Email

xiaojiachen@um.edu.mo

Tel

(853) 8822-4915

Office

N22-6007

Consultation Hours

Tue: 10:00~11:00
Wed: 10:00~11:00

Xiao Jia CHEN 陳肖家

Associate Professor

Academic Qualifications

  • Ph.D. in Biomedical Sciences, University of Macau, Macao, China
  • MSc. in Chinese Medicinal Sciences, University of Macau, Macao, China
  • MSc. in Phamacognosy, Peking University, Beijing, China
  • BSc. in Pharmaceutical Sciences, Peking University, China

Teaching

  1. CMED7014     Advanced Natural Products Chemistry (MSc. Course)
  2. CMED7016    Application of Pharmacokinetics and Metabonomics in Drug Development (MSc. Course)
  3. CMED7018    Bio-Statistics (MSc. Course)
  4. CMED8007    Chemistry of Natural Medicine (Ph.D. Course)

Research Interests

  • Quality evaluation and international standards of Chinese medicines
  • Metabolomics study on Chinese medicines
  • Bioactive components from Chinese medicines

We are looking for postgraduate students who are interested in pharmaceutical analysis and Chinese medicines quality evaluation to join our research group. For further details, please contact Dr. Chen at xiaojiachen@um.edu.mo

Journal Articles

* (co-)corresponding author;  # co-first author

  1. Xiong S, Luo JS, Wang Q, Li ZJ, Li JT, Liu Q, Gao LQ, Fang SH, Li YY, Pan HF, Wang H, Zhang YB, Wang Q, Chen XJ*, Chen TK. Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson’s disease. Biomaterials Science. In press.
  2. Cheng GW, Luo JS, Liu Y, Chen XJ, Wu ZF, Chen TK. Cucurbituril-Oriented Nanoplatforms in Biomedical Applications. ACS Applied Bio Materials. In press.
  3. Ruan YF, Cai ZD, Deng Y, Pan DD, Zhou CY, Cao JX, Chen XJ, Xia Q. An untargeted metabolomic insight into the high-pressure stress effect on the germination of wholegrain Oryza sativa Food Research International. 2021, 140: 109984.
  4. Xia Q, Zheng YR, Liu ZM, Cao JX, Chen XJ, Liu LL, Yu HN, Barba FJ, Pan DD. Nonthermally driven volatilome evolution of food matrices: The case of high pressure processing. Trends in Food Science & Technology. 2020, 106: 365-381.
  5. Zhao YY, Xiong S, Liu PX, Liu W, Wang Q, Liu Y, Tan HX, Chen XJ, Shi XG, Wang Q, Chen TK. Polymeric Nanoparticles-Based Brain Delivery with Improved Therapeutic Efficacy of Ginkgolide B in Parkinson’s Disease. International Journal of Nanomedicine. 2020, 15: 10453-10467.
  6. Xiong S, Li ZJ, Liu Y, Wang Q, Luo JS, Chen XJ, Xie ZJ, Zhang Y, Zhang H, Chen TK. Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson’s disease. Biomaterials. 2020, 260 : 120339.
  7. Liu W, Huang G, Su XY, Li SY, Wang Q, Zhao YY, Liu Y, Luo JS, Li Y, Li CW, Yuan DS, Hong HH, Chen XJ*, Chen TK. Zebrafish: A Promising Model for Evaluating the Toxicity of Carbon Dot-Based Nanomaterials. ACS Applied Materials & Interfaces. 2020, 12(43): 49012-49020.
  8. Liu Y, Zhu DM, Luo JS, Chen XJ, Gao LQ, Liu W, Chen TK. NIR-II-Activated Yolk-Shell Nanostructures as an Intelligent Platform for Parkinsonian Therapy. ACS Applied Bio Materials. 2020, 3(10): 6876-6887.
  9. Xiong S#, Chen XJ#, Liu Y, Fan TJ, Wang Q, Zhang H, Chen TK. Black phosphorus as a versatile nanoplatform: From unique properties to biomedical applications. Journal of Innovative Optical Health Sciences. 2020, 13(5): 2030008.
  10. Leong F, Hua X, Wang M, Chen TK, Song YL, Tu PF, Chen XJ*. Quality standard of traditional Chinese medicines: comparison between European Pharmacopoeia and Chinese Pharmacopoeia and recent advances. Chinese Medicine. 2020, 15(1): 76.
  11. Xiong S, Liu W, Zhou YL, Mo YS, Liu Y, Chen XJ, Pan HF, Yuan DS, Wang Q, Chen TK. Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation. Asian Journal of Pharmaceutical Sciences. 2020, 15(4): 518-528.
  12. Liu Y, Liu W, Xiong S, Luo JS, Li Y, Zhao YY, Wang Q, Zhang ZX, Chen XJ*, Chen TK. Highly stabilized nanocrystals delivering Ginkgolide B in protecting against the Parkinson’s disease. International Journal of Pharmaceutics. 2020, 577: 119053.
  13. Ge YH#, Chen XJ#, Godevac D, Bueno PCP, Abarca LFS, Jang YP, Wang M, Choi YH. Metabolic Profiling of Saponin-Rich Ophiopogon japonicus Roots Based on (1) H NMR and HPTLC Platforms. Planta Medica. 2019, 85(11/12): 917-924.
  14. Xiong S, Liu W, Li DL, Chen XJ, Liu F, Yuan DS, Pan HF, Wang Q, Fang SH, Chen TK. Oral Delivery of Puerarin Nanocrystals To Improve Brain Accumulation and Anti-Parkinsonian Efficacy. Molecular Pharmaceutics. 2019, 16(4): 1444-1455.
  15. Liu Y, Luo JS, Chen XJ, Liu W, Chen TK. Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications. Nano-Micro Letters. 2019, 11(1): 100.
  16. Chen TK, Liu W, Xiong S, Li DL, Fang SH, Wu ZF, Wang Q, Chen XJ*. Nanoparticles Mediating the Sustained Puerarin Release Facilitate Improved Brain Delivery to Treat Parkinson’s Disease. ACS Applied Materials & Interfaces. 2019, 11(48): 45276-45289.
  17. Song QQ, Liu WJ, Chen XJ, Li J, Li P, Yang FQ, Wang YT, Song YL, Tu PF. Serially coupled reversed phase-hydrophilic interaction liquid chromatography-tailored multiple reaction monitoring, a fit-for-purpose tool for large-scale targeted metabolomics of medicinal bile. Analytica Chimica Acta. 2018, 1037: 119-129.
  18. Yan Y, Song QQ, Chen XJ, Li J, Li P, Wang YT, Liu TX, Song YL, Tu PF. Simultaneous determination of components with wide polarity and content ranges in Cistanche tubulosa using serially coupled reverse phase-hydrophilic interaction chromatography-tandem mass spectrometry. Journal of Chromatography A. 2017, 1501: 39-50.
  19. Zhang QR, Yu H, Qi J, Tang DS, Chen XJ, Wan JB, Li P, Hu H, Wang YT, Hu YJ. Natural formulas and the nature of formulas: Exploring potential therapeutic targets based on traditional Chinese herbal formulas. Plos One. 2017, 12(2): e0171628.
  20. Song QQ, Zhao YF, Chen XJ, Li J, Li P, Jiang Y, Wang YT, Song YL, Tu PF. New instrumentation for large-scale quantitative analysis of components spanning a wide polarity range by column-switching hydrophilic interaction chromatography-turbulent flow chromatography-reversed phase liquid chromatography-tandem mass spectrometry. RSC Advances. 2017, 7(51): 31838-31849.
  21. Xu XH, Li T, Fong CMV, Chen XP, Chen XJ, Wang YT, Huang MQ, Lu JJ. Saponins from Chinese Medicines as Anticancer Agents. Molecules. 2016, 21(10): 1326.
  22. Chen MH#, Chen XJ#, Wang M, Lin LG, Wang YT. Ophiopogon japonicus-A phytochemical, ethnomedicinal and pharmacological review. Journal of Ethnopharmacology. 2016, 181: 193-213.
  23. Chen XJ, Qiu JF, Wang YT, Wan JB. Discrimination of Three Panax Species Based on Differences in Volatile Organic Compounds Using a Static Headspace GC-MS-Based Metabolomics Approach. American Journal of Chinese Medicine. 2016, 44(3): 663-676.
  24. Zhang LL, Tian K, Tang ZH, Chen XJ, Bian ZX, Wang YT, Lu JJ. Phytochemistry and Pharmacology of Carthamus tinctorius American Journal of Chinese Medicine. 2016, 44(2): 197-226.
  25. Chen XJ, Zhang XJ, Shui YM, Wan JB, Gao JL. Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites. Evidence-Based Complementary and Alternative Medicine. 2016: 5738694.
  26. Tang ZH, Li T, Tong YG, Chen XJ, Chen XP, Wang YT, Lu JJ. A Systematic Review of the Anticancer Properties of Compounds Isolated from Licorice (Gancao). Planta Medica. 2015, 81(18): 1670-1687.
  27. Chen XJ, Tang ZH, Li XW, Xie CX, Lu JJ, Wang YT. Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo). American Journal of Chinese Medicine. 2015, 43(5): 783-834.
  28. Cai Y, Li XW, Li M, Chen XJ, Hu H, Ni JY, Wang YT. Traceability and Quality Control in Traditional Chinese Medicine: From Chemical Fingerprint to Two-Dimensional Barcode. Evidence-Based Complementary and Alternative Medicine. 2015: 251304.
  29. Yang ZM, Zhao J, Lao KM, Chen XJ, Leong F, Wang CZ, Yuan CS, Li SP. Determination of six polyynes in Oplopanax horridus and Oplopanax elatus using polyethylene glycol modified reversed migration microemulsion electrokinetic chromatography. Electrophoresis. 2014, 35(20): 2959-2964.
  30. Li GL, Han WL, Jiang W, Zhang DM, Ye WC, Chen XJ, Ma AD. Quantitative determination of arenobufagin in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2013, 939: 86-91.
  31. Han DQ, Zhao J, Xu J, Peng HS, Chen XJ, Li SP. Quality evaluation of Polygonum multiflorum in China based on HPLC analysis of hydrophilic bioactive compounds and chemometrics. Journal of Pharmaceutical and Biomedical Analysis. 2013, 72: 223-230.
  32. Xu J, Han QB, Li SL, Chen XJ, Wang XN, Zhao ZZ, Chen HB. Chemistry, bioactivity and quality control of Dendrobium, a commonly used tonic herb in traditional Chinese medicine. Phytochemistry Reviews. 2013, 12(2): 341-367.
  33. Lao KM, Han DQ, Chen XJ, Zhao J, Wang TJ, Li SP. Simultaneous determination of seven hydrophilic bioactive compounds in water extract of Polygonum multiflorum using pressurized liquid extraction and short-end injection micellar electrokinetic chromatography. Chemistry Central Journal. 2013, 7: 45.
  34. Chen XJ, Dinh NP, Zhao J, Wang YT, Li SP, Svec F. Effect of ion adsorption on CEC separation of small molecules using hypercrosslinked porous polymer monolithic capillary columns. Journal of Separation Science. 2012, 35(12): 1502-1505.
  35. Chen XJ, Zhao J, Wang YT, Huang LQ, Li SP. CE and CEC analysis of phytochemicals in herbal medicines. Electrophoresis. 2012, 33(1): 168-179.
  36. Xu J, Guan J, Chen XJ, Zhao J, Li SP. Comparison of polysaccharides from different Dendrobium using saccharide mapping. Journal of Pharmaceutical and Biomedical Analysis. 2011, 55(5): 977-983.
  37. Chen XJ, Yang FQ, Wang YT, Li SP. CE and CEC of nucleosides and nucleotides in food materials. Electrophoresis. 2010, 31(13): 2092-2105.
  38. Chen XJ, Zhao J, Meng Q, Li SP, Wang YT. Simultaneous determination of five flavonoids in licorice using pressurized liquid extraction and capillary electrochromatography coupled with peak suppression diode array detection. Journal of Chromatography A. 2009, 1216(43): 7329-7335.
  39. Jiang Y, Li SP, Wang YT, Chen XJ, Tu PF. Differentiation of Herba Cistanches by fingerprint with high-performance liquid chromatography-diode array detection-mass spectrometry. Journal of Chromatography A. 2009, 1216(11): 2156-2162.
  40. Chen XJ, Tu PF, Jiang Y, Wang YT, Li SP. Effect of stability of internal standard on quantification of 15 flavonoids in Epimedium using CZE. Journal of Separation Science. 2009, 32(2): 275-281.
  41. Chen XJ, Ji H, Wang YT, Li SP. Simultaneous determination of seven flavonoids in Epimedium using pressurized liquid extraction and capillary electrochromatography. Journal of Separation Science. 2008, 31(5): 881-887.
  42. Chen XJ, Ji H, Zhang QW, Tu PF, Wang YT, Guo BL, Li SP. A rapid method for simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and ultra-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. 2008, 46(2): 226-235.
  43. Chen XJ, Guo BL, Li SP, Zhang QW, Tu PF, Wang YT. Simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and high-performance liquid chromatography. Journal of Chromatography A. 2007, 1163(1-2): 96-104.
  44. Jiang Y, Tu PF, Chen XJ, Zhang TY. Isolation of two sucrose esters from Polygala tenuifolia by high speed countercurrent chromatography. Journal of Liquid Chromatography & Related Technologies. 2005, 28(10): 1583-1592.
  45. Zhang YJ, Qian ZM, Chen XJ, Yang FQ, Li SP. Simultaneous HPLC determination of uridine, adenine, guanosine, and adenosine in six tonic traditional Chinese medicines. Chinese Journal of Pharmaceutical Analysis, 2010, 30(1), 33-36.
  46. Chen XJ, Li SP, Wang YT, Tu PF. Comparison of quantitative determination of flavonoids in Herba Epimedii by HPLC, UPLC and CZE. Chinese Pharmaceutical Journal, 2008, 43 (8), 624-628.
  47. Chen XJ, Zhang QW, Ji H, Wang YT, Tu PF, Li SP. Comparison of UV spectrophotometry and HPLC on quantitative determination of total flavonoids of Herba Epimedii. Chinese Journal of Pharmaceutical Analysis, 2007, 27(5), 625-630.

Book and Book Chapters

  1. Li, S.P., Chen, X.J., Yang, F.Q. Application of chemometrics in capillary electrophoresis analysis of herbal medicines. In: Hanrahan, G., Gomez, F.A. (Eds.), Chemometric methods in capillary electrophoresis (pp. 227-242). Hoboken, New Jersey. John Wiley & Sons, Inc., 2010.
  2. Chen, X.J. (associate editor). In: Li, S.P., Wang, Y.T. (Eds.), Chromatographic methods for analysis of commonly used Chinese herbs. Macao. Publications Center, University of Macau. (ISBN: 978-99937-970-6-7), 2009.
  3. Chen, X.J., Wang, Y.T., Li, S.P. Yinyanghuo (Epimedium) In: Li, S.P., Wang, Y.T. (Eds.), Pharmacological Activity-Based Quality Control of Chinese Herbs. (pp. 217-234) New York. Nova Publishers, Inc., 2008.
  4. Guan, J., Chen, X.J., Li, SP. Recent development on analytical techniques for quality control of Chinese herbs. In: Li, S.P., Wang, Y.T. (Eds.), Pharmacological Activity-Based Quality Control of Chinese Herbs. (pp. 73-113) New York. Nova Publishers, Inc., 2008.

  • Chen, X.J. Scientific and Technological R&D Award for Postgraduates, Macao Special Administrative Region. Macao Science and Technology Development Fund, 2012.
  • Chen, X.J., Dinh, N.P., Zhao, J., Li, S.P., Wang, Y.T., Irgum, K., Svec, F. Effect of ion adsorption on capillary electrochromatographic separation of small molecules using hypercrosslinked monolithic capillary columns. CASSS Student Travel Grants. The 38th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (HPLC 2012), 2012.
  • Li, S.P., Wang, Y.T., Yang, F.Q., Li, P., Wan, J.B., Chen, X.J. Application of pressurized liquid extraction in quality control of Chinese medicine. 3rd Prize of the Science and Technology Award, Chinese Pharmaceutical Association, 2008.
  • Chen, X.J., Li, S.P., Wang, Y.T. Comparison of HPLC, UPLC and CZE on quantitative determination of flavonoids in Herba Epimedii. Excellent Paper 2nd Prize. The 8th “SHIMADZU CUP” of National Pharmaceutical Analysis Symposium, Chinese Pharmaceutical Association, 2007.

  • Council Member, Specialty Committee of TCM Network Pharmacology of World Federation of Chinese Medicine Societies
  • Member, International Society for Chinese Medicine
  • Member, International Association of Quality Research in Chinese Medicine