Anna, Wai San CHEANG 鄭慧珊

* co-/corresponding author; ^# co-first author

1. Zhuang T, Lei Y, Chang JJ, Zhou YP, Li Y, Li YX, Yang YF, Chen MH, Meng T, Fu SM, Huang LH, Cheang WS, Cooke JP, Dong ZH, Bai YN, Ruan CC. A2AR-mediated lymphangiogenesis via VEGFR2 signaling prevents salt-sensitive hypertension. European Heart Journal (2023) ehad377 (Impact factor: 39.3)
2. Miao L, Zhang H, Cheong MS, Zhong R, Garcia-Oliveira P, Prieto MA, Cheng KW, Wang M, Cao H, Nie S, Simal-Gandara J, Cheang WS*, Xiao J. Anti-diabetic potential of apigenin, luteolin, and baicalein via partially activating PI3K/Akt/Glut-4 signaling pathways in insulin-resistant HepG2 cells. Food Science and Human Wellness (2023) 12(6):1991-2000 (Impact factor: 7.0)
3. Miao L, Cheong MS, Zhou C, Cheang WS*, Xiao J. Apigenin alleviates diabetic endothelial dysfunction through activating AMPK/PI3K/Akt/eNOS and Nrf2/HO-1 signaling pathways. Food Frontiers (2023) 4(1):420-431 (Impact factor: 9.9)
4. Miao L, Liu C, Cheong MS, Zhong R, Tan Y, Rengasamy KRR, Leung SWS, Cheang WS*, Xiao J. Exploration of natural flavones’ bioactivity and bioavailability in chronic inflammation induced-type-2 diabetes mellitus. Critical Reviews in Food Science and Nutrition (2022) Online ahead of print. DOI: 10.1080/10408398.2022.2095349 (Impact factor: 10.2)
5. Wang Y, Zhang X, Zhou C, Khan H, Fu M, Cheang WS*. Citri Reticulatae Pericarpium (Chenpi) Protects against Endothelial Dysfunction and Vascular Inflammation in Diabetic Rats. Nutrients (2022) 14(24):5221 (Impact factor: 5.9)
6. Zhou Y, Wang Y, Vong CT, Zhu Y, Xu B, Ruan CC, Wang Y, Cheang WS*. Jatrorrhizine improves endothelial function in diabetes and obesity through suppression of endoplasmic reticulum stress. International Journal of Molecular Sciences (2022) 23(20):12064 (Impact factor: 5.6)
7. Fu M, Wang Y, Yu Y, Wen J, Cheong MS, Cheang WS*, Wu J. Changes of volatile substance composition during processing of nine-processed tangerine peel (Jiuzhi Chenpi) determined by gas chromatography-ion mobility spectrometry. Frontiers in Nutrition (2022) 9:963655 (Impact factor: 5.0)
8. Tan Y, Zhang X, Cheang WS*. Isoflavones daidzin and daidzein inhibit lipopolysaccharide-induced inflammation in RAW264.7 macrophages. Chinese Medicine (2022) 17(1):95 (Impact factor: 4.9)
9. Zhang X, Zhou Y, Cheong MS, Khan H, Ruan CC, Fu M, Xiao J, Cheang WS*. Citri Reticulatae Pericarpium extract and flavonoids reduce inflammation in RAW 264.7 macrophages by inactivation of MAPK and NF-κB pathways. Food Frontiers (2022) 3(4): 785 – 795 (Impact factor: 9.9)
10. Zhou C, Tan Y, Xu B, Wang Y, Cheang WS*. 3,4’,5-Trimethoxy-trans-stilbene Alleviates Endothelial Dysfunction in Diabetic and Obese Mice via Activation of the AMPK/SIRT1/eNOS Pathway. Antioxidants (2022) 11(7):1286 (Impact factor: 7.0)
11. Cheng CK, Shang W, Liu J, Cheang WS, Wang Y, Xiang L, Lau CW, Luo JY, Ng CF, Huang Y, Wang L. Activation of AMPK/miR-181b Axis Alleviates Endothelial Dysfunction and Vascular Inflammation in Diabetic Mice. Antioxidants (2022) 11(6):1137 (Impact factor: 7.0)
12. Tan Y, Zhang X, Zhou Y, Miao L, Xu B, Khan H, Wang Y, Yu H, Cheang WS*. Panax notoginseng Extract Suppresses Diet-induced Obesity and Endoplasmic Reticulum Stress in Epididymal White Adipose Tissue in Mice. Chinese Medicine (2022) 17(1):75 (Impact factor: 4.9)
13. Zhou Y, Khan H, Xiao J, Cheang WS*. Effects of Arachidonic Acid Metabolites on Cardiovascular Health and Disease. International Journal of Molecular Sciences (2021) 22(21), 12029 (Impact factor: 5.6)
14. Alam W, Rocca C, Khan H, Hussain Y, Aschner M, Bartolo A, Amodio N, Angelone T, Cheang WS. Current Status and Future Perspectives on Therapeutic Potential of Apigenin: Focus on Metabolic Syndrome-Dependent Organ Dysfunction. Antioxidants (2021) 10(10), 1643 (Impact factor: 7.0)
15. Zhou C, Zhang X, Ruan CC, Cheang WS*. Two methoxy derivatives of resveratrol, 3,3’,4,5’-tetramethoxy-trans-stilbene and 3,4’,5-trimethoxy-trans-stilbene, suppress lipopolysaccharide-induced inflammation through inactivation of MAPK and NF-κB pathways in RAW 264.7 cells. Chinese Medicine (2021) 16(1):69 (Impact factor: 4.9)
16. Zhou Y, Murugan DD, Khan H, Huang Y, Cheang WS*. Roles and Therapeutic Implications of Endoplasmic Reticulum Stress and Oxidative Stress in Cardiovascular Diseases. Antioxidants (2021) 10(8), 1167 (Impact factor: 7.0)
17. Zhou Y, Zhou C, Zhang X, Vong CT, Wang Y, Cheang WS*. Coptisine attenuates diabetes-associated endothelial dysfunction through inhibition of endoplasmic reticulum stress and oxidative stress. Molecules(2021)26(14), 4210 (Impact factor: 4.6)
18. Khan H, Ullah H, Aschner M, Cheang WS, Akkol EK. Neuroprotective effects of quercetin in Alzheimer’s disease. Biomolecules (2020) 10(1):59 (Impact factor: 5.5)
19. Miao L, Tao H, Peng Y, Wang S, Zhong Z, El-Seedi H, Dragan S, Zengin G, Cheang WS, Wang YT, Xiao J. The anti-inflammatory potential of Portulaca oleracea L. (purslane) extract by partial suppression on NF-B and MAPK activation. Food Chemistry (2019) 290:239-45. (Impact factor: 8.8)
20. Zhao C, Lai S, Wu Y, Guan Y, Cao H, Cheang WS, Liu B, Zhao K, Miao S, Riviere C, Capanoglu E, Xiao J. Effects of domestic cooking process on the chemical and biological properties of dietary phytochemicals. Trends in Food Science & Technology (2019) 85:55-66 (Impact factor: 15.3)
21. Cheang WS, Wong WT, Wang L, Cheng CK, Lau CW, Ma RCW, Xu A, Wang N, Huang Y, Tian XY. Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ. Pharmacological Research (2019) 139:384-94 (Impact factor: 9.3)
22. Zhao C, Yang C, Wai STC, Zhang YB, Portillo MP, Paoli P, Wu Y, Cheang WS, Liu B, Carpene C, Xiao J, Cao H. Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus. Critical Reviews in Food Science and Nutrition (2019) 59(6):830-47 (Impact factor: 10.2)
23. Xiong W, Sang W, Linghu KG, Zhong ZF, Cheang WS, Li J, Hu YJ, Yu H, Wang YT (2018) Dual-functional Brij-S20-modified nanocrystal formulation enhances the intestinal transport and oral bioavailability of berberine. International Journal of Nanomedicine (2018) 13:3781-93. (Impact factor: 8.0)
24. Chen L, Teng H, Xie Z, Cheang WS, Skalicka-Woniak K, Georgiev MI, Xiao J. Modifications of dietary flavonoids towards improved bioactivity: An update on structure-activity relationship. Critical Reviews in Food Science and Nutrition (2018) 58(4):513-27. (Impact factor: 10.2)
25. Cheang WS, Wong WT, Zhao L, Xu J, Wang L, Lau CW, Chen ZY, Ma RCW, Xu A, Wang N, Tian XY, Huang Y. PPARδ is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice. Diabetes (2017) 66(2):519-28. (Impact factor: 7.7)
26. Xiang L, Wei J, Tian XY, Wang B, Chan W, Li S, Tang Z, Zhang H, Cheang WS, Zhao Q, Zhao H, Yang Z, Hong Y, Huang Y, Cai Z. Comprehensive analysis of acylcarnitine species in db/db mouse using a novel method of high-resolution parallel reaction monitoring reveals widespread metabolic dysfunction induced by diabetes. Analytical Chemistry (2017) 89(19):10368-10375. (Impact factor: 7.4)
27. Leung FP, Yung LM, Ngai CY, Cheang WS, Tian XY, Lau CW, Zhang Y, Liu J, Chen ZY, Bian ZX, Yao X, Huang Y. Chronic black tea extract consumption improves endothelial function in ovariectomized rats. European Journal of Nutrition (2016) 55:1963-72. (Impact factor: 5.0)
28. Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang L, Wong WT, Wong CM, Lan HY, Yao X, Raizada MK, Huang Y. Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling (2015) 23(11):880-92. (Impact factor: 6.6)
29. Cheang WS, Tian XY, Wong WT, Huang Y. The peroxisome proliferator-activated receptors in cardiovascular diseases: experimental benefits and clinical challenges. British Journal of Pharmacology (2015) 172(23):5512-22. (Impact factor: 7.3)
30. Wang X, #Cheang WS, Yang H, Xiao L, Lai B, Zhang M, Ni J, Luo Z, Zhang Z, Huang Y, Wang N. Nuciferine relaxes rat mesenteric arteries through endothelium-dependent and independent mechanisms. British Journal of Pharmacology (2015) 172(23):5609-18. (Impact factor: 7.3)
31. Cheang WS, Tian XY, Wong WT, Lee SS, Chen ZY, Yao X, Wang N, Huang Y. Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5’ adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. Arteriosclerosis, Thrombosis, and Vascular Biology (2014) 34(4):830-6. (Impact factor: 8.7)
32. Zhang Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo JY,Cheang WS, Lau CW, Kwan KM, Wang N, Yao X & Huang Y.Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis, and Vascular Biology (2014) 34(1):152-9. (Impact factor: 8.7)
33. Tian XY, Wong WT, Wang N, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y. PPARδ activation protects endothelial function in diabetic mice. Diabetes (2012) 61(12):3285-93. (Impact factor: 7.7)
34. Tian XY, Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X, Huang Y. Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circulation Research (2012) 110(9):1211-6. (Impact factor: 20.1)
35. Tian XY, Wong WT, Sayed N, Luo J, Tsang SY, Bian ZX, Lu Y, Cheang WS, Yao X, Chen ZY, Huang Y. NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel. Pharmacological Research (2012) 65(2):239-46. (Impact factor: 9.3)
36. Cheang WS, Wong WT, Tian XY, Yang Q, Lee HK, He GW, Yao X, Huang Y. Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice. Cardiovascular Research (2011) 92(2):267-75. (Impact factor: 10.8)
37. Cheang WS, Wong WT, Shen B, Lau CW, Tian XY, Tsang SY, Yao X, Chen ZY, Huang Y. 4-Aminopyridine-sensitive K⁺ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery. Vascular Pharmacology (2010) 53(3-4):94-8. (Impact factor: 4.0)

Book chapters

1. Nagappan T, *Cheang WS (2020) Ginsenosides in Diets. In: Xiao J., Sarker S., Asakawa Y. (eds) Handbook of Dietary Phytochemicals. Springer, Singapore

• Best Teacher Award 2021/2022, ICMS, University of Macau, Macau (2022)
• 2017 Higher Education Outstanding Scientific Research Output Award (second-class award), Ministry of Education, People Republic of China (2017年度高等學校科學研究優秀成果獎 – 自然科學二等獎, 2018)
• The Talent Development Scholarship 2013-2014, Chinese University of Hong Kong, Hong Kong (2014)
• EMBL Advanced Training Centre Corporate Partnership Programme Fellowship, EMBO|EMBL Symposium: Translating Diabetes, Heidelberg, Germany (2014)
• World Congress Early Career Investigator Travel Awards, International Society of Heart Research, San Diego, USA (2013)
• The Talent Development Scholarship 2012-2013, Chinese University of Hong Kong, Hong Kong (2013)

• Editorial Board Member, Current Issues of Molecular Biology (2023-present)
• Editorial Board Member, PHYTONutrients (2022-present)
• Editorial Board Member, Journal of Clinical Cardiology and Cardiovascular Diagnosis (2021-present)
• Editorial Board Member, Open Access Journal of Pharmaceutical Research (2019-present)
• Editorial Board Member, Food Science and Nutrition Technology (2016-present)
• Editorial Board Member, SM Vascular Medicine (2016-2017)
• Guest Editor, Frontiers in Immunology (2023-present)
• Guest Editor, Antioxidants (2021-present)
• Guest Editor, Molecules (2022-present)
• Guest Editor, Current Issues of Molecular Biology (2022-2023)
• Review Editor, Frontiers in Pharmacology (2022-present)
• Review Editor, Frontiers in Nutrition (2022-present)
• Review Editor, Frontiers in Physiology (2022-present)
• Executive Committee Member, The Chinese Society of Cardiovascular Pharmacology, Chinese Pharmacological Society (中國藥理學會心血管藥理學專業委員會委員, 2021-present)
• Executive Committee Member, Macau Pharmacology Association (澳門藥理協會委員會委員, 2022-present)
• Member, Chinese Association for Physiological Sciences (中國生理學會, 2022-present)
• Member, Society for Redox Biology and Medicine (SfRBM, 2022-present)
• Member, Chinese Pharmacological Society (中國藥理學會, 2021-present)
• Member, International Society for Chinese Medicine (國際中醫藥學會, 2016-present)
• Member, Chinese Association of Pathophysiology (中國病理生理學會, 2009-present)
• Regular reviewer of manuscripts for 50 international peer-reviewed journals, including Antioxidants, Chinese Medicine, European Journal of Pharmacology, Food Science and Human Wellness, Frontiers in Pharmacolgy, Journal of Pharmacy and Pharmacology, Journal of Ethnopharmacology, Life Sciences, Phytomedicine, and Redox Biology.

• Secretary General, The Academic Staff Association, University of Macau (2020-present)
• College Affiliate, Ma Man Kei and Lo Pak Sam College, University of Macau (2019 to present)