Xiuping Chen

Xiuping Chen 陳修平
Associate Professor

 

 

Academic Qualifications

  1. PhD  Peking Union Medical College & Tsinghua University
  2. Post-Doc Texas A&M University, College Station

Research Interests

  • Natural product-based drug discovery
  • Pharmacological evaluation of natural products
  • The material basis of Traditional Chinese Medicine

Teaching

  • Advanced pharmacology
  • Drug target and screening
  • Exploring Chinese Medicine
  • Introduction to Chinese Medicine

Awards and Honors

  1. Macao Science and Technology Awards (Second prize) (2012)(3rd)
  2. Macao Science and Technology Awards (Second prize) (2014)(5th)
  3. 17th SERVIER Young Pharmacologist Award (2013)

We are now looking for postgraduate students who are interested in our research projects on pharmacology and drug discovery. For further information, please contact Dr. Chen at xpchen@um.edu.mo


Selected Publications

Dr. Chen has > 200 scientific publications in peer-reviewed journals with > 5300 citations and the h index is 34. (Google scholar, Oct, 2018)

  1. Wu X, Guo Y, Min X, Pei L*, Chen X*. Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis. Am J Chin Med.2018;46(6):1263-1279.
  2. Luo W, Liu X, Sun W, Lu JJ, Wang Y*, Chen X*. Toosendanin, a natural product, inhibited TGF-β1-induced epithelial-mesenchymal transition through ERK/Snail pathway. Phytother Res. 2018 Oct;32(10):2009-2020
  3. Yu J, Gao H, Wu C, Xu QM, Lu JJ, Chen X*. Diethyl Blechnic, a Novel Natural Product Isolated from Salvia miltiorrhiza Bunge, Inhibits Doxorubicin-Induced Apoptosis by Inhibiting ROS and Activating JNK1/2. Int J Mol Sci. 2018 Jun 19;19(6). pii: E1809.
  4. Wu X, Gao H, Hou Y, Yu J, Sun W, Wang Y, Chen X, Feng Y, Xu QM, Chen X*. Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways. Toxicol Appl Pharmacol. 2018 Jun 12;355:1-8.
  5. Niu Y, Yuan R, Gao H, Kong Q, Lu JJ, Chen X*.2-Methoxy-6-Acetyl-7-Methyljuglone (MAM) Induces iNOS/NO-mediated DNA Damage Response through Activation of MAPKs Pathways. Anticancer Agents Med Chem. 2018 Apr 10.
  6. Yin H, Huang Q, Zhao W, Bardelang D, Siri D, Chen X, Lee SMY, Wang R. Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit[ n]uril ( n = 7, 8). J Org Chem. 2018 Apr 20;83(8):4882-4887.
  7. Guo Y, Wu X, Wu Q, Lu Y, Shi J, Chen X*. Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice. Toxicol Appl Pharmacol. 2018 Apr 1;344:35-45.
  8. Yu J, Wang C, Kong Q, Wu X, Lu JJ, Chen X*. Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products. Phytomedicine. 2018 Feb 1;40:125-139.
  9. Li D, Liu Q, Sun W, Chen X, Wang Y, Sun Y, Lin L. 1,3,6,7-tetrahydroxy-8-prenylxanthone ameliorates inflammatory responses resulted in by the paracrine interaction of adipocytes and macrophages. Br J Pharmacol. 2018 May;175(10):1590-1606.
  10. Luo WW, Zhao WW, Lu JJ, Wang YT*, Chen XP*. Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells. Chin J Nat Med. 2018 Jan;16(1):10-19.
  11. Wu C, Zhao W, Yu J, Li S, Lin L, Chen X*. Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells. Sci Rep. 2018 Jan 12;8(1):574.
  12. Tang ZH, Cao WX, Guo X, Dai XY, Lu JH, Chen X, Zhu H, Lu JJ. Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer. Cancer Lett. 2018 Jan 1;412:1-9.
  13. Tang ZH, Su MX, Guo X, Jiang XM, Jia L, Chen X, Lu JJ. Increased expression of IRE1α associates with the resistant mechanism of osimertinib (AZD9291)-resistant non-small cell lung cancer HCC827/OSIR cells. Anticancer Agents Med Chem. 2018;18(4):550-555.
  14. Xu Y, Chen XP, Zhang F, Hou HH, Zhang JY, Lin SX, Sun AS. Rutaecarpine inhibits intimal hyperplasia in a balloon-injured rat artery model. Chin J Integr Med. 2018 Jun;24(6):429-435.
  15. Wu MY, Wang SF, Cai CZ, Tan JQ, Li M, Lu JJ, Chen XP, Wang YT, Zheng W, Lu JH. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017 Sep 8;8(44):77673-77684.
  16. Kong Q, Ma Y, Yu J, Chen X. Predicted molecular targets and pathways for germacrone, curdione, and furanodiene in the treatment of breast cancer using a bioinformatics approach. Sci Rep. 2017 Nov 14;7(1):15543.
  17. Zhao W, Feng H, Guo S, Han Y, Chen X*. Danshenol A inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) mediated by NOX4 in endothelial cells. Sci Rep. 2017 Oct 11;7(1):12953.
  18. Li Q, Niu Y, Diao H, Wang L, Chen X, Wang Y, Dong L, Wang C. In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing. Biomaterials. 2017 Dec;148:54-68.
  19. Wang YF, Tang ZH, Li T, Xu XH, Chen X, Wang Y, Wang YT, Lu JJ. Baicalein protects tert‑butyl hydroperoxide‑induced hepatotoxicity dependent of reactive oxygen species removal. Mol Med Rep. 2017 Dec;16(6):8392-8398.
  20. Jiang XM, Xu YL, Huang MY, Zhang LL, Su MX, Chen X, Lu JJ. Osimertinib (AZD9291) decreases programmed death ligand-1 in EGFR-mutated non-small cell lung cancer cells. Acta Pharmacol Sin. 2017 Nov;38(11):1512-1520.
  21. Xu XH, Liu QY, Li T, Liu JL, Chen X, Huang L, Qiang WA, Chen X, Wang Y, Lin LG, Lu JJ. Garcinone E induces apoptosis and inhibits migration and invasion in ovarian cancer cells. Sci Rep. 2017 Sep 6;7(1):10718.
  22. Li T, Chen X, Dai XY, Wei B, Weng QJ, Chen X, Ouyang DF, Yan R, Huang ZJ, Jiang HL, Zhu H, Lu JJ. Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor. Toxicol Appl Pharmacol. 2017 Sep 1;330:65-73.
  23. Zhang LL, Xu W, Xu YL, Chen X, Huang M, Lu JJ. Therapeutic potential of Rhizoma Alismatis: a review on ethnomedicinal application, phytochemistry, pharmacology, and toxicology. Ann N Y Acad Sci. 2017 Aug;1401(1):90-101.
  24. Yuan R, Hou Y, Sun W, Yu J, Liu X, Niu Y, Lu JJ, Chen X*. Natural products to prevent drug resistance in cancer chemotherapy: A review. Ann. N.Y. Acad. Sci. 2017 Aug; 1401(1):19-27.
  25. Gao H, Cui Y, Kang N, Liu X, Liu Y, Zou Y, Zhang Z, Li X, Yang S, Li J, Wang C, Xu QM, Chen X*. Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking TLR4 dimerization. Br J Pharmacol. 2017 Sep; 174(17):2880-2896.
  26. Wu X, Gao H, Sun W, Yu J, Hu H, Xu Q, Chen X*. Nepetoidin B, a Natural Product, Inhibits LPS-stimulated Nitric Oxide Production via Modulation of iNOS Mediated by NF-κB/MKP-5 Pathways. Phytother Res. 2017 Jul;31(7):1072-1077.
  27. Feng H, Zhao W, Lu J, Wang Y, Chen X*. Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses adhesion, migration, and invasion of lung cancer A549 cells. Chin J Nat Med. 2017Jun;15(6):427-435.
  28. Feng H, Lu JJ, Wang Y, Pei L, Chen X*. Osthole inhibited TGF β-induced epithelial-mesenchymal transition (EMT) by suppressing NF-κB mediated Snail activation in lung cancer A549 cells. Cell Adh Migr. 2017 Feb 1:1-12.
  29. Sun W, Wu X, Gao H, Yu J, Zhao W, Lu JJ, Wang J, Du G, Chen X*. Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells. Free Radic Biol Med. 2017 Apr 14;108:433-444.
  30. Zhao W, Feng H, Sun W, Liu K, Lu J, Chen X*. Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion. Redox Biology. 2017 Jan 5;11:524-534.
  31. Kang TS, Wang W, Zhong HJ, Liang JX, Ko CN, Lu JJ, Chen XP, Ma DL, Leung CH. A rhodium(III)-based inhibitor of autotaxin with antiproliferative activity. Biochim Biophys Acta. 2017 Feb;1861(2):256-263.
  32. Sun W, Wang S, Zhao W, Wu C, Guo S, Hongwei G, Hongxun T, Lu JJ, Wang Y, Chen XP*. Chemical Constituents and Biological Research on Plants in the Genus Curcuma. Crit Rev Food Sci Nutr. 2017 ; 57(7):1451-1523.
  33. Xu XH, Zhang LL, Wu GS, Chen X, Li T, Chen X, Wang YT, Lu JJ. Solasodine Induces Apoptosis, Affects Autophagy, and Attenuates Metastasis in Ovarian Cancer Cells. Planta Med. 2017; 83:254-260.
  34. Zhao W, Ge H, Liu K, Chen X, Zhang J, Liu B. Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity. Planta Med. 2017 Feb;83(3-04):203-209.
  35. Li W, Papa F, Shi J, Maggi F, Chen X*. The Chemical Constituents and the Hepato-protective Effect of the Essential Oil of Ferulago campestris (Besser) Grecescu (Apiaceae). J Essential Oil Bearing Plants. 2016,19(7): 1701-1708.
  36. Niu Y, Sun W, Lu JJ, Ma DL, Leung CH, Pei L, Chen X*. PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells. Oxid Med Cell Longev. 2016;2016:4313204.
  37. Li T, Chen X, Chen X, Ma DL, Leung CH, Lu JJ. Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells. Sci Rep. 2016 Nov 29;6:37997.
  38. Zhao W, Li C, Gao H, Wu Q, Shi J, Chen X*. Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-κB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium. Front Pharmacol. 2016 Nov 8;7:418.
  39. Tang ZH, Jiang XM, Guo X, Fong CM, Chen X, Lu JJ. Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line. Oncotarget. 2016 Dec 6;7(49):81598-81610.
  40. Chen X, Wu QS, Meng FC, Tang ZH, Chen X, Lin LG, Chen P, Qiang WA, Wang YT, Zhang QW, Lu JJ. Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells. Phytomedicine. 2016 Dec 1;23(13):1555-1565.
  41. Xu XH, Li T, Fong CM, Chen X, Chen XJ, Wang YT, Huang MQ, Lu JJ. Saponins from Chinese Medicines as Anticancer Agents. Molecules. 2016 Oct 5;21(10).
  42. Gao H, Sun W, Zhao J, Wu X, Lu JJ, Chen X*, Xu QM, Khan IA, Yang S. Tanshinones and diethyl blechnics with anti-inflammatory and anti-cancer activities from Salvia miltiorrhiza Bunge (Danshen). Sci Rep. 2016 Sep 26;6:33720.
  43. Zhao W, Wu C, Li S, Chen X*. Adiponectin protects palmitic acid induced endothelial inflammation and insulin resistance via regulating ROS/IKKβ pathways. Cytokine. 2016 Sep 14;88:167-176.
  44. Yang X, Wang Z, Niu Y, Chen X, Lee S, Wang R. Influence of Supramolecular Encapsulation of Camptothecin by Cucurbit[7]uril: Reduced Toxicity and Preserved Anti-Cancer Activity. MedChemComm, 2016, DOI: 10.1039/C6MD00239K,
  45. Tang ZH, Chen X, Wang ZY, Chai K, Wang YF, Xu XH, Wang XW, Lu JH, Wang YT, Chen XP, Lu JJ. Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells. Sci Rep. 2016 May 17;6:26241.
  46. Ren G, Luo W, Sun W, Niu Y, Ma DL, Leung CH, Wang Y, Lu JJ, Chen X*. Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells. Phytomedicine. 2016 Aug 15;23(9):939-47.
  47. Sun W, Bao J, Lin W, Gao H, Zhao W, Zhang Q, Leung CH, Ma DL, Lu J, Chen X*. 2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H(2)O(2)-dependent JNK activation in cancer cells. Free Radic Biol Med. 2016 Jan 21;92:61-77.
  48. Ran X, Zhao W, Li W, Shi J, Chen X*. Cryptotanshinone inhibits TNF-α-induced LOX-1 expression by suppressing reactive oxygen species (ROS) formation in endothelial cells. Korean J Physiol Pharmacol. 2016 Jul;20(4):347-55.
  49. Zhang LL, Xu YL, Tang ZH, Xu XH, Chen X, Li T, Ding CY, Huang MQ, Chen XP, Wang YT, Yuan XF, Lu JJ. Effects of alisol B 23-acetate on ovarian cancer cells: G1 phase cell cycle arrest, apoptosis, migration and invasion inhibition. Phytomedicine. 2016 Jul 15;23(8):800-9.
  50. Ma DL, Wang W, Mao Z, Yang C, Chen XP, Lu JJ, Han QB, Leung CH. A tutorial review for employing enzymes for the construction of G-quadruplex-based sensing platforms. Anal Chim Acta. 2016 Mar 24;913:41-54.
  51. Lu L, Wang M, Mao Z, Kang TS, Chen XP, Lu JJ, Leung CH, Ma DL. A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α. Sci Rep. 2016 Mar 2;6:22458.
  52. Liu LJ, He B, Miles JA, Wang W, Mao Z, Che WI, Lu JJ, Chen XP, Wilson AJ, Ma DL, Leung CH. Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds. Oncotarget. 2016 Mar 22;7(12):13965-75.
  53. Li W, Zhao W, Wu Q, Lu Y, Shi J, Chen X*. Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats. J Diabetes Res. 2016;2016:8541520.
  54. Guo S, Luo W, Liu L, Pang X, Zhu H, Liu A, Lu J, Ma DL, Leung CH, Wang Y, Chen X*. Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. J Drug Target. 2016 Feb 24:1-28.
  55. Ma G, Luo W, Lu J, Ma DL, Leung CH, Wang Y, Chen X*. Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells. Chem Biol Interact. 2016 Jun 25;253:1-9.
  56. Hao W, Zhang X, Zhao W, Zhu H, Liu ZY, Lu J, Chen X*. Cryptotanshinone induces pro-death autophagy through JNK signaling mediated by reactive oxygen species generation in lung cancer cells. Anticancer Agents Med Chem. 2016;16: 593-600.
  57. Wu C, Bao J, He C, Lu J, Chen X*. Cucurbitacin B inhibits proliferation, induces G2/M cycle arrest and autophagy without affecting apoptosis but enhances MTT reduction in PC12 cells. Bangl J Pharmaco 2016;11(1)110-118.
  58. Zhao W, Wu C, Chen X*. Cryptotanshinone Inhibits oxidized LDL-Induced Adhesion Molecule Expression via ROS Dependent NF-κB Pathways. Cell Adh Migr. 2016 May 3;10(3):248-58
  59. Zhang X, Zhao W, Wang Y, Lu J, Chen X*. The Chemical Constituents and Bioactivities of Psoralea corylifolia Linn.: A Review. Am J Chin Med. 2016;44(1):35-60.
  60. Yang X, Wang Z, Niu Y, Chen X, Lee SMY, Wang R. Influence of supramolecular encapsulation of camptothecin by cucurbit 7 uril: reduced toxicity and preserved anti-cancer activity. Medchemcomm. 2016;7:1392﹣
  61. Li W, Shi J, Papa F, Maggi F, Chen X*. Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects d-galactosamin/lipopolysaccharide -induced liver injury in rats. Nat Prod Res. 2016;30(10):1162-5.
  62. Ding Q, Bao J, Zhao W, Lu J, Zhu H, Chen X*. Ethanol enhances cucurbitacin B-induced apoptosis by inhibiting cucurbitacin B-induced autophagy in LO2 hepatocytes. Molecular & Cellular Toxicology.2016, 12(1), 29–36.
  63. Chen X, Zhang H, Hill MA, Zhang C, Park Y. Regulation of Coronary Endothelial Function by Interactions between TNF-α, LOX-1 and Adiponectin in Apolipoprotein E Knockout Mice. J Vasc Res. 2015;52(6):372-82.
  64. Tang ZH, Li T, Tong YG, Chen XJ, Chen XP, Wang YT, Lu JJ. A Systematic Review of the Anticancer Properties of Compounds Isolated from Licorice (Gancao). Planta Med. 2015 Dec;81(18):1670-87.
  65. Wu C, Zhao W, Zhang X, Chen X*. Neocryptotanshinone inhibits lipopolysaccharide -induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9.
  66. Wu C, Chen J, Chen C, Wang W, Wen L, Gao K, Chen X, Xiong S, Zhao H, Li S. Wnt/β-catenin coupled with HIF-1α/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia. Sci Rep. 2015 Nov 5;5:16151.
  67. Gao H, Sun W, Zhao W, Hao W, Leung CH, Lu J, Chen X*. Total Tanshinones-Induced Apoptosis and Autophagy Via Reactive Oxygen Species in Lung Cancer 95D Cells. Am J Chin Med. 2015;43(6):1265-79.
  68. Zhang X, Luo W, Zhao W, Lu J, Chen X*. Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells. J Breast Cancer. 2015 Jun;18(2):112-8.
  69. Ren G, Sha T, Guo J, Li W, Lu J, Chen X*. Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells. J Nat Med. 2015 Oct;69(4):522-30.
  70. Guo S, Chen X*. The human Nox4: gene, structure, physiological function and pathological significance. J Drug Target. 2015 Dec;23(10):888-96.
  71. Ding Q, Bao J, Zhao W, Hu Y, Lu J, Chen X*. Natural autophagy regulators in cancer therapy: a review. Phytochem Rev. 2015(14):1,137-154.
  72. Chen SR, Chen XP, Lu JJ, Wang Y, Wang YT. Potent natural products and herbal medicines for treating liver fibrosis. Chin Med. 2015 Apr 15;10:7.
  73. Tang ZH, Zhang LL, Li T, Lu JH, Ma DL, Leung CH, Chen XP, Jiang HL, Wang YT, Lu JJ. Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells. Oncotarget. 2015 Dec 22;6(41): 43911 -26.
  74. Tang ZH, Li T, Tong YG, Chen XJ, Chen XP, Wang YT, Lu JJ. A Systematic Review of the Anticancer Properties of Compounds Isolated from Licorice (Gancao). Planta Med. 2015 Dec;81(18):1670-87.
  75. Li T, Tang ZH, Xu WS, Wu GS, Wang YF, Chang LL, Zhu H, Chen XP, Wang YT, Chen Y, Lu JJ. Platycodin D triggers autophagy through activation of extracellular signal-regulated kinase in hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2015 Feb 15;749:81-8.
  76. Li T, Xu XH, Tang ZH, Wang YF, Leung CH, Ma DL, Chen XP, Wang YT, Chen Y, Lu JJ. Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells. Acta Pharmacol Sin. 2015 Dec;36(12):1503-13.
  77. Xu W, Li T, Qiu JF, Wu SS, Huang MQ, Lin LG, Zhang QW, Chen XP, Lu JJ. Anti-proliferative activities of terpenoids isolated from Alisma orientalis and their structure-activity relationships. Anticancer Agents Med Chem. 2015;15(2):228-35.
  78. Lu L, Liu LJ, Chao WC, Zhong HJ, Wang M, Chen XP, Lu JJ, Li RN, Ma DL, Leung CH. Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity. Sci Rep. 2015 Sep 29;5:14544.
  79. Wang W, Kang TS, Chan PW, Lu JJ, Chen XP, Leung CH, Ma DL. A label-free G-quadruplex-based mercury detection assay employing the exonuclease III-mediated cleavage of T-Hg(2+)-T mismatched DNA. Sci Technol Adv Mater. 2015 Nov 17;16(6):065004.
  80. Tang ZH, Li T, Chang LL, Zhu H, Tong YG, Chen XP, Wang YT, Lu JJ. Glycyrrhetinic Acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cells. J Agric Food Chem. 2014 Dec 10;62(49): 11910-6.
  81. Chen X*, Guo J, Bao J, Lu J, Wang Y. The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review. Med Res Rev. 2014 Jul;34(4):768-94.
  82. Guo J, Wu G, Bao J, Hao W, Lu J, Chen X*. Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. PLoS One. 2014 Feb 4;9(2):e88140.
  83. Guo J, Zhao W, Hao W, Ren G, Lu J, Chen X*. Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in leukemia K562 cells. Anticancer Agents Med Chem. 2014;14(8):1146-53.
  84. Hao W, Zhang X, Zhao W, Chen X*. Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells. PeerJ. 2014 Sep 9;2:e555.
  85. Zhao W, Ma G, Chen X*. Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-κB pathway. Vascul Pharmacol. 2014 Dec;63(3):162-72.
  86. Tang ZH, Li T, Gao HW, Sun W, Chen XP, Wang YT, Lu JJ. Platycodin D from Platycodonis Radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells. Chin Med. 2014 Jun 9;9:16.
  87. Zhong Z, Tan W, Chen X, Wang Y. Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro. Eur J Pharmacol. 2014 Aug 15;737:1-10.
  88. Li T, Xu WS, Wu GS, Chen XP, Wang YT, Lu JJ. Platycodin D induces apoptosis, and inhibits adhesion, migration and invasion in HepG2 hepatocellular carcinoma cells. Asian Pac J Cancer Prev. 2014;15(4):1745-9.
  89. Zhu H, Liao SD, Shi JJ, Chang LL, Tong YG, Cao J, Fu YY, Chen XP, Ying MD, Yang B, He QJ, Lu JJ. DJ-1 mediates the resistance of cancer cells to dihydroartemisinin through reactive oxygen species removal. Free Radic Biol Med. 2014:S0891-5849 (14)00143-9.
  90. Xu WS, Li T, Wu GS, Dang YY, Hao WH, Chen XP, Lu JJ, Wang YT. Effects of furanodiene on 95-D lung cancer cells: apoptosis, autophagy and G1 phase cell cycle arrest. Am J Chin Med. 2014;42(1):243-55.
  91. Xu WS, Dang YY, Chen XP, Lu JJ, Wang YT. Furanodiene Presents Synergistic Anti-proliferative activity with paclitaxel via altering cell cycle and integrin signaling in 95-D lung cancer cells. Phytotherapy Research. 2014 Feb;28(2):296-9.
  92. Chen X, Lu J, Bao J, Guo J, Shi J, Wang Y. Adiponectin: a biomarker for rheumatoid arthritis? Cytokine Growth Factor Rev. 2013 Feb;24(1):83-9.
  93. Chen X*, Pei L, Lu J. Filling the gap between traditional Chinese medicine and modern medicine, are we heading to the right direction? Complement Ther Med. 2013 Jun;21(3):272-5.
  94. Chen X*. Target network analysis of adiponectin, a multifaceted adipokine. J Cell Biochem. 2013 May;114(5):1145-52.
  95. Kong Q, Sun F, Chen X*. Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation. Cell J. 2013 Summer;15(2):160-5.
  96. Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT. Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway. PLoS ONE. 2013 Oct 29;8(10): e76620.
  97. Wu GS, Guo JJ, Bao JL, Li XW, Chen XP, Lu JJ, Wang YT. Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum – a review. Expert Opin Investig Drugs. 2013;22(8):981-992.
  98. Wu GS, Lu JJ, Guo JJ, Huang MQ, Gan L, Chen XP, Wang YT. Synergistic anti-cancer activity by the combination of dihydroartemisinin and doxorubicin in breast cancer cells. Pharmacological Reports. 2013; 65 (2): 453-9.
  99. Huang MQ, Xu W, Wu SS, Lu JJ, Chen XP. A 90-day subchronic oral toxicity study of triterpene-enriched extract from Alismatis Rhizoma in rats. Food Chem Toxicol. 2013;58: 318-23.
  100. Dai D, Pei L, Tang L, Chen F, Chen X*. LC-MS/MS determination of bakkenolide D in rats plasma and its application in pharmacokinetic studies. Biomed Chromatogr.2013 Sep;27(9):1200-7.
  101. Pei L, Bao Y, Liu S, Zheng J, Chen X*. Material basis of Chinese herbal formulas explored by combining pharmacokinetics with network pharmacology. PLoS One. 2013;8(2):e57414.
  102. Xu Z, Wu G, Wei X, Chen X, Wang Y, Chen L. Celastrol induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells. Am J Chin Med. 2013;41(3):615-28.
  103. Chen X*, Bao J, Guo J, Ding Q, Lu J, Huang M, Wang Y. Biological activities and potential molecular targets of cucurbitacins: a focus on cancer. Anticancer Drugs. 2012 Sep;23(8):777-87.
  104. Huang M, Lu JJ, Huang MQ, Bao JL, Chen XP, Wang YT. Terpenoids: natural products for cancer therapy. Expert Opin Investig Drugs. 2012 Dec;21(12):1801-18.
  105. Huang M, Xie Y, Chen L, Chu K, Wu S, Lu J, Chen X, Wang Y, Lai X. Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza Bunge in diabetic rats. Phytother Res. 2012 Jun;26(6):944-8.
  106. Lu JJ, Bao JL, Chen XP, Huang M, Wang YT. Alkaloids isolated from natural herbs as the anti-cancer agents. Evid-Based Compl Alt. 2012.
  107. Lu JJ, Bao JL, Wu GS, Xu WS, Huang MQ, Chen XP, Wang YT. Quinones derived from plant secondary metabolites as anti-cancer agents. Anti-Cancer Agent Me. 2012, 13(3):456-63.
  108. Lu JJ, Dang YY, Huang M, Xu WS, Chen XP, Wang YT. Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae – A review. J Ethnopharmacol. 2012 143(2): 406-11.
  109. Xu WS, Dang YY, Guo JJ, Wu GS, Lu JJ, Chen XP, Wang YT. Furanodiene induces endoplasmic reticulum stress and presents antiproliferative activities in lung cancer cells. Evid Based Complement Alternat Med. 2012;2012:426521.
  110. Pei L, Bao Y, Ma L, Wang Q, Ye Y, Han X, Liu S, Chen X*. A Sensitive Method for Determination of Platycodin D in Rat Plasma Using Liquid Chromatography/Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study. Planta Med. 2011;78(3): 244-51.
  111. Pei L, Dai D, Bao Y, Chen F, Zheng J, Li J, Liu S, Chen X*. Determination of bakkenolide A in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. J Mass Spectrom. 2012 Aug;47(8):962-8.
  112. Pei L, Liu S, Zheng J, Chen X*. A sensitive method for determination of furanodiene in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. Biomed Chromatogr. 2012 Jul;26(7):826-32.
  113. Zhong ZF, Li YB, Wang SP, Tan W, Chen XP, Chen MW, Wang YT. Furanodiene enhances amoxifen-induced growth inhibitory activity of ERa-positive breast cancer cells in a PPARγ independent manner. J Cell Biochem. 2012;113(8):2643-51.
  114. Zhong Z, Dang Y, Yuan X, Guo W, Li Y, Tan W, Cui J, Lu J, Zhang Q, Chen X*, Wang Y*. Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo. Cell Physiol Biochem. 2012;30(3):778-90.
  115. Zhong ZF, Hoi PM, Wu GS, Xu ZT, Tan W, Chen XP, Cui L, Wu T, Wang YT. Anti-angiogenic effect of furanodiene on HUVECs in vitro and on zebrafish in vivo. J Ethnopharmacol. 2012 Jun 1;141 (2): 721-7.
  116. Wu G, Qian Z, Guo J, Hu D, Bao J, Xie J, Xu W, Lu J, Chen X, Wang Y. Ganoderma lucidum extract induces G1 cell cycle arrest, and apoptosis in human breast cancer cells. Am J Chin Med. 2012;40 (3):631-42.
  117. Wu GS, Lu JJ, Guo JJ, Li YB, Tan W, Dang YY, Zhong ZF, Xu ZT, Chen XP, Wang YT. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia.2012;83(2):408-14.
  118. Xu Z, Chen X, Fu S, Bao J, Dang Y, Huang M, Chen L, Wang Y. Dehydrocorydaline inhibits breast cancer cells proliferation by inducing apoptosis in MCF-7 cells. Am J Chin Med. 2012;40(1):177-85.
  119. Lai Y, Lu J, Chen X, Hu H, Wang Y. Analysis of Anti-cancer Traditional Chinese Medicine Injections based on Market Performance. Mode Tradit Chin Med Mater Med. 2012; 14(5): 1958–1962.
  120. Chen X, Guo J, Bao J, Xu W, Huang Y, Yitao Wang. Screening europrotective Agents Through 4-hydroxynonenal, Ethanol, High Glucose, Homocysteine, Okadaic Acid, Rotenone, and Oxygen-Glucose Deprivation Induced PC12 Injury Models: A Review. Current Psychopharmacology. 2012:1(1)103-110.
  121. Chen X, Pei L, Zhong Z, Guo J, Zhang Q, Wang Y. Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. Phytomedicine. 2011 Nov 15;18(14): 1238-43.
  122. Chen X, Zhong Z, Xu Z, Chen L, Wang Y. No protective effect of curcumin on hydrogen peroxide-induced cytotoxicity in HepG2 cells. Pharmacol Rep. 2011;63(3):724-32.
  123. Chen X, Xu Z, Wang Y. Recent advances in breast cancer metastasis suppressor 1. Int J Biol Markers. 2011; 26(1):1-8.
  124. Chen X, Sun F, Ma L, Wang J, Qin H, Du G. In vitro evaluation on the antioxidant capacity of triethylchebulate, an aglycone from Terminalia chebula Retz fruit. Indian J Pharmacol. 2011 May; 43(3):320-3.
  125. Sun Y, Chen X*. Ox-LDL-induced LOX-1 expression in vascular smooth muscle cells: role of reactive oxygen species. Fundam Clin Pharmacol. 2011;25(5):572-9.
  126. Chen X, Wang Y. Adiponectin and breast cancer. Med Oncol. 2011;28(4):1288-95.
  127. Zhong Z, Chen X, Tan W, Xu Z, Zhou K, Wu T, Cui L, Wang Y. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis. Eur J Pharmacol. 2011; 667(1-3):50-5.
  128. Xu Z, Chen X, Zhong Z, Chen L, Wang Y. Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities. Am J Chin Med. 2011;39(1):15-27.
  129. Xu Z, Chen X, Zhang Q, Chen L, Wang Y. Corydalis yanhusuo W.T. Wang extract inhibits MCF-7 cell proliferation by inducing cell cycle G2/M arrest. Am J Chin Med. 2011;39(3):579-86.
  130. Wu HL, Wang Y, Zhang P, Li SF, Chen X, Chen YK, Li JG, Yang SM, Su YP, Wang JP, Chen B. Reversible immortalization of rat pancreatic β cells with a novel immortalizing and tamoxifen-mediated self-recombination tricistronic vector. J Biotechnol. 2011;151(3): 231 -41.
  131. Tan W, Lu J, Huang M, Li Y, Chen M, Wu G, Gong J, Zhong Z, Xu Z, Dang Y, Guo J, Chen X*, Wang Y*. Anti-cancer natural products isolated from chinese medicinal herbs. Chin Med. 2011 Jul 22;6(1):27.
  132. Chen X, Zhong Z, Xu Z, Chen L, Wang Y. 2′,7′-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy. Free Radic Res. 2010; 44(6):587-604.
  133. Sun Y, Chen X*. Effect of adiponectin on apoptosis: pro-apoptosis or anti-apoptosis ? Biofactors. 2010;36(3):179-86.
  134. Chen X, Zhang H, McAfee S, Zhang C. The reciprocal relationship between adiponectin and LOX-1 in the regulation of endothelial dysfunction in ApoE knockout mice. Am J Physiol Heart Circ Physiol. 2010; 299(3):H605-12.
  135. Sun Y, Xun K, Wang C, Zhao H, Bi H, Chen X*, Wang Y. Adiponectin, an unlocking adipocytokine. Cardiovasc Ther. 2009 ;27(1):59-75.
  136. Sun Y, Xun K, Wang Y, Chen X*. A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs. Anticancer Drugs. 2009; 20(9):757-69.
  137. Chen X, Xun K, Chen L, Wang Y. TNF-alpha, a potent lipid metabolism regulator. Cell Biochem Funct. 2009 Oct;27(7):407-16.
  138. Zhang H, Park Y, Wu J, Chen X, Lee S, Yang J, Dellsperger KC, Zhang C. Role of TNF-alpha in vascular dysfunction. Clin Sci (Lond).2009;116 (3):219-30.
  139. Chen X, Zhang T, Du G. Advanced glycation end products serves as ligand for lectin-like oxidized low density lipoprotein receptor-1 (LOX-1): biochemical and binding characterizations assay. Cell Biochem Funct. 2008;17:1-11.
  140. Sun FY, Chen XP, Wang JH, Qin HL, Yang SR, Du GH. Arjunic Acid, a Strong Free Radical Scavenger from Terminalia arjuna. Am J Chin Med. 2008;36(1):197-207.
  141. Chen XP, Du GH. High-throughput screening for reactive oxygen species scavengers targeting mitochondria. Methods Find Exp Clin Pharmacol. 2008 May;30(4):255-60.
  142. Chen XP, Bradley T. AM Hill, CH Zhang. Role of Reactive Oxygen Species in Tumor Necrosis Factor-alpha Induced Endothelial Dysfunction. Current Hypertension Review. 2008;4(4): 245-255.
  143. Chen XP, Xun KL, Wu Q, Zhang TT, Shi JS, Du GH. Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein induced apoptosis in human umbilical vein endothelial cells: role of reactive oxygen species. Vascular pharmacology. 2007,47(1),1-9.
  144. Chen XP, DU GH. Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance. Chin Med J (Engl). 2007 Mar 5;120(5):421-6.
  145. Chen XP, Zhang TT, Du GH. Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis? Cardiovasc Drug Rev. 2007;25 (2):146- 61.
  146. Chen X, Du G. Target validation: A door to drug discovery. Drug Discov Ther 2007;1(1):23-29.
  147. Zhang TT, Huang ZT, Dai Y, Chen XP, Zhu P, Du GH. High-throughput fluorescence polarization method for identifying ligands of LOX-1. Acta Pharmacol Sin 2006;27(4): 447-52.
  148. Zhang T, Huang Z, Dai Y, Chen X, Zhu P, Du G.. The expression of recombinant human LOX-1 and identifying its mimic ligands by fluorescence polarization-based high throughput screening. J Biotechnol. 2006;125(4): 492-502.
  149. Shi JS, Yu JX, Chen XP, Xu RX. Pharmacological actions of Uncaria alkaloids, rhynchophylline and isorhynchophylline. Acta Pharmacol Sin. 2003;24(2):97-101.

Contact Details

State Key Laboratory of Quality Research in Chinese Medicine

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