the bioactive components from traditional Chinese medicine (TCM) for treatment of neurodegenerative diseases.
  3. Functional TCM-derived food products development.

We are looking for Ph.D. students and master students who are interested in neuropharmacology. For further information, please contact Dr. Chong via email (cmchong@um.edu.mo).

# (co-)corresponding author

  1. Lu C, Zhang S, Lei SS, Wang D, Peng B, Shi R, Chong CM#, Zhong Z, Wang Y. A comprehensive review of classical prescription Yiguan Jian: Phytochemistry, Quality Control, Clinical applications, Pharmacology, and Safety. Journal of Ethnopharmacology. 2024. 319:117230.
  2. Wang D, Qu S, Zhang Z, Tan L, Chen X, Zhong HJ, Chong CM#. Strategies targeting endoplasmic reticulum stress to improve Parkinson’s disease. Frontiers in Pharmacology. 2023. 14: 1288894.
  3. Chen W, Huang Y, Chong CM, Zheng H. Editorial: Post-Stroke Complications: Mechanisms, Diagnosis, and Therapies. Frontiers in Neurology. 2023. 14:1292562
  4. Ai N, Wang D, Qu S, Vong CT, Yuan M, Su H, Ge W, Chong CM#. Azoramide prevents MPP+-induced dopaminergic neuronal death via upregulating ER chaperone BiP expression. Free radical biology and medicine. 2023. 208:299-308.
  5. Liu YJ, Wang H, Zhong HJ, Chong CM#, Yang GJ. Editorial: Community series in epigenetics of the immune component of inflammation-volume II. Frontiers in immunology. 2023. 14:1266133.
  6. Chou SM, Yen YH, Yuan F, Zhang SC, Chong CM#. Neuronal senescence in the aged Brain. Aging and disease. 2023. 14(5):1618-1632.
  7. Lu C, Qu S, Zhong Z, Luo H, Lei SS, Zhong HJ, Su H, Wang Y, Chong CM#. The effects of bioactive components from the rhizome of Gastrodia elata Blume (Tianma) on the characteristics of Parkinson’s disease. Frontiers in Pharmacology. 2022. 13:963327.
  8. Liu YJ, Wang H, Zhong HJ, Chong CM#, Yang GJ. Editorial: Epigenetics of the immune component of inflammation. Frontiers in immunology. 2022. 13:1000836.
  9. Chong CM, Tan Y, Tong J, Ke M, Zhang K, Yan L, Cen X, Lu JH, Yao X, Chen G, Su H, Qin D. Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway. Cell & Bioscience. 2022. 2(1):131.
  10. Zhao Y, Tan DC, Peng B, Yang L, Zhang SY, Shi RP, Chong CM, Zhong ZF, Wang SP, Liang QL, Wang Y. Neuroendocrine-immune regulatory network of Eucommia ulmoides Oliver. Molecules. 2022. 27(12):3697.
  11. Chong CM, Zhong Z, Vong CT, Wang S, Lu JJ, Zhong HJ, Su H, Wang Y. The potentials of Uncariae Ramulus Cum Uncis for treatment of migraine: Targeting CGRP in the trigeminovascular system. Current Neuropharmacology. 2020;19(7):1090-1100.
  12. Ke M*, Chong CM*, Zhu Qi, Zhang K, Cai CZ, Lu J, Qin D, Su H. Comprehensive perspectives on experimental models for Parkinson’s disease. Aging and Disease. 2021. 12(1):223-246. (Co-first author).
  13. Ke M*, Chong CM*, Zeng H, Huang M, Huang Z, Zhang K, Cen X, Lu J, Yao X, Qin D, Su H. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death and Disease. 2020. 11(2):130. (Co-first author).
  14. Ke M*, Chong CM*, Su H. Using induced pluripotent stem cells for modeling Parkinson’s disease. World Journal of Stem Cells. 2019. 11(9):634-649. (Co-first author).
  15. Chong CM, Su H, Lu JJ, Wang Y. The neuroprotective effects of bioactive components from rhizome of Salvia miltiorrhiza (Danshen) on Alzheimer’s disease. Chinese Medicine. 2019. 14:19.
  16. Lei W, Xu Y, Su J, Chong CM, Su H, Fang E, Bao Z, Chen G. Applications of high-throughput ‘omics’ data in the study of frailty. Translational Medicine of Aging. 2019. 3:40-51.
  17. Tan Y, Ke M, Huang Z, Chong CM, Chen X, Lu JH, Yao X, Qin D, Su H. Hydroxyurea facilitates manifestation of disease relevant phenotypes in patient-derived iPSCs-based modeling of late-onset Parkinson’s disease. Aging and disease. 2019. 10(5):1037-1048.
  18. Chong CM, Ke M, Tan Y, Huang Z, Zhang Z, Ai N, Ge W, Qin D, Lu JH, Su H. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling. Cell Death and Disease. 2018. 9(9):879.
  19. Li S, Gaur U, Chong CM, Zeng Z, Wang H, Zheng W. Berberine protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of AMPK kinase. Int J Mol Sci. 2018. 19(6):1736.
  20. Ai N, Chong CM, Chen W, Hu Z, Su H, Chen G, Wong WL, Ge W. Ponatinib exerts anti-angiogenic effects in the zebrafish and human umbilical vein endothelial cells via blocking VEGFR signaling pathway. Oncotarget. 2018. 9(62):31958-31970.
  21. Li S, Ai N, Shen M, Dang Y, Chong CM, Pan P, Kwan YW, Chan SW, Leung PH, Hoi PM, Hou T, L MY. Discovery of a ROCK inhibitor, FPND, which prevents cerebral hemorrhage through maintaining vascular integrity by interference with VE-cadherin. Cell Death Discovery. 2017. 3:17051.
  22. Chong CM, Ai N, Lee MY. ROCK in CNS: different roles of isoforms, and therapeutic target for neurodegenerative disorders. Current drug targets. 2017. 18(4):455-462.
  23. Chong CM, Ai N, Ke M, Tan Y, Huang Z, Lu JH, Ge W, Su H. Roles of nitric oxide synthase isoforms in neurogenesis. Mol Neurobiol. 2017. 55(3):2645-2652.
  24. Chong CM, Zheng W. Artemisinin protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of ERK/CREB signaling. Redox biology. 2016. 9:50-56.
  25. Chong CM, Kou MT, Pan P, Zhou H, Ai N, Li C, Zhong HJ, Leung CH, Hou T, Lee MY. Discovery of a novel ROCK2 inhibitor with anti-migration effect via docking and high-content drug screening. Molecular Biosystems. 2016. 12(9):2713-21.
  26. Zheng W*, Chong CM*, Wang H, Zhou X, Zhang L, Wang R, Meng Q, Lazarovici P and Fang J. Artemisinin conferred ERK mediated neuroprotection to PC12 cells and cortical neurons exposed to sodium nitroprusside-induced oxidative insult. Free radical biology and medicine. 2016. 97:158-167. (Co-first author).
  27. Kou MT, Chong CM, Ai N, Lee MY. The application of Rho-associated protein kinase (ROCK) inhibitors in neurodegenerative diseases. Progress in Modern Biomedicine. 2016. 14: 2780-2783. (Chinese).
  28. Chong CM, Ma D, Zhao C, Franklin RJ, Zhou ZY, Li C, Ai N, Yu H, Hou T, Sa F, Lee MY. Discovery of a novel neuroprotectant, BHDPC that protects against MPP+-induced neuronal death in multiple experimental models. Free radical biology and medicine. 2015. 89:1057-1066.
  29. Cui G, Shan L, Guo L, Chu K, Li G, Quan Q, Zhao Y, Chong CM, Zhang Z, Yu P, Hoi PM, Sun Y, Wang Y, Lee MY. Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy. Scientific report. 2015. 5:10353.
  30. Zhang Z, Li G, Szeto SS, Chong CM, Quan Q, Huang C, Cui W, Guo B, Wang Y, Han Y, Michael Siu KW, Lee SM, Chu IK. Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson’s disease. Free radical biology and medicine. 2015. 84:331-43.
  31. Zhang LQ, Sa F, Chong CM, Wang Y, Zhou ZY, Chang CC, Chan SW, Hoi PM, Lee MY. Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3β pathways. Journal of Ethnopharmacology. 2015. 8741(15):306-2.
  32. Sa F, Zhang LQ, Chong CM, Guo BJ, Li S, Zhang ZJ, Zheng Y, Hoi PM, Lee MY. Discovery of novel anti-Parkinsonian effect of Schisantherin A in in vitro and in vivo. Neuroscience Letters. 2015. 23(593):7-12.
  33. Ai N, Li S, Chong CM, Lee MY. Recent advances of Rho-associated protein kinase (ROCK) in cardio-cerebrovascular diseases. Progress in Modern Biomedicine. 2015. 15:4198−4200. (Chinese).
  34. Wang L, Chan YW, Rego JV, Chong CM, Ai N, Falcao CB, Radis-Baptista G, Lee MY. Rhodamine B-conjugated encrypted vipericidin nonapeptide is a potent toxin to zebrafish and associated with in vitro cytotoxicity. Biochim Biophys Acta. 2015. 1850(6):1253-1260.
  35. Chen JM, Chiu SC, Wei TY, Lin SY, Chong CM, Wu CC, Huang JY, Yang ST, Ku CF, Hsia JY, Yu CT. The involvement of nuclear factor-kappaB in the nuclear targeting and cyclin E1 upregulating activities of hepatoma upregulated protein. Cell Signal. 2015. 27(1):26-36.
  36. Chong CM, Shen MG, Zhou ZY, Pan P, Hoi PM, Li S, Wang L, Ai N, Zhang LQ, Li CW, Yu HD, Hou TJ, Lee MY. Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor in protecting against MPP+-induced oxidative stress and cell death in SH-SY5Y cells. Free radical biology and medicine. 2014. 74:283-93.
  37. Zhong HJ, Lu LJ, Chong CM, Lu L, Ai Z, Wang M, Chan DSH, Chan PWH, Lee MY, Ma DL, Leung CH. Discovery of a Natural Product-Like iNOS Inhibitor by Molecular Docking with Potential Neuroprotective Effects in Vivo. PLOS ONE. 2014. 9(4):e92905.
  38. Torres AF, Huang C, Chong CM, Leung SW, Prieto-da-Silva AR, Havt A, Quinet YP, Martins AM, Lee MY, Gandhi Radis-Baptista. Transcriptome analysis in venom gland of the predatory giant ant Dinoponera quadriceps: insights into the polypeptide toxin arsenal of hymenopterans. PLOS ONE. 2014. 9(1):e87556.
  39. Leung KK, Dong ZQ, Sa F, Chong CM, Lei SW, Tsui KW, Lee MY. Quick, Sensitive and Specific Minor Variant Detection and Quantification for High-throughput Sequencing. Molecular BioSystems. 2014. 10(2):206-14.
  40. Chong CM, Zhou ZY, Valentina RN, Cui GZ, Zhang LQ, Sa F, Hoi PM, Kevin C, Lee MY. Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish. Neuroscience Letters. 2013. 543:121-5.
  41. Chong CM, Gao S, Chiang BY, Hsu WH, Lin TC, Chen TC, Lin CH. An acyloxymethyl ketone-based probe to monitor the activity of glutathionylspermidine amidase in Escherichia coli. ChemBioChem. 2011. 12(15):2306-09.
  42. Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH. Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. EMBO J. 2006. 25(24):5970-82.

  • Young Editorial Consultant of Chinese Medicine
  • Director of Macau Life Sciences Institute (MLSI)
  • The permanent member of Macau Laboratory Technologist Association (MLTA)