Simon, Ming-Yuen LEE 李銘源
•BSc (Hon), City University of Hong Kong
•PhD, The Chinese University of Hong Kong
1.Healthcare Decision Analysis
3.Pharmacology and Safety Evaluation (MCMC101)
•Biochemistry of cancer, cardiovascular and neurodegenerative diseases.
•Molecular pharmacology of Chinese medicine.
•Systems biology: genome, transcriptome, proteome and protein interaction network
Selected Publications(total: over 90)
Omics and Cross-disciplinary Collaboration
1.Li CW, Yu G, Jiang J, Lee SM, Yi C, Yue W, Yang M. A microfluidic linear node array for the study of protein-ligand interactions. Lab on a Chip. 2014 Sep 16;14(20):3993-9.
2.Ma, DL, He, HZ, Zhong HJ, Lin S, Chan, Daniel, Wang L, Lee, SM.Y, Leung, CH, Wong CY. Visualization of Zn2+ Ions in Live Zebrafish Using a Luminescent Iridium(III) Chemosensor. ACS Applied Materials & Interfaces. 2014 Aug 27;6(16):14008-15. Epub 2014 Aug 1.
3.Alba F.C. Torres, Cheng Huang, Cheong Meng Chong, Siu Wai Leung, Alvaro R. B. Prieto-da-Silva, Alexandre Havt, Yves P. Quinet, Alice M. C. Martins, Simon M. Y. Lee* & Gandhi Radis-Baptista*. Transcriptome analysis in venom gland of the predatory giant ant Dinoponera quadriceps: insights into the polypeptide toxin arsenal of hymenopterans. PLoS ONE. 2013 Jan 31;9(1):e87556.
4.Li ZH, Alex D, Siu SO, Chu IK, Renn J, Winkler C, Lou S, Tsui SK, Zhao HY, Yan WR, Mahady GB, Li GH, Kwan YW, Wang YT, Lee SM*. Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Mol Biosyst. 2011 7:2128-38. (Cover page, hot article)
5.S. Li, S. Lou, B. Lei, T.F. Chan, Y.W. Kwan, S.W. Chan, G. P.H. Leung, S.K.W. Tsui *, Lee S.M.**. Transcriptional Profiling of Angiogenesis Activities of Calycosin in Zebrafish. Mol BioSyst. 2011 7 (11): 312-3121.
6.Siu SO, Lam MP, Lau E, Kong RP, Lee SM, Chu IK*. Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics. Proteomics. 2011 Mar 29. doi:10.1002/pmic.201100110.
7.Kong RP, Siu SO, Lee SM, Lo C, Chu IK*. Development of online high-/low-pH reversed-phase-reversed-phase two-dimensional liquid chromatography for shotgun proteomics: A reversed-phase-strong cation exchange-reversed-phase approach. J Chromatogr A. 2011 Jun 10;1218(23):3681-8.
8.Rodriguez AA, Cassoli JS, Sa F, Dong ZQ, Freitas JC , Pimenta AMC, Lima ME, Konno K, Lee SM, Garateix A and Zaharenko AJ. Peptide fingerprinting of the neurotoxic fractions isolated from the secretions of sea anemones Stichodactyla helianthus and Bunodosoma granulifera. New members of the APETxlike family identified by a 454 pyrosequencing approach. Peptides.2012 Mar;34 (1):26-38.
9.Zhao H, Deneau J, Che GO, Li S, Vagnini F, Azadi P, Sonon R, Lee SM, Bojanowski K. Angelica sinensis Isolate SBD.4: Composition, Gene Expression Profiling, Mechanism of Action, and Effect on Wounds in Rats and Humans. Eur J Dermatol. 2012 Jan-Feb;22(1):58-67.?
10.Wong CH, Fung YW, Ng EK, Lee SM, Waye MM, Tsui SK*. LIM domain protein FHL1B interacts with PP2A catalytic β subunit -A novel cell cycle regulatory pathway. FEBS Lett. 2010 Nov 19; 584(22):4511-6.
11.Mils V, Lee SM, Joly W, Wong EW, Baldin V, Waye MM, Ducommun B, and Tsui SK. The LIM-only protein FHL3 interacts with CDC25B2 Phosphatase. Experimental Cell Research. 2003;285:99-106
12.Ng EK, Chan KK, Wong CH, Tsui SK, Ngai SM, Lee SM, Kotaka M, Lee CY, Waye MM, Fung KP. Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220. J Cell Biochem.2002; 84:556-66.
13.Li HY, Kotaka M, Kostin S, Lee SM, Kok LD, Chan KK, Tsui SK, Schaper J, Zimmermann R, Lee CY, Fung KP, Waye MM. Translocation of a human focal adhesion LIM-only protein, FHL2, during myofibrillogenesis and identification of LIM2 as the principal determinants of FHL2 focal adhesion localization. Cell Motil Cytoskeleton. 2001 Jan;48(1):11-23.
1.Chong CM, Shen M, Zhou ZY, Pan P, Hoi PM, Li S, Liang W, Ai N, Zhang LQ, Li CW, Yu H, Hou T*, Lee SM*. Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP(+)-induced oxidative stress and cell death in SH-SY5Y cells. Free Radical Biology and Medicine 2014 Sep;74:283-93.
2.Cui W, Zhang ZJ, Hu SQ, Mak SH, Xu DP, Choi CL, Lee MY*, Wang YQ, Tsim KWK, Rong JH & Han YF*. Sunitinib Produces Neuroprotective Effect Via Inhibiting Nitric Oxide Overproduction. CNS Neuroscience & Therapeutics. 2014 Mar;20(3):244-252.
3.Zhang Z, Lai D, Wang L, Yu P, Zhu L, Guo B, Xu L, Zhou L, Sun Y, Lee SM*, Wang Y*. Neuroprotective effects of the andrographolide analogue AL-1 in the MPP+/MPTP-induced Parkinson’s disease model in vitro and in mice. Pharmacology Biochemistry and Behavior. 2014 Apr 11; 122(2014):191-202
4.Wang Y, Hoi PM, Chan JYW* and Lee SMY*. New perspective on the dual functions of indirubins in cancer therapy and neuroprotection. Anti-Cancer Agents in Medicinal Chemistry. 2014;14(9):1213-9.
5.Zhong HJ, Liu LJ, Chong CM, Lu L, Wang M, Chan DS, Chan PW, Lee SM, Ma DL, Leung CH. Discovery of a Natural Product-Like iNOS Inhibitor by Molecular Docking with Potential Neuroprotective Effects In Vivo. PLoS One. 2014 Apr 1;9(4):e92905.
6.Yang X, Miao XQ, Cao FR, Li S, Ai NN, Chang Q, Lee SMY, Zheng Y. Nanosuspension development of Scutellarein as an active and rapid orally absorbed precursor of its BSC Class IV glycoside scutellarin. Journal of Pharmaceutical Sciences. 2014 Nov;103(11):3576-84.
7.Xu D, Duan H, Zhang Z, Cui W, Wang L, Sun Y, Lang M, Hoi PM, Han Y, Wang Y, Lee SM*. The Novel Tetramethylpyrazine Bis-nitrone (TN-2) Protects Against MPTP/MPP+-Induced Neurotoxicity via Inhibition of Mitochondrial-Dependent Apoptosis. Journal of Neuroimmune Pharmacology. 2013 Nov 14. [Epub ahead of print]
8.Shen M, Yu H, Li Y, Li P, Pan P, Zhou S, Zhang L, Li S, Lee SM*, Hou T*. Discovery of Rho-kinase inhibitors by docking-based virtual screening. . Mol BioSyst.. 2013 Jun;9(6):1511-21
9.Chong CM, Zhoua ZY, Razmovski-Naumovski V, Cui GZ, Zhang LQ, Sa F, Hoi PM, Chan K,* and Lee SM*. Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish. Neuroscience Letters. 2013 May 24;543:121-5.
10.Cui W, Zhang ZJ, Li WM, Han RW, Mak SH, Zhang H, Hu SQ, Yuan S, Li S, Rong JH, Ma ED, Lee SM*, and Han YF*. Unexpected protection against MPP+-induced neurotoxicity via selectively and directly inhibiting neuronal NOS by anti-cancer agent SU4312. British Journal of Pharmacology 2012 Oct 12.
11.Cui W, Zhang ZJ, Li WM, Han RW, Mak SH, Zhang H, Hu SQ, Yuan S, Li S, Rong JH, Ma ED, Lee SM*, and Han YF*. Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase. PloS One. 2012 Sept 25; 7(9); e46253.
12.W. Cui, G.Z. Cui, W. Li, Z. Zhang, S. Hu, S. Mak, H. Zhang, P.R. Carlier, C.L. Choi, Y.T. Wong, S.M. Lee*, Y. Han*. Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR. Brain Res 1401 (2011) 10-17.
Cardiovascular and metabolic diseases
1.Li, S., Dang, Y. Y., Che, G. O., Kwan, Y. W., Chan, S. W., Leung, G. P., Lee SMY*, Hoi MPM* (2014). VEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservation. Toxicol Appl Pharmacol. (In press)
2.Li S, Zhou XL, Dang YY, Kwan YW, Chan SW, Leung GPH, Lee SMY*, Hoi MPM*. Basal Flt1 tyrosine kinase activity is a positive regulator of endothelial survival and vascularization during zebrafish embryogenesis. Biochimica et Biophysica Acta (BBA) (In press)
3.Li RW, Yang C, Sit AS, Kwan YW, Lee SM, Hoi MP, Chan SW, Hausman M, Vanhoutte PM, Leung GP. Uptake and protective effects of ergothioneine in human endothelial cells. Journal of Pharmacology and Experimental Therapeutics. 2014 Sep;350(3):691-700.
4.Zhang ZR, Li JH, Li S, Liu AL, Hoi PM, Tian HY, Ye WC, Lee SM*, Jiang RW*. In vivo Angiogenesis Screening and Mechanism of Action of Novel Tanshinone Derivatives Produced by One-pot Combinatorial Modification of Natural Tanshinone Mixture from Salvia Miltiorrhiza. PLoS One. 2014 Jul 3;9(7):e100416.
5.Cui GZ, Shan LC*, Hung MW, Lei SW, Choi IL, Zhang ZJ, Yu P, Hoi PM*, Wang YQ and Lee SM*. A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways, International Journal of Cardiology. 2013 Jan 3. pii: S0167-5273(12)01640-3
6.Seto SW, Au AL, Poon CC, Zhang Q, Li RW, Yeung JH, Kong SK, Ngai SM, Wan S, Ho HP, Lee SM, Hoi MP, Chan SW, Leung GP*, Kwan YW*. Acute simvastatin inhibits KATP channels of porcine coronary artery myocytes. PLoS One. 2013 Jun 17;8(6):e66404.
7.Li RWS, Yang C, Kwan YW, Chan SW, Lee SMY, Leun GPH*. Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Frontiers in Cardiovascular and Smooth Muscle Pharmacology. 2013;4:14. doi: 10.3389/fphar.2013.00014. Epub 2013 Feb 12.
8.Chan E, Chan JY, Wu JH, Wan CW, Leung GP, Lee SM, Kwan YW, Chan SW. Serum nitric oxide synthase activity is a novel predictor of impaired vasorelaxation in rats. Clinical and Experimental Pharmacology and Physiology. 2012 Jul 24. doi: 10.1111/j.1440-1681.2012.05748.x.
9.?Hu G, Mahady GB, Li S, Hoi MPM, Wang YH and Lee SM*. Polysaccharides from Astragali Radix restore chemical-induced blood vessel loss in zebrafish. Vascular Cell. 2012 Feb 23; 4(1):2.
10.Tang JY#, Li S#, Li ZH, Zhang ZJ, Hu G, Cheang LCV, Alex D, Hoi PM, Kwan YW, Chan SW, Leung G.P.H., Lee SM*, Calycosin Promotes Angiogenesis involving Estrogen Receptor and Mitogen-activated Protein Kinase (MAPK) Signaling Pathway in Zebrafish and HUVEC, PLoS One. 2010 Jul 29; 5(7):e11822
11.Poon CC, Seto SW, Au AL, Zhang Q, Li RW, Lee WY, Leung GP, Kong SK, Yeung JH, Ngai SM, Ho HP, Lee SM, Chan SW, Kwan YW*. Mitochondrial monoamine oxidase-A-mediated hydrogen peroxide generation enhances 5-hydroxytryptamine-induced contraction of rat basilar artery. British Journal of Pharmacology. 2010 Nov 161(5):1086-98.
12.Wu JH, Li Q, Wu MY, Guo DJ, Chen HL, Chen SL, Seto SW, Au AL, Poon CC, LeungGP, Lee SM, Kwan YW, Chan SW. Formononetin, an isoflavone, relaxes rat isolatedaorta through endothelium-dependent and endothelium-independent pathways. J Nutr Biochem. 2010 Jul; 21(7):613-20. [Epub 2009 Jun 29]
13.Seto SW, Lam TY, Or PM, Lee WY, Au AL, Poon CC, Li RW, Chan SW, Yeung JH, Leung GP, Lee SM, Ngai SM, Kwan YW. Folic acid consumption reduces resistin level and restores blunted acetylcholine-induced aortic relaxation in obese/diabetic mice. J Nutr Biochem. 2010 Sep; 21(9):872-80.
14.Yang C, Kwan YW, Au AL, Poon CC, Zhang Q, Chan SW, Lee SM, Leung GP.14,15 -Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP (2) receptors in rat mesenteric artery. Prostaglandins Other Lipid Mediat. 2010 Sep; 93(1-2):44-51.
15.Li RW, Seto SW, Au AL, Kwan YW, Chan SW, Lee SM, Tse CM, Leung GP. Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells. Eur J Pharmacol. 2009 612:15-20.
16.Seto SW, Lam HY, Lau WS, Au AL, Lam TY, Chim SS, Ngai SM, Chan SW, Leung TY, Yeung JH, Kong SK, Leung GP, Lee SM, Kwan YW. Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery. Eur J Pharmacol. 2009 605:129-37.
17. Lam HW, Lin RHC, Leong CW, Hong SJ, Lao SC, Gao JL, Yue P, Kwan YW, Leung AY, Wang YT, Lee SM *. The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo. Journal of Cellular Biochemistry.2008 103:195-211 (Cover page)
18.Seto SW, Au AL, Lam TY, SS Chim, Lee SM., Wan S, Tjiu DC, Shigemura N, Yim AP, Chan SW, Tsui, SK, Leung GP, Kwan YW,. Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. British Journal of Pharmacology 2007; 151:187-197
19.Leong CW, Wong CH, Lao SC, Leong EC, Lao IF, Law PT, Fung KP, Tsang KS, Waye MM, Tsui SK, Wang YT, Lee SM *. Effect of resveratrol on proliferation and differentiation of embryonic cardiomyoblasts. Biochem Biophys Res Commun. 2007 360:173-80.
20.Au AL, Kwok CC, Lee AT, Kwan YW, Lee MM, Zhang RZ, Ngai SM, Lee SM, He GW, Fung KP. Activation of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcineisolated left anterior descending coronary artery by diosgenin. Eur J Pharmacol. 2004;502:123-33.
1.Lam IK, Alex D, Liu AL, Du GH,Wang YH*, Lee SM*.In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel anti-angiogenesis agent. Molecular Nutrition and Food Research. 2012 Jun;56(6):945-56.
2.Leung CH, Chan DS, Yang H, Abagyan R, Lee SM, Zhu GY, Fong WF, Ma DL. A natural product-like inhibitor of NEDD8-activating enzyme. Chem Commun (Camb).2011 Jan 14. [Epub ahead of print]
3.Lam KH, Alex D, Lam IK, Tsui SK, Yang ZF, Lee SM*. Nobiletin,a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model. J Cell Biochem. 2011 Jul 11.
4.Alex D., Leong E.C., Zhang ZJ, Li ZH, Lin HK, Wan SH, Wang YT, Lee SM*. Resveratrol derivative, trans-3,5,4-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation. J Cell Biochem. 2010; 109(2):339-46.
5.Alex D, Lam IK, Lin Z, Lee SM*. Indirubin shows anti-angiogenic activity in an in vivo zebrafish model and an in vitro HUVEC model. J Ethnopharmacol. 2010 Sep 15; 131(2):242-7.
6.Sai F, Gao JL, Fung KP, Zheng Y, Lee SM *, Wang YT. Anticancer effect and apoptosis induction of Smilax Glabra Roxb. extract on hepatoma cell line HepG2 and Hep3B. Chemical and Biological Interaction. 2008 171:1-14.
7.Xiao Y, Yang FQ, Li SP, Fung KP, Hu G, Conceicao Leong, Gao JL, Lao SC, Wang YT, Lee SM *. Furanodiene induces G2/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells. Cancer Biology & Therapy 2007 6:993-1150
1.Leung RK, Dong ZQ, Sa F, Chong CM, Lei SW, Tsui SK*, Lee SM*. Quick, Sensitive and Specific Detection and Evaluation of Quantification of Minor Variants by High-throughput Sequencing. Molecular BioSystems, 2013 Nov 22. [Epub ahead of print] (Cover page and hot article)
2.Yang F, Zhou WL, Liu AL, Qin HL, Lee SM, Wang YT, Du GH. The Protective Effect of 3-Deoxysappanchalcone on In Vitro Influenza Virus-induced Apoptosis and Inflammation. Planta Medica. 2012 Jun;78(10):968-73.
3.Liu AL, Yang F, Zhu M, Zhou D, Lin M, Lee SM*, Wang YT, Du GH. In Vitro Anti-influenza Viral Activities of Stilbenoids from the Lianas of Gnetum pendulum. Planta Med. 2010 Jun 10. [Epub ahead of print]
4.Liu AL, Su SH, Qin HL, Wang HD, Lee SM *, Wang YT, Du GH*. Anti-influenza Viral Constituents from Caesalpinia sappan. 2009. Planta Medica. 75:337-9.
5.Liu AL, Liu B, Qin HL, Lee SM *, Wang YT, Du GH*. Anti-influenza Virus Activities of Flavonoids from the Medicinal Plant Elsholtzia rugulos. 2008. Planta Medica. 74:847-851
6.Liu AL, Wang HD, Lee SM *, Wang YT, Du GH*. Structure-activity Relationship of Flavonoids Against Influenza Virus Neuraminidase. Bioorganic & Medicinal Chemistry 16:7141-7147.
7.Lam WY, Leung KT, Law PT, Lee SM, Chan HL, Fung KP, Ooi VE, Waye MM. Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis. J Cell Biochem. 2005; 97:795-812.
8.Ng R.K., Lau C.Y., Lee SM, Tsui S.K., Fung K.P., Waye M.M. cDNA microarray analysis of early gene expression profiles associated with hepatitis B virus X protein-mediated hepatocarcinogenesis. Biochem Biophys Res Commun. 2004; 322:827-35.
External Competitive Research Grants
1.基於斑馬魚平臺結合多種模型系統研究三七花皂?促血管新生作用及機制, (國家自然科學基金-海外及港澳學者合作研究基金, 2014-1015, P.I.)
2.Novel anti-Parkinson’s leads: pharmacological elucidation of multi-targeted neuroprotections by sunitinib analogs including the natural components from Chinese medicine, , funded by Research Grants Council Earmarked Grants in Hong Kong, 2014 – 2016, Co.I.
4.基於血管生成及腫瘤轉移相關優化”金复康”的研究 (上海市巿屬博士學科點建設基金, 2014, Co.I.)
5.A study on synergistic bone anabolic effects of a combination use of Alendronate and Herba Epimedii in treating osteoporosis of ovariactomized rats, funded by Health and Medical Research Fund, 2012 – 2014, Co.I.
6.Unexpected anti-Parkinson’s neuroprotective and its molecular targets of Sunitinib, a clinical used anti-cancer drug, funded by National Natural Science Foundation, 2013 – 2015, Co.I.
7.Characterization, structural optimization and mechanistic study of the neuroprotective components from Chinese medicine for minimising and treating Parkinson’s disease complications, funded by Science and Technology Development Fund, 2012 – 2015, P.I.
8.Mechanistic studies of active compounds-combination from Chinese medicine for minimising and treating cardio-cerebrovascular complications, funded by Science and Technology Development Fund, 2011 – 2014, P.I.
9.粵澳斑馬魚藥物篩選?發平台的?究(廣州市科技計劃項目, 2011, Co.I)
10.Establishment of a DNA sequencing and bioinformatics analysis platform for genome and transcriptome analysis, funded by Science and Technology Development Fund, 2010 – 2013, P.I.
11. Characterization and mechanistic study of the bioactive components from selected Chinese medicine for proangiogenic and neuroprotective activities, funded by Science and Technology Development Fund, 2008 – 2011, P.I.
12.The theoretical pharmacology study on Chinese Herbs: Tianma and Gouteng (天麻、鉤藤歸經理論研究) funded by National Natural Science Foundation, 2009 – 2012, Co.I.
13.The discovery and mechanism study of angiogenesis inhibitors from three Salvia herbal medicine funded by National Natural Science Foundation, 2010 – 2013, Co.I.
14.A study on molecular mechanism of anti-influenza virus effect of Chinese Medicine with second-generation DNA sequencing technology funded by Open Research Grant-Guangzhou Institute of Respiratory Disease, 2010 – 2012, Co.I.
15.Study on the active ingredients and mechanism of action of Chinese medicine on treatment of atherosclerosis, funded by Science and Technology Development Fund, 2005 – 2008, P.I. with Prof YiTao Wang.
16.Characterization and mechanistic study of the bioactive components from TCM for the anti-proliferative Effect on Human Hepatoma Cells in vitro and in Vivo, funded by Science and Technology Development Fund, 2006 – 2007, P.I.
17.Characterization and mechanistic study of the bioactive components from selected Chinese medicine for anti-breast cancer activities using system biology approach, funded by Science and Technology Development Fund, 2008 – 2011, Co.I.
18.Study of the effects of Herba Epimedii (Yinyanghuo) and Fructus Ligustri Lucidi (Nvzhenzi) on bone and mineral metabolism, funded by Research Grants Council Earmarked Grants in Hong Kong, 2004 – 2006, Co.I.
19.Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis, funded by Research Grants Council Earmarked Grants in Hong Kong, 2003 – 2006, Co.I.
•Founder member of BioEdu programme, funded by Education and Youth Affairs Bureau, Macau SAR Government. (2007-present).
•Vice President of Director Board, Macao Association for Promotion of Science and Technology (2013-present). ?
•Macao-PISA 2008 Science Education Study for Education and Youth Affairs Bureau, Macau SAR Government.
•Member of Scientific Review Committee, Macao Regional Science Fair (affiliation of Intel International Science and Engineering Fair) funded by Education and Youth Affairs Bureau, Macau SAR Government. (2010-present).
•Technical expert of an ISO/IEC 17025 accreditation assessment. Innovation and Technology Commission (ITC), Hong Kong SAR Government (2012-2015).
•Board Member of International Society for Chinese Medicine (2012-present).
•Member of TCM Pharmacology Committee, Chinese Medicine Pharmacological Society World Federation of Chinese Medicine Societies (2012-present).
•Member of Organizing Committee, Distinguished Chinese Scientists Public Lecture Series (2008-present).
•Exhibition of “Application of zebrafish in drug screening for treatment of cardiovascular diseases” which is selected as popular research projects in an activity entitled “Science is by your side: Vote for Your Favourite Local Science Researches”, for Macao Science Center.
•Reviewer editor of Frontiers in Cardiovascular and Smooth Muscle Pharmacology (2010-2013), editorial board member of Journal of Biochemistry – Molecular Biology in the Post-genomic Era (2010-2013) and Chinese Medicine (2013-2015)
•Add-hoc reviewers of over 20 international referred journals (e.g Angiogenesis, Journal of Cellular and Molecular Medicine, European Journal of Medicinal Chemistry, Cell Proliferation, PLoS One, Cancer Science, Caner Investigation, Virology Journal, Journal of Cellular Biochemistry, Basic & Clinical Pharmacology & Toxicology, Journal of Pharmacology and Experimental Therapeutics, Chinese Medicine, Evidence Based Complementary and Alternative Medicine).
Selected Awards and Honors
1. Wang YT, Lee SMY, Chen XP, Chen MW and Lu JJ. Macao Science and Technology Award 2012 – Second Class Prize in Natural Science Award Category
2.Lee SMY. The 16th Chinese Pharmacological Society – Servier Award for young investigator in pharmacology, 2012
3.Zhang ZJ, Macao Science and Technology Award 2012 – Scientific and Technological R&D Award for Postgraduates
4.Li S, et al. The 13th annual conference of the China Association for Science and Technology (CAST), Sept 22 2011, Tianjin, China (First Prize Award)
5.Li S, Lam V, Hu G, and Li ZH. Distinctions of IIM’s Young Researcher’s Award 2010
Institute of Chinese Medical Sciences
University of Macau
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