Yitao WANG 王一濤

Chair Professor
Director, Institute of Chinese Medical Sciences
Director, State Key Laboratory of Quality Research in Chinese Medicine (University of Macau)
Co-Chair & General Secretary, Chinese Joint Research Centre for Drug Discovery and Development (Peking University, National Taiwan University, University of Hong Kong and University of Macau)

Academic Qualifications

  • Postgraduate, Chongqing Medical University
  • BSc, Chengdu University of Chinese Medicine

Teaching

  1. Introduction to Research in Chinese Medicinal Science (MCMC103)
  2. Introduction to Research in Medical Administration (MCMC110)

Research

Research Interests

  • Systematic quality evaluation of Chinese Medicine
  • Drug discovery and development
  • Medicinal administration

Chair Professor Yitao Wang is the founding Director of the Institute of Chinese Medical Sciences at University of Macau and Director of the State Key Laboratory of Quality Research in Chinese Medicine. He is also the Chief Scientist of Chinese Academy of Chinese Medical Sciences and the Director of International Research Centre of Medicinal Administration at Peking University.

Prof. Wang is known internationally for his pioneering contributions to the modernization of Chinese medicine, with an emphasis on systematic evaluation and quality control of Chinese medicine. He has a long-standing interest in efficacy, safety, stability, controllability and systematic evaluation of Chinese medicine. He has published more than 400+ SCI papers (with 45 papers published in journals with IF>5, Web of Science),with a total citation of 15965 times and h-index of 66 (Google scholar),and edited and co-edited 10 books in Chinese medicine. In addition, he has nurtured more than 130 PhD and MSc graduates as well as postdoctoral fellows. His outstanding achievements in academic service have been recognized by over 16 prestigious awards, including the National Council Special Allowance Expert (1992), Macau Medal of Merit-Education (2011), Macao Science and Technology Awards-Natural Science Award (2012, 2014, 2016 & 2018), Macao Science and Technology Awards – Special Award (2018), and National Science and Technology Progress Award (1998, 2016).

Prof Wang obtained his Bachelor degree (Medical Sciences, 1982) from Chengdu University of Chinese Medicine (CUCM), and completed his postgraduate study (Pharmacology, 1986) at Chongqing Medical University. After a research stint as Visiting Scholar at Hiroshima University in Japan, he returned to CUCM in 1989 where he contributed to mark several firsts in the history of CM – by establishing the first state key subject in CM education, the first Bachelor programme in Pharmacology of CM, the first postdoctoral training programme in CM, as well as the first “National training base for talents in science – CM”. He served in turn as Dean and Vice President of CUCM, and moved in 1996 to Beijing to take the post of Vice President and Director of Chinese Academy of Chinese Medical Sciences, where he became in 1999 the Chief Scientist for China’s first National Basic Research Program of China (973 Program) in the field of CM. In 2000, Prof Wang was appointed Professor and Director for the CM Programme at the Hong Kong University of Science and Technology (HKUST). In 2002, Yitao set off for Macau and founded the ICMS at UM, which has in 10 years evolved to be a promising academic hub to provide complete programmes from BSc, MSc, PhD to postdoctoral training in Biomedical Sciences. In 2008, together with other local experts, he drafted the proposal to launch the first state key laboratory in CM. This application was approved in 2010 by the Ministry of Science and Technology of China, which announced to establish in Macao the State Key Laboratory of Quality Research in Chinese Medicine, as China’s first state key laboratory in CM. In 2012, he initiated the creation of the Chinese Joint Research Centre for Drug Discovery and Development among Peking University, National Taiwan University, University of Hong Kong and UM, a strategic partnership to mark the first substantial collaboration in science and technonlogy among the four most elite universities in the Greater China region. In line with these accomplishments, Yitao has also initiated joint training programmes and academic collaborations with world-renown universities (e.g. Harvard University, Yale University, University of Chicago and Cambridge University) and organisations (like the World Health Organisation and the US Pharmacopeial Convention).

Prof Wang has been awarded over 40 major funding grants from national, provincial, and special administrative regional administrations. These supports include the prestigious National Basic Research Programme (973), Mega-projects of Scientific Research for 10th Five-Year Plan, China Ministry of Education Key Project, Macao S&T Development Fund, among others. Yitao also holds adjunct appointments as Director of International Research Centre of Medicinal Administration at Peking University and as adjunct professors / visiting scholars at numerous universities worldwide, and was elected General Secretory for the International Society for Chinese Medicine and Deputy Secretory for the World Federation of Chinese Medicine Societies. In addition, Yitao serves on several of China’s national committee panels including National Science and Technology Programmes, National Basic Research Programme (973), National Natural Science Foundation, the State Science and Technology Awards and National Centre for Drug Evaluation.


Selected Publications

Book chapters / Monographs

  1. Advances in Chinese Medicinal Approach to Cancer. Beijing: People’s Medical Publishing House, 2012, ISBN 9787117162272, 7117162279. Chief Editor
  2. Chromatographic Analysis of Commonly Used Chinese Material Medica, Macao: University of Macau Press, 2009, ISBN 978-99937-970-6-7. Co-Chief Editor.
  3. Pharmacological Activity-Based Quality Control of Chinese Herbs, Nova Science Publishers, Inc, 2008, ISBN-10: 1-60456-823-2. Co-Chief Editor.
  4. Chinese Medical Sciences collection Series (A)–Progress in Medicinal Administration Research. Macao: University of Macau Press, 2005, ISBN 99937-26-50-8. Chief Editor.
  5. Chinese Medical Sciences collection Series (B)–Progress in Traditional Chinese Medical Research. Macao: University of Macau Press, 2005, ISBN 99937-26-51-6. Chief Editor.
  6. Chinese Medical Sciences collection Series (C) – Quality Evaluation for Chinese Medicine 1. Macao: University of Macau Press, 2005, ISBN 99937-26-52-4. Chief Editor.
  7. Chinese Medical Sciences collection Series (C) – Quality Evaluation for Chinese Medicine 2. Macao: University of Macau Press, 2005, ISBN 99937-26-53-2. Chief Editor.
  8. Chinese Medical Sciences collection Series (C) – Quality Evaluation for Chinese Medicine 3. Macao: University of Macau Press, 2005, ISBN 99937-26-54-0. Chief Editor.
  9. Chinese Medical Sciences collection Series (C) – Quality Evaluation for Chinese Medicine 4. Macao: University of Macau Press, 2005, ISBN 99937-26-55-9. Chief Editor.
  10. Chinese Medical Sciences collection Series (C) – Quality Evaluation for Chinese Medicine 5. Macao: University of Macau Press, 2005, ISBN 99937-26-56-7. Chief Editor.
  11. Chinese Medical Sciences collection Series (C) – Quality Evaluation for Chinese Medicine 6. Macao: University of Macau Press, 2005, ISBN 99937-26-57-5. Chief Editor.
  12. Chinese Terms in Chinese Medicine and Pharmacy. Beijing: Science Press, 2005, ISBN 7-03-015154-2, Associate Editor.
  13. Intellectual Property Protection of TCM. Beijing: China Press of TCM, 2003, ISBN 7-80-15641-89, Chief Editor.
  14. Drug Administration of European Union and Traditional Chinese Medicine. China International Culture Press Limited, 1999, Associate Editor.
  15. Traditional Chinese Medicine pharmacology and application. Beijing: People’s Medical Publishing House, 1997, ISBN 7-117-03057-7/R.3058, Associate Editor.
  16. New product development from Traditional Chinese Medicine. Beijing: People’s Medical Publishing House, 1997, ISBN 7-117-02640-5, Chief Editor.

International peer-reviewed journals (01/2010-2018/11)

  1. Xiong W, Zhao GD, Yin XQ, Gang LHK, Chu JMT, Wong GTC, Li HF, Yu H, Wang YT. Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations. Carbohydrate Polymers. 2019; 204:89-96.
  2. Zhou FY, Wang AQ, Li D, Wang YT, Lin LG. Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SIRT3-TGF-beta-Smad signaling pathway. Toxicology and Applied Pharmacology. 2018; 341:38-50.
  3. Zhong ZF, Yu HB, Wang SP, Wang YT, Cui L. Anti-cancer effects of Rhizoma Curcumae against doxorubicin-resistant breast cancer cells. Chinese Medicine. 2018; 13.
  4. Zhao QQ, Miriyala N, Su Y, Chen WJ, Gao XJ, Shao L, Yan R, Li HF, Yao XJ, Cao DS, Wang YT, Ouyang DF. Computer-Aided Formulation Design for a Highly Soluble Lutein-Cyclodextrin Multiple-Component Delivery System. Molecular Pharmaceutics. 2018; 15:1664-1673.
  5. Zhang LL, Feng ZL, Su MX, Jiang XM, Chen XP, Wang YT, Li A, Lin LG, Lu JJ. Downregulation of Cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells. European Journal of Pharmacology. 2018; 830:17-25.
  6. Zhang L, Dou XW, Zhang C, Ying GY, Liu CM, Luo JY, Li Q, Li P, Wang YT, Yang MH. Facile preparation of stable PEG-functionalized quantum dots with glycine-enhanced photoluminescence and their application for screening of aflatoxin B-1 in herbs. Sensors and Actuators B-Chemical. 2018; 261:188-195.
  7. Zhane JM, Fang XB, Li ZY, Chan HF, Lin ZX, Wang YT, Chen MW. Redox-sensitive micelles composed of disulfide-linked Pluronic-linoleic acid for enhanced anticancer efficiency of brusatol. International Journal of Nanomedicine. 2018; 13:939-956.
  8. Xiong W, Sang W, Linghu KG, Zhong ZF, Cheang WS, Li J, Hu YJ, Yu H, Wang YT. Dual-functional Brij-S20-modified nanocrystal formulation enhances the intestinal transport and oral bioavailability of berberine. International Journal of Nanomedicine. 2018; 13:3781-3793.
  9. Xia FB, Li A, Chai YS, Xiao X, Wan JB, Li P, Wang YT. UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar. Frontiers in Pharmacology. 2018; 9.
  10. Wei JC, Wei B, Yang W, He CW, Su HX, Wan JB, Li P, Wang YT. Trace determination of carbamate pesticides in medicinal plants by a fluorescent technique. Food and Chemical Toxicology. 2018; 119:430-437.
  11. Wang SP, Xu YQ, Li CY, Tao HX, Wang AQ, Sun CY, Zhong ZF, Wu X, Li P, Wang YT. Gambogic acid sensitizes breast cancer cells to TRAIL-induced apoptosis by promoting the crosstalk of extrinsic and intrinsic apoptotic signalings. Food and Chemical Toxicology. 2018; 119:334-341.
  12. Wang AQ, Wang SP, Zhou FY, Li P, Wang YT, Gan LS, Lin LG. Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Biomedicine & Pharmacotherapy. 2018; 101:334-341.
  13. Wang AQ, Li D, Wang SP, Zhou FY, Li P, Wang YT, Lin LG. gamma-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction. Journal of Functional Foods. 2018; 40:544-553.
  14. Tao HX, Xiong W, Zhao GD, Peng Y, Zhong ZF, Xu L, Duan R, Tsim KWK, Yu H, Wang YT. Discrimination of three Siegesbeckiae Herba species using UPLC-QTOF/MS-based metabolomics approach. Food and Chemical Toxicology. 2018; 119:400-406.
  15. Song QQ, Liu WJ, Chen XJ, Li J, Li P, Yang FQ, Wang YT, Song YL, Tu PF. Serially coupled reversed phase-hydrophilic interaction liquid chromatography-tailored multiple reaction monitoring, a fit-for-purpose tool for large-scale targeted metabolomics of medicinal bile. Analytica Chimica Acta. 2018; 1037:119-129.
  16. Shen SN, Liao QW, Huang L, Li D, Zhang QW, Wang YT, Lee SMY, Lin LG. Water soluble fraction from ethanolic extract of Clausena lansium seeds alleviates obesity and insulin resistance, and changes the composition of gut microbiota in high-fat diet-fed mice. Journal of Functional Foods. 2018; 47:192-199.
  17. Sang W, Zhong ZF, Linghu KG, Xiong W, Tse AKW, Cheang WS, Yu H, Wang YT. Siegesbeckia pubescens Makino inhibits Pam(3)CSK(4)-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-kappa B activation. Chinese Medicine. 2018; 13.
  18. Qu LP, Zou WJ, Wang YT, Wang M. European regulation model for herbal medicine: The assessment of the EU monograph and the safety and efficacy evaluation in marketing authorization or registration in Member States. Phytomedicine. 2018; 42:219-225.
  19. Ma XW, Hu YC, Li X, Zheng XT, Wang YT, Zhang JM, Fu CM, Geng FN. Periplaneta americana Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Keap1/Nrf-2 Activation, Intestinal Barrier Function, and Gut Microbiota Regulation. Frontiers in Pharmacology. 2018; 9.
  20. Luo WW, Zhao WW, Lu JJ, Wang YT, Chen XP. Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells. Chinese Journal of Natural Medicines. 2018; 16:10-19.
  21. Luo W, Liu X, Sun W, Lu JJ, Wang YT, Chen XP. Toosendanin, a natural product, inhibited TGF-1-induced epithelial-mesenchymal transition through ERK/Snail pathway. Phytotherapy Research. 2018; 32:2009-2020.
  22. Liu Y, Song QQ, Liu WJ, Li P, Li J, Zhao YF, Zhang L, Tu PF, Wang YT, Song YL. Authentic compound-free strategy for simultaneous determination of primary coumarins in Peucedani Radix using offline high performance liquid chromatography-nuclear magnetic resonance spectroscopy-tandem mass spectrometry. Acta Pharmaceutica Sinica B. 2018; 8:645-654.
  23. Liu WJ, Song QQ, Yan Y, Liu Y, Li P, Wang YT, Tu PF, Song YL, Li J. Integrated approach for confidence-enhanced quantitative analysis of herbal medicines, Cistanche salsa as a case. Journal of Chromatography A. 2018; 1561:56-66.
  24. Liu JX, Shen SN, Tong Q, Wang YT, Lin LG. Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3. European Journal of Pharmacology. 2018; 834:176-187.
  25. Li F, Li XM, Sheng DK, Chen SR, Nie X, Liu ZY, Wang DC, Zhao Q, Wang YT, Wang Y, Zhou GC. Discovery and preliminary SAR of 14-aryloxy-andrographolide derivatives as antibacterial agents with immunosuppressant activity. Rsc Advances. 2018; 8:9440-9456.
  26. Li A, Zhang JY, Xiao X, Wang SS, Wan JB, Chai YS, Li P, Wang YT. Hepatorenal protective effects of medicinal herbs in An-Gong-Niu-Huang Wan (AGNH) against cinnabar- and realgar-induced oxidative stress and inflammatory damage in mice. Food and Chemical Toxicology. 2018; 119:445-456.
  27. Chen SR, Li F, Ding MY, Wang DC, Zhao Q, Wang YT, Zhou GC, Wang Y. Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice. Bioorganic & Medicinal Chemistry. 2018; 26:5053-5061.
  28. Chen SR, Dai Y, Zhao J, Lin LG, Wang YT, Wang Y. A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F. Frontiers in Pharmacology. 2018; 9.
  29. Cao JL, Wang SS, Hu H, He CW, Wan JB, Su HX, Wang YT, Li P. Online comprehensive two-dimensional hydrophilic interaction chromatography x reversed-phase liquid chromatography coupled with hybrid linear ion trap Orbitrap mass spectrometry for the analysis of phenolic acids in Salvia miltiorrhiza. Journal of Chromatography A. 2018; 1536:216-227.
  30. Bao JL, Ding RB, Jia XJ, Liang YE, Liu F, Wang K, Zhang C, Li P, Wang YT, Wan JB, He CW. Fast identification of anticancer constituents in Forsythiae Fructus based on metabolomics approaches. Journal of Pharmaceutical and Biomedical Analysis. 2018; 154:312-320.
  31. Zhong ZF, Yu HB, Wang CM, Qiang WA, Wang SP, Zhang JM, Yu H, Cui L, Wu T, Li DQ, Wang YT. Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-kappa B-Independent Mechanism. Frontiers in Pharmacology. 2017; 8.
  32. Zhong ZF, Yu HB, Wang CM, Qiang WA, Wang SP, Zhang JM, Yu H, Cui L, Wu T, Li DQ, Wang YT. Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-kappa B-Independent Mechanism (vol 8, 648, 2017). Frontiers in Pharmacology. 2017; 8.
  33. Zhong ZF, Tan W, Tian K, Yu H, Qiang WA, Wang YT. Combined effects of furanodiene and doxorubicin on the migration and invasion of MDA-MB-231 breast cancer cells in vitro. Oncology Reports. 2017; 37:2016-2024.
  34. Zhao QQ, Zhang WX, Wang RM, Wang YT, Ouyang DF. Research Advances in Molecular Modeling in Cyclodextrins. Current Pharmaceutical Design. 2017; 23:522-531.
  35. Zhang WX, Zhao QQ, Deng JL, Hu YJ, Wang YT, Ouyang DF. Big data analysis of global advances in pharmaceutics and drug delivery 1980-2014. Drug Discovery Today. 2017; 22:1201-1208.
  36. Zhang WX, Wang YT, Ouyang DF. Diversity of Pharmacy Faculty Members between UK and US. Indian Journal of Pharmaceutical Education and Research. 2017; 51:20-24.
  37. Zhang QR, Yu H, Qi J, Tang DS, Chen XJ, Wan JB, Li P, Hu H, Wang YT, Hu YJ. Natural formulas and the nature of formulas: Exploring potential therapeutic targets based on traditional Chinese herbal formulas. Plos One. 2017; 12.
  38. Zhang JM, Zheng YF, Xie X, Wang L, Su ZR, Wang YT, Leong KW, Chen MW. Cleavable Multifunctional Targeting Mixed Micelles with Sequential pH-Triggered TAT Peptide Activation for Improved Antihepatocellular Carcinoma Efficacy. Molecular Pharmaceutics. 2017; 14:3644-3659.
  39. Zhang JM, Wang L, Chan HF, Xie W, Chen S, He CW, Wang YT, Chen MW. Co-delivery of paclitaxel and tetrandrine via iRGD peptide conjugated lipid-polymer hybrid nanoparticles overcome multidrug resistance in cancer cells. Scientific Reports. 2017; 7.
  40. Zhang JM, Li JJ, Shi Z, Yang Y, Xie X, Lee SM, Wang YT, Leong KW, Chen MW. pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities. Acta Biomaterialia. 2017; 58:349-364.
  41. Yao DN, Xi XY, Huang YK, Hu H, Hu YJ, Wang YT, Yao WB. A national survey of clinical pharmacy services in county hospitals in China. Plos One. 2017; 12.
  42. Yan Y, Song QQ, Chen XJ, Li J, Li P, Wang YT, Liu TX, Song YL, Tu PF. Simultaneous determination of components with wide polarity and content ranges in Cistanche tubulosa using serially coupled reverse phase-hydrophilic interaction chromatography-tandem mass spectrometry. Journal of Chromatography A. 2017; 1501:39-50.
  43. Xu XH, Zhang LL, Wu GS, Chen X, Li T, Chen XP, Wang YT, Lu JJ. Solasodine Induces Apoptosis, Affects Autophagy, and Attenuates Metastasis in Ovarian Cancer Cells. Planta Medica. 2017; 83:254-260.
  44. Xu XH, Liu QY, Li T, Liu JL, Chen X, Huang L, Qiang WA, Chen XP, Wang YT, Lin LG, Lu JJ. Garcinone E induces apoptosis and inhibits migration and invasion in ovarian cancer cells. Scientific Reports. 2017; 7.
  45. Wu X, Wang SP, Li MX, Wang AQ, Zhou YY, Li P, Wang YT. Nanocarriers for TRAIL delivery: driving TRAIL back on track for cancer therapy. Nanoscale. 2017; 9:13879-13904.
  46. Wu WJ, Yan R, Li T, Li YP, Zhou RN, Wang YT. Pharmacokinetic alterations of rhubarb anthraquinones in experimental colitis induced by dextran sulfate sodium in the rat. Journal of Ethnopharmacology. 2017; 198:600-607.
  47. Wu MY, Wang SF, Cai CZ, Tan JQ, Li M, Lu JJ, Chen XP, Wang YT, Zheng W, Lu JH. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017; 8:77673-77684.
  48. Wei JC, Cao JL, Hu H, Yang Q, Yang FQ, Wan JB, Su HX, He CW, Li P, Wang YT. Sensitive and Selective Detection of Oxo-Form Organophosphorus Pesticides Based on CdSe/ZnS Quantum Dots. Molecules. 2017; 22.
  49. Wang YF, Xu YL, Tang ZH, Li T, Zhang LL, Chen XP, Lu JH, Leung CH, Ma DL, Qiang WA, Wang YT, Lu JJ. Baicalein Induces Beclin 1-and Extracellular Signal-Regulated Kinase-Dependent Autophagy in Ovarian Cancer Cells. American Journal of Chinese Medicine. 2017; 45:123-136.
  50. Wang YF, Tang ZH, Li T, Xu XH, Chen XP, Wang Y, Wang YT, Lu JJ. Baicalein protects tert-butyl hydroperoxide-induced hepatotoxicity dependent of reactive oxygen species removal. Molecular Medicine Reports. 2017; 16:8392-8398.
  51. Wang SP, Wang AQ, Shao M, Lin LG, Li P, Wang YT. Schisandrin B reverses doxorubicin resistance through inhibiting P-glycoprotein and promoting proteasome-mediated degradation of survivin. Scientific Reports. 2017; 7.
  52. Wang SP, Shao M, Zhong ZF, Wang AQ, Cao JL, Lu YC, Wang YT, Zhang JM. Co-delivery of gambogic acid and TRAIL plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles for the treatment of triple negative breast cancer. Drug Delivery. 2017; 24:1791-1800.
  53. Wang CM, Lei CK, Wang RB, Xiao JB, Wang YT. Ten years of exploration, a new journey to start: advancing Chinese Medicine to the next level. Chinese Medicine. 2017; 12.
  54. Tang ZH, Zhang LL, Chen X, Chen XP, Wang YT, Lu JJ. The effects and mechanisms of two main constituents from Glycyrrhiza uralensis Fisch-induced autophagy in non-small cell lung cancer. Biochemical Pharmacology. 2017; 139:123-123.
  55. Tan W, Zhong ZF, Wang SP, Liu H, Yu H, Tan R, Hu XD, Pan TR, Wang YT. The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance. Current Medicinal Chemistry. 2017; 24:3698-3710.
  56. Sun W, Wang S, Zhao WW, Wu CH, Guo SH, Gao HW, Tao HX, Lu JJ, Wang YT, Chen XP. Chemical constituents and biological research on plants in the genus Curcuma. Critical Reviews in Food Science and Nutrition. 2017; 57:1451-1523.
  57. Song YL, Song QQ, Liu Y, Li J, Wan JB, Wang YT, Jiang Y, Tu PF. Integrated work-flow for quantitative metabolome profiling of plants, Peucedani Radix as a case. Analytica Chimica Acta. 2017; 953:40-47.
  58. Song QQ, Zhao YF, Chen XJ, Li J, Li P, Jiang Y, Wang YT, Song YL, Tu PF. New instrumentation for large-scale quantitative analysis of components spanning a wide polarity range by column-switching hydrophilic interaction chromatography-turbulent flow chromatography-reversed phase liquid chromatography-tandem mass spectrometry. Rsc Advances. 2017; 7:31838-31849.
  59. Song QQ, Liu WJ, Yan Y, Li P, Li J, Tu PF, Wang YT, Song YL. Polarity-extended quantitative analysis of bear bile and its analogues using serially coupled reversed phase-hydrophilic interaction liquid chromatography-tailored multiple reaction monitoring. Rsc Advances. 2017; 7:52822-52831.
  60. Niu YM, Li Q, Xie RY, Liu S, Wang RB, Xing PF, Shi YC, Wang YT, Dong L, Wang CM. Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material. Biomaterials. 2017; 139:39-55.
  61. Nie X, Chen SR, Wang K, Peng YR, Wang YT, Wang DC, Wang Y, Zhou GC. Attenuation of Innate Immunity by Andrographolide Derivatives Through NF-kappa B Signaling Pathway. Scientific Reports. 2017; 7.
  62. Ni JY, Zhao JR, Ung COL, Hu YJ, Hu H, Wang YT. Obstacles and opportunities in Chinese pharmaceutical innovation. Globalization and Health. 2017; 13.
  63. Liu LJ, Wang WH, Zhong ZF, Lin S, Lu LH, Wang YT, Ma DL, Leung CH. Inhibition of TLR1/2 dimerization by enantiomers of metal complexes (vol 52, pg 12278, 2016). Chemical Communications. 2017; 53:1325-1325.
  64. Li YX, Gong XH, Liu MC, Peng C, Li P, Wang YT. A New Strategy for Quality Evaluation and Identification of Representative Chemical Components in Polygonum multiflorum Thunb. Evidence-Based Complementary and Alternative Medicine. 2017.
  65. Li YX, Gong XH, Liu MC, Peng C, Li P, Wang YT. Investigation of Liver Injury of Polygonum multiflorum Thunb. in Rats by Metabolomics and Traditional Approaches. Frontiers in Pharmacology. 2017; 8.
  66. Li Q, Niu YM, Diao HJ, Wang LT, Chen XP, Wang YT, Dong L, Wang CM. In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing. Biomaterials. 2017; 148:54-68.
  67. Li A, Zhang XX, Shu M, Wu MJ, Wang J, Zhang JY, Wang R, Li P, Wang YT. Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy. Phytomedicine. 2017; 30:28-41.
  68. Li A, Zhang JY, Zhang XX, Wang J, Wang SS, Xiao X, Wang R, Li P, Wang YT. Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor beta-independent mechanism. Scientific Reports. 2017; 7.
  69. Jing WH, Gao XJ, Han BL, Wei B, Hu N, Li S, Yan R, Wang YT. Mori Cortex regulates P-glycoprotein in Caco-2 cells and colons from rats with experimental colitis via direct and gut microbiota-mediated mechanisms. Rsc Advances. 2017; 7:2594-2605.
  70. Huang LJ, Chen SR, Yuan CM, Gu W, Guo BJ, Wang YT, Wang Y, Hao XJ. C-21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents. Bioorganic & Medicinal Chemistry. 2017; 25:3512-3524.
  71. Huang L, Feng ZL, Wang YT, Lin LG. Anticancer carbazole alkaloids and coumarins from Clausena plants: A review. Chinese Journal of Natural Medicines. 2017; 15:881-888.
  72. Guo BJ, Bian ZX, Qiu HC, Wang YT, Wang Y. Biological and clinical implications of herbal medicine and natural products for the treatment of inflammatory bowel disease. Annals of the New York Academy of Sciences. 2017; 1401:37-48.
  73. Feng ZL, Li D, Liu QY, Liu JX, Huang L, Zhang QW, Wang YT, Lin LG. Anti-inflammatory abietane diterpenoids from the seeds of Podocarpus nagi. Phytochemistry Letters. 2017; 21:260-263.
  74. Feng HT, Zhao WW, Lu JJ, Wang YT, Chen XP. Hypaconitine inhibits TGF-beta 1-induced epithelial-mesenchymal transition and suppresses adhesion, migration, and invasion of lung cancer A549 cells. Chinese Journal of Natural Medicines. 2017; 15:427-435.
  75. Feng HT, Lu JJ, Wang YT, Pei LX, Chen XP. Osthole inhibited TGF beta-induced epithelial-mesenchymal transition (EMT) by suppressing NF-kappa B mediated Snail activation in lung cancer A549 cells. Cell Adhesion & Migration. 2017; 11:464-475.
  76. Chen X, Wu QS, Meng FC, Tang ZH, Chen XP, Lin LG, Chen P, Qiang WA, Wang YT, Zhang QW, Lu JJ. Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells (vol 23, pg 1555, 2016). Phytomedicine. 2017; 29:E1-E1.
  77. Chen FQ, Zhang JM, Fang XF, Yu H, Liu YL, Li H, Wang YT, Chen MW. Reversal of paclitaxel resistance in human ovarian cancer cells with redox-responsive micelles consisting of alpha-tocopheryl succinate-based polyphosphoester copolymers. Acta Pharmacologica Sinica. 2017; 38:859-873.
  78. Cao H, Wang YT, Xiao JB. Dietary Polyphenols and Type 2 Diabetes: Human Study and Clinical Trial. Free Radical Biology and Medicine. 2017; 112:158-158.
  79. Cao H, Chai TT, Wang X, Morais-Braga MFB, Yang JH, Wong FC, Wang RB, Yao HK, Cao JG, Cornara L, Burlando B, Wang YT, Xiao JB, Coutinho HDM. Phytochemicals from fern species: potential for medicine applications. Phytochemistry Reviews. 2017; 16:379-440.
  80. Bao JL, Ding RB, Liang YE, Liu F, Wang K, Jia XJ, Zhang C, Chen MW, Li P, Su HX, Wan JB, Wang YT, He CW. Differences in Chemical Component and Anticancer Activity of Green and Ripe Forsythiae Fructus. American Journal of Chinese Medicine. 2017; 45:1513-1536.
  81. Zou LD, Chen FQ, Bao JL, Wang SP, Wang L, Chen MW, He CW, Wang YT. Preparation, characterization, and anticancer efficacy of evodiamine-loaded PLGA nanoparticles. Drug Delivery. 2016; 23:908-916.
  82. Zhong ZF, Tan W, Qiang WW, Scofield VL, Tian K, Wang CM, Qiang WA, Wang YT. Furanodiene alters mitochondrial function in doxorubicin-resistant MCF-7 human breast cancer cells in an AMPK-dependent manner. Molecular Biosystems. 2016; 12:1626-1637.
  83. Zhong ZF, Qiang WW, Tan W, Zhang HT, Wang SP, Wang CM, Qiang WN, Wang YT. Chinese Herbs Interfering with Cancer Reprogramming Metabolism. Evidence-Based Complementary and Alternative Medicine. 2016.
  84. Zhong ZF, Qiang WA, Wang CM, Tan W, Wang YT. Furanodiene enhances the anti-cancer effects of doxorubicin on ER alpha-negative breast cancer cells in vitro. European Journal of Pharmacology. 2016; 774:10-19.
  85. Zhang M, Kong XJ, Zheng J, Wan JB, Wang YT, Hu YJ, Shao R. Research and development of antibiotics: insights from patents and citation network. Expert Opinion on Therapeutic Patents. 2016; 26:617-627.
  86. Zhang LL, Xu YL, Tang ZH, Xu XH, Chen X, Li T, Ding CY, Huang MQ, Chen XP, Wang YT, Yuan XF, Lu JJ. Effects of alisol B 23-acetate on ovarian cancer cells: G1 phase cell cycle arrest, apoptosis, migration and invasion inhibition. Phytomedicine. 2016; 23:800-809.
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  92. Wang SP, Zhang JM, Wang YT, Chen MW. Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy. Nanomedicine-Nanotechnology Biology and Medicine. 2016; 12:411-420.
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  94. Wang CZ, Yu CH, Wen XD, Chen LN, Zhang CF, Calway T, Qiu YP, Wang YW, Zhang ZY, Anderson S, Wang YT, Jia W, Yuan CS. American Ginseng Attenuates Colitis-Associated Colon Carcinogenesis in Mice: Impact on Gut Microbiota and Metabolomics. Cancer Prevention Research. 2016; 9:803-811.
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  105. Li Q, Guo GW, Meng FC, Wang HH, Niu YM, Zhang QW, Zhang JF, Wang YT, Dong L, Wang CM. A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis. Acs Macro Letters. 2016; 5:617-621.
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  108. Guo SH, Luo WW, Liu LJ, Pang XC, Zhu H, Liu AL, Lu JJ, Ma DL, Leung CH, Wang YT, Chen XP. Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. Journal of Drug Targeting. 2016; 24:934-942.
  109. Chen XJ, Qiu JF, Wang YT, Wan JB. Discrimination of Three Panax Species Based on Differences in Volatile Organic Compounds Using a Static Headspace GC-MS-Based Metabolomics Approach. American Journal of Chinese Medicine. 2016; 44:663-676.
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  116. Bao JL, Liu F, Zhang C, Wang K, Jia XJ, Wang XT, Chen MW, Li P, Su HX, Wang YT, Wan JB, He CW. Anti-melanoma activity of Forsythiae Fructus aqueous extract in mice involves regulation of glycerophospholipid metabolisms by UPLC/Q-TOF MS-based metabolomics study. Scientific Reports. 2016; 6.
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  119. Zhong ZF, Tan W, Wang SP, Qiang WA, Wang YT. Anti-proliferative activity and cell cycle arrest induced by evodiamine on paclitaxel-sensitive and -resistant human ovarian cancer cells. Scientific Reports. 2015; 5.
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  121. Zhang YL, Bao JL, Wang K, Jia XJ, Zhang C, Huang BR, Chen MW, Wan JB, Su HX, Wang YT, He CW. Pulsatilla Saponin D Inhibits Autophagic Flux and Synergistically Enhances the Anticancer Activity of Chemotherapeutic Agents Against HeLa Cells. American Journal of Chinese Medicine. 2015; 43:1657-1670.
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  125. Zhang JM, Chen RIE, Fang XF, Chen FQ, Wang YT, Chen MW. Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles for enhanced delivery and antitumor efficacy of paclitaxel. Nano Research. 2015; 8:201-218.
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  127. Zhang C, Chen SH, Bao JL, Zhang YL, Huang BR, Jia XJ, Chen MW, Wan JB, Su HX, Wang YT, He CW. Low Doses of Camptothecin Induced Hormetic and Neuroprotective Effects in PC12 Cells. Dose-Response. 2015; 13.
  128. Yu XW, Hu H, Chen XP, Hu YJ, Wang YT. Technology Road Mapping for Innovation Pathways of Fibrates: A Cross-Database Patent Review. Tropical Journal of Pharmaceutical Research. 2015; 14:1459-1467.
  129. Xu YQ, Sun ZQ, Wang YT, Xiao F, Chen MW. Function of Nogo-A/Nogo-A Receptor in Alzheimer’s Disease. Cns Neuroscience & Therapeutics. 2015; 21:479-485.
  130. Wang YF, Li T, Tang ZH, Chang LL, Zhu H, Chen XP, Wang YT, Lu JJ. Baicalein Triggers Autophagy and Inhibits the Protein Kinase B/Mammalian Target of Rapamycin Pathway in Hepatocellular Carcinoma HepG2 Cells. Phytotherapy Research. 2015; 29:674-679.
  131. Wang Y, Liu JJ, Li Q, Wang YT, Wang CM. Two natural glucomannan polymers, from Konjac and Bletilla, as bioactive materials for pharmaceutical applications. Biotechnology Letters. 2015; 37:1-8.
  132. Wang SP, Yang Y, Wang YT, Chen MW. Gambogic acid-loaded pH-sensitive mixed micelles for overcoming breast cancer resistance. International Journal of Pharmaceutics. 2015; 495:840-848.
  133. Wang SP, Wang L, Chen MW, Wang YT. Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression. Chemico-Biological Interactions. 2015; 235:76-84.
  134. Wang SP, Qiu JG, Shi Z, Wang YT, Chen MW. Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer. Biotechnology Advances. 2015; 33:224-241.
  135. Wang SP, Chen R, Morott J, Repka MA, Wang YT, Chen MW. mPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer. Expert Opinion on Drug Delivery. 2015; 12:361-373.
  136. Wang RM, Zhou H, Siu SWI, Gan Y, Wang YT, Ouyang DF. Comparison of Three Molecular Simulation Approaches for Cyclodextrin-Ibuprofen Complexation. Journal of Nanomaterials. 2015.
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  138. Wang AQ, Liu QY, Ye Y, Wang YT, Lin LG. Identification of hepatoprotective xanthones from the pericarps of Garcinia mangostana, guided with tert-butyl hydroperoxide induced oxidative injury in HL-7702 cells. Food & Function. 2015; 6:3013-3021.
  139. Wang AQ, Lin LG, Wang YT. Traditional Chinese Herbal Medicine Penthorum chinense Pursh: A Phytochemical and Pharmacological Review. American Journal of Chinese Medicine. 2015; 43:601-620.
  140. Tang ZH, Zhang LL, Li T, Lu JH, Ma DL, Leung CH, Chen XP, Jiang HL, Wang YT, Lu JJ. Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1 alpha-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells. Oncotarget. 2015; 6:43911-43926.
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  142. Tan W, Zhong ZF, Wang SP, Suo ZW, Yang X, Hu XD, Wang YT. Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7. Evidence-Based Complementary and Alternative Medicine. 2015.
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  144. Song YL, Jing WH, Yan R, Wang YT. Research progress of the studies on the roots of Peucedanum praeruptorum dunn (Peucedani radix). Pakistan Journal of Pharmaceutical Sciences. 2015; 28:71-81.
  145. Song MH, Ung C, Hu H, Wang YT. Community pharmacists’ perceptions about pharmaceutical care of OTC western medicine: a survey in Harbin of China. International Journal of Clinical Pharmacy. 2015; 37:1014-1020.
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  147. Liu QY, Wang YT, Lin LG. New insights into the anti-obesity activity of xanthones from Garcinia mangostana. Food & Function. 2015; 6:383-393.
  148. Liu JJ, Zhan XD, Wan JB, Wang YT, Wang CM. Review for carrageenan-based pharmaceutical biomaterials: Favourable physical features versus adverse biological effects. Carbohydrate Polymers. 2015; 121:27-36.
  149. Lin ZQ, Mei D, Chen MW, Wang YT, Chen XH, Wang ZY, He B, Zhang H, Wang XQ, Dai WB, Yin YX, Zhang Q. A comparative study of thermo-sensitive hydrogels with water-insoluble paclitaxel in molecule, nanocrystal and microcrystal dispersions. Nanoscale. 2015; 7:14838-14847.
  150. Li XW, Yang Y, Henry RJ, Rossetto M, Wang YT, Chen SL. Plant DNA barcoding: from gene to genome. Biological Reviews. 2015; 90:157-166.
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  152. Li T, Xu XH, Tang ZH, Wang YF, Leung CH, Ma DL, Chen XP, Wang YT, Chen Y, Lu JJ. Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells. Acta Pharmacologica Sinica. 2015; 36:1503-1513.
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  154. Li SK, Miao XQ, Wyman IW, Li Y, Zheng Y, Wang YT, Macartney DH, Wang RB. High-affinity host-guest complex of cucurbit 7 uril with a bis(thiazolium) salt. Rsc Advances. 2015; 5:56110-56115.
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  156. Leung KH, He HZ, He BY, Zhong HJ, Lin S, Wang YT, Ma DL, Leung CH. Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe. Chemical Science. 2015; 6:2166-2171.
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  158. Jing WH, Yan R, Wang YT. A practical strategy for chemical profiling of herbal medicines using ultra-high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry: a case study of Mori Cortex. Analytical Methods. 2015; 7:443-457.
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  163. Hamano R, Wu XQ, Wang YT, Oppenheim JJ, Chen X. Characterization of MT-2 cells as a human regulatory T cell-like cell line. Cellular & Molecular Immunology. 2015; 12:780-782.
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  165. Guo JJ, Pan W, Chen MW, Wang CM, Wang YT. Overview of Taiwan’s indigenous ethnopharmacology in the perspective of traditional knowledge protection. Chinese Journal of Integrative Medicine. 2015; 21:949-954.
  166. Fang XB, Xu YQ, Zhang JM, Lu XH, Wang YT, Chen MW. Synthesis and Characterization of an Amphiphilic Linoleic Acid-g-Quaternary Chitosan with Low Toxicity. Journal of Nanomaterials. 2015.
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  168. Chen XJ, Tang ZH, Li XW, Xie CX, Lu JJ, Wang YT. Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo). American Journal of Chinese Medicine. 2015; 43:783-834.
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  171. Chen RE, Wang SP, Zhang JM, Chen MW, Wang YT. Aloe-emodin loaded solid lipid nanoparticles: formulation design and in vitro anti-cancer study. Drug Delivery. 2015; 22:666-674.
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  173. Chen FQ, Zhang JM, Wang L, Wang YT, Chen MW. Tumor pH(e)-triggered charge-reversal and redox-responsive nanoparticles for docetaxel delivery in hepatocellular carcinoma treatment. Nanoscale. 2015; 7:15763-15779.
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  177. Bao JL, Huang BR, Zou LD, Chen SH, Zhang C, Zhang YL, Chen MW, Wan JB, Su HX, Wang YT, He CW. Hormetic Effect of Berberine Attenuates the Anticancer Activity of Chemotherapeutic Agents. Plos One. 2015; 10.
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  179. Zhong ZF, Tan W, Chen XP, Wang YT. Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro. European Journal of Pharmacology. 2014; 737:1-10.
  180. Zhang XJ, Su HX, He CW, Wang YT, Yang FQ, Wan JB. Discrimination of Pterocephalus hookeri collected at flowering and non-flowering stages using GC-MS-based fatty acid profiling. Analytical Methods. 2014; 6:2141-2149.
  181. Zhang JM, Li YB, Gao W, Repka MA, Wang YT, Chen MW. Andrographolide-loaded PLGA-PEG-PLGA micelles to improve its bioavailability and anticancer efficacy. Expert Opinion on Drug Delivery. 2014; 11:1367-1380.
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  183. Zhan XD, Jia LX, Niu YM, Qi HX, Chen XP, Zhang QW, Zhang JF, Wang YT, Dong L, Wang CM. Targeted depletion of tumour-associated macrophages by an alendronate-glucomannan conjugate for cancer immunotherapy. Biomaterials. 2014; 35:10046-10057.
  184. Yuan YF, Song YL, Jing WH, Wang YT, Yang XY, Liu DY. Simultaneous determination of caffeine, gallic acid, theanine, (-)-epigallocatechin and (-)-epigallocatechin-3-gallate in green tea using quantitative H-1-NMR spectroscopy. Analytical Methods. 2014; 6:907-914.
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  186. Yang Y, Wang SP, Wang YT, Wang XH, Wang Q, Chen MW. Advances in self-assembled chitosan nanomaterials for drug delivery. Biotechnology Advances. 2014; 32:1301-1316.
  187. Yang Y, Dang YY, Li Q, Lu JJ, Li XW, Wang YT. Complete Chloroplast Genome Sequence of Poisonous and Medicinal Plant Datura stramonium: Organizations and Implications for Genetic Engineering. Plos One. 2014; 9.
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  192. Xu JC, Kong XJ, Qiu L, Geng XM, Hu YJ, Wang YT. Research and development of anti-Alzheimer’s drugs: an analysis based on technology flows measured by patent citations. Expert Opinion on Therapeutic Patents. 2014; 24:791-800.
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  194. Wu WJ, Yan R, Yao MC, Zhan Y, Wang YT. Pharmacokinetics of anthraquinones in rat plasma after oral administration of a rhubarb extract. Biomedical Chromatography. 2014; 28:564-572.
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  196. Wang SP, Wang L, Shi Z, Zhong ZF, Chen MW, Wang YT. Evodiamine Synergizes with Doxorubicin in the Treatment of Chemoresistant Human Breast Cancer without Inhibiting P-Glycoprotein. Plos One. 2014; 9.
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  201. Tang ZH, Li T, Gao HW, Sun W, Chen XP, Wang YT, Lu JJ. Platycodin D from Platycodonis Radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells. Chinese Medicine. 2014; 9.
  202. Tang ZH, Li T, Chang LL, Zhu H, Tong YG, Chen XP, Wang YT, Lu JJ. Glycyrrhetinic Acid Triggers a Protective Autophagy by Activation of Extracellular Regulated Protein Kinases in Hepatocellular Carcinoma Cells. Journal of Agricultural and Food Chemistry. 2014; 62:11910-11916.
  203. Song YL, Yan HX, Chen JF, Wang YT, Jiang Y, Tu PF. Characterization of in vitro and in vivo metabolites of carnosic acid, a natural antioxidant, by high performance liquid chromatography coupled with tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2014; 89:183-196.
  204. Song YL, Jing WH, Yang FQ, Shi Z, Yao MC, Yan R, Wang YT. Simultaneously enantiospecific determination of (+)-trans-khellactone, ( plus /-)-praeruptorin A, ( plus /-)-praeruptorin B, (+)-praeruptorin E, and their metabolites, ( plus /-)-cis-khellactone, in rat plasma using online solid phase extraction-chiral LC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis. 2014; 88:269-277.
  205. Song YL, Jing WH, Yan R, Wang YT. A pretreatment free method for the determination of seven natural products in a high-salt matrix by online guard column extraction coupled with tandem mass spectrometry. Analytical Methods. 2014; 6:623-628.
  206. Song YL, Jing WH, Yan R, Wang YT. Metabolic characterization of (+/-)-praeruptorin A in vitro and in vivo by high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2014; 90:98-110.
  207. Song YL, Jing WH, Tu PF, Wang YT. Development of enantiospecific and chemoselective methods for the determination of praeruptorin A enantiomers and their metabolites in rat plasma using chiral and achiral LC-MS/MS. Analytical Methods. 2014; 6:4831-4839.
  208. Song YL, Jing WH, Tu PF, Wang YT. Characterization of Peucedani Radix extract-derived angular-type pyranocoumarins in rats using ultra-high performance liquid chromatography coupled with hybrid triple quadrupole-linear ion trap mass spectrometry. Analytical Methods. 2014; 6:5198-5206.
  209. Song YL, Jing WH, Tu PF, Wang YT. Enantiomeric separation of angular-type pyranocoumarins from Peucedani Radix using AD-RH chiral column. Natural Product Research. 2014; 28:545-550.
  210. Song YL, Jing WH, Du G, Yang FQ, Yan R, Wang YT. Qualitative analysis and enantiospecific determination of angular-type pyranocoumarins in Peucedani Radix using achiral and chiral liquid chromatography coupled with tandem mass spectrometry. Journal of Chromatography A. 2014; 1338:24-37.
  211. Song YL, Jing WH, Chen YG, Yuan YF, Yan R, Wang YT. H-1 nuclear magnetic resonance based-metabolomic characterization of Peucedani Radix and simultaneous determination of praeruptorin A and praeruptorin B. Journal of Pharmaceutical and Biomedical Analysis. 2014; 93:86-94.
  212. Song J, Wang YC, Song YL, Chan H, Bi C, Yang X, Yan R, Wang YT, Zheng Y. Development and Characterisation of Ursolic Acid Nanocrystals Without Stabiliser Having Improved Dissolution Rate and In Vitro Anticancer Activity. Aaps Pharmscitech. 2014; 15:11-19.
  213. Shen DY, Wei JC, Wan JB, Huang XJ, Xiang C, Li BC, Zhang QW, Wang YT, Li P. Four new C-21 steroidal glycosides from Cynanchum otophyllum Schneid. Phytochemistry Letters. 2014; 9:86-91.
  214. Qiu L, Chen ZY, Lu DY, Hu H, Wang YT. Public funding and private investment for R&D: a survey in China’s pharmaceutical industry. Health Research Policy and Systems. 2014; 12.
  215. Pratheeshkumar P, Son YO, Wang X, Divya SP, Joseph B, Hitron JA, Wang L, Kim D, Yin YQ, Roy RV, Lu J, Zhang Z, Wang YT, Shi XL. Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-kappa B signaling pathways in SKH-1 hairless mice skin. Toxicology and Applied Pharmacology. 2014; 280:127-137.
  216. Pratheeshkumar P, Son YO, Divya SP, Roy RV, Hitron JA, Wang L, Kim D, Dai J, Asha P, Zhang Z, Wang YT, Shi XL. Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways. Toxicology and Applied Pharmacology. 2014; 281:230-241.
  217. Niu YM, Bai J, Kamm RD, Wang YT, Wang CM. Validating Antimetastatic Effects of Natural Products in an Engineered Microfluidic Platform Mimicking Tumor Microenvironment. Molecular Pharmaceutics. 2014; 11:2022-2029.
  218. Ni JY, Xu JC, Hu YJ, Su L, Wang YT. Cross-regional Pharmaceutical Technology Transfer in China Patterns and Proposed Investment Strategies. Therapeutic Innovation & Regulatory Science. 2014; 48:226-235.
  219. Ma ZQ, Hu H, He TT, Guo H, Zhang MY, Chen MW, Wang YT. AN ASSESSMENT OF TRADITIONAL UIGHUR MEDICINE IN CURRENT XINJIANG REGION (CHINA). African Journal of Traditional Complementary and Alternative Medicines. 2014; 11:301-314.
  220. Liu LJ, Leung KH, Chan DSH, Wang YT, Ma DL, Leung CH. Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening. Cell Death & Disease. 2014; 5.
  221. Liu JJ, Wang YT, Qiu L, Yu YY, Wang CM. Saponins of Panax notoginseng: chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases. Expert Opinion on Investigational Drugs. 2014; 23:523-539.
  222. Lin LG, Xie H, Wang YT, Ding J, Ye Y. Chemical Constituents from the Heartwood of Haematoxylon campechianum as Protein Tyrosine Kinase Inhibitors. Chemistry & Biodiversity. 2014; 11:776-783.
  223. Lin LG, Ke CQ, Wang YT, Ye Y. Two New Alkaloids from Roots of Stemona tuberosa. Records of Natural Products. 2014; 8:317-322.
  224. Li T, Xu WS, Wu GS, Chen XP, Wang YT, Lu JJ. Platycodin D Induces Apoptosis, and Inhibits Adhesion, Migration and Invasion in HepG2 Hepatocellular Carcinoma Cells. Asian Pacific Journal of Cancer Prevention. 2014; 15:1745-1749.
  225. Huang L, Wu Q, Li YH, Wang YT, Bi HC. PXR-Mediated Upregulation of CYP3A Expression by Herb Compound Praeruptorin C from Peucedanum praeruptorum Dunn (vol 2013, 156574, 2013). Evidence-Based Complementary and Alternative Medicine. 2014.
  226. Huang L, Huang M, Li YH, Li RM, Zeng Y, Kuang SY, Zhang L, Wang YT, Bi HC. Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn (vol 148, pg 596, 2013). Journal of Ethnopharmacology. 2014; 155:1399-1399.
  227. Hu N, Mei M, Ruan JQ, Wu WJ, Wang YT, Yan R. Regioselective Glucuronidation of Oxyresveratrol, a Natural Hydroxystilbene, by Human Liver and Intestinal Microsomes and Recombinant UGTs. Drug Metabolism and Pharmacokinetics. 2014; 29:229-236.
  228. Chen YG, Song YL, Wang Y, Yuan YF, Huang XJ, Ye WC, Wang YT, Zhang QW. Metabolic differentiations of Pueraria lobata and Pueraria thomsonii using H-1 NMR spectroscopy and multivariate statistical analysis. Journal of Pharmaceutical and Biomedical Analysis. 2014; 93:51-58.
  229. Chen XP, Guo JJ, Bao JL, Lu JJ, Wang YT. The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review. Medicinal Research Reviews. 2014; 34:768-794.
  230. Chen RE, Zhang JM, Hu YY, Wang SP, Chen MW, Wang YT. Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review. American Journal of Chinese Medicine. 2014; 42:275-288.
  231. Chen MW, Chen WR, Zhang JM, Long XY, Wang YT. Lobelia chinensis: chemical constituents and anticancer activity perspective. Chinese Journal of Natural Medicines. 2014; 12:103-107.
  232. Cao JL, Wei JC, Chen MW, Su HX, Wan JB, Wang YT, Li P. Application of two-dimensional chromatography in the analysis of Chinese herbal medicines. Journal of Chromatography A. 2014; 1371:1-14.
  233. Zhao HY, Hu H, Wang YT. Comparative metabolism and stability of andrographolide in liver microsomes from humans, dogs and rats using ultra-performance liquid chromatography coupled with triple-quadrupole and Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry. 2013; 27:1385-1392.
  234. Zhang XJ, Huang LL, Cai XJ, Li P, Wang YT, Wan JB. Fatty acid variability in three medicinal herbs of Panax species. Chemistry Central Journal. 2013; 7.
  235. Yao XL, Ye CH, Liu Q, Wan JB, Zhen J, Xiang AP, Li WQ, Wang YT, Su HX, Lu XL. Motoneuron Differentiation of Induced Pluripotent Stem Cells from SOD1G93A Mice. Plos One. 2013; 8.
  236. Xu ZT, Wu GS, Wei X, Chen XP, Wang YT, Chen LD. Celastrol Induced DNA Damage, Cell Cycle Arrest, and Apoptosis in Human Rheumatoid Fibroblast-Like Synovial Cells. American Journal of Chinese Medicine. 2013; 41:615-628.
  237. Xu WS, Li T, Wu GS, Dang YY, Chen XP, Lu JJ, Wang YT. Furanodiene induces G1 cell cycle arrest and activates the signaling molecules regulating apoptosis and autophagy, and slightly inhibits key steps of cell metastasis in 95-D lung cancer cells. Acta Pharmacologica Sinica. 2013; 34:17-17.
  238. Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT. Ganoderiol A-enriched extract suppresses migration and adhesion via inhibiting FAK-SRC-paxillin cascade pathway in MDA-MB-231 cells. Acta Pharmacologica Sinica. 2013; 34:32-32.
  239. Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT. Ganoderiol A-Enriched Extract Suppresses Migration and Adhesion of MDA-MB-231 Cells by Inhibiting FAK-SRC-Paxillin Cascade Pathway. Plos One. 2013; 8.
  240. Wu GS, Lu JJ, Guo JJ, Huang MQ, Gan L, Chen XP, Wang YT. Synergistic anti-cancer activity of the combination of dihydroartemisinin and doxorubicin in breast cancer cells. Pharmacological Reports. 2013; 65:453-459.
  241. Wu GS, Guo JJ, Bao JL, Li XW, Chen XP, Lu JJ, Wang YT. Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum – a review. Expert Opinion on Investigational Drugs. 2013; 22:981-992.
  242. Wang SP, Zhong ZF, Wan JB, Tan W, Wu GS, Chen MW, Wang YT. Oridonin Induces Apoptosis, Inhibits Migration and Invasion on Highly-Metastatic Human Breast Cancer Cells. American Journal of Chinese Medicine. 2013; 41:177-196.
  243. Wang SP, Zhang JM, Chen MW, Wang YT. Delivering flavonoids into solid tumors using nanotechnologies. Expert Opinion on Drug Delivery. 2013; 10:1411-1428.
  244. Wang L, Zhang JM, Hong YL, Feng Y, Chen MW, Wang YT. Phytochemical and Pharmacological Review of Da Chuanxiong Formula: A Famous Herb Pair Composed of Chuanxiong Rhizoma and Gastrodiae Rhizoma for Headache. Evidence-Based Complementary and Alternative Medicine. 2013.
  245. Wan JB, Li P, Yang RL, Zhang QW, Wang YT. SEPARATION AND PURIFICATION OF 5 SAPONINS FROM Panax Notoginseng BY PREPARATIVE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY. Journal of Liquid Chromatography & Related Technologies. 2013; 36:406-417.
  246. Wan JB, Bai X, Cai XJ, Rao Y, Wang YS, Wang YT. Chemical differentiation of Da-Cheng-Qi-Tang, a Chinese medicine formula, prepared by traditional and modern decoction methods using UPLC/Q-TOFMS-based metabolomics approach. Journal of Pharmaceutical and Biomedical Analysis. 2013; 83:34-42.
  247. Su HX, Wang LH, Huang WH, Qin DJ, Cai JL, Yao XL, Feng CQ, Li ZY, Wang YT, So KF, Pan GJ, Wu WT, Pei DQ. Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells. Stem Cell Research. 2013; 10:338-348.
  248. Shen H, Leung WI, Ruan JQ, Li SL, Lei JPC, Wang YT, Yan R. Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria. Chinese Medicine. 2013; 8.
  249. Lu JJ, Bao JL, Wu GS, Xu WS, Huang MQ, Chen XP, Wang YT. Quinones Derived from Plant Secondary Metabolites as Anti-cancer Agents. Anti-Cancer Agents in Medicinal Chemistry. 2013; 13:456-463.
  250. Li YB, Zhong ZF, Chen MW, Bao JL, Wu GS, Zhang QW, Lee SMY, Hoi PM, Wang YT. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evidence-Based Complementary and Alternative Medicine. 2013.
  251. Li YB, Wang ZQ, Yan X, Chen MW, Bao JL, Wu GS, Ge ZM, Zhou DM, Wang YT, Li RT. IC-4, a new irreversible EGFR inhibitor, exhibits prominent anti-tumor and anti-angiogenesis activities. Cancer Letters. 2013; 340:88-96.
  252. Li YB, Gao JL, Zhong ZF, Hoi PM, Lee SMY, Wang YT. Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacological Reports. 2013; 65:700-709.
  253. Li XW, Gao HH, Wang YT, Song JY, Henry R, Wu HZ, Hu ZG, Yao H, Luo HM, Luo K, Pan HL, Chen SL. Complete chloroplast genome sequence of Magnolia grandiflora and comparative analysis with related species. Science China-Life Sciences. 2013; 56:189-198.
  254. Jing WH, Song YL, Yan R, Wang YT. Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2013; 77:175-188.
  255. Huang L, Wu Q, Li YH, Wang YT, Bi HC. PXR-Mediated Upregulation of CYP3A Expression by Herb Compound Praeruptorin C from Peucedanum praeruptorum Dunn. Evidence-Based Complementary and Alternative Medicine. 2013.
  256. Huang L, Huang M, Li YH, Li RM, Zeng Y, Kuang SY, Zhang L, Wang YT, Bi HC. Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn. Journal of Ethnopharmacology. 2013; 148:596-602.

 

  1. Huang L, Bi HC, Li YH, Zhang JQ, Kuang SY, Zhang L, Wang YT, Huang M. Regulation of Human Pregnane X Receptor and its Target Gene Cytochrome P450 3A by Praeruptorin A Isolated from the Herbal Medicine Peucedanum praeruptorum. Planta Medica. 2013; 79:1509-1515.
  2. Hu YY, Wang SP, Wu X, Zhang JM, Chen R, Chen MW, Wang YT. Chinese herbal medicine-derived compounds for cancer therapy: A focus on hepatocellular carcinoma. Journal of Ethnopharmacology. 2013; 149:601-612.
  3. Hu YJ, Scherngell T, Man SN, Wang YT. Is the United States Still Dominant in the Global Pharmaceutical Innovation Network? Plos One. 2013; 8.
  4. Han W, Wang SP, Liang RX, Wang L, Chen MW, Li H, Wang YT. Non-ionic surfactant vesicles simultaneously enhance antitumor activity and reduce the toxicity of cantharidin. International Journal of Nanomedicine. 2013; 8:2187-2196.
  5. Guo Y, Hu YJ, Zheng ML, Wang YT. Patent indicators: a window to pharmaceutical market success. Expert Opinion on Therapeutic Patents. 2013; 23:765-771.
  6. Gao L, Fang JS, Bai XY, Zhou D, Wang YT, Liu AL, Du GH. In silico Target Fishing for the Potential Targets and Molecular Mechanisms of Baicalein as an Antiparkinsonian Agent: Discovery of the Protective Effects on NMDA Receptor-Mediated Neurotoxicity. Chemical Biology & Drug Design. 2013; 81:675-687.
  7. Chen XP, Lu JJ, Bao JL, Guo JJ, Shi JS, Wang YT. Adiponectin: A biomarker for rheumatoid arthritis? Cytokine & Growth Factor Reviews. 2013; 24:83-89.
  8. Chen MW, Zhang JM, Lai YF, Wang SP, Li P, Xiao J, Fu CM, Hu H, Wang YT. Analysis of Pogostemon cablin from pharmaceutical research to market performances. Expert Opinion on Investigational Drugs. 2013; 22:245-257.
  9. Chen MW, Chen RE, Wang SP, Tan W, Hu YY, Peng XS, Wang YT. Chemical components, pharmacological properties, and nanoparticulate delivery systems of Brucea javanica. International Journal of Nanomedicine. 2013; 8:85-92.
  10. Zhou RN, Song YL, Ruan JQ, Wang YT, Yan R. Pharmacokinetic Evidence on the Contribution of Intestinal Bacterial Conversion to Beneficial Effects of Astragaloside IV, a Marker Compound of Astragali Radix, in Traditional Oral Use of the Herb. Drug Metabolism and Pharmacokinetics. 2012; 27:586-597.
  11. Zhong ZF, Li YB, Wang SP, Tan W, Chen XP, Chen MW, Wang YT. Furanodiene enhances tamoxifen-induced growth inhibitory activity of ERa-positive breast cancer cells in a PPAR gamma independent manner. Journal of Cellular Biochemistry. 2012; 113:2643-2651.
  12. Zhong ZF, Hoi PM, Wu GS, Xu ZT, Tan W, Chen XP, Cui L, Wu T, Wang YT. Anti-angiogenic effect of furanodiene on HUVECs in vitro and on zebrafish in vivo. Journal of Ethnopharmacology. 2012; 141:721-727.
  13. Zhong ZF, Dang YY, Yuan X, Guo W, Li YB, Tan W, Cui JR, Lu JJ, Zhang QW, Chen XP, Wang YT. Furanodiene, a Natural Product, Inhibits Breast Cancer Growth Both in vitro and in vivo. Cellular Physiology and Biochemistry. 2012; 30:778-790.
  14. Zhao BX, Wang Y, Zhang DM, Huang XJ, Bai LL, Yan Y, Chen JM, Lu TB, Wang YT, Zhang QW, Ye WC. Virosaines A and B, Two New Birdcage-Shaped Securinega Alkaloids with an Unprecedented Skeleton from Flueggea virosa. Organic Letters. 2012; 14:3096-3099.
  15. Zhang H, Zhang QW, Wang L, Zhang XQ, Ye WC, Wang YT. Two new anthraquinone malonylglucosides from Polygonum cuspidatum. Natural Product Research. 2012; 26:1323-1327.
  16. Yi Y, Zhang QW, Li SL, Wang Y, Ye WC, Zhao J, Wang YT. Simultaneous quantification of major flavonoids in “Bawanghua”, the edible flower of Hylocereus undatus using pressurised liquid extraction and high performance liquid chromatography. Food Chemistry. 2012; 135:528-533.
  17. Yang F, Zhou WL, Liu AL, Qin HL, Lee SMY, Wang YT, Du GH. The Protective Effect of 3-Deoxysappanchalcone on In Vitro Influenza Virus-induced Apoptosis and Inflammation. Planta Medica. 2012; 78:968-973.
  18. Xu ZT, Chen XP, Fu S, Bao JL, Dang YY, Huang MQ, Chen LD, Wang YT. Dehydrocorydaline Inhibits Breast Cancer Cells Proliferation by Inducing Apoptosis in MCF-7 Cells. American Journal of Chinese Medicine. 2012; 40:177-185.
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  20. Xu WS, Dang YY, Guo JJ, Wu GS, Lu JJ, Chen XP, Wang YT. Furanodiene Induces Endoplasmic Reticulum Stress and Presents Antiproliferative Activities in Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2012.
  21. Wu GS, Qian ZM, Guo JJ, Hu DJ, Bao JL, Xie J, Xu WS, Lu JJ, Chen XP, Wang YT. Ganoderma lucidum Extract Induces G1 Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells. American Journal of Chinese Medicine. 2012; 40:631-642.
  22. Wu GS, Lu JJ, Guo JJ, Li YB, Tan W, Dang YY, Zhong ZF, Xu ZT, Chen XP, Wang YT. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012; 83:408-414.
  23. Wang SP, Wu X, Tan M, Gong J, Tan W, Bian BL, Chen MW, Wang YT. Fighting fire with fire: Poisonous Chinese herbal medicine for cancer therapy. Journal of Ethnopharmacology. 2012; 140:33-45.
  24. Wang SP, Hu YY, Tan W, Wu X, Chen RE, Cao JL, Chen MW, Wang YT. Compatibility art of traditional Chinese medicine: From the perspective of herb pairs. Journal of Ethnopharmacology. 2012; 143:412-423.
  25. Wang SP, Chen TK, Chen RE, Hu YY, Chen MW, Wang YT. Emodin loaded solid lipid nanoparticles: Preparation, characterization and antitumor activity studies. International Journal of Pharmaceutics. 2012; 430:238-246.
  26. Wan JB, Zhang QW, Hong SJ, Li P, Li SP, Wang YT. Chemical Investigation of Saponins in Different Parts of Panax notoginseng by Pressurized Liquid Extraction and Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry. Molecules. 2012; 17:5836-5853.
  27. Song YL, Zhang QW, Li YP, Yan R, Wang YT. Enantioseparation and Absolute Configuration Determination of Angular-Type Pyranocoumarins from Peucedani Radix Using Enzymatic Hydrolysis and Chiral HPLC-MS/MS Analysis. Molecules. 2012; 17:4236-4251.
  28. Song YL, Jing WH, Zhao HY, Yan R, Li PT, Wang YT. Stereoselective metabolism of (+/-)-praeruptorin A, a calcium channel blocker from Peucedani Radix, in pooled liver microsomes of rats and humans. Xenobiotica. 2012; 42:221-237.
  29. Mei M, Ruan JQ, Wu WJ, Zhou RN, Lei JPC, Zhao HY, Yan R, Wang YT. In Vitro Pharmacokinetic Characterization of Mulberroside A, the Main Polyhydroxylated Stilbene in Mulberry (Morus alba L.), and Its Bacterial Metabolite Oxyresveratrol in Traditional Oral Use. Journal of Agricultural and Food Chemistry. 2012; 60:2299-2308.
  30. Lu JJ, Pan W, Hu YJ, Wang YT. Multi-Target Drugs: The Trend of Drug Research and Development. Plos One. 2012; 7.
  31. Lu JJ, Dang YY, Huang M, Xu WS, Chen XP, Wang YT. Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae – A review. Journal of Ethnopharmacology. 2012; 143:406-411.
  32. Lu JJ, Bao JL, Chen XP, Huang M, Wang YT. Alkaloids Isolated from Natural Herbs as the Anticancer Agents. Evidence-Based Complementary and Alternative Medicine. 2012.
  33. Li F, Zhang LD, Li BC, Yang J, Yu H, Wan JB, Wang YT, Li P. Screening of free radical scavengers from Erigeron breviscapus using on-line HPLC-ABTS/DPPH based assay and mass spectrometer detection. Free Radical Research. 2012; 46:286-294.
  34. Huang MQ, Xie YL, Chen LD, Chu KD, Wu SS, Lu JJ, Chen XP, Wang YT, Lai XP. Antidiabetic Effect of the Total Polyphenolic Acids Fraction from Salvia miltiorrhiza Bunge in Diabetic Rats. Phytotherapy Research. 2012; 26:944-948.
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  36. Gong J, Chen MW, Zheng Y, Wang SP, Wang YT. Polymeric micelles drug delivery system in oncology. Journal of Controlled Release. 2012; 159:312-323.
  37. Du G, Xiao Y, Yang HR, Wang L, Song YL, Wang YT. Rapid determination of pesticide residues in herbs using selective pressurized liquid extraction and fast gas chromatography coupled with mass spectrometry. Journal of Separation Science. 2012; 35:1922-1932.
  38. Ding RB, Tian K, Huang LL, He CW, Jiang Y, Wang YT, Wan JB. Herbal medicines for the prevention of alcoholic liver disease: A review. Journal of Ethnopharmacology. 2012; 144:457-465.
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  45. Xu ZT, Chen XP, Zhang QW, Chen LDA, Wang YT. Corydalis yanhusuo WT Wang Extract Inhibits MCF-7 Cell Proliferation by Inducing Cell Cycle G2/M Arrest. American Journal of Chinese Medicine. 2011; 39:579-586.
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  53. Li YB, Lin ZQ, Zhang ZJ, Wang MW, Zhang HA, Zhang Q, Lee SMY, Wang YT, Hoi PM. Protective, Antioxidative and Antiapoptotic Effects of 2-Methoxy-6-Acetyl-7-Methyljuglone from Polygonum cuspidatum in PC12 Cells. Planta Medica. 2011; 77:354-361.
  54. Li YB, Gao JL, Lee SMY, Zhang QW, Hoi PM, Wang YT. Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt. International Journal of Molecular Medicine. 2011; 27:205-211.
  55. Li GH, Zhang QW, Wang L, Zhang XQ, Ye WC, Wang YT. New Isoflavone C-Glycosides from Pueraria lobata. Helvetica Chimica Acta. 2011; 94:423-428.
  56. Jing WH, Song YL, Yan R, Bi HC, Li PT, Wang YT. Transport and metabolism of (+/-)-praeruptorin A in Caco-2 cell monolayers. Xenobiotica. 2011; 41:71-81.
  57. Huang L, Bi HC, Liu YH, Wang YT, Xue XP, Huang M. CAR-mediated Up-regulation of CYP3A4 Expression in LS174T Cells by Chinese Herbal Compounds. Drug Metabolism and Pharmacokinetics. 2011; 26:331-340.
  58. He BC, Gao JL, Luo XJ, Luo JY, Shen JK, Wang LY, Zhou QX, Wang YT, Luu HH, Haydon RC, Wang CZ, Du W, Yuan CS, He TC, Zhang BQ. Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/beta-catenin signaling. International Journal of Oncology. 2011; 38:437-445.
  59. Du G, Zhao HY, Song YL, Zhang QW, Wang YT. Rapid simultaneous determination of isoflavones in Radix puerariae using high-performance liquid chromatography-triple quadrupole mass spectrometry with novel shell-type column. Journal of Separation Science. 2011; 34:2576-2585.
  60. Du G, Song YL, Wang YT. Rapid simultaneous determination of multiple pesticide residues in traditional Chinese medicines using programmed temperature vaporizer injection-fast gas chromatography coupled with mass spectrometry. Journal of Separation Science. 2011; 34:3372-3382.
  61. Deng YH, Alex D, Huang HQ, Wang N, Yu N, Wang YT, Leung GPH, Lee SMY. Inhibition of TNF-alpha-mediated Endothelial Cell-Monocyte Cell Adhesion and Adhesion Molecules Expression by the Resveratrol Derivative, trans-3,5,4 ‘-Trimethoxystilbene. Phytotherapy Research. 2011; 25:451-457.
  62. Chen XP, Zhong ZF, Xu ZT, Chen LD, Wang YT. No protective effect of curcumin on hydrogen peroxide-induced cytotoxicity in HepG2 cells. Pharmacological Reports. 2011; 63:724-732.
  63. Chen XP, Xu ZT, Wang YT. Recent advances in breast cancer metastasis suppressor 1. International Journal of Biological Markers. 2011; 26:1-8.
  64. Chen XP, Wang YT. Adiponectin and breast cancer. Medical Oncology. 2011; 28:1288-1295.
  65. Chen XP, Pei LX, Zhong ZF, Guo JJ, Zhang QW, Wang YT. Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. Phytomedicine. 2011; 18:1238-1243.
  66. Chen MW, Zhong ZF, Tan W, Wang SP, Wang YT. Recent advances in nanoparticle formulation of oleanolic acid. Chinese Medicine. 2011; 6.
  67. Chen MW, Wang SP, Tan M, Wang YT. Applications of Nanoparticles in Herbal Medicine: Zedoary Turmeric Oil and Its Active Compound beta-Elemene. American Journal of Chinese Medicine. 2011; 39:1093-1102.
  68. Zhong ZF, Chen XP, Zhou KY, Wu T, Cui LA, Wang YT. Rhizoma curcuma exerts synthetic effect of anti-breast cancer through suppressing cell proliferation, metastasis and angiogenesis in vitro. International Journal of Molecular Medicine. 2010; 26:S39-S39.
  69. Wan JB, Zhang QW, Hong SJ, Guan J, Ye WC, Li SP, Lee MYS, Wang YT. 5,6-Didehydroginsenosides from the Roots of Panax notoginseng. Molecules. 2010; 15:8169-8176.
  70. Tan W, Li N, Ming S, Lee Y, Wang YT. Anti-diabetic berberine inhibits MCF-7 human breast cancer cell growth though a metabolic control. International Journal of Molecular Medicine. 2010; 26:S33-S33.
  71. Ruan JQ, Wang YT, Yan R. In Vivo and In Vitro Pharmacokinetic Characterization of Calycosin. Drug Metabolism Reviews. 2010; 42:262-263.
  72. Ruan JQ, Leong WI, Yan R, Wang YT. Characterization of Metabolism and in Vitro Permeability Study of Notoginsenoside R1 from Radix Notoginseng. Journal of Agricultural and Food Chemistry. 2010; 58:5770-5776.
  73. Qin XL, Bi HC, Wang XD, Li JL, Wang Y, Xue XP, Chen X, Wang CX, Xu LJ, Wang YT, Huang M. Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). International Journal of Pharmaceutics. 2010; 389:114-121.
  74. Liang QY, Chow AHL, Wang YT, Tong HHY, Zheng Y. Removal of toxic aristolochic acid components from Aristolochia plants by supercritical fluid extraction. Separation and Purification Technology. 2010; 72:269-274.
  75. Hu YM, Wang YT, Sze SCW, Tsang KW, Wong HK, Liu Q, Zhong LD, Tong Y. Identification of the major chemical constituents and their metabolites in rat plasma and various organs after oral administration of effective Erxian Decoction (EXD) fraction by liquid chromatography-mass spectrometry. Biomedical Chromatography. 2010; 24:479-489.
  76. Du G, Zhao HY, Zhang QW, Li GH, Yang FQ, Wang Y, Li YC, Wang YT. A rapid method for simultaneous determination of 14 phenolic compounds in Radix Puerariae using microwave-assisted extraction and ultra high performance liquid chromatography coupled with diode array detection and time-of-flight mass spectrometry. Journal of Chromatography A. 2010; 1217:705-714.
  77. Dang YY, Li XC, Zhang QW, Li SP, Wang YT. Preparative isolation and purification of six volatile compounds from essential oil of Curcuma wenyujin using high-performance centrifugal partition chromatography. Journal of Separation Science. 2010; 33:1658-1664.
  78. Chen XP, Zhong ZF, Xu ZT, Chen LD, Wang YT. 2 ‘,7 ‘-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy. Free Radical Research. 2010; 44:587-604.
  79. Chen XJ, Yang FQ, Wang YT, Li SP. CE and CEC of nucleosides and nucleotides in food materials. Electrophoresis. 2010; 31:2092-2105.

Academic service

  • Advisory committee / Panel member – Executive Director and Deputy Secretary-General, World Federation of Chinese Medicine Societies – Vice President, Professional Committee of Pharmacology, World Federation of Chinese Medicine Societies – Vice President, Standardization Committee, World Federation of Chinese Medicine Societies – Secretary-General, International Society of Chinese Medicine – Senior consultant of the FP7 EU-China Consortium on Modernisation of Chinese medicine research (GP-TCM) – Executive Chair, Research Association of Senior Education of Chinese Medicine – Standing Committee Member, Chinese Pharmacological Society (CNPHAR) – Member, Expert Committee of National Drug Evaluation of China – Member, Expert Committee of Major Program of National Natural Science Foundation of China – Member, National Committee on Assessment of State Science and Technology Award – Member, National Committee on Assessment for the Secrecy of Science and Technology – Member, National Assessment Committee on Protective Chinese Medicine

Contact

Room 1050, 1F, N22
Institute of Chinese Medical Sciences
University of Macau, Macao, China
Telephone: (853) 8822 4691
Fax: (853) 2884 1358
Email: YTWang@umac.mo

SECRETARY TO THE DIRECTOR

Chloe I-Man LAO (Ms) Room 1050, 1F, N22
Institute of Chinese Medical Sciences
University of Macau, Macao, China
Telephone: (853) 8822 4691
Fax: (853) 2884 1358
Email: IManLao@umac.mo