Email

chengweihe@um.edu.mo

Tel

(853) 8822-8516

Office

N22-5006a

Consultation Hours

Mon: 10:00~12:00
Tue: 10:00~12:00

Chengwei HE 何承偉

Associate Professor

Academic Qualifications

  • PhD, Sun Yat-sen University Zhongshan School of Medicine
  • Post-Doc, Harvard Medical School and Massachusetts General Hospital

Teaching

  1. BSc Course: Nutrition and Food Safety (GEST022)
  2. MSc Course: Systems Biology (CMED7011)
  3. PhD Course: Advanced Pharmacology (CMED8010)

Research Interests

  • Anticancer and anti-inflammatory pharmacology of Chinese medicinal herbs and natural compounds.
  • Molecular basis and therapeutic strategies for cancer drug resistance and metastasis.
  • Cellular stress responses: pharmacological implications and molecular mechanisms.

We are looking for highly motivated master and PhD students and postdoctoral fellows with related research interests and background. For more information, please contact Dr. He at chengweihe@um.edu.mo.

  1. Zhong R, Farag MA, Chen M, He CW*, Xiao J. Recent advances in the biosynthesis, structure–activity relationships, formulations, pharmacology, and clinical trials of fisetin. eFood. 2022;3:e3. https://doi.org/10.1002/efd2.3.
  2. Zhong J, Tan L, Chen M, He CW*. Pharmacological activities and molecular mechanisms of Pulsatilla saponins. Chin Med. 2022; 17(1):59. https://doi.org/10.1186/s13020-022-00613-8.
  3. Zhong R, Miao L, Zhang H, Tan L, Zhao Y, Tu Y, Angel Prieto M, Simal-Gandara J, Chen L, He CW*, Cao H. Anti-inflammatory activity of flavonols via inhibiting MAPK and NF-κB signaling pathways in RAW264.7 macrophages. Curr Res Food Sci. 2022; 5:1176-1184. https://doi.org/10.1016/j.crfs.2022.07.007.
  4. Miao Z, Zhao Y, Chen M, He CW*. Using flavonoids as a therapeutic intervention against rheumatoid arthritis: The known and unknown. Pharmacological Research – Modern Chinese Medicine. 2022; 3: 100014. https://doi.org/10.1016/j.prmcm.2021.100014.
  5. Tu Y, Tan L, Lu T, Wang K, Wang H, Han B, Zhao Y, Chen H, Li Y, Chen H, Chen M, He CW*. Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways. Biochem Pharmacol. 2022; 12:114912. https://doi.org/10.1016/j.bcp.2022.114912.
  6. Zhao Y, Wang H, He CW*. Drug resistance of targeted therapy for advanced non-small cell lung cancer harbored EGFR mutation: from mechanism analysis to clinical strategy. J Cancer Res Clin Oncol. 2021;147(12):3653-3664. https://doi.org/10.1007/s00432-021-03828-8.
  7. Zhang C, Li Q, Qin G, Zhang Y, Li C, Han L, Wang R, Wang S, Chen H, Liu K, He CW*. Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo. Chin Med. 2021;16(1):41. https://doi.org/1186/s13020-021-00447-w.
  8. Tu Y, Yang Y, Li Y, He CW*. Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases. Pharmacol Res. 2021;169:105615. https://doi.org/10.1016/j.phrs.2021.105615.
  9. Han B, He CW*. Targeting autophagy using saponins as a therapeutic and preventive strategy against human diseases. Pharmacol Res. 2021;166:105428. https://doi.org/10.1016/j.phrs.2021.105428.
  10. Jia Y, Wang Y, Li R, Li S, Zhang M, He CW, Chen H*. The structural characteristic of acidic-hydrolyzed corn silk polysaccharides and its protection on the H2O2-injured intestinal epithelial cells. Food Chem. 2021;356:129691. https://doi.org/10.1016/j.foodchem.2021.129691.
  11. Li S, Wang Y, Xue Z, Jia Y, Li R, He CW, Chen H*. The structure-mechanism relationship and mode of actions of antimicrobial peptides: A review. Trends in Food Science & Technology, 2021;109:103-115. https://doi.org/10.1016/j.tifs.2021.01.005.
  12. Tu Y, Wang K, Tan L, Han B, Hu Y, Ding H, He CW*. Dolichosin A, a coumestan isolated from Glycine tabacina, inhibits IL-1β-induced inflammation in SW982 human synovial cells and suppresses RANKL-induced osteoclastogenesis: From network pharmacology to experimental pharmacology. J Ethnopharmacol. 2020;258:112855. https://doi.org/10.1016/j.jep.2020.112855.
  13. Tan L, Tu Y, Wang K, Han B, Peng H, He CW*. Exploring protective effect of Glycine tabacina aqueous extract against nephrotic syndrome by network pharmacology and experimental verification. Chin Med. 2020;15:79. https://doi.org/10.1186/s13020-020-00361-7.
  14. Tu Y, Wang K, Liang Y, Jia X, Wang L, Wan JB, Han J, He CW*. Glycine tabacina ethanol extract ameliorates collagen-induced arthritis in rats via inhibiting pro-inflammatory cytokines and oxidation. Journal of Ethnopharmacology, 2019; 237, 20-27. https://doi.org/10.1016/j.jep.2019.03.035.
  15. Wang K, Tu Y, Wan JB, Chen M and He CW*. Synergistic anti-breast cancer effect of pulsatilla saponin D and camptothecin through interrupting autophagic–lysosomal function and promoting p62- mediated ubiquitinated protein aggregation. Carcinogenesis. 2019; https://doi.org/10.1093/carcin/bgz140.
  16. Jia X, Zhang C, Bao J, Wang K, Tu Y, Wan JB, He CW*. Flavonoids from Rhynchosia minima root exerts anti-inflammatory activity in lipopolysaccharide stimulated RAW 264.7 cells via MAPK/NF-κB signaling pathway. Inflammopharmacology. 2019; https://doi.org/10.1007/s10787-019-00632-2.
  17. Tu Y, Wang K, Wan JB, He CW*. Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice. Journal of Functional Foods. 2019; https://doi.org/10.1016/j.jff.2019.103528.
  18. Zhang C, Li C, Jia X, Wang K, Tu Y, Wang R, Liu K, Lu T, He CW*. In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways. 2019; 24(5). https://doi.org/10.3390/molecules24050875.
  19. He CW*. Editorial: Implication of hormetic effect in traditional Chinese medicine. Longhua Chinese Medicine, 2018; https://doi.org/10.21037/lcm.2018.05.02.
  20. Bao J, Ding RB, Jia X, Liang Y, Liu F, Wang K, Zhang C, Li P, Wang Y, Wan JB, He CW*. Fast identification of anticancer constituents in Forsythiae Fructus based on metabolomics approaches. Journal of Pharmaceutical and Biomedical Analysis. 2018; 154:312-320. https://doi.org/10.1016/j.jpba.2018.03.020.
  21. Jia X, Liang Y, Zhang C, Wang K, Tu Y, Chen M, Li P, Wan JB, He CW*. Polysaccharide PRM3 from Rhynchosia minima root enhances immune function through TLR4-NF-κB pathway. Biochimica et Biophysica Acta – General Subjects. 2018; 1862(8):1751-1759. https://doi.org/10.1016/j.bbagen.2018.05.012.
  22. Bao J, Ding RB, Liang Y, Liu F, Wang K, Jia X, Zhang C, Chen M, Li P, Su H, Wan JB, Wang Y, He CW*. Differences in Chemical Component and Anticancer Activity of Green and Ripe Forsythiae Fructus. American Journal of Chinese Medicine, 2017; 45(07):1513-1536. https://doi.org/10.1142/S0192415X17500823.
  23. Jia XJ, Li P, Wan JB, He CW*. A review on phytochemical and pharmacological properties of Litsea coreana. Pharmaceutical Biology, 2017; 55(1):1368-1374. https://doi.org/10.1080/13880209.2017.1302482.
  24. Zhang C, Li C, Chen S, Li Z, Ma L, Jia X, Wang K, Bao J, Liang Y, Chen M, Li P, Su HX, Lee MY, Liu K, Wan JB*, He CW*. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Scientific Reports, 2017; 7. https://doi.org/10.1038/srep41082.
  25. Bao JL, Liu F, Zhang C, Wang K, Jia XJ, Chen M, Li P, Su HX, Wang YT, Wan JB, He CW*. Anti-melanoma activity of Forsythiae Fructus aqueous extract in mice involves regulation of glycerophospholipid metabolisms by UPLC/Q-TOF MS-based metabolomics study. Scientific Reports, 2016; 6. https://doi.org/10.1038/srep39415.
  26. Jia XJ, Hu J, He MX, Zhang QW, Li P, Wan JB, He CW*. Α-glucosidase inhibitory activity and structural characterization of polysaccharide fraction from Rhynchosia minima Journal of Functional Foods, 2016; 28:76-82. https://doi.org/10.1016/j.jff.2016.10.026.
  27. Zhang C, Li CW, Chen SH, Li ZP, Jia XJ, Wang K, Bao JL, Liang YE, Wang XT, Chen M, Li P, Su HX, Wan JB, Lee MY, Liu KC, He CW*. Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways. Redox Biology, 2016; 11. https://doi.org/10.1016/j.redox.2016.10.019.
  28. Shi Z, Wu D, Yao JP, Yao X, Huang Z, Li P, Wan JB, He CW*, Su H*. Protection against Oxygen-Glucose Deprivation/Reperfusion Injury in Cortical Neurons by Combining Omega-3 Polyunsaturated Acid with Lyciumbarbarum Polysaccharide. Nutrients. 2016; 8(1). https://doi.org/10.3390/nu8010041.
  29. Bao J, Ding R, Zou L, Zhang C, Wang K, Liu F, Li P, Chen M, Wan JB, Su HX, Wang YT, He CW*. Forsythiae Fructus Inhibits B16 Melanoma Growth Involving MAPKs/Nrf2/HO-1 Mediated Anti-Oxidation and Anti-Inflammation. American Journal of Chinese Medicine, 2016; 44(5):1043-1061. https://doi.org/10.1142/S0192415X16500580.
  30. Jia X, Ma L, Li P, Chen M, He CW*. Prospects of Poria cocos polysaccharides: isolation process, structural features and bioactivities. Trends in Food Science & Technology, 2016; 54: 52-62. https://doi.org/10.1016/j.tifs.2016.05.021.
  31. Wang K, Zhang C, Bao J, Jia X, Liang Y, Wang X, Chen M, Su HX, Li P, Wan JB, He CW*. Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death. Scientific Reports, 2016; 6. https://doi.org/10.1038/srep26064.
  32. Zhang C, Jia X, Bao J, Chen S, Wang K, Zhang Y, Li P, Wan JB, Su HX, Wang YT, Mei Z, He CW*. Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways. BMC Complementary and Alternative Medicine, 2016; 16. https://doi.org/10.1186/s12906-016-1036-x.
  33. Zhang C, Jia X, Wang K, Bao J, Li P, Chen M, Wan JB, Su HX, Mei Z, He CW*. Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells. PLoS One, 2016; 11(1):e0147405. https://doi.org/10.1371/journal.pone.0147405.
  34. Zhou LD, Chen FQ, Bao JL, Wang SP, Wang L, Chen M*, He CW*, Wang YT Preparation, Characterization, and Antitumor Efficacy of Evodiamine Loaded PLGA Nanoparticles. Drug Delivery, 2016; 23(3):898-906. https://doi.org/10.3109/10717544.2014.920936.
  35. Feng R, Wang M, Yan C, Li P, Chen M, He CW*, Wan JB*. Endogenous n-3 Fatty Acids Alleviate Carbon-Tetrachloride-Induced Acute Liver Injury in Fat-1 Transgenic Mice. Oxidative Medicine and Cellular Longevity. 2016; https://doi.org/10.1155/2016/7962948.
  36. Hu J, Jia X, Fang X, Li P, He CW*, Chen M*. Ultrasonic extraction, antioxidant and anticancer activities of novel polysaccharides from Chuanxiong rhizome. International Journal of Biological Macromolecules. 2016; 85:277-84. https://doi.org/10.1016/j.ijbiomac.2015.12.046.
  37. Bao J, Huang B, Zou L, Chen S, Zhang C, Zhang Y, Chen M, Wan JB, Su HX, Wang YT, He CW*. Hormetic effect of berberine attenuates the anticancer activity of chemotherapeutic agents. PLOS One, 2015; 10(9):e0139298. https://doi.org/10.1371/journal.pone.0139298.
  38. Jia X, Zhang C, Hu J, He M, Bao J, Wang K, Li P, Chen M, Wan JB, Su HX, Zhang QW, He CW*. Ultrasound-Assisted Extraction, Antioxidant and Anticancer Activities of the Polysaccharides from Rhynchosia minima Root. Molecules, 2015; 20(11):20901-20911. https://doi.org/10.3390/molecules201119734.
  39. Jia X, Zhang C, Qiu J, Wang L, Bao J, Wang K, Zhang Y, Chen, Wan JB, Su HX, Han J, He CW*. Purification, structural characterization and anticancer activity of the novel polysaccharides from Rhynchosia minima root. Carbohydrate Polymers, 2015; 132: 67-71. https://doi.org/10.1016/j.carbpol.2015.05.059.
  40. Jia X, Chen M, Wan JB, Su HX, He CW*. Review on extraction, characterization and application of soybean polysaccharide. RSC Advances, 2015; 5: 73525-73534. https://doi.org/10.1039/C5RA12421B.

(*Corresponding author)

  1. Huang CJ, Lin HH, Wan JB, He CW, Hu YJ. Research and development of hepatitis b drugs: an analysis based on technology flows measured by patent citations. Innovation Value Chain of Chinese Pharmaceuticals (pp.159-186). United States-China Intellectual Property Institute Inc. 2017
  2. He CW. Experimental approaches for tumor immunology. In: Advances and modern experimental approaches in anticancer research of Chinese medicine. Beijing: People’s Medical Publishing House Co., LTD. 2012
  3. He CW. Genome and proteome. In: Molecular Diognostics. Beijing: Chinese Medical and Pharmaceutical Science Press. 2004

  1. 何承偉, 屠言貝, 王愷，張慶文。一種化合物、其製備方法及應用以及抗類風濕性關節炎的藥物。中國發明專利。專利號：ZL20191056。授權公告號：CN110330503B。
  2. 何承偉, 屠言貝, 王愷。一種化合物、其製備方法及應用以及抗類風濕性關節炎的藥物。中國發明專利。專利號：ZL202010457352.5。授權公告號：CN111440183B。
  3. 何承偉, 屠言貝, 王愷。一種化合物、其製備方法及應用以及抗類風濕性關節炎的藥物。中國發明專利。專利號：ZL202010456536.6。授權公告號：CN111533755B。
  4. 何承偉，王愷，梁葉兒，陳美婉，李鵬，萬建波，胡言佳。一種烟豆水提取物及其用途。中國發明專利。授權公告號：CN108938709 A。
  5. 何承偉，王愷，梁葉兒，陳美婉，李鵬，萬建波，王一濤。烟豆或其提取物在製備治療和預防關節炎的藥物中的用途。中國發明專利。授權公告號：CN108938710A。