Tel
(853) 8822 8518
Office
N22-7013
Consultation Hours
Tue: 16:00-17:00
Wed: 16:00-17:00
Huanxing Su 蘇煥興
Professor
Academic Qualifications
B. Med Zhejiang University, Clinical Medicine
MPhil The Chinese University of Hong Kong, Neuroscience
PhD The University of Hong Kong , Neuroscience
Working experience
16/08/2020- Present Professor, University of Macau
16/08/2015- 15/08/2020 Associate Professor, University of Macau
13/09/2011-15/08/2015 Programme Coordinator of Bachelor of Science (Biomedical Science), University of Macau
16/08/2011-15/08/2015 Assistant Professor, University of Macau
01/09/1994-01/08/2005 Lecturer, School of Medicine, Zhejiang University
Teaching
| HSCI2008 | Human Anatomy | |
| Biomedical Statistics | Undergraduate Course | |
| Anatomy and Physiology I | Undergraduate Course | |
| Anatomy and Physiology II | Undergraduate Course | |
| Final Year Projects | Undergraduate Course | |
| Targets and Models for Drug Screen | Postgraduate Course | |
| Research Ethics | Postgraduate Course | |
| Functional Food Product Development in Chinese Medicine | Postgraduate Course |
Research Interests
- Establishing human induced pluripotent stem cells (iPSCs)-based cell models to elucidate pathogenic mechanisms in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis
- Investigating beneficial effects of omega-3 polyunsaturated fatty acids and finding effective treatments for cerebral small vessel disease and vascular dementia
- Studying glymphatic function in brain disorders
(1). Mechanistic studies on cell cycle and cell division during cell reprograming (Ministry of Science and Technology 973 program of China; Project Code: 2012CB966802; Duration: 2012, 01-2016, 12). PI.
(2). Application of induced pluripotent stem cells in treatment of multiple sclerosis (Start-up Research Grant (SRG) 2012; Project Code: SRGO14.ICMS12-SHX; Duration: 2012, 01-2012, 12). PI.
(3). Using patient-derived induced pluripotent stem cells for drug screens for efficacy and preclinical predictive toxicology (Multi-year research grant from the University of Macau; Project Code: MYRG122 (Y1-L3)-ICMS12-SHX; Duration: 2012, 06-2015, 05). PI.
(4). Therapeutic potentials of ginsenoside and neural progenitor cell transplantation in stroke (Multi-year research grant from the University of Macau; Project Code: MYRG110 (Y1-L2)-ICMS13-SHX; Duration: 2013, 05-2016, 04). PI.
(5). Therapeutic potentials of a combination of ginsenoside Rd administration and neural progenitor cell transplantation in stroke (Macao Science and Technology Development Fund; Project Code: FDCT 003/2012/A; Duration: 2012, 10-2014, 04). PI.
(6). Using patient-specific induced pluripotent stem cells to establish drug screening platforms for neurodegenerative diseases (Macao Science and Technology Development Fund; Project Code: FDCT 018/2013/A1; Duration: 2014, 01-2016, 12). PI.
(7). Driving metabolite clearance from the brain to maintain its homeostasis via activating the Glymphatic System and exploring its underlying mechanisms (Macao Science and Technology Development Fund; Project Code: FDCT 063/2015/A2; Duration: 2016, 01-2018, 06). PI.
(8). Mechanistic studies on the development of cerebral small vessel diseases and therapeutic potentials of omega-3 polyunsaturated fatty acids in the treatment of cerebral small vessel diseases and vascular cognition impairment (Macao Science and Technology Development Fund; Project Code: FDCT 020/2017/A1; Duration: 2017, 08-2020, 07). PI.
(9). Driving metabolite clearance from the brain to maintain its homeostasis via activating the Glymphatic System (Multi-year research grant from the University of Macau; Project Code: MYRG2016-00184-ICMS-QRCM; Duration: 2017, 01-2019, 12). PI.
(10). Roles and action mechanisms of SENP3 in autism (FDCT-NSFC; Project Code: FDCT 039/2017/AFJ; Duration: 2018, 01-2020, 12). PI.
(11). Study of neprilysin gene therapy targeting the glymphatic pathway for the treatment of Alzheimer’s disease and cerebral amyloid angiopathy (Multi-year research grant from the University of Macau; Project Code: MYRG2018-00242-ICMS; 2018, 09-2021, 08). PI.
(12). Mechanistic studies on clearance of amyloid beta in the brain and therapeutic roles of glymphatic pathways in prevention and treatment of neurodegenerative diseases (Macao Science and Technology Development Fund; Project Code: FDCT 049/2019/A1; Duration: 2019, 07-2022, 06). PI.
(13). Study of pathophysiological mechanisms and cognitive consequences of microinfarcts and beneficial effects of omega-3 polyunsaturated fatty acids on attenuating microinfarcts and improving vascular dementia (Multi-year research grant from the University of Macau; Project Code: MYRG2019-00160-ICMS; 2020, 01-2021, 12). PI.
Peng Y, Shi Z, Kumaran Satyanarayanan S, He C, Li P, Wan JB, Su H*. Fish oil alleviates LPS-induced inflammation and depressive-like behavior in mice via restoration of metabolic impairments. Brain Behav Immun. 2020 Nov;90:393-402.
Tong J, Satyanarayanan SK, Su H*. Nutraceuticals and probiotics in the management of psychiatric and neurological disorders: A focus on microbiota-gut-brain-immune axis. Brain Behav Immun. 2020 Nov;90:403-419.
Ke M, Chong CM, Zeng H, Huang M, Huang Z, Zhang K, Cen X, Lu JH, Yao X, Qin D*, Su H*. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death Dis. 2020 Feb 18;11(2):130.
Liu Q, Yan L, Huang M, Zeng H, Satyanarayanan SK, Shi Z, Chen D, Lu JH, Pei Z, Yao X, Su H*. Experimental alcoholism primes structural and functional impairment of the glymphatic pathway. Brain Behav Immun. 2020 Mar;85:106-119.
Yan L, Xie Y, Satyanarayanan SK, Zeng H, Liu Q, Huang M, Ma Y, Wan JB, Yao X, Su KP, Su H*. Omega-3 polyunsaturated fatty acids promote brain-to-blood clearance of β-Amyloid in a mouse model with Alzheimer’s disease. Brain Behav Immun. 2020 Mar;85:35-45.
Tan Y, Ke M, Huang Z, Chong C, Cen X, Lu JH, Yao X*, Qin D*, Su H*. Hydroxyurea facilitates manifestation of disease relevant phenotypes in patients-derived iPSCs-based modeling of late-onset Parkinson’s disease. Aging and disease. 2019 Oct 1;10(5):1037-1048.
Chong CM, Ke M, Tan Y, Huang ZJ, Zhang K, Ai N, Ge W, Qin DJ, Lu JH, Su H*. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling. Cell Death Dis. 2018 Aug 29;9(9):879.
Luo C, Ren H, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su KP, Su H*. Enriched Brain Omega-3 Polyunsaturated Fatty Acids Confer Neuroprotection against Microinfarction. EBioMedicine. 2018 Jun;32:50-61.
Luo C, Liang F, Ren H, Yao X, Liu Q, Li M, Qin D, Yuan TF, Pei Z, Su H*. Collateral blood flow in different cerebrovascular hierarchy provides endogenous protection in cerebral ischemia. Brain Pathology. 2017 Nov;27(6):809-821.
Ren H, Yang Z, Luo C, Zeng H, Li P, Kang JX, Wan JB, He C, Su H*. Enriched Endogenous Omega-3 Fatty Acids in Mice Ameliorate Parenchymal Cell Death After Traumatic Brain Injury. Mol Neurobiol. 2017 Jul;54(5):3317-3326.
Huang X, Chen Y-Y, Shen Y, Cao Y, Li A, Liu Q, Li Z, Zhang L-B, Dai W, Tan T, Arias-Carrion O, Xue Y-X, Su H* and Yuan T-F*. Methamphetamine abuse impairs motor cortical plasticity and function. Molecular Psychiatry 2017 Sep;22(9):1274-1281.
Ren H, Luo C, Feng Y, Yao X, Shi Z, Liang F, Kang JX, Wan JB, Pei Z, Su H*. Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system. FASEB J, 2017 Jan;31(1):282-293.
Luo C, Yao X, Li J, He B, Liu Q, Ren H, Liang F, Li M, Lin H, Peng J, Yuan TF, Pei Z, Su H*. Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control. Cell Death Dis. 2016 Mar 31;7:e2160.
Editorial Board Member: Brain, Behavior, and Immunity
Editorial Board Member: Aging and disease