Email

xiaojiachen@um.edu.mo

Tel

(853) 8822-4915

Office

N22-6007

Consultation Hours

Tue: 15:00~16:00
Thu: 15:00~16:00

Xiaojia CHEN 陳肖家

Associate Professor

Academic Qualifications

  • Ph.D. in Biomedical Sciences, University of Macau, Macao, China
  • MSc. in Chinese Medicinal Sciences, University of Macau, Macao, China
  • MSc. in Phamacognosy, Peking University, Beijing, China
  • BSc. in Pharmaceutical Sciences, Peking University, China

Teaching

HSCI2011Analytical ChemistryB.Sc. Course
CMED7014Advanced Natural Products ChemistryM.Phil. Course
CMED7016Application of Pharmacokinetics and Metabonomics in Drug DevelopmentM.Phil. Course
CMED7018Bio-StatisticsM.Phil. Course
CMED7033Application of Medical StatisticsM.Sc. Course
CMED8007Chemistry of Natural MedicinePh.D. Course

Research Interests

  • Quality evaluation and international standards of Chinese medicines
  • Metabolomics study on Chinese medicines
  • Bioactive components from Chinese medicines

Selected journal articles (* co-/corresponding author; # co-first author)

  1. Liu W#, Wang LJ#, Yuan Q, Hao W, Wang YT, Wu DT, Chen XJ*, Wang SP*. Agaricus bisporus polysaccharides ameliorate ulcerative colitis in mice by modulating gut microbiota and its metabolism. Food & Function. 2024, 15(3): 1191-1207.
  2. Zhang HL, Lin SY, Xie RW, Zhong WZ, Wang H, Farag MA, Hussain H, Arroo RRJ, Chen XJ*, Xiao JB*. Thermal degradation of (2R, 3R)-dihydromyricetin in neutral aqueous solution at 100 ℃. Food Chemistry. 2024, 435: 137560.
  3. Liu F, Zheng YR, Hong HJ, Liu LL, Chen XJ*, Xia Q*. Identification of Efficacy-Associated Markers to Discriminate Flos Chrysanthemum and Flos Chrysanthemi Indici Based on Fingerprint–Activity Relationship Modeling: A Combined Evaluation over Chemical Consistence and Quality Consistence. Molecules. 2023, 28(17): 6254.
  4. Xia Q, Zheng YR, Wang LB, Chen XJ*. Proposing Signaling Molecules as Key Optimization Targets for Intensifying the Phytochemical Biosynthesis Induced by Emerging Nonthermal Stress Pretreatments of Plant-Based Foods: A Focus on γ-Aminobutyric Acid. Journal of Agricultural and Food Chemistry. 2023, 71(34): 12622-12644.
  5. Du S, Guan YC, Xie AH, Yan Z, Gao SJ, Li WR, Rao L*, Chen XJ*, Chen TK*. Extracellular vesicles: a rising star for therapeutics and drug delivery. Journal of Nanobiotechnology. 2023, 21(1): 231.
  6. Lin XP#, Li ZJ#, Du S, Wang Q, Guan YC, Cheng GP, Hong HJ, Li JQ, Chen XJ*, Chen TK*. Occam’s Razor-Inspired Nb2C delivery platform potentiates breast cancer therapy and inhibits lung metastasis. Chemical Engineering Journal. 2023, 464: 142732.
  7. Liu Q, Lu JJ, Hong HJ, Yang Q, Wang YT, Chen XJ*. Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms. Phytomedicine. 2023, 113: 154718.
  8. Chen MH#, Leong F#, Gao SJ, Chen X, Lu JJ, Lin LG, Wang YT, Chen XJ*. Comparison of Ophiopogon japonicus and Liriope spicata var. prolifera from Different Origins Based on Multi-Component Quantification and Anticancer Activity. Molecules. 2023, 28(3): 1045.
  9. Zhang HL#, Wang ML#, Liang YW, Lv XM, Xie RW, Chen XJ*, Xiao JB*. Discovery of nitrogenous derivatives of dihydromyricetin in cell culture medium. eFood. 2022, 3(5): e34.
  10. Liu Q, Shen JM, Hong HJ, Yang Q, Liu W, Guan Z, Wang YT, Chen XJ*. Cell metabolomics study on the anticancer effects of Ophiopogon japonicus against lung cancer cells using UHPLC/Q-TOF-MS analysis. Frontiers in Pharmacology. 2022, 13: 1017830.
  11. Liu Y, Luo JS, Liu YJ, Liu W, Yu GT, Huang YT, Yang Y*, Chen XJ*, Chen TK*. Brain-Targeted Biomimetic Nanodecoys with Neuroprotective Effects for Precise of Parkinson’s Disease. ACS Central Science. 2022, 8(9): 1336-1349.
  12. Xia Q, Liu QQ*, Denoya GI, Yang CJ, Barba FJ, Yu HN*, Chen XJ*. High Hydrostatic Pressure-Based Combination Strategies for Microbial Inactivation of Food Products: The Cases of Emerging Combination Patterns. Frontiers in Nutrition. 2022, 9 : 878904.
  13. Hong HJ#, Yang Q#, Liu Q, Leong F, Chen XJ*. Chemical Comparison of Monk Fruit Products Processed by Different Drying Methods Using High-Performance Thin-Layer Chromatography Combined With Chemometric Analysis. Frontiers in Nutrition. 2022, 9 : 887992.
  14. Hu Y#, Wang Z#, Liu JY, Yang W, Yang Q, Liu YC, You QY, Chen XJ*, Wan JB*. Chemical Stability of a Chinese Herbal Spirit Using LC-MS-Based Metabolomics and Accelerated Tests. Frontiers in Pharmacology. 2022, 13: 857706.
  15. Wang M#*, Yao PF#, Sun PY, Liang W, Chen XJ*. Key quality factors for Chinese herbal medicines entering the EU market. Chinese Medicine. 2022, 17(1): 29.
  16. Hua X#, Hong HJ#, Zhang DY, Liu Q, Leong F, Yang Q, Hu YJ*, Chen XJ*. Rapid Screening of Lipase Inhibitors from Ophiopogonis Radix Using High-Performance Thin Layer Chromatography by Two Step Gradient Elution Combined with Bioautographic Method. Molecules. 2022, 27(4): 1155.
  17. Zhang HL#, Wang ML#, Yi LZ, Hogger P, Arroo R, Bajpai VK, Prieto MA, Chen XJ*, Simal-Gandara J*, Cao H*. Stability profiling and degradation products of dihydromyricetin in Dulbecco’s modified eagle’s medium. Food Chemistry. 2022, 378: 132033.
  18. Mo YS#, Liu W#, Liu PX, Liu Q, Yuan ZY, Wang Q, Yuan DS, Chen XJ*, Chen TK*. Multifunctional Graphene Oxide Nanodelivery Platform for Breast Cancer Treatment. International Journal of Nanomedicine. 2022, 17: 6413-6425.
  19. Xiong S, Luo JS, Wang Q, Li ZJ, Li JT, Liu Q, Gao LQ, Fang SH, Li YY, Pan HF, Wang H, Zhang YB, Wang Q*, Chen XJ*, Chen TK*. Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson’s disease. Biomaterials Science. 2021, 9(5): 1705-1715.
  20. Liu W, Huang G, Su XY, Li SY, Wang Q, Zhao YY, Liu Y, Luo JS, Li Y, Li CW, Yuan DS, Hong HH*, Chen XJ*, Chen TK*. Zebrafish: A Promising Model for Evaluating the Toxicity of Carbon Dot-Based Nanomaterials. ACS Applied Materials & Interfaces. 2020, 12(43): 49012-49020.
  21. Leong F#, Hua X#, Wang M, Chen TK, Song YL, Tu PF, Chen XJ*. Quality standard of traditional Chinese medicines: comparison between European Pharmacopoeia and Chinese Pharmacopoeia and recent advances. Chinese Medicine. 2020, 15(1): 76.
  22. Liu Y, Liu W, Xiong S, Luo JS, Li Y, Zhao YY, Wang Q, Zhang ZX, Chen XJ*, Chen TK*. Highly stabilized nanocrystals delivering Ginkgolide B in protecting against the Parkinson’s disease. International Journal of Pharmaceutics. 2020, 577: 119053.
  23. Chen TK*, Liu W, Xiong S, Li DL, Fang SH, Wu ZF, Wang Q, Chen XJ*. Nanoparticles Mediating the Sustained Puerarin Release Facilitate Improved Brain Delivery to Treat Parkinson’s Disease. ACS Applied Materials & Interfaces. 2019, 11(48): 45276-45289.
  24. Ge YH#, Chen XJ#, Godevac D, Bueno PCP, Abarca LFS, Jang YP, Wang M, Choi YH*. Metabolic Profiling of Saponin-Rich Ophiopogon japonicus Roots Based on (1) H NMR and HPTLC Platforms. Planta Medica. 2019, 85(11/12): 917-924.
  25. Chen MH#, Chen XJ#, Wang M, Lin LG*, Wang YT*. Ophiopogon japonicus-A phytochemical, ethnomedicinal and pharmacological review. Journal of Ethnopharmacology. 2016, 181: 193-213.
  26. Chen XJ#, Qiu JF#, Wang YT*, Wan JB*. Discrimination of Three Panax Species Based on Differences in Volatile Organic Compounds Using a Static Headspace GC-MS-Based Metabolomics Approach. American Journal of Chinese Medicine. 2016, 44(3): 663-676.
  27. Chen XJ, Zhang XJ, Shui YM, Wan JB*, Gao JL*. Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites. Evidence-Based Complementary and Alternative Medicine. 2016: 5738694.
  28. Chen XJ#, Tang ZH#, Li XW, Xie CX, Lu JJ*, Wang YT*. Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo). American Journal of Chinese Medicine. 2015, 43(5): 783-834.
  29. Chen XJ, Dinh NP, Zhao J, Wang YT, Li SP*, Svec F*. Effect of ion adsorption on CEC separation of small molecules using hypercrosslinked porous polymer monolithic capillary columns. Journal of Separation Science. 2012, 35(12): 1502-1505.
  30. Chen XJ, Zhao J, Wang YT*, Huang LQ*, Li SP*. CE and CEC analysis of phytochemicals in herbal medicines. Electrophoresis. 2012, 33(1): 168-179.
  31. Chen XJ#, Yang FQ#, Wang YT, Li SP*. CE and CEC of nucleosides and nucleotides in food materials. Electrophoresis. 2010, 31(13): 2092-2105.
  32. Chen XJ, Zhao J*, Meng Q, Li SP*, Wang YT*. Simultaneous determination of five flavonoids in licorice using pressurized liquid extraction and capillary electrochromatography coupled with peak suppression diode array detection. Journal of Chromatography A. 2009, 1216(43): 7329-7335.
  33. Chen XJ, Tu PF, Jiang Y, Wang YT, Li SP*. Effect of stability of internal standard on quantification of 15 flavonoids in Epimedium using CZE. Journal of Separation Science. 2009, 32(2): 275-281.
  34. Chen XJ, Ji H, Wang YT, Li SP*. Simultaneous determination of seven flavonoids in Epimedium using pressurized liquid extraction and capillary electrochromatography. Journal of Separation Science. 2008, 31(5): 881-887.
  35. Chen XJ, Ji H, Zhang QW, Tu PF, Wang YT, Guo BL, Li SP*. A rapid method for simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and ultra-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis. 2008, 46(2): 226-235.
  36. Chen XJ, Guo BL, Li SP*, Zhang QW, Tu PF, Wang YT*. Simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and high-performance liquid chromatography. Journal of Chromatography A. 2007, 1163(1-2): 96-104.
  37. Chen XJ, Li SP*, Wang YT, Tu PF*. Comparison of quantitative determination of flavonoids in Herba Epimedii by HPLC, UPLC and CZE. Chinese Pharmaceutical Journal, 2008, 43 (8), 624-628.
  38. Chen XJ, Zhang QW, Ji H, Wang YT, Tu PF, Li SP*. Comparison of UV spectrophotometry and HPLC on quantitative determination of total flavonoids of Herba Epimedii. Chinese Journal of Pharmaceutical Analysis, 2007, 27(5), 625-630.

Book and Book Chapters

  1. Chen XJ (associate editor) In: Mei QX (Eds.), General Introduction to Clinical Pharmacy of Traditional Chinese Medicine. Macao. Hall de Cultura. (ISBN: 9789998146792), 2022.
  2. Chen XJ, Liu Q. Clinical pharmacokinetics of traditional Chinese medicine. In: Mei QX (Eds.), General Introduction to Clinical Pharmacy of Traditional Chinese Medicine (pp. 348-368). Macao. Hall de Cultura. 2022.
  3. Li SP, Chen XJ, Yang FQ. Application of chemometrics in capillary electrophoresis analysis of herbal medicines. In: Hanrahan, G., Gomez, F.A. (Eds.), Chemometric methods in capillary electrophoresis (pp. 227-242). Hoboken, New Jersey. John Wiley & Sons, Inc., 2010.
  4. Chen XJ (associate editor). In: Li SP, Wang YT (Eds.), Chromatographic methods for analysis of commonly used Chinese herbs. Macao. Publications Center, University of Macau. (ISBN: 978-99937-970-6-7), 2009.
  5. Chen XJ, Wang YT, Li SP. Yinyanghuo (Epimedium) In: Li SP, Wang YT (Eds.), Pharmacological Activity-Based Quality Control of Chinese Herbs. (pp. 217-234) New York. Nova Publishers, Inc., 2008.
  6. Guan J, Chen XJ, Li SP. Recent development on analytical techniques for quality control of Chinese herbs. In: Li SP, Wang YT (Eds.), Pharmacological Activity-Based Quality Control of Chinese Herbs. (pp. 73-113) New York. Nova Publishers, Inc., 2008.

  1. Wang YT, Li P, Wan JB, Hu YJ, Yu H, Chen XJ, Wang SP, Zhong ZF, Luo H. Integrated innovation of quality-related cutting-edge technology and international development of Chinese medicine. 2020 International Award for Contribution to Chinese Medicine-Achievement Award in Medical Science. World Federation of Chinese Medicine Societies. 2021.
  2. Chen XJ. Scientific and Technological R&D Award for Postgraduates, Macao Special Administrative Region. Macao Science and Technology Development Fund, 2012.
  3. Chen XJ, Dinh NP, Zhao J, Li SP, Wang YT, Irgum K, Svec F. Effect of ion adsorption on capillary electrochromatographic separation of small molecules using hypercrosslinked monolithic capillary columns. CASSS Student Travel Grants. The 38th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (HPLC 2012), 2012.
  4. Li SP, Wang YT, Yang FQ, Li P, Wan JB, Chen XJ. Application of pressurized liquid extraction in quality control of Chinese medicine. 3rd Prize of the Science and Technology Award, Chinese Pharmaceutical Association, 2008.
  5. Chen XJ, Li SP, Wang YT. Comparison of HPLC, UPLC and CZE on quantitative determination of flavonoids in Herba Epimedii. Excellent Paper 2nd Prize. The 8th “SHIMADZU CUP” of National Pharmaceutical Analysis Symposium, Chinese Pharmaceutical Association, 2007.

  • Council Member, Specialty Committee of Traditional Chinese Medicine in General Hospital of World Federation of Chinese Medicine Societies
  • Council Member, Specialty Committee of TCM Network Pharmacology of World Federation of Chinese Medicine Societies
  • Member, International Society for Chinese Medicine
  • Member, International Association of Quality Research in Chinese Medicine