Chon Kit CHOU 曹俊傑

 

Chon Kit CHOU 曹俊傑
Lecturer (Macau Fellow), Institute of Chinese Medical Sciences, University of Macau
Currently pursuing his 2-year academic training in Radboudumc, Radboud University Medical Center, Nijmegen, Netherlands

Academic Qualifications

  • 2018: PhD Graduate Institute of Natural Products, Kao Hsiung Medical University, Kao Hsiung, Taiwan
  • 2013: MSc Department of Biotechnology, Kao Hsiung Medical University, Kao Hsiung, Taiwan

Research

Current research focuses on studying the long-term memory effects of trained immunity and the following research topics:

(1) Understanding the molecular mechanisms by which ubiquitination contributes to cancer and autoimmune diseases.

(2) Discovery and characterization of bioactive compounds from traditional Chinese medicine (TCM) with anticancer and anti-inflammatory effects.


First Author Publications

  1. Chon-Kit Chou, Xin Chen*. “Preferential Expansion of CD4+Foxp3+ Regulatory T Cells (Tregs) In Vitro by Tumor Necrosis Factor” Methods in Molecular Biology (Accepted).
  2. Chon-Kit Chou, Hurng-Wern Huang, Chun-Feng Yang, Hans-Uwe Dahms, Shih-Shin Liang, Tsu-Nai Wang, Po-Lin Kuo, Edward Hsi, Eing-Mei Tsai*, Chien-Chih Chiu*. “Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes” Environmental Toxicology. 2019 Feb 5; 34(4):401-414.
  3. Chon-Kit Chou, Wangta Liu, Yu-Jie Hong, Hans-Uwe Dahms, Chen-Hao Chiu, Wen-Tsan Chang, Ching-Ming Chien, Chia-Hung Yen, Yuan-Bin Cheng*, Chien-Chih Chiu*. “Ethyl acetate extract of Scindapsus hederaceus exerts the inhibitory bioactivity on human non-small cell lung cancer cells through modulating ER stress” International Journal of Molecular Sciences. 2018 Jun 21; 19(7):1832.
  4. Chon-Kit Chou, Ya-Ting Yang, Ho-Chun Yang, Shih-Shin Liang, Tsu-Nai Wang, Po-Lin Kuo, Hui-Min David Wang, Eing-Mei Tsai*, Chien-Chih Chiu*. “The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression” Archivum Immunologiae et Therapiae Experimentalis. 2017 Dec 5; 66(3):183-197.
  5. Chon-Kit Chou, Chin-Ju Tang, Han-Lin Chou, Chun-Yen Liu, Ming-Chong Ng, Yu-Ting Chang, Shyng-Shiou F. Yuan, Eing-Mei Tsai, Chien-Chih Chiu*. “The Potential Role of Krüppel-Like Zinc-Finger Protein Glis3 in Genetic Diseases and Cancers” Archivum Immunologiae et Therapiae Experimentalis. 2017 May 18; 65(5):381-389.
  6. Chon-Kit Chou, Yu-Ting Chang , Michal Korinek, Yei-Tsung Chen, Ya-Ting Yang, Steve Leu, I-Ling Lin, Chin-Ju Tang, Chien-Chih Chiu*. “The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases” International Journal of Molecular Sciences. 2017 Feb 24; 18(3):483.
  7. Chou-Kit Chou, Chang-Yi Wu, Jeff Yi-Fu Chen, Ming-Chong Ng, Hui-Min David Wang, Jen-Hao Chen, Shyng-Shiou F. Yuan, Eing-Mei Tsai, Jan-Gowth Chang, Chien-Chih Chiu*. “BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9” International Journal of Molecular Sciences. 2015 Jul 3; 16(7):15104-15117.

 

Co-authored Publications

  1. Ruixin Li, Shaokui Chen, Yibo Chen, Chon-Kit Chou, Xin Chen*. “Scutellarin inhibits TNF-induced proliferative expansion of tumor associated TNFR2-expressing CD4+Foxp3+ regulatory T cells” Cancer Letters (under review).
  2. Sheng-Kai Hsu, Chien-Chih Chiu, Hans-Uwe Dahms, Chon-Kit Chou, Chih-Mei Chen, Wen-Tsan Chang, Kai-Chun Cheng, Hui-Min David Wang, I-Ling Lin*. “Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells” International Journal of Molecular Sciences.2019 May 22, 20(10), 2518.
  3. Yen-Chung Huang, Jebiti Haribabu, Ching-Ming Chien, Gopal Sabapathi, Chon-Kit Chou, Ramasamy Karvembu, Ponnambalam Venuvanalingam, Wei-Min Ching, Ming-Li Tsai, Sodio C.N. Hsu*. “Half-sandwich Ru(η6-p-cymene) complexes featuring pyrazole appended ligands: Synthesis, DNA binding and in vitro cytotoxicity” Journal of Inorganic Biochemistry. 2019 May; 194: 74-84.
  4. Ching-Ming Chien, Juan-Cheng Yang, Pin-Hsuan Wu, Chang-Yi Wu, Guan-Yu Chen, Yang-Chang Wu, Chon-Kit Chou, Chih-Hua Tseng, Yeh-Long Chen, Li-Fang Wang*, Chien-Chih Chiu*. “Phytochemical naphtho[1,2-b] furan-4,5‑dione induced topoisomerase IImediated DNA damage response in human non-small-cell lung cancer” Phytomedicine. 2019 June 15; 54:109-119.
  5. Wen-Tsan Chang, Wangta Liu, Yi-Han Chiu, Bing-Hung Chen, Shih-Chang Chuang, Yen-Chun Chen, Yun-Tzh Hsu, Mei-Jei Lu, Shean-Jaw Chiou, Chon-Kit Chou and Chien-Chih Chiu*. “A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression” Molecules. 2017 May 21; 22(5).
  6. Michal Korinek, Kuan-Ming Chen, Yu-Han Jiang,Mohamed El-Shazly, Joel Stocker, Chon-Kit Chou, Tsong-Long Hwang, Yang-Chang Wu, Bing-Hung Chen*, Fang-Rong Chang*. “Anti-allergic potential of Typhonium blumei: Inhibition of degranulation via suppression of PI3K/PLCγ2 phosphorylation and calcium influx” Phytomedicine. 2016 Dec 15; 23(14):1706-1715.
  7. Hueiwang Anna Jeng*, Chih-Hong Pan, Mu-Rong Chao, Chien-Chih Chiu, Guodong Zhou, Chon-Kit Chou, Wen-Yi Lin. “Sperm quality and DNA integrity of coke oven workers exposed to polycyclic aromatic hydrocarbons” Int J Occup Med Environ Health. 2016 Nov 18; 29(6):915-926.
  8. Wen-Tsan Chang,Yao Fong, Shih-Chang Chuang, Chon-Kit Chou, Han-Lin Chou, Chun-Feng Yang, Chih-Hua Tseng, Yeh-Long Chen, Chien-Chih Chiu*. “9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1,2-c]quinolin-11-one (BPIQ), a quinoline derivative inhibits human hepatocellular carcinoma cells by inducing ER stress and apoptosis” Anticancer Agents Med Chem. 2016 Aug 2;17(5): 692-700.
  9. Chih-Hua Tseng,You-Ren Chen, Cherng-Chyi Tzeng, Wangta Liu, Chon-Kit Chou, Chien-Chih Chiu*, Yeh-Long Chen*. “Discovery of indeno[1,2-b]quinoxaline derivatives as potential anticancer agents” Eur J Med Chem. 2016 Jan 27; 108:258-73.
  10. Chih-Hua Tseng,Cherng-Chyi Tzeng, Chien-Chih Chiu, Chih-Yao Hsu, Chon-Kit Chou, Yeh-Long Chen*. “Discovery of 2-[2-(5-nitrofuran-2-yl)vinyl]quinoline derivatives as a novel type of antimetastatic agents” Bioorg Med Chem. 2015 Jan 1; 23(1):141-8.
  11. Ching-Yu Yen, Shih-Shin Liang, Lo-Yi Han, Han-Lin Chou, Chon-Kit Chou,Shinne-Ren Lin, and Chien-Chih Chiu*. “Cardiotoxin III inhibits proliferation and migration of oral cancer cells through MAPK and MMP signaling” 2013 Apr 8; 2013:650946.
  12. Chien-Chih Chiu, Jo-Wen Haung, Fang-Rong Chang, Kuang-Jing Huang, Hsuan-Min Huang, Hurng-Wern Huang, Chon-Kit Chou, Yang-Chang Wu*, Hsueh-Wei Chang*. “Golden Berry-Derived 4β-hydroxywithanolide E for Selectively Killing Oral Cancer Cells by Generating ROS, DNA Damage, and Apoptotic Pathways” PLoS One. 2013 May 21; 8(5):e64739.
  13. Chien-Chih Chiu,Po-Len Liu, Kuang-Jing Huang, Hui-Min Wang, Kuo-Feng Chang, Chon-Kit Chou, Fang-Rong Chang, Inn-Wen Chong, Kang Fang, Jia-Shing Chen, Hsueh-Wei Chang*, and Yang-Chang Wu*. “Goniothalamin inhibits growth of human lung cancer cells through DNA damage, apoptosis, and reduced migration ability” J Agric Food Chem. 2011 Apr 27; 59(8):4288-93.

Contact Details

Institute of Chinese Medical Sciences
University of Macau
Macao, China

Room 1033, N22 Research Building
Telephone: (853) 8822-8539
E-mail: ckchou@um.edu.mo