Reagan, Ligen LIN 林理根

Study on obesity and diabetes: (#co-first author; *corresponding author)

1. Lin, L.-G., Saha, P.K., Ma, X.-J., Henshaw, I.O., Shao, L.-J., Chang, B.H.J., Bura,s E.D., Tong, Q., Chan, , McGuinness, O.P., and Sun, Y.-X. (2011) Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell, 10, 996-1010.
2. Lin, L.-G., Pang, W.-J., Chen, K.-Y., Wang, F., Gengler, J., Sun, Y.-X. and Tong, Q. (2012) Adipocyte expression of PU.1 transcription factor causes insulin resistance through up-regulation of ROS production and inflammatory cytokine gene expression. American Journal of Physiology-Endocrinology and Metabolism, 302, E1550-E1559.
3. Pang, W.-J., Lin, L.-G., Xiong, Y., Wei, N., Wang, Y., Shen, Q.-W., Yang, G.-S. (2013) Knockdown of PU.1 as IncRNA inhibits adipogenesis through enhancing PU.1 mRNA translation Journal of Cellular Biochemistry, 114, 2500-2512.
4. Ma, X.-J., Lin, L.-G.#, Yue, J., Pradhan, G., Qiu, G.-J., Minze, L.J., Wu, H.-Z., Sheikh-Hamad, D., Smith, C.W., Sun, Y.-X. (2013) Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance Nutrition & Diabetes, 3 e99.
5. Lin, L.-G., Chen, K.-Y., Khalek, W.A., Ward, J.L., Yang, H., Chantal, B., Wrutniak-Cabello, C., Tong, Q. (2014) Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3 Plos One, 9(1), e85636.
6. Lin, L.-G., Nuotio-Antar, A. M., Ma, X.-J., Liu, F., Fiorotto, M. L., Sun, Y.-X. (2014). Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake, Journal of Nutrition, 144, 1349-1355.
7. Lin L.-G., Lee J. H., Bongmba O. Y., Ma X.-J., Zhu X.-W., Sheikh-Hamad D., Sun Y.-X., (2014). The suppression of ghrelin signaling mitigates age-associated thermogenic impairment, Aging, 6(12), 1019-1032.
8. Liu, Q.-Y., Wang, Y.-T., Lin, L.-G.* (2015). New insights into the anti-obesity activity of xanthones from Garcinia mangostana, Food & Function, 6, 383-393.
9. Lin, L.-G., Lee, J. H., Buras, E. D., Yu, K.-J., Wang, R.-T., Smith, C. W., Wu, H.-Z., Sheikh-Hamad, D., Sun, Y.-X. (2016). Ghrelin receptor regulates adipose tissue inflammation in aging, Aging, 8(1), 178-191.
10. Lee, J. H., Lin, L.-G., Xu, P.-W., Saito, K., Wei, Q., Meadows, A., Bongmba, O., Pradhan, G., Zheng, H., Xu, Y., Sun, Y.-X. (2016). Neuronal deletion of ghrelin receptor almost completely prevents diet-induced obesity, Diabetes, 65, 2169-2178.
11. Wu, C.-S., Bongmba, O. Y. N., Yue, J., Lee, J. H., Lin L.-G., Saito, K., Pradhan, G., Li, D.-P., Pan, H.-L., Xu, A., Guo, S.-D., Xu, Y., Sun, Y.-X. (2017). Suppression of GHS-R in AgRP neurons mitigates diet-induced obesity by activating thermogenesis. International Journal of Molecular Sciences, 18, 832.
12. Ma, X.-J., Lin L.-G.#, Yue, J., Wu, C.-S., Guo, C. A., Wang, R.-T., Yu, K.-J., Devaraj, S., Murano, P., Chen, Z., Sun, Y.-X. (2017). Suppression of ghrelin exacerbates HFCS-induced adiposity and insulin resistance. International Journal of Molecular Sciences, 18, 1302.
13. Liu, J.-X., Li, D., Zhang, T., Tong, Q., Ye, R. D., Lin L.-G.* (2017). SIRT3 protects hepatocytes from oxidative injury by enhancing ROS scavenging and mitochondrial integrity. Cell Death and Disease 8, e3158.
14. Wang, A.-Q., Li, D., Wang, S.-P., Zhou, F.-Y., Li, P., Wang, Y.-T., Lin, L.-G.* (2018). γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction. Journal of Functional Foods 40, 544-553.
15. Zhou, F.-Y., Wang, A.-Q., Li, D., Wang, Y.-T., Lin, L.-G.* (2018). Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SIRT3-TGF-β-Smad signaling pathway. Toxicology and Applied Pharmacology 341, 38-50.
16. Wang, A.-Q., Wang, S.-P., Zhou, F.-Y., Li, P., Wang, Y.-T., Gan, L.-S., Lin, L.-G.* (2018). Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Biomedicine & Pharmacotherapy 101, 334-341.
17. Li, D., Liu, Q.-Y., Sun, W., Chen, X.-P., Wang, Y., Sun, Y.-X., Lin, L.-G.* (2018). 1,3,6,7-Tetrahydroxy-8-prenylxanthone ameliorates inflammatory responses resulting from the paracrine interaction of adipocytes and macrophages. British Journal of Pharmacology 175, 1590-1606.
18. Zhang, L.-L., Feng, Z.-L., Su, M.-X., Jiang, X.-M., Chen, X.-P., Wang, Y.-T., Li, A., Lin, L.-G.*, Lu, J.-J.* (2018). Downregulation of cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells. European Journal of Pharmacology 830, 17-25.
19. Shen, S.-N., Liao, Q.-W., Huang, L., Li, D., Zhang, Q.-W., Wang, Y.-T., Lee, S. M.-Y., Lin, L.-G.* (2018). Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice. Journal of Functional Foods 47, 192-199.
20. Liu, J.-X., Shen, S.-N., Tong, Q., Wang, Y.-T., Lin, L.-G.* (2018). Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3. European Journal of Pharmacology 834, 176-187.
21. Lin, L.-G., Lee, J. H., Wang, R.-T., Wang, R., Sheikh-Hamad, D., Zang, Q. S., Sun, Y.-X.* (2018). aP2-Cre mediated ablation of GHS-R attenuates adiposity and improves insulin sensitivity during aging. International Journal of Molecular Sciences, 19, 3002.
22. Shen, S.-N., Liao, Q.-W., Feng, Y., Liu, J.-X., Pan, R.-L., Lee, S. M.-Y., Lin, L.-G.* (2019). Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase. Food Chemistry 270, 305-314.
23. Zhang, L.-L., Jiang, X.-M., Huang, M.-Y., Feng, Z.-L, Chen, X.-P., Wang, Y.-T., Li, H., Li, A., Lin, L.-G.*, Lu, J.-J.* (2019). Nagilactone E suppressed TGF-β1-induced epithelial-mesenchymal transition, migration and invasion in non-small cell cancer cells. Phytomedicine 52, 32-39.
24. Wang, A.-Q., Zhou, F.-Y., Li, D., Lu, J.-J., Wang, Y.-T., Lin, L.-G.* (2019). γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis. Toxicology and Applied Pharmacology 363, 142-153.
25. Liu, J.-X., Lin, L.-G.* (2019). Small molecules for fat combustion: targeting thermosensory and satiety signals in the central nervous system. Drug Discovery Today 24, 300-306.
26. Liu, J.-X., Wang, Y.-T., Lin, L.-G.* (2019). Small molecules for fat combustion: targeting obesity. Acta Pharmaceutica Sinica B 9, 220-236.
27. Shen, S.-N., Liao, Q.-W., Liu, J.-X., Pan, R.-L., Lee, S. M.-Y., Lin, L.-G.* (2019). Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism. Journal of Cachexia, Sarcopenia and Muscle 10, 429-444.
28. Shen, S.-N., Liao, Q.-W., Zhang, T., Pan, R.-L., Lin, L.-G.* (2019). Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance. British Journal of Pharmacology 176, 3983-4001.
29. Li, D., Liu, Q.-Y., Lu, X.-Q., Li, Z.-Q., Wang, C.-M., Leung, C.-H., Wang, Y.-T., Peng, C., Lin, L.-G.* (2019). α-Mangostin remodels visceral adipose tissue inflammation to ameliorate age-related metabolic disorders in mice. Aging, 11, 11084-11103.
30. Zhang, T., Liu, J.-X., Shen, S.-N., Tong, Q., Ma, X.-J., Lin, L.-G.* (2020). SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity. Cell Death & Differentiation, 27, 329-344.
31. Zhang, T., Liu, J.-X., Tong, Q., Lin, L.-G.* (2020). SIRT3 acts as a positive autophagy regulator to promote lipid mobilization in adipocytes via activating AMPK. International Journal of Molecular Sciences, 21, 372.
32. Li, A., Xiao, X., Feng, Z.-L., Chen, X.-P., Liu, L.-J., Lin, L.-G.*, Lu, J.-J., Zhang, L.-L. (2020). Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway. Toxicology and Applied Pharmacology, 389, 114882.
33. Zhang, L.-L., Guo, J., Jiang, X.-M., Chen, X.-P., Wang, Y.-T., Li, A., Lin, L.-G.*, Li, H., Lu, J.-J. (2020). Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity. Acta Pharmacologica Sinica, 41, 698-705.
34. Zhang, T., Fang, Z.-J., Linghu, K.-G., Liu, J.-X., Gan, L.-S., Lin, L.-G.* (2020). Small molecule-driven SIRT3-autophagy-mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes. British Journal of Pharmacology, 177, 4645-4665.
35. Li, G.-D., Ko, C.-N., Li, D., Yang, C., Wang, W.-H., Yang, G.-J., Primo, C. D., Wong, V. K. W., Xiang, Y.-Z., Lin, L.-G.*, Ma, D. L., Leung, C. H. (2021). A small molecule HIF-1α stabilizer that accelerates diabetic wound healing. Nature Communications, 12, 3363.
36. Li, D., Zhang, T., Lu, J.-J., Peng, C., Lin, L.-G.* (2021). Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation. Critical Reviews in Food Science and Nutrition, 61, 1947-1965.
37. Zhang, T., Linghu, K.-G., Lou, R.-H., Li, Z.-Q., Liu, J.-X., Li, R.-S., Qin, Z.-H., Guo, B., Lin, L.-G.* (2021). Autophagy-regulating miRNAs: potential targets for obesity and related metabolic diseases. Drug Discovery Today, 26, 1532-1538.

Study on natural products chemistry:

1. Lin, L.-G.; Zhong, Q.-X.; Cheng, T.-Y.; Tang, C.-P.; Ke, C.-Q.; Lin, G.; Ye, Y. (2006). Stemoninines from the Roots of Stemona tuberosa Journal of Natural Products, 69, 1051-1054.
2. Lin, L.-G.; Tang, C.-P.; Xu, R.-S.; Ye, Y. (2007). Cochinchistemonine, an unprecedented skeleton alkaloid from Stemona cochinchinensis, Tetrahedron Letters. 48, 1559-1561.
3. Lin, L.-G.; Pham, H.-D.; Tang, C.-P.; Ke, C.-Q.; Yang, X.-Z.; Ye, Y. (2007). Alkaloids from the roots of Stemona cochinchinensis, Helv. Chim. Acta. 90, 2167-2175.
4. Lin, L.-G.; Yang, X.-Z.; Tang, C.-P.; Ke, C.-Q.; Zhang, J.-B.; Ye, Y. (2008). Antibacterial stilbenoids from the roots of Stemona tuberosa, Phytochemistry. 69, 457-463.
5. Lin, L.-G.; Tang, C.-P.; Ke, C.-Q.; Zhang, Y.; Ye, Y. (2008). Terpenoids from stems of Cipadessa baccifera, Journal of Natural Products. 71, 628-632.
6. Lin, L.-G.; Cheng, T.-Y.; Tang, C.-P.; Ke, C.-Q.; Rudd, J. A.; Lin, G.; Ye, Y. (2008). Anti-tussive alkaloids from roots of Stemona tuberosa, Journal of Natural Products. 71, 1107-1110.
7. Lin, L.-G.; Xie, H.; Li, H.-L.; Tong, L.-J.; Tang, C.-P.; Ke, C.-Q.; Lin, L.-P.; Geng, M.-Y.; Jiang, H.-L.; Zhao, W.-M.; Ding, J.; Ye, Y. (2008). Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening, Journal of Medicinal Chemistry. 71, 628-632.
8. Lin, L.-G., Leung, H. P.-H.; Zhu, J.-Y.; Tang, C.-P.; Ke, C.-Q.; Rudd, J. A.; Lin, G.; Ye, Y. (2008). Croomine- and tuberostemonine-type alkaloids from roots of Stemona tuberosa and their antitussive activity, Tetrahedron. 64, 10155-10161.
9. Lin, L.-G.*, Liu, Q.-Y., Ye, Y. (2014). Naturally occurring homoisoflavonoids and their pharmacological activities, Planta Medica, 80, 1053-1066.
10. Lin, L.-G.*, Han, B., Wang, A.-Q., Tang, C.-P., Dien, P.-H., Ye, Y. (2014). Two new N-oxide alkaloids from Stemona cochinchinensis, Molecules, 19, 20257-20265.
11. Guo, Y.-P., Lin, L.-G.*, Wang, Y.-T. (2015). Chemistry and pharmacology of the herb pair Flos Lonicerae japonicae-Forsythiae fructus, Chinese Medicine, 10, 16.
12. Wang, A.-Q., Lin, L.-G.*, Wang, Y.-T. (2015). Traditional Chinese Herbal Medicine Penthorum chinense Pursh: A Phytochemical and Pharmacological Review, American Journal of Chinese Medicine, 43(4), 601-620.
13. Wang, A.-Q., Liu, Q.-Y., Ye, Y., Wang, Y.-T., Lin, L.-G.* (2015). Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells, Food & Function, 6, 3013-3021.
14. Chen, M.-H., Chen, X.-J., Wang, M., Lin, L.-G.*, Wang, Y.-T. (2016). Ophiopogon japonicus-A phytochemical, ethnomedicinal and pharmacological review, Journal of Ethnopharmacolgy, 181, 193-213.
15. Wang, A.-Q., Wang, S.-P., Jiang, Y., Chen, M.-W., Wang, Y.-T., Lin, L.-G.* (2016). Bio-assay guided identification of hepatoprotective polyphenols from Penthorum chinense Pursh on t-BHP induced oxidative stress injured LO2 cells, Food & Function, 7, 2074-2083.
16. Bao, H., Zhang, L.-L., Liu, Q.-Y., Feng, L., Ye, Y., Lu, J.-J., Lin, L.-G.* (2016). Cytotoxic and pro-apoptotic effects of cassane diterpenoids from the seeds of Caesalpinia sappan in cancer cells, Molecules, 21, 791.
17. Liu, Q.-Y., Li, D., Wang, A.-Q., Dong, Z., Yin, S., Zhang, Q.-W., Ye, Y., Li, L.-C., Lin, L.-G.* (2016). Nitric oxide inhibitory xanthones from the pericarps of Garcinia mangostana. Phytochemistry, 131, 115-123.
18. Lin, L.-G.*, Ung, O. L. C., Feng, Z.-L., Huang, L., Hu, H. (2016). Naturally occurring diterpenoid dimers: source, biosynthesis, chemistry and bioactivities. Planta Medica, 82, 1309-1328.
19. Huang, X.-H., Tao, L.-X., Ke, C.-Q., Tang, C.-P., Zhang, H.-Y., Ye, Y., Lin, L.-G.*, Yao, S. (2017). Taxodikaloids A and B, two dimeric abietane-type diterpenoids from Taxodium ascendens possessing an oxazoline ring linkage. Organic Letters, 19, 556-559.
20. Wu, J.-W., Tang, C.-P., Ke, C.-Q., Yao, S., Liu, H.-C., Lin L.-G.*, Ye, Y. (2017). Dicarabrol A, dicarabrone C and dipulchellin A, unique sesquiterpene lactone dimers from Carpesium abrotanoides. RSC Advances, 7, 4639-4644.
21. Bao, H., Zhang, Q.-W., Ye, Y., Lin L.-G.* (2017). Naturally occurring furanoditerpenoids: distribution, chemistry and their pharmacological activities. Phytochemistry Review, 16, 235-270.
22. Niu, B., Ke, C.-Q., Li, B.-H., Li, Y.-Y., Yi, Y.-J., Luo, Y.-W., Shuai, L., Yao, S., Lin L.-G., Li, J., Ye, Y. (2017). Cucurbitane glucosides from the crude extract of Siraitia grosvenorii with moderate effects on PGC-1α promoter activity. Journal of Natural Products, 80, 1428-1435.
23. Feng, Z.-L., Zheng, L.-L., Zheng, Y.-D., Liu, Q.-Y., Liu, J.-X., Feng, L., Huang, L., Zhang, Q.-W., Lu, J.-J., Lin, L.-G.* (2017), Norditerpenoids and dinorditerpenoids from the seeds of Podocarpus nagi as cytotoxic agents and autophagy inducers. Journal of Natural Products, 80, 2110-2117.
24. Huang, L., Li, D., Xu, Y.-S., Feng, Z.-L., Meng, F.-C., Zhang, Q.-W., Gan, L.-S., Lin L.-G.* (2017). Clausoxamine, an alkaloid possessing a 1,3-oxazine-4-one ring from the seeds of Clausena lansiu and the anti-obesity effect of lansiumamide B ASC advances 7, 46900-46905.
25. Wang, S.-P., Wang, A.-Q., Shao, M., Lin L.-G., Li, P., Wang, Y.-T. (2017). Schisandrin B reverses doxorubicin resistance through inhibiting P-glycoprotein and promoting proteasome-mediated degradation of survivin. Scientific Reports 7, 8419.
26. Xu, X.-H., Liu, Q.-Y., Li, T., Liu, J.-L., Chen, X., Huang, L., Qiang, W.-A., Chen, X.-P., Wang, Y.-T., Lin L.-G.*, Lu, J.-J. (2017). Garcinone E induces apoptosis and inhibits migration and invasion in ovarian cancer cells. Scientific Reports 7, 10718.
27. Meng, F.-C., Liu, H., Huang, X.-J., Chang, Y., Ren, D., Lin, L.-G., Zeng, Q.-Q., Zhang, Q.-W. (2017). Four new norlignan glycoside isomers from the twigs of Cephalotaxus oliveri Mast. Tetrahedron: Asymmetry 28, 1686-1689.

28. Feng, Z.-L., Zhang, T., Liu, J.-X., Chen, X.-P., Gan, L.-S., Ye, Y., Lin, L.-G.* (2018). New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect. Journal of Natural Medicines, 72, 882-889.
29. Fang, Z.-J., Shen, S.-N., Wang, J.-M., Wu, Y.-J., Zhou, C.-X., Mo, J.-X., Lin, L.-G.*, Gan, L.-S.* (2019). Triterpenoids from Cyclocarya paliurus that enhance glucose uptake in 3T3-L1 adipocytes. Molecules, 24, 187.
30. Fang, Z.-J., Zhang, T., Chen, S.-X., Wang, Y.-L., Zhou, C.-X., Mo, J.-X., Wu, Y.-J., Xu, Y.-K., Lin, L.-G.*, Gan, L.-S.* (2019). Cycloartane triterpenoids from Actaea vaginata with anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages. Phytochemistry 160, 1-10.
31. Ke, J.-H., Zhang, L.-S., Chen, S.-X., Shen, S.-N., Zhang, T., Zhou, C.-X., Mo, J.-X., Lin, L.-G.*, Gan, L.-S.* (2019). Benzofurans from Eupatorium chinense enhance insulin-stimulated glucose uptake in C2C12 myotubes and suppress inflammatory response in RAW264.7 macrophages. Fitoterapia 134, 346-354.
32. Zhang, L.-S., Shen, S.-N., Gao, Y.-L., Shi, S.-Y., Zhou, C.-X., Mo, J.-X., Xu, Y.-K., Lin, L.-G.*, Gan, L.-S.* (2019). Tautomerism and bioactivities of curcumenol, a common sesquiterpenoid widely existing in edible plants. Food & Function 10, 1288-1294.
33. Feng, Z.-L., Chen, S.-X., Wang, W., Feng, L., Dong, Y.-Y., Zou, Y.-P., Ke, C.-Q., Tang, C.-P., Yao, S., Zhang, H.-Y., Gan, L.-S., Ye, Y,, Lin, L.-G.* (2019). Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity. Fitoterapia, 139, 104378.
34. Shen, S.-N., Yu, H., Gan, L.-S., Ye, Y., Lin, L.-G.* (2019). Natural constituents from food sources: potential therapeutic agents against muscle wasting. Food & Function, 10, 6967-6986.
35. Feng, Z.-L., Lu, X.-Q., Gan, L.-S., Zhang, Q.-W., Lin, L.-G.* (2020). Xanthones, a promising anti-inflammatory scaffold: structure, activity and drug likeness analysis. Molecules, 25, 598.
36. Ren, Y.-M., Zhou, S.-Z., Zhang, T., Qian, M.-J., Zhang, R., Yao, S., Zhu, H., Tang, C.-P., Lin, L.-G.*, Ye, Y. (2020). Targeted isolation of two disesquiterpenoid macrocephadiolides A and B from Ainsliaea macrocephala using a molecular networking-based dereplication strategy. Organic Chemistry Frontiers, 7, 1481-1489.
37. Xu, Y.-S., Feng, Z.-L., Zhang, T., Lv, P., Cao, J., Li, D., Peng, C., Lin, L.-G.* (2020). Pimarane diterpenoids from the seeds of Caesalpinia minax as PTP1B inhibitors and insulin sensitizers. Molecules, 25, 4674.
38. Chen, J.-L., Tang, C.-L., Zhou, Y., Zhang, R.-F., Ye, S.-X., Zhao, Z.-M., Lin, L.-G.*, Yang, D.-P.. (2020). Anti-inflammatory property of the essential oil from Cinnamomum caphorra (Lin.) Presl leaves and the evaluation of its underlying mechanism by using metabolic analysis. Molecules, 25, 4796.
39. Wang, Q.-Q., Zhang, T., Ke, C.-Q., Tang, C.-P., Yao, S., Lin, L.-G.*, Ye, Y. (2020). Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1β production in macrophages through activating autophagy. Bioorganic Chemistry, 105, 104451.
40. Feng, Z.-L., Cao, J., Zhang, Q.-W., Lin, L.-G.* (2020). The drug likeness analysis of anti-inflammatory clerodane diterpenoids. Chinese Medicine, 15, 126.
41. Xu, Y.-S., Zhang, T., Feng, L., Feng, Z.-L., Zhang, Q.-W., Ye, Y., Gan, L.-S., Lin, L.-G.* (2021). Biscaesalmins A and B from Caesalpinia minax, highly oxidized dimeric cassane diterpenoids as interleukin-1β inhibitors. Chinese Chemical Letters, 32, 1475-1479.
42. Xu, F., Zhang, L.-S., Zhou, C.-X., Mo, J.-X., Shen, S.-N., Zhang, T., Li, J., Lin, L.-G.*, Wu, R.-H., Gan, L.-S. (2021). Alkyl-benzofuran dimers from Eupatorium chinense with insulin-sensitizing and anti-inflammatory activities. Bioorganic Chemistry, 113, 105030.
43. Feng, Z.-L., Chen, J.-L., Feng, L., Chen, C., Ye, Y., Lin, L.-G.* (2021). Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities. Food & Function, 12, 6432-6441.

1. Identification and characterization of adipogenic inhibitors from Garcinia mangostana Linn, Start-Up Research Grant of University of Macau (SRG2013-00038-ICMS-QRCM), 10/2013 – 09/2014.
2. Adipose tissue inflammation mediates high fructose corn syrup (HFCS)-induced insulin resistance, Macao Science and Technology Development Fund (042/2013/A2), 01/2014 – 12/201
3. Identification and characterization of novel therapeutic agents for treatment and/or prevention of obesity, Multi-Year Research Grant of University of Macau (MYRG2014-00020-ICMS-QRCM), 05/2014 – 04/201
4. Screening for SIRT1 activators from traditional anti-aging medicine-Cistanche, as candidates for treatment of aging-related adipose tissue inflammation, Macao Science and Technology Development Fund (120/2013/A3), 11/2014 – 10/201
5. Screening for NADPH oxidase inhibitors from tropical fruit waste components, as candidates for ameliorating aging-related adipose tissue oxidative stress, Multi-Year Research Grant of University of Macau (MYRG2015-00153-ICMS-QRCM), 04/2015 – 03/201
6. The effect of myricanol on enhancing skeletal muscle insulin sensitivity and metabolic flexibility and its underlying mechanisms,Macao Science and Technology Development Fund (102/2017/A), 01/2018 – 01/201
7. Xanthones from plants of the genus Garcinia ameliorate aging-related insulin resistance targeting adipose tissue inflammation, Shanghai Institute of Materia Medica (SIMM1803KF-16), 05/2018 – 05/201
8. Honokiol ameliorates liver oxidative damage and fibrosis through the deacetylase SIRT3, Multi-Year Research Grant of University of Macau (MYRG2017-00109-ICMS), 01/2018 – 12/2020.
9. Identification of naturally occurring autophagy regulators using a cell imaging-based high-throughput assay, and their roles in prevention and treatment of obesity, Multi-Year Research Grant of University of Macau (MYRG2018-00037-ICMS), 01/2019 – 12/2021.
10. Xanthones from plants of the genus Garcinia ameliorate aging-related insulin resistance targeting the deacetylase SIRT3 and adipose tissue remodeling, National Natural Science Foundation of China (81872754), 01/2019 – 12/2022.
11. The deacetylase SIRT3 acts as a therapeutic target against nonalcoholic fatty liver disease through adipose tissue-liver axis, Macao Science and Technology Development Fund (0031/2019/A1), 10/2019 – 09/2022.
12. Discovery of hypoglycemic lead compounds from Cyclocarya paliurus using bioactivity-based molecular networking strategy,Multi-Year Research Grant of University of Macau (MYRG2020-00091-ICMS), 01/2022 – 12/2023.
13. The cyclic diarylheptanoid myricanol mitigates sarcopenia, its target identification, structural optimization, and mechanism studies, National Natural Science Foundation of China (82073715), 01/2021 – 12/2024.

1. Ye, Y., Lin, G., Lin, L-G., Anthony, J.R., Li, X.-Q., Tang, C.-P., Ke, C.-Q. Use of alkaloids compounds in preparingof medicament for treating cough. CN 200710045498.3. 2009.
2. Ye, Y., Lin, G., Lin, L-G., Anthony, J., Li, X.-Q., Tang, C.-P., Ke, C.-Q. Total alkaloid extract, and extraction method thereof and use in preparing medicament for treating cough. CN 200710046888.2. 2009.
3. Ye, Y., Lin, G., Lin, L-G., Anthony, J.R., Li, X.-Q., Tang, C.-P., Ke, C.-Q. The use of alkaloids in preparation of medicament for treating cough. WO 2009//030116. 2009.
4. Lin, L-G., Lu, J.-J., Feng, Z.-L., Zhang, L.-L., Liu, Q.-Y. Norditerpenoids from Podocarpus nagi and application thereof in preparation of anti-tumor drugs. China patent, CN 106946903 B.
5. Lin, L-G., Huang, L., Li, D. An extract from the seeds of Clausena lansium with anti-hyperglycemia, weight losing and anti-hyperlipidemia effects, and preparation method and application thereof. China patent, application number 201710909565.5, 2017.
6. Lu, J.-J., Lin, L.-G. Li, A., Zhang, L.-L. Norditerpenoids from Podocarpus nagi and application thereof in preparation of drugs for treating pulmonary fibrosis. China patent, application number 201810346526.3, 2018.
7. Lin, L.-G., Pan, R.-L., Shen, S.-N. Diarylheptanoids from Myrica rubra with anti-hyperglycemia, weight losing and anti-hyperlipidemia effects, and preparation method and application thereof. China patent, CN110016007A.

• Member: the Endocrine Society
• Member: Chinese Chemical Society
• Member: the International Society for Chinese Medicine
• Member: the International Association of Quality Research in Chinese Medicine