Email

yonghuazhao@um.edu.mo

Tel

(853) 8822-4877

Office

N22-6043

Consultation Hours

Tue: 15:00-17:30
Thu: 15:00-17:30

Yong Hua ZHAO 趙永華

Assistant Professor, Institute of Chinese Medical Sciences

Academic Qualifications

  • M.D. in Chinese Internal Medicine, Guangzhou University of Chinese Medicine, China
  • M.Sc. in Integrative Clinical Medicine, Liaoning University of Traditional Chinese Medicine, China
  • B.Sc. in Chinese Medicine, Heilongjiang University of Chinese Medicine, China

Teaching

HSCI3009Chinese Medicine
CMED7001Pharmacology and Safety EvaluationM.Sc. Course
CMED7019Standardization and Quality Management of Chinese MedicineM.Sc. Course
CMED8005Quality Research in Chinese MedicinePhD Course

Research Interests

  • Pharmacological research of Chinese medicines on cardio/cerebral vascular disease
  • Extracellular vesicles and biomimetic nanomaterials for ischemic stroke treatment
  • Neurocognitive disorders study based on Gut-brain axis
  • Functional foods for intervention of metabolic syndrome
  • Clinical research of cardio/cerebral vascular and metabolic diseases

Dr. Yonghua ZHAO has abundant Chinese Medical experiences on the study and treatment of cardio/cerebral vascular disease. After he was awarded a Master of Science degree in Integrative Clinical Medicine, he worked in the department of emergency internal medicine as Physician in the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine. Subsequently, he received his MD degree in Chinese Internal Medicine from Guangzhou University of Chinese Medicine. In 2004, he migrated to Macao and was in charge of Chinese Medicine teaching, research and clinical works in Macau University of Science and Technology. In 2019, he moved to Institute of Chinese Medical Sciences, University of Macau. His interesting mainly focuses on pharmacological research of Chinese Medicine on cardio/cerebral vascular disease and neurocognitive disorders by Gut-brain axis. Dr. Zhao hosted seven projects funded by The Science and Technology Development Fund (FDCT) of Macao Special Administrative Region, one project funded by the National Natural Science Foundation of China (General Programme), and one project funded by Guangdong Natural Science Fund (General Programme), as well as three grants of UM. He has published 72 SCI articles, which of the first or corresponding author account for 47.

We are actively looking for postdoctoral fellows, MSc and PhD students, as well as research assistants who can participate in our research projects on Neuropharmacology, Exosome Application, Neurocognitive Disorder and Gut Microbiota Analysis. For further information, please contact Dr. Zhao:  yonghuazhao@um.edu.mo

  1. Yan Han, Xinglin Zeng, Lin Hua, Xingping Quan, Ying Chen, Manfei Zhou, Yaochen Chuang, Yang Li, Shengpeng Wang, Xu Shen, Lai Wei, Zhen Yuan*, Yonghua Zhao*. The fusion of multi-omics profile and multimodal EEG data contributes to the personalized diagnostic strategy for neurocognitive disorders. Microbiome. 2024, 12(1):12. (IF: 15.5).
  2. Jinfen Chen, Pengde Lu, Jiayue Liu, Li Yang, Yiyang Li, Yanling Chen, Yitao Wang, Jianbo Wan*, Yonghua Zhao*. 20(S)-protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis. Phytotherapy research. 2023, 37: 4690–4705. (IF: 7.2)
  3. Xingping Quan, Xiao Liang, Yuanfu Ding, Yan Han, Junyan Li, Mengchen Yuan, Yiyang Li, Zhen Yuan, Ruibing Wang*, and Yonghua Zhao*. Cryo-Shocked Platelet Coupled with ROS-Responsive Nanomedicine for Targeted Treatment of Thromboembolic Disease. ACS Nano. 2023, 17(7):6519-6533. (IF: 18.027)
  4. Yiyang Li, Bowen Liu, Tingting Zhao, Xingping Quan, Yan Han, Yaxin Cheng, Yanling Chen, Xu Shen, Ying Zheng, Yonghua Zhao*. Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood-brain barrier permeability via regulating Caveolin-1-dependent ZO-1 and Claudin-5 endocytosis in acute ischemic stroke. Journal of Nanobiotechnology. 2023, 21:70. (IF: 9.429)
  5. Xingping Quan, Yan Han, Pengde Lu, Yuanfu Ding, Qingfu Wang, Yiyang Li, Jianwen Wei, Qiaoxian Huang, Ruibing Wang*, Yonghua Zhao*. Annexin V-modified platelet-biomimetic nanomedicine for targeted therapy of acute ischemic stroke. Advanced Healthcare Materials. 2022, e2200416. (IF: 11.092)
  6. Yan Han, Xingping Quan, Yaochen Chuang, Xingqiao Liang, Yang Li, Zhen Yuan, Ying Bian, Lai Wei, Ji Wang, Yonghua Zhao*. A multi-omics analysis for prediction of neurocognitive disorders risk among the elderly in Macao. Clinical and Translational Medicine. 2022, 12:e909. (IF: 11.492)
  7. Bowen Liu, Tingting Zhao, Yiyang Li, Yan Han, Youhua Xu, Hua Yang, Shengpeng Wang, Yonghua Zhao*, Ping Li, Yitao Wang*. Notoginsenoside R1 ameliorates mitochondrial dysfunction to circumvent neuronal energy failure in acute phase of focal cerebral ischemia. Phytotherapy Research. 2022, 36(5):2223-2235. (IF: 5.882)
  8. Lu Shi, Yongcheng An, Long Cheng, Yiyang Li, Huimin Li, Chen Wang, Yinglan Lv, Yuhui Duan, Hongyu Dai, Changhao He, Huilin Zhang, Yan Huang, Wanxin Fu, ShengPeng Wang, Baosheng Zhao*, Yitao Wang, Yonghua Zhao*. Qingwei San treats oral ulcer subjected to stomach heat syndrome in db/db mice by targeting TLR4/MyD88/NF-κB pathway. Chinese Medicine. 2022, 17(1):1. (IF: 5.455)
  9. Yiyang Li, Bowen Liu, Ying Chen, Xingping Quan, Yan Han, Ying Zheng*, Yonghua Zhao*. Extracellular Vesicle Application as a Novel Therapeutic Strategy for Ischemic Stroke. Translational Stroke Research. 2022, 13(1):171-187. (IF: 6.829)
  10. Li Yang , Yongchao Gao, Vivek K Bajpai, Heba A El-Kammar, Jesus Simal-Gandara, Hui Cao, Ka-Wing Cheng, Mingfu Wang, Randolph R J Arroo , Liang Zou, Mohamed A Farag*, Yonghua Zhao*, Jianbo Xiao*. Advance toward isolation, extraction, metabolism and health benefits of kaempferol, a major dietary flavonoid with future perspectives. Critical Reviews in Food Science and Nutrition. 2021; 23:1-17. (IF: 11.176)
  11. Meng Xu, Tao Feng, Bowen Liu, Fen Qiu, Youhua Xu, Yonghua Zhao*, and Ying Zheng*. Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies. Theranostics. 2021; 11(18): 8926 – 8944. (IF: 11.556)
  12. Bowen Liu, Yiyang Li, Yan Han, Shengpeng Wang, Hua Yang, Yonghua Zhao*, Ping Li, Yitao Wang*. Notoginsenoside R1 intervenes degradation and redistribution of tight junctions to ameliorate blood-brain barrier permeability by Caveolin-1/MMP2/9 pathway after acute ischemic stroke. Phytomedicine. 2021, 90:153660. (IF: 5.340)
  13. Zhuo Zhang, Yaochen Chuang, Xinyu Ke, Ji Wang, Youhua Xu, Yonghua Zhao* and Ying Bian*. The influence of TCM constitutions and neurocognitive function in elderly Macau individual. Chinese Medicine. 2021, 16:32. (IF: 5.455)
  14. Jia Hu, Cheng Zeng, Jie Wei, Fengqi Duan, Sijun Liu, Yonghua Zhao*, Hongmei Tan*. The combination of Panax ginseng and Angelica sinensis alleviates ischemia brain injury by suppressing NLRP3 inflammasome activation and microglial pyroptosis. Phytomedicine. 2020, 76:153251. (IF: 4.268)
  15. Erdan Luo, Daiyan Zhang, Hua Luo, Bowen Liu, Keming Zhao, Yonghua Zhao*, Ying Bian* , Yitao Wang. Treatment efficacy analysis of traditional Chinese medicine for novel coronavirus pneumonia (COVID-19): an empirical study from Wuhan, Hubei Province, China. Chinese Medicine. 2020, 15:34. (IF: 2.960)
  16. Peng‑De Lu and Yong‑Hua Zhao*. Targeting NF‑κB pathway for treating ulcerative colitis: comprehensive regulatory characteristics of Chinese medicines. Chinese Medicine. 2020, 15:15. (IF: 2.960)
  17. Zhen-Yan Xia, Cheng Luo, Bo-Wen Liu, Xi-Qing Bian, Yang Li, Ai-Ming Pang, You-Hua Xu, Hong-Mei Tan, Yong-Hua Zhao*. Shengui Sansheng Pulvis maintains blood-brain barrier integrity by vasoactive intestinal peptide after ischemic stroke. Phytomedicine. 2020, 67:153158. (IF: 4.180)
  18. Cheng Luo, Xiqing Bian, Qian Zhang, Zhenyan Xia, Bowen Liu, Qi Chen, Chienchih Ke, Jian-Lin Wu* and Yonghua Zhao*. Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke. Frontier in Pharmacology. 2019, 10:386. (IF:3.845)
  19. Bowen Liu, Cheng Luo, Zhaoguang Zheng, Zhenyan Xia, Qian Zhang, Chienchih Ke, Renshyan Liu, Yonghua Zhao*. Shengui Sansheng San extraction is an angiogenic switch via regulations of AKT/mTOR, ERK1/2 and Notch1 signal pathways after ischemic stroke. Phytomedicine. 2018, 44: 20–31. (IF: 3.610)
  20. Nai-Wei Liu, Chien-Chih Ke, Yonghua Zhao*, Yi-An Chen, Kim-Chuan Chan, David Tat-Wei Tan, Jhih-Shian Lee, You-Yin Chen, Tun-Wei Hsu, Ya-Ju Hsieh, Chi-Wei Chang, Bang-Hung Yang, Wen-Sheng Huang, Ren-Shyan Liu. Evolutional Characterization of Photochemically Induced Stroke in Rats: A Multimodality Imaging and Molecular Biological Study. Translational Stroke Research. 2017, 8(3):244-256. (IF: 8.266)

  1. Xingping Quan, Xiaofeng Gong, and Yonghua Zhao. Chapter: Novel Therapeutic Strategy Based on Nanomedicine Targeting Thrombosis for SARS-CoV-2 in Bioactive Compounds Against SARS-CoV-2. CRC Press, 2023: 221-229.
  2. Yonghua Zhao, Yitao Wang. Chapter: The collaborative status and perspective of traditional medicine field between China and Portuguese-speaking countries. THE ANNUAL REPORT ON THE DEVELOPMENT OF ECONOMIC AND TRADE COOPERATION BETWEEN CHINA AND PORTUGUESE-SPEAKING COUNTRIES （2018-2019）. Social Sciences Academic Press (China), 2020-04, 177-187.
  3. Yonghua Zhao, Chapter: Pharmacology of Traditional Chinese Medicine in Medical Textbook of National Designation: Chinese Medicine. Higher Education Press, 2018, 167-216.
  4. Qian Zhang and Yonghua Zhao, Chapter: Combination treatment of mesenchymal stem cells (MSCs) and Angelica sinensis’ active ingredients for ischemic stroke in Cellular and Molecular Approaches to Regeneration & Repair. Springer Press, 2017: 239-257.
  5. Yonghua Zhao, Current Topics on Chinese Medical Treatment of Internal Medical Diseases, Macau University of Science and Technology Press, 2010.

Member of the Guiding Committee for Bachelor’s degree Teaching of Clinical Integrating Chinese with Western medicine in Guangdong Province higher education

Executive Member of the Standing in Cardiovascular Committee of Guangdong Province Integrative Medicine

Academic Advisor of Integrative Medical Committee (Macao)

Member of council in the Specialty Committee of Hypertension of WFCMS

Chinese Medical license, the Health Bureau of Macao Special Administrative Region, 2007

Middle level specialty and technology license, the Personnel Ministry of PR China, 2003

Integrative medical license, Ministry of Health, PR China, 2002.