Siu Wai LEUNG

Email

swleung@um.edu.mo

Tel

(853) 8822-8524

Office

N22-1012

Consultation Hours

Mon: 15:00~16:00
Fri: 15:00~16:00

Siu Wai LEUNG 梁少偉

Assistant Professor
PhD FRSB FRSPH

Academic Qualifications

  • BSc in Biochemistry, The Chinese University of Hong Kong
  • MPhil in Biochemistry, The Chinese University of Hong Kong
  • MSc in Artificial Intelligence, The University of Edinburgh, UK
  • PhD in Informatics (AI), The University of Edinburgh, UK

Teaching

PhD courses

  • Healthcare Decision Analysis (2013-4 and 2016-)
  • Research Ethics (2014-6)

MSc courses

  • Biomedical Informatics (2009-)
  • Computational Pharmacy (2015-)

Research Interests

  • Medical informatics for evidence-based medicine, particularly in artificial intelligence and knowledge management for translational medicine
  • Distributed multi-agent systems for scientific experimentation, particularly in automated experimentation
  • Data-intensive and social computing for evaluating scientific evidence, particularly in open systematic reviewing and open meta-analysis of clinical trials and omics experiments
  • Systems biology and pathway medicine, particularly in multi-level network modelling
  • Bioinformatics and structural biology, particularly in DNA linguistics for sequence assembly and structural modelling

Academic Positions

  • Fellow (FRSB), Royal Society of Biology, UK
  • Fellow (FRSPH), Royal Society for Public Health, UK
  • Honorary Fellow, College of Science and Engineering, University of Edinburgh, UK
  • Scientific Advisory Committee Member, Key Laboratory for Traditional Medicine Patent Information and Resources, State Administration of Traditional Chinese Medicine, China

Journal papers and book chapters (peer-reviewed)

  1. Zhu H and Leung S (2017) Identification of MicroRNA biomarkers by meta-analysis. In Mohini Gore and Umesh B Jagtap (eds) Computational Drug Discovery and Design, Methods in Molecular Biology series, Springer. (In press)
  2. Yuen C, Zhu H, and Leung S (2017) Building molecular interaction networks from microarray data for drug target screening. In Mohini Gore and Umesh B Jagtap (eds) Computational Drug Discovery and Design, Methods in Molecular Biology series, Springer. (In press)
  3. Jia Y and Leung S (2017) How Efficacious is Danshen (Salvia miltiorrhiza) Dripping Pill in Treating Angina Pectoris? Evidence Assessment for Meta-Analysis of Randomized Controlled Trials. Journal of Alternative and Complementary Medicine, 26(6):676-684.
    Available at: http://online.liebertpub.com/doi/pdfplus/10.1089/acm.2017.0069.
  4. Leung S and Hu H (eds.) (2016) Evidence-based research methods for Chinese medicine. ISBN 978-9811022890, Springer.
  5. Sun Y, Zhou H, Zhu H and Leung S (2016) Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products. Scientific Reports, 6, 19312.
    Available at: http://www.nature.com/articles/srep19312
  6. Jia Y, Zhu H and Leung S (2016) Comparative efficacy of selective serotonin reuptake inhibitors (SSRI) in treating major depressive disorder: a protocol for network meta-analysis of randomized controlled trials. BMJ Open. 6:e010142.
  7. Available at: doi:10.1136/bmjopen-2015-010142.
  8. Zhou Y, Zhu Y, and Leung S (2016) PLS-frailty model for cancer survival analysis based on gene expression profiles. In Abdi et al. (eds) The Multiple Facets of Partial Least Methods. ISBN 978-3319406411, Springer.
  9. Zhu Y, Zhu H, Leung S (2016) Is self-monitoring of blood glucose effective in improving glycemic control in type 2 diabetes without insulin treatment: a meta-analysis of randomized controlled trials. BMJ Open. 6:e010524.
    Available at: doi:10.1136/bmjopen-2015-010524.
  10. Zhu H and Leung S (2015) Identification of microRNA biomarkers in type 2 diabetes: a meta-analysis of controlled profiling studies. Diabetologia. 58:900-911.Available at: http://link.springer.com/article/10.1007/s00125-015-3510-2
  11. Jia Y and Leung S (2015) Comparative efficacy of tongxinluo capsule and beta-blockers in treating angina pectoris: meta-analysis of randomized controlled trials. Journal of Alternative and Complementary Medicine. 21(11): 686-99. Available at: http://online.liebertpub.com/doi/10.1089/acm.2014.0290
  12. Lao Y, Jia, Y, Leung S (2015) Glycemic control efficacy of oral anti-diabetic drugs in treating type 2 diabetes: a protocol for network meta-analysis. BMJ Open.
    Available at: http://bmjopen.bmj.com/content/5/3/e006139.full.pdf
  13. Chan K and Leung S (2015) Dynamic geometry software improves mathematical achievement: systematic review and meta-analysis. Journal of Educational Computing Research. 51(3): 311-325.
  14. Jia Y and Leung S (2014) Drug efficacy in treating angina pectoris: a protocol for network meta-analysis of randomised controlled trials. BMJ Open. 4:e005453.Available at: http://bmjopen.bmj.com/content/4/6/e005453.full.pdf
  15. Sun Y, Zhou Y, Chen X, Che W, Leung S (2014) The efficacy of dapagliflozin combined with hypoglycemic drugs in treating type 2 diabetes: meta-analysis of randomized controlled trials. BMJ Open. 4:e004619.Available at: http://bmjopen.bmj.com/content/4/4/e004619.full.pdf
  16. Zhu H, Zhu S, Zhang X, Guo Y, Shi Y, Chen Z, Leung S (2013) Comparative efficacy of glimepiride and metformin in monotherapy of type 2 diabetes mellitus: meta-analysis of randomized controlled trials. Diabetology & Metabolic Syndrome. 5(1):70. Available at: http://www.biomedcentral.com/content/pdf/1758-5996-5-70.pdf
  17. Sun Y, Zhou Y, Chen X, Che W, Leung S (2013) The efficacy of dapagliflozin combined with hypoglycemic drugs in treating type 2 diabetes: protocol for meta-analysis of randomized controlled trials. Systematic Reviews. 2(1):103. Available at: http://www.biomedcentral.com/content/pdf/2046-4053-2-103.pdf
  18. Jia Y, Leung S, Lee MY, Cui G, Huang X, Pan F (2013) The efficacy of Guanxinning injection in treating angina pectoris: systematic review and meta-analysis of randomized controlled trials. Evidence-based Complementary and Alternative Medicine. 2013:282707.Available at: http://dx.doi.org/10.1155/2013/282707
  19. Jia Y, Chen C, Ng CS, Leung S (2012) Meta-Analysis of randomized controlled trials on the efficacy of di’ao xinxuekang capsule and isosorbide dinitrate in treating angina pectoris. Evidence-based Complementary and Alternative Medicine. 2012:9041-47. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgiartid=3310218&tool=pmcentrez&rendertype=abstract
  20. Jia Y, Huang F, Zhang S, Leung S (2012) Is danshen (Salvia miltiorrhiza) dripping pill more effective than isosorbide dinitrate in treating angina pectoris? A systematic review of randomized controlled trials. International Journal of Cardiology. 157(3):330–40.Available at: http://www.ncbi.nlm.nih.gov/pubmed/21251721
  21. Leung S, Lee J, Johnson C, Robertson D (2012) Design preferences and cognitive styles: experimentation by automated website synthesis. Automated Experimentation. 4:2. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386886/?tool=pmcentrez&rendertype=abstract
  22. Jia Y, Zhang S, Huang F, Leung S (2012) Could ginseng-based medicines be better than nitrates in treating ischemic heart disease? A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine. 20(3):155–66. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22500665
  23. Ng C, Wang S, Cheong J, et al. (2012) Systematic review and meta-analysis of randomized controlled trials comparing Chinese patent medicines compound danshen dripping pills and di’ao xinxuekang in treating angina pectoris. Journal of Chinese Integrative Medicine. 10(1):25–34. Available at: http://www.jcimjournal.com/en/showAbstrPage.aspx?articleID=jcim20120105
  24. Jia Y, Huang F, Zhang S, Leung S (2012) Assessment of the quality of randomized controlled trials in treating coronary heart disease by Chinese patent medicine. Chinese Journal of Integrated Traditional and Western Medicine. 32(4):560-68. Available at: http://www.ncbi.nlm.nih.gov /pubmed/22803444
  25. Jia Y, Bao F, Huang F, Leung S (2011) Is tongxinluo more effective than isosorbide dinitrate in treating angina pectoris? A systematic review and meta-analysis of randomized controlled trials. Journal of Alternative and Complementary Medicine. 17(12):1109–17. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22132707
  26. Jia Y, Zhang S, Bao F, Huang F, Leung S (2011) Indirect comparison of tongxinluo capsule and danshen dripping pill for angina pectoris: a systematic review. Chinese Journal of Evidence-based Medicine. 11(8):919-31.
    Available at: http://www.crd.york.ac.uk/crdweb/ShowRecord.asp? LinkFrom=OAI&ID=12011005718
  27. Leung S, Quan X, Besana P, et al. (2011) OpenKnowledge for peer-to-peer experimentation in protein identification by MS/MS. Automated Experimentation. 3(1):3.
    Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3377912&tool=pmcentrez&rendertype=abstract

  1. Jia Y and Leung S (2017) Efficacy of Chinese herbal drugs for angina pectoris: a frequentist network meta-analysis. The Lancet-CAMS Health Summit 2017. 10-12 December, Beijing, China. (Poster)
  2. Guo G, Jia Y, and Leung S (2017) Is Dengzhanxixin injection more effective than nitrates in treating angina pectoris? A meta-analysis of randomized controlled trials. The 16th Meeting of Consortium for Globalization of Chinese Medicine. 18-20 August, Guangzhou, China. (Invited talk and poster)
  3. Wei W, Zhu H, and Leung S (2017) Meta-analysis of differential expression of non-coding RNAs in ovarian cancer for discovering drug targets of natural products. The 16th Meeting of Consortium for Globalization of Chinese Medicine. 18-20 August, Guangzhou, China. (Invited talk and poster)
  4. Leung S (2017) Promoting awareness of ethical authorship. 1st COPE (Committee on Publication Ethics) Beijing Seminar. 26 March, Beijing, China. (Invited talk)
  5. Leung S (2016) “Chinese Medicine” practices in publication ethics. Springer Nature Editors Conference. 28 April, Shanghai, China. (Invited talk)
  6. Jia Y and Leung S (2016) The assessment of evidence assessment from meta-analysis on Chinese herbal drugs. The 15th Meeting of Consortium for Globalization of Chinese Medicine. Taipei, Taiwan. (Invited talk and poster).
  7. Zhu H and Leung S (2016) Meta-analysis of case-controlled gene expression profiles to identify biomarkers for ovarian cancer. The 9th Asia-pacific Conference on Evidence-Based Medicine. 27-29 May, Chengdu, China. (Oral presentation honoured with the Excellent Presentation Award)
  8. Jia Y, Li N, and Leung S (2016) Efficacy of thiazolidinediones in treating type 2 diabetes: Bayesian and Frequentist multi-level meta-analyses of randomized control trials. The 9th Asia-Pacific Conference on Evidence-Based Medicine. 27-29 May, Chengdu, China. (Oral presentation)
  9. Leung S (2015) Publication ethics ensure research integrity: the roles of the Chinese Medicine journal. Springer Nature Open Research Day Workshop. 20 October, Beijing, China. (Invited talk)
  10. Zhu H and Leung S (2015) Meta-analysis on the association between microRNAs and type 2 diabetes mellitus. The 14th Meeting of Consortium on Globalization of Chinese Medicine. 17-20 August, London, Ontario, Canada. (Invited talk)
  11. Jia Y and Leung S (2015) Comparative efficacies of Chinese herbal medicine and nitrates in treating stable angina pectoris: network meta-analysis of randomized controlled trials. The 2nd International Conference of Traditional and Complementary Medicine on Health. Taipei, Taiwan. (Poster)
  12. Jia Y and Leung S (2015) Comparative efficacy of chemical drugs and Chinese herbal drugs in treating stable angina pectoris: a network meta-analysis of randomized controlled trials. The 8th Asia-Pacific Conference on Evidence-Based Medicine. Chongqing, China. (Oral presentation)
  13. Leung S (2014) Chinese medicine works. IEEE Conference on Medical Informatics for Chinese Medicine. 17-20 December, Guangzhou, China. (Invited keynote presentation)
  14. Jia Y and Leung S (2014) Efficacy of tongxinluo in treating angina pectoris: a meta-analysis of randomized controlled trials. The 13th Meeting of Consortium on Globalization of Chinese Medicine. 26-29 August, Beijing, China. (Invited talk)
  15. Zhou Y and Leung S (2014) Partial least squares components representing frailty improve survival analysis with gene expression profiles. International Conference on Partial Least Squares and Related Methods. 26-28 May, Paris, France.
  16. Li N, Lao Y, Jia, Y, Leung S (2013) A multilevel model framework for network meta-analysis. International Conference on Evaluation of Post-marketing of Chinese Medicine. 16-18 October, Beijing, China. (Invited plenary talk)
  17. Li N, Lao Y, Leung S (2013) Multilevel models for network meta-analysis. World Statistics Congress. 25-30 August, Hong Kong SAR, China.
  18. Leung S (2012) Open systematic reviewing for Chinese medicine. Summit Forum on Chinese Medicine and Natural Products. 2-4 November, Haikou, Hainan, China. (Invited plenary talk)
  19. Leung S (2012) Correcting statistical reporting errors of CHINESE MEDICINE. World Congress on Good Medical Research. 6-9 June, Vienna, Austria.
  20. Leung S (2011) Evidence-based, integrative, and systems approaches to Chinese medicine. The 4th CLSS-UK (Chinese Life Scientists Society in UK) North Life Science Symposium. 25 June. Edinburgh, UK. (Invited talk)
  21. Leung S (2010) Open systematic reviewing. International Workshop on Computational Ecology. 30 November-3 December, Okinawa, Japan. (Invited talk)
  22. Gerloff D, Quan X, de Pinninck A, Besana P, Leung S, Schorlemmer M, Robertson D (2009)  Bioinformatics experimentation in a new agent-based infrastructure OpenKnowledge. Network Tools and Applications in Biology (NETTAB) Workshop. 10-13 June, Catania, Sicily, Italy.
  23. Leung S (2009) Open and distributed technologies for evidence-based medicine. Conference on Evidence-Based Medicine and Traditional Chinese Medicine. 22-24 May, Guangzhou, China. (Invited talk)
  24. Leung S (2008) Experimentation with DNA grammars in analysing E. coli promoter sequences. Living Texts: Textual Analysis and Biology. 16-17 October, Edinburgh, UK. (Invited talk)