Ruibing WANG

Ruibing WANG

Associate Professor, Institute of Chinese Medical Sciences

 

Group Webpage: https://rwang.sklqrcm.um.edu.mo/

Academic Qualifications

  • Ph.D. in Organic Chemistry, Queen’s University, Canada
  • B.Sc. in Chemistry (Gifted Class), Jilin University, China

Teaching

B.Sc. Courses

Modern Drug Discovery (GEST021)

M.Sc. and Ph.D. Courses

CMED7013 Emerging Materials in Clinical Medicine (M.Sc. Course)
CMED7017 Across the Gap between Science and Industry (M.Sc. Course)
CMED8002 Advanced Pharmaceutics (Ph.D. Course)


Research

Research Interests

  • Supramolecular Medicine
    We are interested in supramolecular interactions between macrocyclic molecules (such as cucurbiturils, cyclodextrins, pillararenes and calixarenes) and synthetic/natural drugs, with intentions to explore the beneficial roles of these macrocycles as emerging excipients for enhancing the water solubility, stability, transcellular activity, and ultimately therapeutic efficacy with reduced side effects of guest medicines. In many cases, these macrocycles may act as reversal agents (or antidotes) towards toxic effects of guest drugs. Our collaborators include colleagues here at UM, as well as external scientists from Canada, France, USA, Hong Kong and mainland China.

  • Supramolecular Biomaterials
    We intend to incorporate high potency ingredients (e.g. particularly those of natural products) into stimuli-responsive, supramolecularly self-assembled materials for various biomedical applications such as precision medicine and controlled drug release for targeted therapy. These material matrices include natural polysaccharides, natural and synthetic macrocycles and their derivatives. By placing real-world clinical applications as our study aim, we work closely with scientists and clinicians in the region and around the world.

  • Biomimetic Drug Delivery
    Constantly inspired by Nature and ancient principles of Chinese medicine, we are highly interested in developing biomimetic drug delivery systems, particularly those based on supramolecular assembly, for improved therapeutics in a variety of diseases, such as inflammatory diseases, infections and cancers.

Dr. Ruibing Wang has multidisciplinary background and experience in Supramolecular Chemistry, Nanomaterials, Pharmaceutics, and Radiopharmaceuticals. During his PhD studies at Queen’s University, he was among the earliest group of researchers to look into a group of novel macrocyclic molecules, cucurbiturils, and their supramolecular encapsulation of various guest molecules including drug molecules for stability and water-solubility enhancement. Due to his excellent thesis work, he was nominated for “Governor General Gold Medal” and received “Queen’s University Outstanding Thesis in Physical Sciences”. After graduation with PhD degree and a brief postdoctoral stay at Queen’s, he moved to the Steacie Institute for Molecular Sciences at the National Research Council (NRC) of Canada as a Research Associate (later promoted to Associate Research Officer) for about two years, where he worked on fluorescent quantum dots development and studied their various applications including bioimaging. He subsequently joined BTG International (Canada branch, recently merged by Boston Scientific) as a Senior Scientist, where he had led various innovation and applied research projects around radiopharmaceuticals and interventional medicine development. In late 2014, he joined the University of Macau (UM) as an Assistant Professor in Pharmaceutical Sciences and was promoted to Associate Professor in 2019. His current research interest is mainly focused on supramolecular medicine, supramolecular biomaterials, biomimetic drug delivery systems and molecular imaging. Since joining UM, he has received several prestigious awards including Faculty-Level Academic Award in 2018, Macau Science and Technology Awards (3rd Prize, Natural Science Award) in 2018, Faculty-Level Best Teacher Award in 2019, UM Teaching Excellence Award in 2019, China Macrocyclic Arenes and Supramolecular Chemistry Rising Star Award in 2019, and Chinese Periodic Table of Young Chemist in 2019. So far, he has published about 150 peer-reviewed SCI papers with a total citation of over 3,500 times and an H-index of 33.


Selected Publications

      1. Cheng Gao, Qiaoxian Huang, Conghui Liu, Cheryl H.T Kwong, Ludan Yue, Jian-Bo Wan, Simon M. Y. Lee* and Ruibing Wang (correspondence author),* “Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines,” Nature Communications, 2020, 11, 2622
        Highlighted by Nature Review Cardiology, 2020, https://doi.org/10.1038/s41569-020-0404-x.
      2. Xue Yang, Ruibing Wang (correspondence author),* Anthony Kermagoret,* and David Bardelang,* “Oligomeric Cucurbituril Complexes: from Peculiar Assemblies to Emerging Applications,” Angewandte Chemie, 2020, DOI: 10.1002/anie.202004622, in press.
      3. Chen Sun, Ludan Yue, Qian Cheng, Ziyi Wang and Ruibing Wang (correspondence author),* “Macrocycle-Based Polymer Nanocapsules for Hypoxia-Responsive Payload Delivery,” ACS Materials Letters, 2020, 2, 266-271.
        Featured by X-Mol Platform at https://mp.weixin.qq.com/s/zy4tYTsXy6QAwFwf5uFFRw
      4. Chenwen Li, Yang Zhao, Juan Cheng, Jiawei Guo, Qixiong Zhang, Xiangjun Zhang, Jiong Ren, Fengchao Wang, Jun Huang, Houyuan Hu, Ruibing Wang (correspondence author),* and Jianxiang Zhang*, “A Proresolving Peptide Nanotherapy for Site-Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota,” Advanced Science, 2019, 6, 1900610.
      5. Sébastien Combes, Khoa Truong Tran, Mehmet Menaf Ayhan, Hakim Karoui, Antal Rockenbauer, Alain Tonetto, Valérie Monnier, Laurence Charles, Roselyne Rosas, Stéphane Viel, Didier Siri, Paul Tordo, Sylvain Clair, Ruibing Wang (correspondence author),* David Bardelang,* and Olivier Ouari,* “Triangular regulation of cucurbit[8]uril 1:1 complexes,” Journal of the American Chemical Society, 2019, 141, 5897.
        Featured as a Supplementary Cover Story
      6. Cheng Gao, Qiaoxian Huang, Qingping Lan, Yu Feng, Fan Tang, Maggie P.M. Hoi, Jianxiang Zhang, Simon M. Y. Lee,* and Ruibing Wang (correspondence author),* “A user-friendly herbicide derived from photo-responsive supramolecular vesicles,” Nature Communications, 2018, 9, 2967. Extensive media coverage (e.g. Xinhua News)
        Highlighted
        by X-MOL Platform (Aug. 18, 2018) http://www.x-mol.com/news/13859
      7. Songling Han, Siyu Chen, Lanlan Li, Jin Li, Huijie An, Hui Tao, Yi Jia, Shan Lu, Ruibing Wang (correspondence author),* and Jianxiang Zhang,* “Multiscale and Multifunctional Emulsions by Host-Guest Interaction-Mediated Self-Assembly,” ACS Central Science, 2018, 4, 600.
        Highlighted by Hero Image of the ACS Central Science home page
      8. Linting Li, Min Liu, Ludan Yue, Rui Wang, Ning Zhang, Yujie Liang, Liang Zhang, Lixin Cheng,* Jiang Xia,* and Ruibing Wang (correspondence author),* “Host–Guest Protein Assembly for Affinity Purification of Methyllysine Proteomes,” Analytical Chemistry, 2020, DOI: 10.1021/acs.analchem.0c01643, in press.
      9. Cheng Gao, Cheryl H. T. Kwong, Chen Sun, Zheng Li, Siyu Lu, Ying-Wei Yang,* Simon Ming-Yuen Lee,* and Ruibing Wang (correspondence author),* “Selective Decoating-Induced Activation of Supramolecularly Coated Toxic Nanoparticles for Multiple Applications,” ACS Applied Materials & Interfaces, 2020, 12, 25604–25615.
      10. Lin Qi, Ruibing Wang (correspondence author),* and Hua-Zhong Yu,* “Electrochemical Quantitation of Supramolecular Excipient@Drug Complexation: A General Assay Strategy based on Competitive Host Binding with Surface-Immobilized Redox Guest,” Analytical Chemistry, 2020, 92, 2168.
      11. Ludan Yue, Chen Sun, Cheryl Kwong and Ruibing Wang (correspondence author),* “Cucurbit[7]uril-functionalized Magnetic Nanoparticles for Imaging-guided Cancer Therapy,” Journal of Materials Chemistry B, 2020, 8, 2749-2753. IF: 5.047.
        Featured as a backcover story
      12. Yuanfu Ding, Jianwen Wei, Shengke Li, Yating Pan, Lianhui Wang and Ruibing Wang (correspondence author),* “Host-guest Interactions Initiated Supramolecular Chitosan Nanogels for Selective Intracellular Drug Delivery,” ACS Applied Materials & Interfaces, 2019, 11, 28665.
      13. Chen Sun, Haipeng Zhang, Ludan Yue, Shengke Li, Qian Cheng, and Ruibing Wang (correspondence author),* “Facile preparation of cucurbit[6]uril-based polymer nanocapsules for targeted photodynamic therapy,” ACS Applied Materials & Interfaces, 2019, 11, 22925.
        Highlighted by Polymer Technology Platform at http://www.polymer.cn/sci/kjxw15695.html
      14. Xiangjun Zhang, Qian Cheng, Lanlan Li, Liqing Shangguan, Chenwen Li, Shengke Li, Feihe Huang,* Jianxiang Zhang,* and Ruibing Wang (correspondence author),* “Supramolecular therapeutics to treat the side effects induced by a depolarizing neuromuscular blocking agent,” Theranostics, 2019, 9, 3107.
        Featured on Theranostics Wechat Page
      15. Wen-Chao Geng, Qiaoxian Huang, Zhe Xu, Ruibing Wang (correspondence author),* and Dong-Sheng Guo,* “Gene delivery based on macrocyclic amphiphiles,” Theranostics, 2019, 9, 3094.
      16. Xiangjun Zhang, Xiaoqiu Xu, Shengke Li, Lanlan Li, Jianxiang Zhang,* and Ruibing Wang (correspondence author),* “A synthetic receptor as a specific antidote for paraquat poisoning,” Theranostics, 2019, 9, 633.
        Featured on Theranostics Wechat Page
      17. Tangxin Xiao,*  Lijie Qi,  Weiwei Zhong,  Lin Chen,*   Ruibing Wang (correspondence author),* and  Leyong Wang,  “Stimuli-responsive nanocarriers constructed from pillar[n]arene-based supra-amphiphiles,” Materials Chemistry Frontiers, 2019, 3, 1973.
      18. Qian Cheng, Shengke Li, Chen Sun, Ludan Yue and Ruibing Wang (correspondence author),* “Stimuli-responsive perallyloxycucurbit[6]uril-based nanoparticles for selective drug delivery in melanoma cells,” Materials Chemistry Frontiers, 2019, 3, 199.Featured as an Inside Cover Story
      19. Qian Cheng, Kun-Xu Teng, Yuanfu Ding, Ludan Yue, Qing-Zheng Yang* and Ruibing Wang (correspondence author),* “Dual stimuli-responsive bispillar[5]arene-based nanoparticles for precisely selective drug delivery in cancer cells,” Chemical Communications, 2019, 55, 2340.
      20. Ludan Yue,   Chen Sun,   Qian Cheng,   Yuan-Fu Ding,   Jianwen Wei and Ruibing Wang (correspondence author),* “Gold nanorods with noncovalently tailorable surface for multi-modality image-guided chemo-photothermal cancer therapy,” Chemical Communications, 2019, 55, 13506.
        Invited contribution and Featured as a Front Cover Story
      21. Chen Sun, Haipeng Zhang, Shengke Li, Xiangjun Zhang, Qian Cheng, Yuanfu Ding, Lianhui Wang, Ruibing Wang (correspondence author),* “Polymeric Nanomedicine with “Lego” Surface Allowing Modular Functionalization and Drug Encapsulation,” ACS Applied Materials & Interfaces, 2018, 10, 25090.
      22. Qian Cheng, Hang Yin, Roselyne Rosas, Didier Gigmes, Olivier Ouari, Ruibing Wang (correspondence author),* Anthony Kermagoret* and David Bardelang,* “A pH-driven ring translocation switch against cancer cells,” Chemical Communications, 2018, 54, 13825.
        Featured by CNRS at http://www.inc.cnrs.fr/fr/cnrsinfo/des-machines-moleculaires-contre-le-cancer
      23. Qian Cheng, Hang Yin, Chen Sun, Ludan Yue, Yuanfu Ding, Wim Dehaen* and Ruibing Wang (correspondence author),* ”Glutathione-responsive homodithiacalix[4]arene-based nanoparticles for selective intracellular drug delivery,“ Chemical Communications, 2018, 54, 8128.
        Highlighted by CBG Information
      24. Qiaoxian Huang,# Kit Ieng Kuok,# Xiangjun Zhang,  Ludan Yue, Simon M. Y. Lee, Jianxiang Zhang* and  Ruibing Wang (correspondence author),* “Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor,” Nanoscale, 2018, 10, 10333.
        Featured as a Front Cover Article
      25. Qiaoxian Huang, Shengke Li, Yuan-Fu Ding, Hang Yin, Lian-Hui Wang, and Ruibing Wang (correspondence author),* “Macrocycle-Wrapped Polyethylenimine for Gene Delivery with Reduced Cytotoxicity,” Biomaterials Science, 2018, 6, 1031.
        Featured as an inside Cover Article
      26. Yuan-Fu Ding, Shengke Li, Lijun Liang, Qiaoxian Huang, Lihui Yuwen, Wenjing Yang, Ruibing Wang (correspondence author),* and Lian-Hui Wang,* “Highly Biocompatible Chlorin e6-loaded Chitosan Nanoparticles for Improved Photodynamic Cancer Therapy,” ACS Applied Materials & Interfaces, 2018, 10, 9980.
      27. Songling Han, Huijie An, Hui Tao, Lanlan Li, Yuantong Qi, Yongchang Ma, Xiaohui Li, Ruibing Wang (correspondence author),* and Jianxiang Zhang,* “Advanced emulsions via noncovalent interaction-mediated interfacial self-assembly,” Chemical Communications, 2018, 54, 3174.
      28. Hang Yin, Frédéric Dumur, Yiming Niu, Mehmet Menaf Ayhan, Olivier Grauby, Wei Liu, Chunming Wang, Didier Siri, Roselyne Rosas, Alain Tonetto, Didier Gigmes, Ruibing Wang (correspondence author),* David Bardelang,* and Olivier Ouari,* “A chameleonic dye adapts to various environments shining on macrocycles or peptide and polysaccharide aggregates,” ACS Applied Materials & Interfaces, 2017, 9, 33220.
      29. Cheng Gao, Fan Tang, Guiyi Gong, Jianxiang Zhang, Maggie P.M. Hoi, Simon M.Y. Lee,* and Ruibing Wang (correspondence author),* “pH-responsive prodrug nanoparticles based on a sodium alginate derivative for selective co-release of doxorubicin and curcumin in tumor cells,” Nanoscale, 2017, 9, 12533.
      30. Xue Yang, Shengke Li, Qingwen Zhang, Ying Zheng, David Bardelang, Lianhui Zhang, and Ruibing Wang (correspondence author),* “Concealing the Taste of the Guinness World’s Most Bitter Substance by a Synthetic Nanocontainer,” Nanoscale, 2017, 9, 10606. 

Awards

2019        2018-2019 Top 1% Reviewer in Cross-Fields by Publons
2019         2018-2019 Top 1% Reviewer in Chemistry by Publons
2019         Periodic Table of Chinese Young Chemist (Chinese Chemical Society
2019         China Macrocyclic Arenes and Supramolecular Chemistry Rising Star Award, China
2019         University of Macau Teaching Excellence Award, Macau
2019         Faculty Level Best Teacher Award, University of Macau, Macau
2018         Macau Science and Technology Awards (3rd Prize, Natural Science Award), Macau
2018         Faculty Level Academic Award, University of Macau, Macau
2013         Business Excellerator Stage Award, BTG plc, Ottawa, Canada
2011         Business Excellerator Sprinter Award, Nordion Inc., Ottawa, Canada
2008         Physical Sciences Outstanding Thesis Award at Queen’s, Kingston, Canada
2003-2007   Queen’s Graduate Awards, Kingston, Canada
2005-2006   Graduate Dean’s Doctoral Field Travel Grant at Queen’s, Kingston, Canada
2002         Outstanding Graduate of Jilin University (top 1%), Changchun, China
1998-2002   Excellent Undergraduate Scholarship, Changchun, China
2000-2001   Excellent Student Leader of Jilin University, Changchun, China
2001-2002   Zhanhong Scholarship, Jilin University, Changchun, China
1998-2000   DongRong Scholarship, Jilin University, Changchun, China

Students Awards

2020 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Qian Cheng (MSc Student)

2020 UM Macao Postdoctoral Fellowship (aka “Million Dollar Postdoc”): Cheng Gao (PhD Student)

2018 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Xue Yang (MSc Student)

2018 UM Macao PhD Fellowship (aka “Million Dollar PhD Scholarship”): Qiaoxian Huang (MSc Student)

2016 Macao SAR Science and Technology Awards – Scientific and Technological R&D Awards for Postgraduate Students: Huanxian Chen (MSc Student)

2016/2017 Macao SAR Government MSc Student Scholarship: Jess Kuok (MSc Student)


Professional Affiliation

Founding Member and Vice President, Macau Society of Nuclear Medicine and Molecular Imaging (MSNMMI), since 2016

Council Member, the 1st Board of Specialty Committee of TCM Network Pharmacology of World Federation of Chinese Medicine Societies, since 2015

Council Member, the 3rd Board of Specialty Committee of TCM Pharmaceutics of World Federation of Chinese Medicine Societies, since 2018

Member, Chinese Chemical Society

Member, International Society for Chinese Medicine

Member, International Society of Quality Research of Chinese Medicine

Member, Macao Society for Promotion of Science and Technology


Professional Community Service

Member of Editorial Advisory Board, ACS Applied Biomaterials, Jan. 2020-Present

Editor, Journal of Nanomaterials, February 2012-Present

Editor, Chinese Journal of Chemical Education (Chinese Core journal), Jan 2017-Present

Member of Youth Editorial Board, Chinese Chemical Letters, Jan. 2019-Present

Grant Reviewer for National Science Foundation of China (NSFC), French National Research Agency (ANR) and Czech Science Foundation (GACR)


Contact Details

N22-8009
Institute of Chinese Medical Sciences
SKL of Quality Research in Chinese Medicine
University of Macau, N22
Avenida da Universidade, Taipa, Macau
Email: rwang@um.edu.mo
Tel: +853-8822-4689
Group Webpage: https://rwang.sklqrcm.um.edu.mo/